Journal
CHEMISTRY & BIODIVERSITY
Volume 8, Issue 11, Pages 2104-2109Publisher
WILEY-BLACKWELL
DOI: 10.1002/cbdv.201000243
Keywords
Delphinium honanense; Diterpene alkaloids; Alkaloids; Honatisine; Cytotoxic activity
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A novel diterpene alkaloid named honatisine (1) has been isolated from the whole plants of Delphinium honanense, along with six known alkaloids, siwanine E (2), isoatisine (3), atisine (4), delcorinine (5), uraphine (6), and nordhagenine A (7). Their structures were deduced on the basis of their spectral data. All of them were evaluated by a SRB assay for their cytotoxicity, and compound 1 showed a significant cytotoxic activity (IC50=3.16 mu M) against the MCF-7 cell line.
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