Article
Biochemistry & Molecular Biology
Mohammad T. Hussan, Noriko Matsui, Hideaki Matsui
Summary: The presence of ectopic DNA in the cytoplasm leads to inflammation and cell death. Cyclic GMP-AMP synthase (cGAS) has been widely reported as the main sensor for the leakage of nuclear DNA into the cytoplasm. Our recent study demonstrated that mitochondria-derived cytoplasmic double-stranded DNA (dsDNA), which has escaped lysosomal degradation, induces significant cytotoxicity in cultured cells and in vivo. Cytoplasmic mitochondrial DNA is believed to be involved in various diseases and disorders, and more and more published papers have confirmed this. However, the current method for evaluating mitochondrial DNA in the cytoplasm may not be quantitative. In this article, we introduce a detailed method for evaluating ectopic mitochondrial DNA in cells, which is useful for both basic research and the study of aging, Parkinson's disease, Alzheimer's disease, heart failure, autoimmune diseases, cancer, and other conditions.
CURRENT ISSUES IN MOLECULAR BIOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Evelyn Y. Xue, Fangyuan Kang, Yimin Zhou, Dennis K. P. Ng
Summary: In this study, a far-red-absorbing boron dipyrromethene-based photosensitizer responsive to cancer-associated human NAD(P)H:quinone oxidoreductase 1 was developed, allowing controlled restoration of photodynamic activity for selective elimination of cancer cells.
CHEMICAL COMMUNICATIONS
(2023)
Article
Cell Biology
Juan Wang, Mengjie Huangfu, Xiaojuan Li, Mengjie Han, Guoxiang Liu, Dan Yu, Luwei Zhou, Tong Dou, Yisa Liu, Xiao Guan, Riming Wei, Xu Chen
Summary: Osthole has been found to induce both apoptosis and pyroptosis, with the latter mediated by NQO1-mediated ROS accumulation. The occurrence of apoptosis is related to the GSDME protein.
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2022)
Article
Chemistry, Applied
Noor Uddin, Faisal Rashid, Ali Haider, Syed Ahmed Tirmizi, Ahmad Raheel, Muhammad Imran, Sumera Zaib, Paula L. Diaconescu, Jamshed Iqbal, Saqib Ali
Summary: Three triorganotin (IV) cyclopentane carboxylates were synthesized and tested for their anticancer activity. Complex 2 showed the strongest potency against HeLa and MCF-7 cells, inducing apoptosis and affecting enzyme release. The high activity was attributed to its Lewis acidity and reactivity against VEGFR 2 Kinase.
APPLIED ORGANOMETALLIC CHEMISTRY
(2021)
Article
Toxicology
Hauke Reimann, Helga Stopper, Henning Hintzsche
Summary: Although micronuclei are widely used as biomarkers for genotoxic damage, their biological consequences are still not well-understood. In this study, live cell imaging was used to investigate the fate of micronuclei and micronucleated cells in HeLa cells treated with various genotoxic agents. The results showed that most micronuclei persist for multiple cell cycles or reincorporate, while micronucleated cells are more prone to cell death, senescence, and mitotic errors compared to non-micronucleated cells.
ARCHIVES OF TOXICOLOGY
(2022)
Article
Virology
Madelaine Sugasti-Salazar, Yessica Y. Llamas-Gonzalez, Dalkiria Campos, Jose Gonzalez-Santamaria
Summary: The study found that p38 kinase plays a crucial role in the replication of the Mayaro virus and inhibiting p38 can reduce viral replication. Modulating p38α/p38β isoforms through different approaches can affect MAYV replication.
Article
Genetics & Heredity
Ritu Raina, Abdulmajeed G. Almutary, Sali Abubaker Bagabir, Nazia Afroze, Sharmila Fagoonee, Shafiul Haque, Arif Hussain
Summary: This study demonstrates that chrysin can promote cytostatic behavior and inhibit migration capacity of HeLa cells by reducing the methylation levels of tumor-suppressor genes and modulating the expression of chromatin-modifying enzymes. Additionally, chrysin treatment results in decreased global DNA methylation, indicating its potential as an epigenetic modifier for cancer treatment.
FRONTIERS IN GENETICS
(2022)
Article
Pharmacology & Pharmacy
Wei Zhao, Ying Duan, Hong-Mei Li, Shengying Li, Yuemao Shen, Youming Zhang, Yue-zhong Li, Ya-Jie Tang
Summary: This study preliminarily disclosed the intrinsic regularity between different types of heterocycle-substituted DMEP derivative compounds and their antitumor activity mechanisms, including inducing severe DNA damage and promoting cell cycle arrest.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Oncology
Wenxiu Zhao, Lingxiang Jiang, Ting Fang, Fei Fang, Yingchun Liu, Ye Zhao, Yuting You, Hao Zhou, Xiaolin Su, Jiangwei Wang, Sheng Liu, Yaomin Chen, Jun Wan, Xiumei Huang
Summary: This study identified high NQO1 expression in HCC tumors and demonstrated that beta-Lapachone selectively kills HCC cells with high NQO1 levels, potentially making it a promising chemotherapeutic agent for NQO1-positive HCC patients.
FRONTIERS IN ONCOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Karina Budkina, Krystel El Hage, Marie-Jeanne Clement, Benedicte Desforges, Ahmed Bouhss, Vandana Joshi, Alexandre Maucuer, Loic Hamon, Lev P. Ovchinnikov, Dmitry N. Lyabin, David Pastre
Summary: The study demonstrates how YB-1 unwinds mRNA secondary structures through specific structural mechanisms, facilitating SG disassembly and potentially inhibiting SG assembly in cancer cells.
NUCLEIC ACIDS RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Yi Peng, Jie Pan, Fengting Ou, Wenchao Wang, Haihong Hu, Lu Chen, Su Zeng, Kui Zeng, Lushan Yu
Summary: The study found that analog 6 showed higher sensitivity to cervical cancer cells (HeLa) compared to fenbendazole, inducing oxidative stress and inhibiting cell proliferation, enhancing apoptosis, and suppressing cell migration and invasion. The modified analog 6 demonstrated reduced toxicity to normal cells without compromising its anti-cancer effect.
CHEMICO-BIOLOGICAL INTERACTIONS
(2022)
Article
Biochemistry & Molecular Biology
Karina Budkina, Krystel El Hage, Marie-Jeanne Clement, Benedicte Desforges, Ahmed Bouhss, Vandana Joshi, Alexandre Maucuer, Loic Hamon, Lev P. Ovchinnikov, Dmitry N. Lyabin, David Pastre
Summary: The study reveals that YB-1 can unwind mRNA secondary structures under cellular stress by utilizing its cold-shock domain and C-terminal domain. YB-1 aids in stress granule disassembly during recovery, and its overexpression inhibits stress granule assembly in cancer cells by promoting mRNA translation initiation.
NUCLEIC ACIDS RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Lucie Madrova, Olga Souckova, Radana Brumarova, Dana Dobesova, Jan Vaclavik, Stepan Kouril, Julie de Sousa, Jaroslava Friedecka, David Friedecky, Veronika Baresova, Marie Zikanova, Tomas Adam
Summary: This study investigated the metabolic changes in CRISPR-Cas9 genome-edited HeLa cells deficient in purine de novo synthesis (PDNS) enzymes. The results showed that deficiencies in key enzymes of PDNS affected the pool of purine nucleotides and methylation activity.
Article
Biochemistry & Molecular Biology
Kerong Guo, Jian Li, Yingdong Jia, Xiaojuan Yang, Xiqing Yan, Liqiang Wu
Summary: In this study, novel quinolinedione-linked sulfonylpiperazine derivatives were investigated as NQO1-directed antitumor agents. Most of the compounds showed higher effectiveness in inhibiting cancer cell proliferation compared to 5-Fu and TSA. Among them, compound 22r exhibited significant anti-proliferative activity against NQO1-rich cancer cells and was recognized as an excellent substrate for NQO1. Mechanistic studies revealed that 22r induced ROS production, DNA damage, and apoptosis in HepG2 cells. Remarkably, compound 22r also showed excellent anticancer activity in HepG2 xenograft models. Overall, this study demonstrated that compound 22r could be a promising strategy for the treatment of malignant tumors.
BIOORGANIC CHEMISTRY
(2023)
Article
Medicine, Research & Experimental
Qun Long, Xiao Xiao, Ping Yi, Yuancui Liu, Krishnapriya M. Varier, Qing Rao, Jingrui Song, Jianfei Qiu, Chunlin Wang, Wuling Liu, Babu Gajendran, Zhixu He, Sheng Liu, Yanmei Li
Summary: This study investigated the anti-leukemic effect of a new Calothrixin B derivative, L20, which showed significant cytotoxicity in HEL cells and induced apoptosis and G(2)/M arrest. The mechanism involved DNA damage, modulation of p38 MAPK pathways, and mitochondrial-mediated apoptosis.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Rheumatology
Alejandro Ibanez-Costa, Carlos Perez-Sanchez, Alejandra Maria Patino-Trives, Maria Luque-Tevar, Pilar Font, Ivan Arias de la Rosa, Cristobal Roman-Rodriguez, Ma Carmen Abalos-Aguilera, Carmen Conde, Antonio Gonzalez, Sergio Pedraza-Arevalo, Mercedes del Rio-Moreno, Ricardo Blazquez-Encinas, Pedro Segui, Jerusalem Calvo, Rafaela Ortega Castro, Alejandro Escudero-Contreras, Nuria Barbarroja, Ma Angeles Aguirre, Justo P. Castano-Fuentes, Raul M. Luque, Eduardo Collantes-Estevez, Chary Lopez-Pedrera
Summary: This study identified altered expression of several splicing machinery elements in leucocytes of rheumatoid arthritis patients, with 8 elements equally affected in all leucocyte subtypes. These alterations could discriminate patients from healthy donors, classify high disease activity, recognize radiological involvement, and identify patients with atheroma plaques. The signature was also found in RA synovial fluid and ankle joints of arthritic mice, and could be reversed by anti-TNF therapy.
ANNALS OF THE RHEUMATIC DISEASES
(2022)
Article
Medicine, General & Internal
Ivan Arias de la Rosa, Maria Dolores Lopez-Montilla, Cristobal Roman-Rodriguez, Carlos Perez-Sanchez, Ignacio Gomez-Garcia, Clementina Lopez-Medina, Maria Lourdes Ladehesa-Pineda, Maria Del Carmen Abalos-Aguilera, Desiree Ruiz, Alejandra Maria Patino-Trives, Maria Luque-Tevar, Isabel Anon-Onate, Maria Jose Perez-Galan, Rocio Guzman-arbarroja, Maria M. Malagon, Chary Lopez-Pedrera, Alejandro Escudero-Contreras, Eduardo Collantes-Estevez, Nuria Barbarroja
Summary: The study evaluated the clinical and molecular signs of cardiovascular disease (CVD) in Psoriatic Arthritis (PsA) patients and their relationship with disease features. It also identified a patient profile that could benefit from treatment with methotrexate (MTX) and/or apremilast to reduce CVD risk. The results showed that cardiometabolic comorbidities were associated with disease activity and inflammatory status in PsA patients. Certain CVD-related molecules were found to be altered in these patients and associated with key clinical features. Different patient phenotypes were identified based on the rates of cardiometabolic comorbidities, and their response to treatment varied. The study suggests that novel CVD-related proteins could be therapeutic targets in PsA, and apremilast could be an effective treatment for patients with high CVD risk.
JOURNAL OF INTERNAL MEDICINE
(2022)
Article
Geriatrics & Gerontology
Sara Lopez-Bellon, Sandra Rodriguez-Lopez, Jose A. Gonzalez-Reyes, M. Isabel Buron, Rafael de Cabo, Jose M. Villalba
Summary: The study showed that overexpression of CYB5R3 can activate mitochondrial function in skeletal muscle, delaying aging process and improving mitochondrial structure and autophagic recycling in old mice.
Article
Multidisciplinary Sciences
Ivan Arias-de la Rosa, Alejandro Escudero-Contreras, Miriam Ruiz-Ponce, Laura Cuesta-Lopez, Cristobal Roman-Rodriguez, Carlos Perez-Sanchez, Patricia Ruiz-Limon, Rocio Guzman-Ruiz, Fernando Leiva-Cepas, Juan Alcaide, Pedro Segui, Chamaida Plasencia, Ana Martinez-Feito, Pilar Font, Maria C. Abalos, Rafaela Ortega, Maria M. Malagon, Francisco J. Tinahones, Eduardo Collantes-Estevez, Chary Lopez-Pedrera, Nuria Barbarroja
Summary: This study investigated the association between adipose tissue dysfunction, autoimmunity, and disease activity in rheumatoid arthritis (RA). It was found that insulin resistance and altered adipocytokine profile were related to disease activity, the presence of anti-citrullinated protein antibodies (ACPAs), and worse response to therapy in RA. Adipose tissue in the context of arthritis exhibited an inflammatory state with macrophage and B/plasma cell infiltration, and ACPAs could induce inflammation and insulin resistance in macrophages while promoting defective adipocyte differentiation. Biologicals partially restored this defect.
Article
Oncology
Javier Frontinan-Rubio, Emilio Llanos-Gonzalez, Sonia Garcia-Carpintero, Juan Ramon Peinado, Inmaculada Ballesteros-Yanez, Margarita Villar Rayo, Jose de la Fuente, Victor M. Perez-Garcia, Luis A. Perez-Romasanta, Marcos Malumbres, Francisco J. Alcain, Mario Duran-Prado
Summary: This study proposes a therapeutic strategy for glioblastoma multiforme (GBM) using coenzyme Q(10) (CoQ(10)) as a pleiotropic factor that targets multiple hallmarks of the disease. The results show that CoQ(10) treatment decreases tumor volume, hypoxia, vascularization, and inflammatory cell infiltration while also inhibiting tumor cell migration and invasion by modulating the actin cytoskeleton and downregulating matrix metalloproteases (MMPs).
Review
Immunology
Nuria Barbarroja, Miriam Ruiz-Ponce, Laura Cuesta-Lopez, Carlos Perez-Sanchez, Chary Lopez-Pedrera, Ivan Arias-de La Rosa, Eduardo Collantes-Estevez
Summary: Liver disease is a significant cause of increased morbidity and mortality worldwide. Inflammation and the accumulation of fat in the liver can lead to hepatic damage, progressing to fibrosis and eventually cirrhosis, which are closely associated with cardiovascular disease. Patients with inflammatory conditions like rheumatoid arthritis and psoriatic arthritis have a higher risk of liver disease compared to the general population, possibly due to chronic inflammation, autoimmunity, treatments, and metabolic deregulation.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Environmental Sciences
Silvana Arias, John R. Agudelo, Francisco J. Molina, Emilio Llanos-Gonzalez, Francisco J. Alcain, Rosario Ballesteros, Magin Lapuerta
Summary: This study investigates the unregulated emissions in gas and particles from a Euro 6b diesel engine, operated with four unconventional and advanced biofuels, blended with diesel fuel and pure hydro -treated vegetable oil. The results show that carbonyl emissions were higher than gaseous PAH emissions at low-speed phase, and both gas and particle emissions contribute to the toxicity associated with carcinogenic PAH.
Article
Immunology
Ch Lopez-Pedrera, A. M. Patino-Trives, T. Cerdo, R. Ortega-Castro, I. Sanchez-Pareja, A. Ibanez-Costa, L. Munoz-Barrera, M. C. Abalos-Aguilera, D. Ruiz-Vilchez, P. Segui Azpilcueta, M. Espinosa, N. Barbarroja, A. Escudero-Contreras, J. P. Castano, R. Luque, R. Ortega, M. A. Aguirre, C. Perez-Sanchez
Summary: This study characterized the splicing machinery (SM) of leukocytes from patients with primary antiphospholipid syndrome (APS), systemic lupus erythematosus (SLE), and antiphospholipid syndrome with lupus (APS + SLE), and assessed its clinical involvement. The results showed that leukocytes from APS, SLE, and APS + SLE patients displayed significant and specific alterations in SM-components (SMC), which were associated with clinical features. This study identified a specific alteration of SMC in leukocytes from APS, SLE, and APS + SLE patients, which may be responsible for the development of distinctive clinical profiles.
JOURNAL OF AUTOIMMUNITY
(2023)
Article
Rheumatology
Gustavo G. M. Balbi, Yasaman Ahmadzadeh, Maria G. Tektonidou, Vittorio Pengo, Savino Sciascia, Amaia Ugarte, H. Michael Belmont, Chary Lopez-Pedrera, Paul R. Fortin, Denis Wahl, Maria Gerosa, Guilherme R. de Jesus, Lanlan Ji, Tatsuya Atsumi, Maria Efthymiou, D. Ware Branch, Cecilia Nalli, Esther Rodriguez Almaraz, Michelle Petri, Ricard Cervera, Jason S. Knight, Bahar Artim-Esen, Rohan Willis, Maria Laura Bertolaccini, Hannah Cohen, Robert Roubey, Doruk Erkan, Danieli Castro Oliveira de Andrade
Summary: The objective of this study was to quantify the damage burden measured by Damage Index for Antiphospholipid Syndrome (DIAPS) in aPL-positive patients with or without a history of thrombosis, and to identify clinical and laboratory characteristics associated with damage in these patients. The study found that DIAPS is of great significance in identifying patients with a higher damage burden and selected traditional cardiovascular risk factors, steroid use, and specific aPL profiles may help in identifying these patients.
Article
Immunology
Nuria Barbarroja, Maria Dolores Lopez-Montilla, Laura Cuesta-Lopez, Carlos Perez-Sanchez, Miriam Ruiz-Ponce, Clementina Lopez-Medina, Maria Lourdes Ladehesa-Pineda, Chary Lopez-Pedrera, Alejandro Escudero-Contreras, Eduardo Collantes-Estevez, Ivan Arias-de la Rosa
Summary: This study characterized the inflammatory proteome of synovial fluid in patients with Psoriatic Arthritis (PsA) using a high-throughput proteomic platform. The results showed the presence of 79 inflammation-related proteins in the synovial fluid of PsA patients, and identified two specific phenotypes based on the levels of these proteins. Additionally, compared to patients with osteoarthritis, PsA patients had significantly altered levels of 39 proteins specifically related to cell migration and inflammatory response.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Emilio Llanos-Gonzalez, Francisco J. Sancho-Bielsa, Javier Frontinan-Rubio, Yoana Rabanal-Ruiz, Sonia Garcia-Carpintero, Eduardo Chicano, Isabel Ubeda-Banon, Alicia Flores-Cuadrado, Lydia Gimenez-Llort, Francisco Javier Alcain, Juan Ramon Peinado, Mario Duran-Prado
Summary: Despite the proteopathic nature of Alzheimer's disease, the spatiotemporal signature of disrupted protein modules in AD brains is poorly understood. By using MALDI-MSI and functional bioinformatic analysis, a protocol was developed to study how deregulated protein modules arise in an age-dependent manner in the AD mice model and identify which modules can be restored to a non-pathological condition through early intervention with ubiquinol.
Article
Medicine, General & Internal
I Arias-de la Rosa, M. Ruiz-Ponce, L. Cuesta-Lopez, C. Perez-Sanchez, F. Leiva-Cepas, Md Gahete, P. Navarro, R. Ortega, J. Cordoba, E. Perez-Pampin, A. Gonzalez, A. J. Lucendo, E. Collantes-Estevez, Ch Lopez-Pedrera, A. Escudero-Contreras, N. Barbarroja
Summary: Rheumatoid arthritis patients may experience mild to moderate liver inflammation due to the infiltration of T, B cells, and macrophages, as well as the action of anticitrullinated protein antibodies (ACPAs). This phenomenon is independent of obesity or diabetes and is associated with systemic inflammation and disease activity levels.
EUROPEAN JOURNAL OF INTERNAL MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Luz Marina Sanchez-Mendoza, Carlos Perez-Sanchez, Sandra Rodriguez-Lopez, Chary Lopez-Pedrera, Miguel Calvo-Rubio, Rafael de Cabo, Maria I. Buron, Jose A. Gonzalez-Reyes, Jose M. Villalba
Summary: The study investigates the effect of sex on metabolic adaptations induced by overexpression of CYB5R3 and the modulation of key markers related to mitochondrial function in skeletal muscle. It was found that CYB5R3 overexpression leads to enhanced mitochondrial biogenesis and function, as well as increased mitochondrial abundance in skeletal muscle. These beneficial actions are predominantly observed in females, with differences in NADH levels and the abundance of cytochrome c and DRP-1. The results also show ultrastructural changes in transgenic females, including an increase in the number and size of mitochondria.
FREE RADICAL BIOLOGY AND MEDICINE
(2023)
Article
Hematology
Chary Lopez-Pedrera, Rafael Oteros, Alejandro Ibanez-Costa, Maria Luque-Tevar, Laura Munoz-Barrera, Nuria Barbarroja, Eduardo Chicano-Galvez, Juan Marta-Enguita, Josune Orbe, Francisco Velasco, Carlos Perez-Sanchez
Summary: This study analyzed the proteomic profile of thrombi in patients with ischemic stroke and discovered new insights into the pathways and players involved in its etiology, severity, and prognosis. The study identified protein markers associated with stroke severity and highlighted the prominent role of neutrophils in stroke severity.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2023)
Article
Biochemistry & Molecular Biology
Sotirios P. Fortis, Anthimia Batrinou, Hara T. Georgatzakou, Ioannis Tsamesidis, Grigorios Alvanidis, Effie G. Papageorgiou, Kontantinos Stamoulis, Dimitrios Gkiliopoulos, Georgia K. Pouroutzidou, Anna Theocharidou, Eleana Kontonasaki, Anastasios G. Kriebardis
Summary: This study evaluated the compatibility of human blood cells with silica-based mesoporous nanomaterials (MSNs) manufactured using the solgel method, with Ca and Ce as doping elements. The results showed that these nanomaterials had no impact on the viability of lymphocytes and monocytes, but reduced the viability of granulocytes. Additionally, the expression of Pselectin in platelets and the level of internal reactive oxygen species increased when exposed to MSNs. The presence of Ce in the MSNs improved their hemocompatibility to some extent. Further research is needed to understand how MSNs may affect different blood components and design safe and effective MSNs for biomedical applications.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Retraction
Biochemistry & Molecular Biology
Tiechao Jiang, Dongli Jiang, Dong You, Lirong Zhang, Long Liu, Qini Zhao
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Article
Biochemistry & Molecular Biology
Yuting Chen, Lin Chen, Shiheng Zhu, Hui Yang, Zhongming Ye, Huanhuan Wang, Haipeng Wu, Yao Wu, Qian Sun, Xiaoshan Liu, Hairong Liang, Huanwen Tang
Summary: This study investigates the impact of exosomal derived miR-1246 from HQ-transformed cells on cell-to-cell communication in recipient TK6 cells. The results show that exosomal miR-1246 targets CCNG2, regulating TK6 cell cycle arrest, highlighting its potential as a biomarker for HQ-induced malignant transformation.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Article
Biochemistry & Molecular Biology
Shuping Yu, Yaming Mu, Kai Wang, Ling Wang, Chunying Wang, Zexin Yang, Yu Liu, Shuxian Li, Meihua Zhang
Summary: Fetal growth restriction (FGR) is a common complication in obstetrics, and its exact cause is unknown. In this study, we constructed 1-NP exposed pregnant mice models and found that 1-NP induced FGR. Additionally, we observed significant ferroptosis in placental trophoblasts from 1-NP exposed mice and human FGR patients. Using in vitro cell models, we demonstrated that 1-NP impaired trophoblast biological function and induced cellular ferroptosis. We also identified the ERK signaling pathway and CYP1B1 as key regulators of 1-NP-induced ferroptosis. This study provides new insights into the aetiology of FGR and the reproductive toxicity of environmental pollutants.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Article
Biochemistry & Molecular Biology
Lei Hou, Yingying Zhao, Shiyu Zhao, Xuexia Zhang, Xia Yao, Jianjun Yang, Ziteng Wang, Shuaibing Liu
Summary: This study systematically characterized the UGTs enzymes involved in the formation of M4 and the inhibitory effects of ciprofol and its metabolite M4 on P450s enzymes. In vitro-in vivo extrapolation and PBPK simulations were performed to predict potential drug-drug interactions caused by ciprofol.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Review
Biochemistry & Molecular Biology
Disheng Liu, Lu Wang, Wuhua Ha, Kan Li, Rong Shen, Degui Wang
Summary: Renal fibrosis is a common outcome of renal injuries, characterized by structural destruction and functional decline of the kidneys. Hypoxia induces the activation of HIF-1 alpha, which regulates cellular metabolism, proliferation, apoptosis, and inflammation, contributing to the development of renal fibrosis. Understanding the regulation and cascade reactions mediated by HIF-1 alpha can provide new insights for studying the mechanism of renal fibrosis.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Article
Biochemistry & Molecular Biology
Zhao-Bo Luo, Liu-Hui Yang, Sheng-Zhong Han, Shuang-Yan Chang, Hongye Liu, Zhi-Yong An, Xiu-Li Zhang, Biao-Hu Quan, Xi-Jun Yin, Jin-Dan Kang
Summary: This study demonstrates that cyclophosphamide (CTX) treatment has detrimental effects on oocytes and embryos, leading to DNA damage, apoptosis, and abnormal histone modification. Supplementation with LBH589 can effectively restore the developmental potential of embryos by increasing histone modification levels and restoring protein expression of NF-kappa B, a key regulator of early embryo development.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Article
Biochemistry & Molecular Biology
Sheng Chen, Hanqing Xu, Yi He, Chen Meng, Yunhui Fan, Yunkun Qu, Yingguang Wang, Wei Zhou, Xiaojian Huang, Hongbo You
Summary: Osteoarthritis is a heterogeneous disease that affects the entire joint. This study found that Carveol can reverse the inflammatory state of macrophages, promote their anti-inflammatory effects, and protect cartilage by activating the NRF2/HO-1/NQO1 pathway and reducing ROS clearance. The results also showed that Carveol can alleviate the pathological changes of osteoarthritis in mice, suggesting its potential therapeutic efficacy.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Article
Biochemistry & Molecular Biology
Liyi Wei, Tingting Wang, Mingcui Luo, Shuai Zhang, Mengxi Lu, Xinli Zhou, Xuelei Cheng, Hui Wang, Dan Xu
Summary: This study found that azithromycin during pregnancy may have toxic effects on fetal hippocampal development, especially in the late pregnancy, high dose, and multi-course situation. The results also suggest that the SOX2/Wnt signaling pathway may be involved in this toxicity.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Review
Biochemistry & Molecular Biology
Di Wu, Faheem Ahmed Khan, Kejia Zhang, Nuruliarizki Shinta Pandupuspitasari, Windu Negara, Kaifeng Guan, Fei Sun, Chunjie Huang
Summary: Retinoic acid (RA) is a signaling molecule derived from vitamin A/retinol, with implications in various aspects of health and disease. It regulates cell functioning through both transcriptional and non-genomic mechanisms, influencing cell-fate determination, neurogenesis, visual function, inflammatory responses, and gametogenesis commitment.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Review
Biochemistry & Molecular Biology
Bilal Murtaza, Lili Wang, Xiaoyu Li, Muhammad Yasir Nawaz, Muhammad Kashif Saleemi, Aisha Khatoon, Xu Yongping
Summary: Mycotoxins in food pose significant concerns for food safety and public health, potentially causing a range of adverse symptoms and cancer development. Deoxynivalenol (DON) is particularly worrisome due to its harm to vital organs. Altered mycotoxins present possible risks to the environment and well-being, necessitating further research into their adverse consequences. Accurately assessing the risk posed by modified mycotoxins remains challenging.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Article
Biochemistry & Molecular Biology
Emine Toraman, Buesra Budak, Cemil Bayram, Selma Sezen, Behzad Mokhtare, Ahmet Hacimueftueoglu
Summary: The study suggests that parthenolide (PTL) may have therapeutic effects in treating testicular toxicity caused by paclitaxel (PTX) through reducing oxidative stress and increasing glutathione levels. PTL also promotes the expression of genes involved in reproduction and sperm production.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Correction
Biochemistry & Molecular Biology
Cuicui Zhuang, Hui Huo, Wanfa Fu, Wanyue Huang, Lulu Han, Miao Song, Yanfei Li
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Article
Biochemistry & Molecular Biology
Taotao Zhao, Jia Lv, Mingyuan Peng, Jiahui Mi, Shaosan Zhang, Jie Liu, Tong Chen, Zilong Sun, Ruiyan Niu
Summary: This study explores the protective effects of fecal microbiota transplantation (FMT) and short-chain fatty acids (SCFAs) supplementation on learning and memory impairment caused by fluoride exposure in mice. The results show that FMT and SCFAs can improve memory deficits and alleviate pathological damages caused by fluoride, possibly by activating the BDNF-PI3K/AKT pathway. Furthermore, the disordered gut microbiome caused by fluoride can be restored through frequent FMT.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Article
Biochemistry & Molecular Biology
Yong Liu, Zhaofei Pang, Yadong Wang, Jichang Liu, Guanghui Wang, Jiajun Du
Summary: This study reveals that silencing PKD2 promotes ferroptosis in LUAD by increasing reactive oxygen species, malondialdehyde accumulation, intracellular iron content and cell death. Overexpression of PKD2 prevents autophagic degradation of ferritin and promotes proliferation, migration and invasion of LUAD cells. Moreover, targeting PKD2 enhances the efficacy of carboplatin through ferroptosis and apoptosis in LUAD.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)