Article
Chemistry, Applied
Wei-ming Huang, Fang-you Chen, Yu-ting Bian, Tian-jiao Ning, Zhi-chao Chen, Peng-cheng Shuang, Yong-ming Luo
Summary: Phytochemical investigation on Chloranthus multistachys Pei led to the discovery of three pairs of new sesquiterpene enantiomers, whose structures and configurations were determined by various techniques. However, these compounds did not show anti-inflammatory activity according to the evaluation using the RAW 264.7 macrophage inflammatory model.
NATURAL PRODUCT RESEARCH
(2022)
Article
Chemistry, Medicinal
Xiang-xiang Bian, Xuan Zhao, Shan-shan Liu, Lan Wu, Xiu-wen Yin, Chuan-pu Shen
Summary: Chloranthus fortunei is a widely distributed perennial herb in south China with anti-inflammatory properties. Five previously unreported compounds were isolated from the plant, with compound 1 showing therapeutic potential for ameliorating acute lung injury.
Article
Chemistry, Multidisciplinary
Rong Lin, Ronghao Sun, Ting Xiao, Suyu Pei, Qiang Zhang, Yexin Cheng, Xiaowei Guo, Zhongyi Yang, Xiaoting Gu, Fubo Zhang, Chunfeng Xie, Cheng Yang
Summary: A new phenylpropenol ester and three new lindenane sesquiterpenes were isolated from Chloranthus japonicus, and one of the compounds showed moderate efficacy in inhibiting cell migration and vasculogenic mimicry in human hepatocarcinoma cells, possibly by altering protein expression and restraining epithelial-mesenchymal transition.
ARABIAN JOURNAL OF CHEMISTRY
(2022)
Article
Plant Sciences
Qian Yang, An Jia, Xizi Liu, Shiyi Han, Siyang Fan
Summary: A new sesquiterpene, a new sesquiterpene dimer, and two new diterpenes were isolated from Chloranthus elatior, along with 51 known compounds. The structures of the new compounds were mainly established by mass spectrometric, NMR, and electronic circular dichroism experiments. The compounds were tested for their anti-hDHODH activity, with two compounds showing the most activity.
Article
Chemistry, Medicinal
Xia Liu, Yi-Xuan Yang, Xin Gao, Qian Liu, Xiao-Na Zhang, Xiao-Feng Niu, Hui Zhang
Summary: A new sesquiterpene was isolated from the root extract of Chloranthus multistachys C. Pei. The structure of the new compound was characterized using spectroscopic methods such as 1D and 2D NMR and HR-ESI-MS.
CHEMISTRY OF NATURAL COMPOUNDS
(2021)
Article
Plant Sciences
Yuting Bian, Fangyou Chen, Weiming Huang, Zhichao Chen, Pengcheng Shuang, Yongming Luo
Summary: Two new compounds (1 and 2) along with eight known sesquiterpenes (3-10) and six other known compounds (11-16) were isolated from the whole plant of Chloranthus henryi. The structures and absolute configurations of the new compounds were determined using HR-ESI-MS, NMR spectroscopic, and X-ray crystallography. These compounds were reported for the first time from this species.
RECORDS OF NATURAL PRODUCTS
(2022)
Article
Biology
Ui Jeong Yun, Chu Won Nho, Kye Won Park, Dong Kwon Yang
Summary: Chloranthus japonicus has been found to promote adipocyte differentiation, with its hexane extract identified as the most potent inducer. Mechanistic studies showed that CJHE acts on the Wnt pathway to stimulate adipogenesis. This natural product may have potential use in treating metabolic syndrome.
Article
Chemistry, Organic
Jun-Su Zhou, Qun-Fang Liu, Flavia M. Zimbres, Joshua H. Butler, Maria B. Cassera, Bin Zhou, Jian-Min Yue
Summary: Four new lindenane sesquiterpenoid trimers, named trichloranoids A-D (1-4), were isolated from Chloranthus spicatus, along with a known analogue (5). Their structures were determined through various methods, including DP4+ probability and TDDFT-ECD calculations. Compounds 1 and 2 each contained a unique skeletal unit in their western hemisphere, likely formed biogenetically via a biradical rearrangement of the vinylcyclopropane. Compounds 1, 4, and 5 showed moderate antimalarial activities.
ORGANIC CHEMISTRY FRONTIERS
(2021)
Article
Plant Sciences
Jun-Su Zhou, Su-Ling Huang, Yuan Gao, Qun-Fang Liu, Ying Leng, Bin Zhou, Jian-Min Yue
Summary: Seven new phenolic-monoterpenoid hybrid molecules, Spicatulides A-G (1-7), along with two known compounds (8 and 9), were isolated and identified from Chloranthus spicatus. Compound 1 possesses a novel skeleton with an aryl-fused 2-oxabicyclo[4.3.1]decane moiety, while compound 2 is the first reported denudaquinol-normonoterpenoid adduct. Spectroscopic data analyses and TDDFT-ECD calculations were used to determine the structures and absolute configurations of these compounds. Compounds 3, 5, 6, and 9 showed dose-dependent activity in reducing lipogenesis in HepG2 cells.
JOURNAL OF NATURAL PRODUCTS
(2022)
Article
Genetics & Heredity
Yihui Wang, Zhixiang Zhang, Yifei Xie
Summary: In this study, the complete chloroplast genome of Elaeocarpus japonicus was reported, which consisted of 111 functional genes and showed a close relationship with Averrhoa carambola in the phylogenetic tree.
MITOCHONDRIAL DNA PART B-RESOURCES
(2021)
Article
Chemistry, Applied
Xue-Jiao Wang, Jun-Li Xin, Sheng-Zhou Yu, Li-Long Pan, Jin-Feng Hu, Juan Xiong
Summary: Two new eudesmanolide-type enantiomers and thirteen known sesquiterpenoids were isolated from Chloranthus henryi var. hupehensis, along with the determination of their absolute configurations. The inhibitory activities of these compounds against LPS-induced NO production in murine BV-2 microglial cells were evaluated, and two dimeric sesquiterpenoids showed the most potent activities.
NATURAL PRODUCT RESEARCH
(2023)
Article
Chemistry, Organic
Siyuan Wang, Yunpeng Sun, Yaqi Li, Wenjun Xu, Qianqian Li, Yanbing Mu, Lingyi Kong, Jun Luo
Summary: In this study, seven lindenane-type sesquiterpenoid trimers were isolated from Chloranthus fortunei. Four of them were new compounds, while the other three were known analogues. Their structures and absolute configurations were determined using various analytical techniques. Compound 1 exhibited a unique feature of two lindenane units connected by a C-15-C-15' bond. Compound 2 had a 5/7/5-fused ring system, which was believed to be formed through keto-enol tautomerism and Cope rearrangement. Compounds 3-6 were derived from trishizukaol A (7) via vinylcyclopropane rearrangement. The biomimetic conversion from 7 to 3-6 was successfully achieved. Compound 1-7 showed anti-inflammatory activity with IC50 values ranging from 2.90 to 22.80 nmol/L.
JOURNAL OF ORGANIC CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Wei-ming Huang, Yu-ting Bian, Fang-you Chen, Tian-jiao Ning, Zhi-ying Zhu, Zhi-chao Chen, Yong-ming Luo
Summary: This study isolated twelve undescribed sesquiterpenoids and four known compounds from Chloranthus multistachys. The structures of the undescribed compounds were determined using spectroscopic techniques and crystallography. Some of these compounds exhibited moderate anti-inflammatory activities.
Article
Chemistry, Medicinal
Fang-You Chen, Wan-Wan Yu, Feng-Xiang Lin, Ji-Wu Huang, Wei-Ming Huang, Peng-Cheng Shuang, Yu-Ting Bian, Yong-Ming Luo
Summary: Three rare sesquiterpenoids with unique structures were isolated from the roots of Chloranthus henryi, showing moderate neuroprotective activities on PC12 cells damaged with hydrogen peroxide through experimental studies.
Article
Plant Sciences
Jian-Jun Chen, Wei Bai, Yu-Bo Lu, Zi-Yun Feng, Kun Gao, Jian-Min Yue
Summary: A bioactivity-guided study on the leaves of Picrasma javanica resulted in the isolation of 19 quassinoids, including 13 new compounds. The structures of the new compounds were determined through a combination of spectroscopic analysis, X-ray crystallography, and ECD data interpretation. Some of the new compounds showed moderate inhibitory effects against phytopathogenic fungi, with compounds 6 and 15 exhibiting comparable activity to the positive control carbendazim. Additionally, preliminary structure-activity relationships of these quassinoids were investigated.
JOURNAL OF NATURAL PRODUCTS
(2021)
