Article
Chemistry, Medicinal
Yu-Xin Lin, Jin-Tao Sun, Zheng-Zheng Liao, Yan Sun, Xiang-Ge Tian, Ling-Ling Jin, Chao Wang, Ai-Jing Leng, Jian Zhou, Da-Wei Li
Summary: Four new lanostane triterpenoids were isolated from the fruiting bodies of Ganoderma lucidum, which showed potential application for anti-neuroinflammation by inhibiting the activity of FAAH without cytotoxicity.
Article
Plant Sciences
Panida Chinthanom, Vanicha Vichai, Pranee Rachtawee, Thitiya Boonpratuang, Masahiko Isaka
Summary: Investigation of cultivated fruiting bodies of Ganoderma weberianum led to the discovery of 11 previously unreported lanostane dimers and several new derivatives. Ganoweberianone D (4a) and isoganoweberianone D (4b) exhibited significant antimalarial activity.
JOURNAL OF NATURAL PRODUCTS
(2023)
Article
Biochemistry & Molecular Biology
Li Yang, De-Xian Kong, Na Xiao, Qing-Yun Ma, Qing-Yi Xie, Jiao-Cen Guo, Chun Ying Deng, Hai-Xia Ma, Yan Hua, Hao-Fu Dai, You-Xing Zhao
Summary: Eight new lanostane triterpenoids, along with eighteen known compounds, were isolated from Ganoderma weberianum. The structures and configurations of the new compounds were determined through spectroscopic analysis, NMR chemical shifts, and ECD calculations. Some of the isolated compounds showed significant alpha-glucosidase inhibitory activity, inhibition of hepatic glucose production, and antitumor activity against HeLa cells.
BIOORGANIC CHEMISTRY
(2022)
Article
Chemistry, Applied
Shayane da Silva Milhorini, Daniel de Lima Bellan, Matheus Zavadinack, Fernanda Fogagnoli Simas, Fhernanda Ribeiro Smiderle, Arquimedes Paixa de Santana-Filho, Guilherme Lanzi Sassaki, Marcello Iacomini
Summary: In this study, a fucoxylomannan (FXM) was isolated from Ganoderma lucidum mushroom, which exhibited anti-proliferative effects on melanoma cells, including reduction in cell viability, cell density, and anchorage-independent clonogenic capacity. However, no impact on non-tumoral cells was observed.
CARBOHYDRATE POLYMERS
(2022)
Article
Biochemistry & Molecular Biology
Arunrat Yangchum, Ryoma Fujii, Wilunda Choowong, Pranee Rachtawee, Maneerat Pobkwamsuk, Thitiya Boonpratuang, Seiji Mori, Masahiko Isaka
Summary: In the search for medicinally active compounds in Ganoderma mushrooms, eleven previously undescribed lanostane triterpenoids were isolated, including a novel chlorinated derivative. Two of these compounds exhibited moderate antimalarial activity.
Article
Chemistry, Multidisciplinary
Qosimjon Khalilov, Sodik Numonov, Parviz Sukhrobov, Khayrulla Bobakulov, Farukh Sharopov, Madina Habasi, Jiangyu Zhao, Tao Yuan, Haji Akber Aisa
Summary: Laetiporus sulphureus is a medicinal mushroom with diverse pharmacological activities. Four new triterpenoids and twelve known analogues were isolated from the mushroom. The isolated compounds showed strong anti-inflammatory activity.
Article
Biochemistry & Molecular Biology
Da-Wei Li, Min Liu, Yue-Qi Leng, Jin-Fang Hu, Sa Deng, Ai-Jing Leng, Xiao-Chi Ma, Ruo-Yu Wang, Jian Zhou, Chao Wang
Summary: This study investigated the bioactive phytochemicals in Ganoderma lucidum and found that its triterpenoids showed inhibitory effects on the enzyme FAAH, indicating their potential for treating neuroinflammation.
Article
Biochemistry & Molecular Biology
Jiao-Cen Guo, Li Yang, Qing-Yun Ma, Ya-Zhe Ge, Fan-Dong Kong, Li-Man Zhou, Fei Zhang, Qing-Yi Xie, Zhi-Fang Yu, Hao-Fu Dai, You-Xing Zhao
Summary: This study isolated ten new compounds from the fruiting bodies of Ganoderma australe, including seven undescribed lostane-type triterpenoids and one polyhydroxylated sterol. These new compounds showed significant a-glucosidase inhibitory activities and one exhibited weak cytotoxicity against cancer cells.
BIOORGANIC CHEMISTRY
(2021)
Article
Plant Sciences
Qian Xu, Chen-Yi Sheng
Summary: Three new lanostane triterpenoids were isolated from Ganoderma hainanense and their structures were elucidated using spectral methods. Compound 3 showed significant cytotoxic activities against breast cancer cell lines.
JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH
(2023)
Article
Chemistry, Applied
Xiu-run Huang, Fang Cai, Jing Chen, Chang-hui Wu, Ye Li, Jian-hua Xu, Peng Li
Summary: A new lanostane-type triterpene, 3-oxo-5 alpha-lanosta-7,9(11)-dien-24-oic acid methyl ester (2), and three known compounds were isolated from the fruiting bodies of Ganoderma lucidum. The cytotoxic activity of these compounds against cancer cell lines was evaluated, and it was found that compound 1 exhibited strong cytotoxicity against SK-Hep-1, HepG2, and Hela cells, while compound 4 showed moderate cytotoxicity against Hela and Hela/VCR cells.
NATURAL PRODUCT RESEARCH
(2023)
Article
Chemistry, Applied
Arunrat Yangchum, Pranee Rachtawee, Kitlada Srichomthong, Rattaket Choeyklin, Thitiya Boonpratuang, Chawanee Thongpanchang, Masahiko Isaka
Summary: Chemical investigation of artificially cultivated fruiting bodies of Ganoderma cf. mastoporum, strain TBRC-BCC 47851, led to the discovery of three undescribed lanostane triterpenoids (1-3) and twelve known compounds. The structures of these new compounds were determined through NMR spectroscopy and mass spectrometry. However, the new compounds showed no activity in the antimalarial and antitubercular assays.
NATURAL PRODUCT RESEARCH
(2023)
Article
Plant Sciences
Jing-Xia Shi, Guo-Yu Chen, Qian Sun, Shi-Yang Meng, Wei-Qun Chi
Summary: A chemical study of the 90% EtOH extract from the fruiting bodies of Ganoderma applanatum led to the isolation of three new lanostane triterpenoids, which were evaluated for their antimicrobial activities against six pathogenic microorganisms. Compounds 1 and 2 showed some activities against three Gram positive bacteria with MIC values less than 60 μg/ml.
JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH
(2022)
Article
Chemistry, Applied
Dawei Li, Yueqi Leng, Zhengzheng Liao, Jinfang Hu, Yan Sun, Sa Deng, Chao Wang, Xiangge Tian, Jian Zhou, Ruoyu Wang
Summary: Two new nor-triterpenoids, ganodrenol A and B, and a new natural product, ganodrenol C, along with three known nor-triterpenoids, were isolated from the fruiting bodies of Ganoderma lucidum. The chemical structures of these compounds were determined by various analytical techniques. Compound 4 showed strong inhibition against FAAH, but exhibited no significant cytotoxicity.
NATURAL PRODUCT RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Xueqing Zhang, Xiaoxu Gao, Guoqing Long, Yongcheng Yang, Gang Chen, Guoli Hou, Xuting Huo, Jingming Jia, Anhua Wang, Gaosheng Hu
Summary: This study isolated and identified 10 undescribed lanostane triterpenoids and 21 known compounds from statically cultured mycelial mat of G. lucidum. The hepatoprotective activities of these compounds in H2O2-induced HepG2 cells were evaluated, and the structure-activity relationship was discussed.
Article
Biochemistry & Molecular Biology
Li Yang, Ting-Ting Zhang, Qing-Yun Ma, Qing-Yi Xie, Jiao-Cen Guo, Jia-Ju Lu, Zhi-Fang Yu, Hao-Fu Dai, You-Xing Zhao
Summary: Twelve previously undescribed and four known lanostane triterpenoids were isolated from Ganoderma calidophilum. Compound 4 showed significant inhibitory activity against human leukaemia, gastric cancer, and cervical cancer cell lines. Compound 16 exhibited inhibitory potency against protein tyrosine phosphatase 1B and alpha-glucosidase.
