Journal
CHEMISTRY & BIODIVERSITY
Volume 9, Issue 1, Pages 162-169Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/cbdv.201100049
Keywords
Flavonoids; 5; 7-dihydroxy-; Antidiabetic activity
Funding
- National Nature Science Foundation of China [30772635]
Ask authors/readers for more resources
In a study to evaluate the structural elements essential for the antidiabetic activity of flavonoids, we synthesized two series of flavonoids, 5,7-dihydroxyflavanones and 5,7-dihydroxyflavones. In a screening for potential antidiabetic activity, most of the flavonoids showed a remarkable in vitro activity, and compounds 1f, 2d, and 3c were significantly more effective than the positive control, metformin. The biological activity was mainly affected by structural modification at the ring B moiety of the flavonoid skeleton. The results suggest that 5,7-dihydroxyflavonoids can be considered as promising candidates in the development of new antidiabetic lead compounds.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available