Macro-/micro-environment-sensitive chemosensing and biological imaging

Nitroreductase Detection and Hypoxic Tumor Cell Imaging by a Designed Sensitive and Selective Fluorescent Probe, 7-[(5-Nitrofuran-2-yl)methoxy]-3H-phenoxazin-3-one

(2013) Zhao Li et al.   ANALYTICAL CHEMISTRY

Development of Azo-Based Fluorescent Probes to Detect Different Levels of Hypoxia

(2013) Wen Piao et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Two-Color Probe to Monitor a Wide Range of pH Values in Cells

(2013) Min Hee Lee et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Intracellular Thermometry by Using Fluorescent Gold Nanoclusters

(2013) Li Shang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

High selectivity imaging of nitroreductase using a near-infrared fluorescence probe in hypoxic tumor

(2013) Kehua Xu et al.   CHEMICAL COMMUNICATIONS

Solvatochromic Pyrene Analogues of Prodan Exhibiting Extremely High Fluorescence Quantum Yields in Apolar and Polar Solvents

(2013) Yosuke Niko et al.   CHEMISTRY-A EUROPEAN JOURNAL

Activatable Rotor for Quantifying Lysosomal Viscosity in Living Cells

(2013) Lu Wang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A Self-Calibrating Bipartite Viscosity Sensor for Mitochondria

(2013) Zhigang Yang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Full-Range Intracellular pH Sensing by an Aggregation-Induced Emission-Active Two-Channel Ratiometric Fluorogen

(2013) Sijie Chen et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Mapping microbubble viscosity using fluorescence lifetime imaging of molecular rotors

(2013) Neveen A. Hosny et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Design and synthesis of triphenylamine-malonitrile derivatives as solvatochromic fluorescent dyes

(2013) Yang Yang et al.   SENSORS AND ACTUATORS B-CHEMICAL

Dicyanostilbene-based two-photon thermo-solvatochromic fluorescence probes with large two-photon absorption cross sections: Detection of solvent polarities, viscosities, and temperature

(2013) Chibao Huang et al.   SENSORS AND ACTUATORS B-CHEMICAL

Environment-responsive multicolor fluorescent dyes based on nitrophenyl or nitrophenylethynyl oligothiophene derivatives: correlation between fluorescence and π-conjugation length

(2013) Sojiro Hachiya et al.   TETRAHEDRON LETTERS

Quantum Dot–Fluorescent Protein FRET Probes for Sensing Intracellular pH

(2012) Allison M. Dennis et al.   ACS Nano

Localized Intracellular pH Measurement Using a Ratiometric Photoinduced Electron-Transfer-Based Nanosensor

(2012) María J. Marín et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A Tunable Ratiometric pH Sensor Based on Carbon Nanodots for the Quantitative Measurement of the Intracellular pH of Whole Cells

(2012) Wen Shi et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

2-Nitroimidazole-Tricarbocyanine Conjugate as a Near-Infrared Fluorescent Probe for in Vivo Imaging of Tumor Hypoxia

(2012) Kensuke Okuda et al.   BIOCONJUGATE CHEMISTRY

Mapping protein-specific micro-environments in live cells by fluorescence lifetime imaging of a hybrid genetic-chemical molecular rotor tag

(2012) Evangelos Gatzogiannis et al.   CHEMICAL COMMUNICATIONS

Environment-Sensitive Fluorophores with Benzothiadiazole and Benzoselenadiazole Structures as Candidate Components of a Fluorescent Polymeric Thermometer

(2012) Seiichi Uchiyama et al.   CHEMISTRY-A EUROPEAN JOURNAL

Ratiometric Detection of Viscosity Using a Two-Photon Fluorescent Sensor

(2012) Fei Liu et al.   CHEMISTRY-A EUROPEAN JOURNAL

Ruthenium Complexes with Hydrophobic Ligands That Are Key Factors for the Optical Imaging of Physiological Hypoxia

(2012) Hirokazu Komatsu et al.   CHEMISTRY-A EUROPEAN JOURNAL

Polymeric temperature and pH fluorescent sensor synthesized by reversible addition-fragmentation chain transfer polymerization

(2012) Guofeng Liu et al.   JOURNAL OF POLYMER SCIENCE PART A-POLYMER CHEMISTRY

Dual-Emitting Quantum Dot/Quantum Rod-Based Nanothermometers with Enhanced Response and Sensitivity in Live Cells

(2012) Aaron E. Albers et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Reversible Off–On Fluorescence Probe for Hypoxia and Imaging of Hypoxia–Normoxia Cycles in Live Cells

(2012) Shodai Takahashi et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

l-DNA Molecular Beacon: A Safe, Stable, and Accurate Intracellular Nano-thermometer for Temperature Sensing in Living Cells

(2012) Guoliang Ke et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Multicolored pH-Tunable and Activatable Fluorescence Nanoplatform Responsive to Physiologic pH Stimuli

(2012) Kejin Zhou et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Water soluble extended naphthalene diimides as pH fluorescent sensors and G-quadruplex ligands

(2012) Filippo Doria et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Fluorescence Switching of Imidazo[1,5-a]pyridinium Ions: pH-Sensors with Dual Emission Pathways

(2012) Johnathon T. Hutt et al.   ORGANIC LETTERS

Environmental polarity estimation in living cells by use of quinoxaline-based full-colored solvatochromic fluorophore PQX and its derivatives

(2012) Kentaro Kudo et al.   PHOTOCHEMICAL & PHOTOBIOLOGICAL SCIENCES

Two-in-one: a pH-sensitive, acridine-based, fluorescent probe binds G-quadruplexes in oncogene promoters

(2012) Claudia Percivalle et al.   MedChemComm

Intracellular temperature mapping with a fluorescent polymeric thermometer and fluorescence lifetime imaging microscopy

(2012) Kohki Okabe et al.   Nature Communications

Quantum Dot Nano Thermometers Reveal Heterogeneous Local Thermogenesis in Living Cells

(2011) Jui-Ming Yang et al.   ACS Nano

Evaluating Nanoparticle Sensor Design for Intracellular pH Measurements

(2011) Rikke V. Benjaminsen et al.   ACS Nano

Dual-fluorophore ratiometric pH nanosensor with tuneable pKa and extended dynamic range

(2011) Veeren M. Chauhan et al.   ANALYST

Development of Ultrabright Semiconducting Polymer Dots for Ratiometric pH Sensing

(2011) Yang-Hsiang Chan et al.   ANALYTICAL CHEMISTRY

Targeted Luminescent Near-Infrared Polymer-Nanoprobes for In Vivo Imaging of Tumor Hypoxia

(2011) Joanna Napp et al.   ANALYTICAL CHEMISTRY

Highly Selective Fluorescent Probe for Vicinal-Dithiol-Containing Proteins and In Situ Imaging in Living Cells

(2011) Chusen Huang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Tunable, Ultrasensitive pH-Responsive Nanoparticles Targeting Specific Endocytic Organelles in Living Cells

(2011) Kejin Zhou et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Detection of liposome membrane viscosity perturbations with ratiometric molecular rotors

(2011) Matthew E. Nipper et al.   BIOCHIMIE

Near-Infrared pH-Activatable Fluorescent Probes for Imaging Primary and Metastatic Breast Tumors

(2011) Hyeran Lee et al.   BIOCONJUGATE CHEMISTRY

Expanding the dynamic measurement range for polymeric nanoparticle pH sensors

(2011) Honghao Sun et al.   CHEMICAL COMMUNICATIONS

Development of a quinoxaline-based fluorescent probe for quantitative estimation of protein binding site polarity

(2011) Kentaro Kudo et al.   CHEMICAL COMMUNICATIONS

Fluorescent and pH-responsive diblock copolymer-coated core–shell CdSe/ZnS particles for a color-displaying, ratiometric pH sensor

(2011) Kwanyeol Paek et al.   CHEMICAL COMMUNICATIONS

Dual colored mesoporous silica nanoparticles with pH activable rhodamine-lactam for ratiometric sensing of lysosomal acidity

(2011) Shuqi Wu et al.   CHEMICAL COMMUNICATIONS

Development of FRET-Based Dual-Excitation Ratiometric Fluorescent pH Probes and Their Photocaged Derivatives

(2011) Lin Yuan et al.   CHEMISTRY-A EUROPEAN JOURNAL

Rational Design, Synthesis, and Spectroscopic and Photophysical Properties of a Visible-Light-Excitable, Ratiometric, Fluorescent Near-Neutral pH Indicator Based on BODIPY

(2011) Noël Boens et al.   CHEMISTRY-A EUROPEAN JOURNAL

Novel aliphatic N-oxide of naphthalimides as fluorescent markers for hypoxic cells in solid tumor

(2011) Hong Yin et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

8-Hydroxyquinoline-Substituted Boron–Dipyrromethene Compounds: Synthesis, Structure, and OFF–ON–OFF Type of pH-Sensing Properties

(2011) Yuting Chen et al.   JOURNAL OF ORGANIC CHEMISTRY

Rational Design of Ratiometric Near-Infrared Fluorescent pH Probes with Various pKaValues, Based on Aminocyanine

(2011) Takuya Myochin et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Imaging Intracellular pH in Live Cells with a Genetically Encoded Red Fluorescent Protein Sensor

(2011) Mathew Tantama et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Fluorescence Ratiometry and Fluorescence Lifetime Imaging: Using a Single Molecular Sensor for Dual Mode Imaging of Cellular Viscosity

(2011) Xiaojun Peng et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Water-Soluble Dual-Emitting Nanocrystals for Ratiometric Optical Thermometry

(2011) Emily J. McLaurin et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Ratiometric Temperature Sensing with Semiconducting Polymer Dots

(2011) Fangmao Ye et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A New Half-Condensed Schiff Base Compound: Highly Selective and Sensitive pH-Responsive Fluorescent Sensor

(2011) Uday Chand Saha et al.   ORGANIC LETTERS

A New Prodrug-Derived Ratiometric Fluorescent Probe for Hypoxia: High Selectivity of Nitroreductase and Imaging in Tumor Cell

(2011) Lei Cui et al.   ORGANIC LETTERS

2D luminescence imaging of pH in vivo

(2011) S. Schreml et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

CdTe Quantum Dots as Nanothermometers: Towards Highly Sensitive Thermal Imaging

(2011) Laura M. Maestro et al.   Small

A Dual-Emission Förster Resonance Energy Transfer Nanoprobe for Sensing/Imaging pH Changes in the Biological Environment

(2010) Ya-Ling Chiu et al.   ACS Nano

Temperature Sensing Using Fluorescent Nanothermometers

(2010) Fiorenzo Vetrone et al.   ACS Nano

Ratiometric pH-dot ANSors

(2010) Xiaojuan Wang et al.   ANALYST

A Nanogel for Ratiometric Fluorescent Sensing of Intracellular pH Values

(2010) Hong-shang Peng et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Phosphorescent Light–Emitting Iridium Complexes Serve as a Hypoxia-Sensing Probe for Tumor Imaging in Living Animals

(2010) Shaojuan Zhang et al.   CANCER RESEARCH

A quantum dot-based ratiometric pH sensor

(2010) Takashi Jin et al.   CHEMICAL COMMUNICATIONS

A newly designed cell-permeable SNARF derivative as an effective intracellular pH indicator

(2010) Eiji Nakata et al.   CHEMICAL COMMUNICATIONS

Ratiometric pH sensor based on mesoporous silica nanoparticles and Förster resonance energy transfer

(2010) Juying Lei et al.   CHEMICAL COMMUNICATIONS

A PNIPAM-based fluorescent nanothermometer with ratiometric readout

(2010) Chun-Yen Chen et al.   CHEMICAL COMMUNICATIONS

A highly sensitive viscosity probe based on ferrocene-BODIPY dyads

(2010) Xiaodong Yin et al.   DALTON TRANSACTIONS

A Novel Coumarin Fluorescent Sensor to Probe Polarity Around Biomolecules

(2010) Giovanni Signore et al.   Journal of Biomedical Nanotechnology

Luminescent terbium and europium probes for lifetime based sensing of temperature between 0 and 70 °C

(2010) Jiangbo Yu et al.   JOURNAL OF MATERIALS CHEMISTRY

Fluorescent nanoparticles for ratiometric pH-monitoring in the neutral range

(2010) Anja Schulz et al.   JOURNAL OF MATERIALS CHEMISTRY

Ratiometric fluorescent nanoparticles for sensing temperature

(2010) Hong-Shang Peng et al.   JOURNAL OF NANOPARTICLE RESEARCH

Switchable Nile Red-Based Probe for Cholesterol and Lipid Order at the Outer Leaflet of Biomembranes

(2010) Oleksandr A. Kucherak et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Hypoxia-Sensitive Fluorescent Probes forin VivoReal-Time Fluorescence Imaging of Acute Ischemia

(2010) Kazuki Kiyose et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Polarity-Sensitive Coumarins Tailored to Live Cell Imaging

(2010) Giovanni Signore et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Delivery and Subcellular Targeting of Dendrimer-Based Fluorescent pH Sensors in Living Cells

(2010) Lorenzo Albertazzi et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

BODIPY-Based Chain Transfer Agent: Reversibly Thermoswitchable Luminescent Gold Nanoparticle Stabilized by BODIPY-Terminated Water-Soluble Polymer

(2010) Atsushi Nagai et al.   LANGMUIR

BODIPY-Conjugated Thermo-Sensitive Fluorescent Polymers Based On 2-(2-methoxyethoxy)ethyl methacrylate

(2010) R. París et al.   MACROMOLECULES

Tunable Dual Emission in Doped Semiconductor Nanocrystals

(2010) Vladimir A. Vlaskin et al.   NANO LETTERS

CdSe Quantum Dots for Two-Photon Fluorescence Thermal Imaging

(2010) Laura Martinez Maestro et al.   NANO LETTERS

Quantum-dot/dopamine bioconjugates function as redox coupled assemblies for in vitro and intracellular pH sensing

(2010) Igor L. Medintz et al.   NATURE MATERIALS

A charge transfer type pH responsive fluorescent probe and its intracellular application

(2010) Zhipeng Liu et al.   NEW JOURNAL OF CHEMISTRY

PMMA based soluble polymeric temperature sensors based on UCST transition and solvatochromic dyes

(2010) Christian Pietsch et al.   Polymer Chemistry

A Fluorescent Thermometer Based on a Pyrene-Labeled Thermoresponsive Polymer

(2010) Christian Pietsch et al.   SENSORS

Molecular rotors: synthesis and evaluation as viscosity sensors

(2010) Jeyanthy Sutharsan et al.   TETRAHEDRON

Indolequinone-rhodol conjugate as a fluorescent probe for hypoxic cells: enzymatic activation and fluorescence properties

(2010) Hirokazu Komatsu et al.   MedChemComm

Soluble Polymeric Dual Sensor for Temperature and pH Value

(2009) Christian Pietsch et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Design of a bioreductively-activated fluorescent pH probe for tumor hypoxia imaging

(2009) Eiji Nakata et al.   BIOORGANIC & MEDICINAL CHEMISTRY

New Approach for Local Structure Analysis of the Tyrosine Domain in Proteins by Using a Site-Specific and Polarity-Sensitive Fluorescent Probe

(2009) Suming Chen et al.   CHEMBIOCHEM

A fluorescent thermometer operating in aggregation-induced emission mechanism: probing thermal transitions of PNIPAM in water

(2009) Li Tang et al.   CHEMICAL COMMUNICATIONS

Fluorescent Indicators for Intracellular pH

(2009) Junyan Han et al.   CHEMICAL REVIEWS

Molecular Rotors Based on the Boron Dipyrromethene Fluorophore

(2009) Andrew C. Benniston et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Cardiovascular disease in obstructive sleep apnoea syndrome: the role of intermittent hypoxia and inflammation

(2009) J. F. Garvey et al.   EUROPEAN RESPIRATORY JOURNAL

Membrane-Bound Molecular Rotors Measure Viscosity in Live Cells via Fluorescence Lifetime Imaging

(2009) James A. Levitt et al.   Journal of Physical Chemistry C

Hydrophilic Fluorescent Nanogel Thermometer for Intracellular Thermometry

(2009) Chie Gota et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Imaging intracellular viscosity of a single cell during photoinduced cell death

(2009) Marina K. Kuimova et al.   Nature Chemistry

A dual-emissive-materials design concept enables tumour hypoxia imaging

(2009) Guoqing Zhang et al.   NATURE MATERIALS

Characterization of local polarity and structure of Cys121 domain in β-lactoglobulin with a new thiol-specific fluorescent probe

(2008) Xiaochun Wang et al.   ANALYST

Novel nitroheterocyclic hypoxic markers for solid tumor: Synthesis and biological evaluation

(2008) Weiping Zhu et al.   BIOORGANIC & MEDICINAL CHEMISTRY

The Biology of Cancer: Metabolic Reprogramming Fuels Cell Growth and Proliferation

(2008) Ralph J. DeBerardinis et al.   Cell Metabolism

Emission under Hypoxia: One-Electron Reduction and Fluorescence Characteristics of an Indolequinone–Coumarin Conjugate

(2008) Kazuhito Tanabe et al.   CHEMBIOCHEM

A Molecular Rotor Based on an Unhindered Boron Dipyrromethene (Bodipy) Dye

(2008) Mohammed A. H. Alamiry et al.   CHEMISTRY OF MATERIALS

Versatile Nitro-Fluorophore as Highly Effective Sensor for Hypoxic Tumor Cells: Design, Imaging and Evaluation

(2008) Min Dai et al.   JOURNAL OF FLUORESCENCE

Temperature-Dependent Fluorescence Lifetime of a Fluorescent Polymeric Thermometer, Poly(N-isopropylacrylamide), Labeled by Polarity and Hydrogen Bonding Sensitive 4-Sulfamoyl-7-aminobenzofurazan

(2008) Chie Gota et al.   JOURNAL OF PHYSICAL CHEMISTRY B

A Versatile Amino Acid Analogue of the Solvatochromic Fluorophore 4-N,N-Dimethylamino-1,8-naphthalimide: A Powerful Tool for the Study of Dynamic Protein Interactions

(2008) Galen Loving et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Two-Photon Fluorescent Turn-On Probe for Lipid Rafts in Live Cell and Tissue

(2008) Hwan Myung Kim et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Molecular Rotor Measures Viscosity of Live Cells via Fluorescence Lifetime Imaging

(2008) Marina K. Kuimova et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A Hemicyanine-Conjugated Copolymer as a Highly Sensitive Fluorescent Thermometer

(2008) Yasuhiro Shiraishi et al.   LANGMUIR

Environment sensitive phenothiazine dyes strongly fluorescence in protic solvents

(2007) Feng Han et al.   JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY A-CHEMISTRY