Journal
CHEMISTRY & BIODIVERSITY
Volume 10, Issue 7, Pages 1185-1192Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/cbdv.201200175
Keywords
Fungi; Antimicrobial activity; Penicillium purpurogenum; Purpurides B and C; Sesquiterpenes
Funding
- NSFC [21002094, 21172204]
- 973 program of China [2010CB833804]
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Purpurides B and C (1 and 2, resp.), two new sesquiterpene alcohol esters generated from a drimane-type sesquiterpenoid lactone and an amino acid, together with two known analogs, berkedrimane B (3) and purpuride (4), were isolated from the aciduric fungus Penicillium purpurogenum JS03-21. Their structures were elucidated by spectroscopic analysis, X-ray single-crystal diffraction, and application of Marfey's method. Compounds 1-4 showed modest antifungal activities against Candida albicans with MIC values in the range of 1.2-3.3M. Compounds 1 and 2 showed moderate antimicrobial activities against Enterobacter aerogenes and Pseudomonas aeruginosa with MIC values in the range of 1.2-2.6M.
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