Journal
CHEMISTRY & BIODIVERSITY
Volume 8, Issue 10, Pages 1901-1907Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/cbdv.201000237
Keywords
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Funding
- China Medical University [CMU98-CT-05]
- Taiwan Department of Health Clinical Trial and Research Center of Excellence [DOH99-TD-B-111-004]
- Cancer Research Center of Excellence [DOH99-TD-C-111-005]
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Calocetriol (1), diacetylcalocediol (2), and ferrugimenthenol (3) were isolated from the bark of Calocedrus macrolepis var. formosana. Among them, 1 and 2 are secoabietane-type diterpenoids, and 3, with a novel C-20-C-10 skeleton, is classified as a meroterpenoid. The structures of 1-3 were elucidated by spectroscopic analyses, and their biological activities were also evaluated. Compound 3 exhibited significant cytotoxic activity against human oral epidermoid carcinoma KB cells with an IC50 value of 9.0 +/- 0.1 mu M.
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