Article
Chemistry, Organic
Blaise Kimbadi Lombe, Lea Winand, Jan Diettrich, Melanie Tobermann, Wolf Hiller, Marcel Kaiser, Markus Nett
Summary: In this study, we report the discovery of massinidine, an aguanidine alkaloid with antiplasmodial activity, from bacteria of the genus Massilia. The biosynthetic genes of massinidine were identified and validated through heterologous expression. Bioinformatic analysis reveals the widespread potential for massinidine biosynthesis in various proteobacteria.
Review
Pharmacology & Pharmacy
Amelia Palermo
Summary: Metabolomics enables the analysis of metabolites and lipids in biological systems, and can guide the discovery of lead compounds from natural sources. In combination with other omics, metabolomics can elucidate compound toxicity and mode of action. This article discusses the workflows, limitations, and future opportunities of metabolomics and big data in streamlining pharmaceutical discovery and development.
DRUG DISCOVERY TODAY
(2023)
Review
Chemistry, Medicinal
Aitor Carneiro, Eugenio Uriarte, Fernanda Borges, Maria Joao Matos
Summary: Propargylamine is widely used in medicinal chemistry and chemical biology due to its unique reactivity. This review discusses the applications and potential of propargylamine-based compounds in drug discovery, highlighting their impact in various therapeutic fields.
FUTURE MEDICINAL CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Shan-Ju Yeh, Ming-Hsun Chung, Bor-Sen Chen
Summary: Alzheimer's disease (AD) is characterized by progressive cognitive decline and neurodegenerative disorder, with unclear molecular mechanisms. Research on candidate genetic and epigenetic networks (GEN) aims to identify potential biomarkers for drug targets in AD treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
News Item
Multidisciplinary Sciences
Carrie Arnold
Summary: There are lingering questions regarding the ability of AI tools to truly disrupt the pharmaceutical industry.
Review
Biochemistry & Molecular Biology
Rachel E. Williams, Karen Mruk
Summary: Epilepsy is a major global health concern, and the search for new drug therapies is crucial. Aquatic vertebrates, such as zebrafish and African clawed frogs, have become popular models for seizure research due to their cost-effectiveness, genetic similarities to humans, and ease of drug dosing. Previous studies using these models have produced promising data and raised further questions for understanding drug-resistant seizures and developing effective treatments.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Chemistry, Multidisciplinary
Marcelo D. T. Torres, Jicong Cao, Octavio L. Franco, Timothy K. Lu, Cesar de la Fuente-Nunez
Summary: Antibiotic resistance poses a significant global health challenge, with the need for innovative strategies becoming more urgent. Antimicrobial peptides (AMPs) offer a natural template for the discovery, design, and production of antibiotics, potentially leading the way for future advancements in peptide drug discovery through computational and synthetic biology approaches.
Review
Microbiology
Gary Liu, Jonathan M. Stokes
Summary: This short review discusses the utility of machine-learning and deep-learning approaches in antibiotic discovery, calls for the sharing of high-quality screening datasets, and aims to facilitate the wider adoption of these computational methods.
CURRENT OPINION IN MICROBIOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Shivkanya Fuloria, Mahendran Sekar, Farrah Syazana Khattulanuar, Siew Hua Gan, Nur Najihah Izzati Mat Rani, Subban Ravi, Vetriselvan Subramaniyan, Srikanth Jeyabalan, M. Yasmin Begum, Kumarappan Chidambaram, Kathiresan Sathasivam, Sher Zaman Safi, Yuan Seng Wu, Rusli Nordin, Mohammad Nazmul Hasan Maziz, Vinoth Kumarasamy, Pei Teng Lum, Neeraj Kumar Fuloria
Summary: Viniferin, a derivative of resveratrol, exhibits a range of important biological activities and has potential applications in clinical research and future drug development. It can be the most effective nutritional supplement and supplementary medication, especially as a therapeutic approach.
Article
Biotechnology & Applied Microbiology
Fabien Vincent, Arsenio Nueda, Jonathan Lee, Monica Schenone, Marco Prunotto, Mark Mercola
Summary: Phenotypic drug discovery has re-emerged as a systematic approach to drug discovery based on therapeutic effects in realistic disease models. This article discusses recent successes with this approach and explores ongoing challenges and strategies to address them.
NATURE REVIEWS DRUG DISCOVERY
(2022)
Review
Chemistry, Multidisciplinary
Jiang Hong Cai, Xuan Zhe Zhu, Peng Yue Guo, Peter Rose, Xiao Tong Liu, Xia Liu, Yi Zhun Zhu
Summary: Drug discovery is a challenging process with a high failure rate. Click chemistry and computer-aided drug design (CADD) have emerged as promising approaches for new drug development. This review summarizes the recent advancements in click and computational chemistry, including efficient synthesis of drug candidates, modification of natural products, targeted delivery systems, and computer-aided drug discovery for target identification and compound optimization. These advancements provide inspiration for novel drug development in the future.
FRONTIERS IN CHEMISTRY
(2023)
Article
Medicine, General & Internal
Cheng Zhang, Mengnan Shi, Woonghee Kim, Muhammad Arif, Martina Klevstig, Xiangyu Li, Hong Yang, Cemil Bayram, Ismail Bolat, Ozlem Ozdemir Tozlu, Jihad Sebhaoui, Shazia Iqbal, Yongjun Wei, Xiaojing Shi, Jens Nielsen, Hasan Turkez, Mathias Uhlen, Jan Boren, Adil Mardinoglu, Ahmet Haamuftuoglu, Serkan Yildtrim
Summary: This study investigated the effect of PKLR in an NAFLD model and identified two potential drug candidates through drug repositioning. These candidates showed significant inhibition of PKLR expression and triglyceride levels in in vitro models, and were also effective in reducing hepatic steatosis in in vivo rat models.
Review
Multidisciplinary Sciences
Surat Parvatam, Sham Bharadwaj
Summary: This article reviews the use of systems and computational tools in the drug discovery pipeline and describes the importance of data integration in systems biology. The article also analyzes global and local funding patterns, regulations, and challenges, and proposes recommendations to make India a key player in this field.
Article
Computer Science, Information Systems
Shanghao Shi, Yang Xiao, Wenjing Lou, Chonggang Wang, Xu Li, Y. Thomas Hou, Jeffrey H. Reed
Summary: The article discusses the spectrum access system (SAS) as a key component of spectrum sharing paradigm and emphasizes the importance of ensuring security and privacy against potential attacks. It introduces the SAS system, its three-tier access model, functional architecture, and spectrum management protocol, while providing a comprehensive analysis of security and privacy attacks with corresponding countermeasures. Future research directions are suggested focusing on SAS server, device, environment sensing, and communication protocol security.
IEEE INTERNET OF THINGS JOURNAL
(2021)
Article
Chemistry, Medicinal
Junping Pei, Guan Wang, Lu Feng, Jifa Zhang, Tingting Jiang, Qiu Sun, Liang Ouyang
Summary: This article discusses strategies targeting lysosomal pathways and lysosome-based degradation techniques, as well as the advantages and challenges of lysosome-based degrading drugs. These tools can directly regulate protein levels in vivo and provide new strategies for treating diseases.
JOURNAL OF MEDICINAL CHEMISTRY
(2021)