Chemistry and Structural Biology of DNA Damage and Biological Consequences

Crystal Structure of a Replicative DNA Polymerase Bound to the Oxidized Guanine Lesion Guanidinohydantoin ,

(2010) Pierre Aller et al.   BIOCHEMISTRY

DNA Oligomers Containing Site-Specific and Stereospecific Exocyclic Deoxyadenosine Adducts of 1,2,3,4-Diepoxybutane: Synthesis, Characterization, and Effects on DNA Structure

(2010) Uthpala Seneviratne et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Mechanism of error-free and semitargeted mutagenic bypass of an aromatic amine lesion by Y-family polymerase Dpo4

(2010) Olga Rechkoblit et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structural and Functional Analysis ofSulfolobus solfataricusY-Family DNA Polymerase Dpo4-Catalyzed Bypass of the Malondialdehyde−Deoxyguanosine Adduct,

(2009) Robert L. Eoff et al.   BIOCHEMISTRY

Thecis-(5R,6S)-Thymine Glycol Lesion Occupies the Wobble Position When Mismatched with Deoxyguanosine in DNA

(2009) Kyle L. Brown et al.   BIOCHEMISTRY

Differential Base Stacking Interactions Induced by Trimethylene Interstrand DNA Cross-Links in the 5′-CpG-3′ and 5′-GpC-3′ Sequence Contexts

(2009) Hai Huang et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Exocyclic Deoxyadenosine Adducts of 1,2,3,4-Diepoxybutane: Synthesis, Structural Elucidation, and Mechanistic Studies

(2009) Uthpala Seneviratne et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Structural Perturbations Induced by the α-Anomer of the Aflatoxin B1Formamidopyrimidine Adduct in Duplex and Single-Strand DNA

(2009) Kyle L. Brown et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Stereospecific Formation of the (R)-γ-Hydroxytrimethylene InterstrandN2-dG:N2-dG Cross-Link Arising from the γ-OH-1,N2-Propano-2′-deoxyguanosine Adduct in the 5′-CpG-3′ DNA Sequence

(2009) Hai Huang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Solution structure of DNA containing α-OH-PdG: the mutagenic adduct produced by acrolein

(2009) Tanya Zaliznyak et al.   NUCLEIC ACIDS RESEARCH

Binding of the human nucleotide excision repair proteins XPA and XPC/HR23B to the 5 R -thymine glycol lesion and structure of the cis -(5 R ,6 S ) thymine glycol epimer in the 5′-GTgG-3′ sequence: destabilization of two base pairs at the lesion site

(2009) Kyle L. Brown et al.   NUCLEIC ACIDS RESEARCH

Impact of Conformational Heterogeneity of OxoG Lesions and Their Pairing Partners on Bypass Fidelity by Y Family Polymerases

(2009) Olga Rechkoblit et al.   STRUCTURE

Insertion of dNTPs Opposite the 1,N2-Propanodeoxyguanosine Adduct bySulfolobus solfataricusP2 DNA Polymerase IV†‡

(2008) Yazhen Wang et al.   BIOCHEMISTRY

Solution Structure of Duplex DNA Containing the Mutagenic Lesion 1,N2-Etheno-2′-deoxyguanine†‡

(2008) Tanya Zaliznyak et al.   BIOCHEMISTRY

The Stereochemistry oftrans-4-Hydroxynonenal-Derived Exocyclic 1,N2-2′-Deoxyguanosine Adducts Modulates Formation of Interstrand Cross-Links in the 5′-CpG-3′ Sequence†

(2008) Hai Huang et al.   BIOCHEMISTRY

Structure of the 1,N2-Ethenodeoxyguanosine Adduct Opposite Cytosine in Duplex DNA: Hoogsteen Base Pairing at pH 5.2†

(2008) Ganesh Shanmugam et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Conformational Properties of Equilenin−DNA Adducts: Stereoisomer and Base Effects

(2008) Shuang Ding et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Conformational Interconversion of thetrans-4-Hydroxynonenal-Derived (6S,8R,11S) 1,N2-Deoxyguanosine Adduct When Mismatched with Deoxyadenosine in DNA

(2008) Hai Huang et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Base Excision Repair and its Role in Maintaining Genome Stability

(2008) Joke Baute et al.   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

Differential Nucleotide Excision Repair Susceptibility of Bulky DNA Adducts in Different Sequence Contexts: Hierarchies of Recognition Signals

(2008) Yuqin Cai et al.   JOURNAL OF MOLECULAR BIOLOGY

Rearrangement of the (6S,8R,11S) and (6R,8S,11R) Exocyclic 1,N2-Deoxyguanosine Adducts oftrans-4-Hydroxynonenal toN2-Deoxyguanosine Cyclic Hemiacetal Adducts When Placed Complementary to Cytosine in Duplex DNA

(2008) Hai Huang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Interconversion of thecis-5R,6S- andtrans-5R,6R-Thymine Glycol Lesions in Duplex DNA

(2008) Kyle L. Brown et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Protein-Template-Directed Synthesis across an Acrolein-Derived DNA Adduct by Yeast Rev1 DNA Polymerase

(2008) Deepak T. Nair et al.   STRUCTURE

Biological Properties of Single Chemical−DNA Adducts: A Twenty Year Perspective

(2007) James C. Delaney et al.   CHEMICAL RESEARCH IN TOXICOLOGY

DNA Adduct Structure–Function Relationships: Comparing Solution with Polymerase Structures

(2007) Suse Broyde et al.   CHEMICAL RESEARCH IN TOXICOLOGY