Which form is that? The importance of selenium speciation and metabolism in the prevention and treatment of disease

Effect of Supplementation With High-Selenium Yeast on Plasma Lipids

(2013) Margaret P. Rayman et al.   ANNALS OF INTERNAL MEDICINE

The abilities of selenium dioxide and selenite ion to coordinate DNA-bound metal ions and decrease oxidative DNA damage

(2013) William E. Hart et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

A randomized controlled Alzheimer’s disease prevention trial’s evolution into an exposure trial: The preadvise trial

(2013) R. J. Kryscio et al.   Journal of Nutrition Health & Aging

Advanced Prostate Cancer Risk in Relation to Toenail Selenium Levels

(2013) Milan S. Geybels et al.   JNCI-Journal of the National Cancer Institute

Selenoprotein P and selenoprotein M block Zn2+-mediated Aβ42 aggregation and toxicity

(2013) Xiubo Du et al.   Metallomics

Elevated amyloid-β plaque deposition in dietary selenium-deficient Tg2576 transgenic mice

(2013) Mamoru Haratake et al.   Metallomics

A Low Selenium Level Is Associated with Lung and Laryngeal Cancers

(2013) Katrzyna Jaworska et al.   PLoS One

Enhancement of Auranofin-Induced Apoptosis in MCF-7 Human Breast Cells by Selenocystine, a Synergistic Inhibitor of Thioredoxin Reductase

(2013) Chaoran Liu et al.   PLoS One

Neutralization by Metal Ions of the Toxicity of Sodium Selenide

(2013) Marc Dauplais et al.   PLoS One

Selenium Metabolism in Cancer Cells: The Combined Application of XAS and XFM Techniques to the Problem of Selenium Speciation in Biological Systems

(2013) Claire Weekley et al.   Nutrients

Selenium and prostate cancer: systematic review and meta-analysis

(2012) Rachel Hurst et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Selenoproteins and Cancer Prevention

(2012) Cindy D. Davis et al.   Annual Review of Nutrition

Selenocysteine in Thiol/Disulfide-Like Exchange Reactions

(2012) Robert J. Hondal et al.   ANTIOXIDANTS & REDOX SIGNALING

Thioredoxin reductase 1 deficiency enhances selenite toxicity in cancer cells via a thioredoxin-independent mechanism

(2012) Ryuta Tobe et al.   BIOCHEMICAL JOURNAL

Glutathione peroxidases

(2012) Regina Brigelius-Flohé et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Recent Advances in the Development of Thioredoxin Reductase Inhibitors as Anticancer Agents

(2012) Yang Liu et al.   CURRENT DRUG TARGETS

Subacute toxicity of nano-selenium compared to other selenium species in mice

(2012) Ilona Benko et al.   ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY

Antioxidant vitamins and mineral supplementation, life span expansion and cancer incidence: a critical commentary

(2012) Piero Dolara et al.   EUROPEAN JOURNAL OF NUTRITION

Selenium-containing amino acids as direct and indirect antioxidants

(2012) Aldwin Suryo Rahmanto et al.   IUBMB LIFE

Cytotoxic Mechanism of Selenomethionine in Yeast

(2012) Toshihiko Kitajima et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Therapeutic effect of organoselenium dietary supplementation in a sporadic dementia of Alzheimer's type model in rats

(2012) Simone Pinton et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Selenium and human health

(2012) Margaret P Rayman   LANCET

Does a role for selenium in DNA damage repair explain apparent controversies in its use in chemoprevention?

(2012) Soumen Bera et al.   MUTAGENESIS

Photochemically Generated Elemental Selenium Forms Conjugates with Serum Proteins That Are Preferentially Cytotoxic to Leukemia and Selected Solid Tumor Cells

(2012) Jean-Pierre Daziano et al.   PHOTOCHEMISTRY AND PHOTOBIOLOGY

Methylseleninic Acid Enhances Paclitaxel Efficacy for the Treatment of Triple-Negative Breast Cancer

(2012) Yanfeng Qi et al.   PLoS One

Sodium Selenide Toxicity Is Mediated by O2-Dependent DNA Breaks

(2012) Gérald Peyroche et al.   PLoS One

A Randomized Trial of Selenium Supplementation and Risk of Type-2 Diabetes, as Assessed by Plasma Adiponectin

(2012) Margaret P. Rayman et al.   PLoS One

Methylselenol Formed by Spontaneous Methylation of Selenide Is a Superior Selenium Substrate to the Thioredoxin and Glutaredoxin Systems

(2012) Aristi P. Fernandes et al.   PLoS One

Protection of cisplatin-induced spermatotoxicity, DNA damage and chromatin abnormality by selenium nano-particles

(2012) Mohammad Amin Rezvanfar et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Induction of apoptosis and autophagy by sodium selenite in A549 human lung carcinoma cells through generation of reactive oxygen species

(2012) Shin-Hyung Park et al.   TOXICOLOGY LETTERS

Comprehensive speciation of selenium in selenium-rich yeast

(2012) Katarzyna Bierla et al.   TRAC-TRENDS IN ANALYTICAL CHEMISTRY

Biosynthesis of Selenocysteine, the 21st Amino Acid in the Genetic Code, and a Novel Pathway for Cysteine Biosynthesis

(2012) Anton A. Turanov et al.   Advances in Nutrition

Toxicology and pharmacology of selenium: emphasis on synthetic organoselenium compounds

(2011) Cristina W. Nogueira et al.   ARCHIVES OF TOXICOLOGY

Methylseleninic acid inhibits HDAC activity in diffuse large B-cell lymphoma cell lines

(2011) Shireen Kassam et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Current knowledge in species-related bioavailability of selenium in food

(2011) Celine Thiry et al.   FOOD CHEMISTRY

Catalytic activity of selenomethionine in removing amino acid, peptide, and protein hydroperoxides

(2011) Aldwin Suryo Rahmanto et al.   FREE RADICAL BIOLOGY AND MEDICINE

Interaction of selenite and tellurite with thiol-dependent redox enzymes: Kinetics and mitochondrial implications

(2011) Maria Pia Rigobello et al.   FREE RADICAL BIOLOGY AND MEDICINE

Ethaselen: a potent mammalian thioredoxin reductase 1 inhibitor and novel organoselenium anticancer agent

(2011) Lihui Wang et al.   FREE RADICAL BIOLOGY AND MEDICINE

Low doses of selenium specifically stimulate the repair of oxidative DNA damage in LNCaP prostate cancer cells

(2011) Viviana de Rosa et al.   FREE RADICAL RESEARCH

Interactions of Cu(I) with Selenium-Containing Amino Acids Determined by NMR, XAS, and DFT Studies

(2011) Hsiao C. Wang et al.   INORGANIC CHEMISTRY

Modeling the Mechanism of the Glutathione Peroxidase Mimic Ebselen

(2011) Sonia Antony et al.   INORGANIC CHEMISTRY

Dietary supplementation with methylseleninic acid, but not selenomethionine, reduces spontaneous metastasis of Lewis lung carcinoma in mice

(2011) Lin Yan et al.   INTERNATIONAL JOURNAL OF CANCER

Methylseleninic acid downregulates hypoxia-inducible factor-1α in invasive prostate cancer

(2011) Indu Sinha et al.   INTERNATIONAL JOURNAL OF CANCER

Vitamin E and the Risk of Prostate Cancer

(2011) Eric A. Klein et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Superoxide Flashes

(2011) Qi Ma et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Silver speciation in liver of marine mammals by synchrotron X-ray absorption fine structure and X-ray fluorescence spectroscopies

(2011) Emiko Nakazawa et al.   JOURNAL OF ENVIRONMENTAL MONITORING

Metabolism of Selenite in Human Lung Cancer Cells: X-Ray Absorption and Fluorescence Studies

(2011) Claire M. Weekley et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

GPx-Like Activity of Selenides and Selenoxides: Experimental Evidence for the Involvement of Hydroxy Perhydroxy Selenane as the Active Species

(2011) Vanessa Nascimento et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Selenium homeostasis and induction of thioredoxin reductase during long term selenite supplementation in the rat

(2011) Suvd Erkhembayar et al.   JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY

Preventing metal-mediated oxidative DNA damage with selenium compounds

(2011) Erin E. Battin et al.   Metallomics

Intracellular glutathione content influences the sensitivity of lung cancer cell lines to methylseleninic acid

(2011) Chengfei Liu et al.   MOLECULAR CARCINOGENESIS

Low levels of selenium compounds are selectively toxic for a human neuron cell line through ROS/RNS increase and apoptotic process activation

(2011) Tullia Maraldi et al.   NEUROTOXICOLOGY

Selenomethionine Incorporation into Amyloid Sequences Regulates Fibrillogenesis and Toxicity

(2011) Javier Martínez et al.   PLoS One

Selenium and Lung Cancer: A Systematic Review and Meta Analysis

(2011) Heidi Fritz et al.   PLoS One

Advances in metal-induced oxidative stress and human disease

(2011) Klaudia Jomova et al.   TOXICOLOGY

Functional Mimics of Glutathione Peroxidase: Bioinspired Synthetic Antioxidants

(2010) Krishna P. Bhabak et al.   ACCOUNTS OF CHEMICAL RESEARCH

The Chemical Nature of Mercury in Human Brain Following Poisoning or Environmental Exposure

(2010) Malgorzata Korbas et al.   ACS Chemical Neuroscience

Establishing optimal selenium status: results of a randomized, double-blind, placebo-controlled trial

(2010) Rachel Hurst et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Chemopreventive mechanisms of α-keto acid metabolites of naturally occurring organoselenium compounds

(2010) John T. Pinto et al.   AMINO ACIDS

Why do proteins use selenocysteine instead of cysteine?

(2010) Thomas Nauser et al.   AMINO ACIDS

Surveying selenium speciation from soil to cell—forms and transformations

(2010) Bente Gammelgaard et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Serum selenium and serum lipids in US adults: National Health and Nutrition Examination Survey (NHANES) 2003–2004

(2010) Martin Laclaustra et al.   ATHEROSCLEROSIS

Thioredoxin and thioredoxin reductase: Current research with special reference to human disease

(2010) Arne Holmgren et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Selenium compounds are substrates for glutaredoxins: a novel pathway for selenium metabolism and a potential mechanism for selenium-mediated cytotoxicity

(2010) Marita Wallenberg et al.   BIOCHEMICAL JOURNAL

Thioredoxin reductase 1 knockdown enhances selenazolidine cytotoxicity in human lung cancer cells via mitochondrial dysfunction

(2010) Robyn L. Poerschke et al.   BIOCHEMICAL PHARMACOLOGY

Anti-hemolytic and Peroxyl Radical Scavenging Activity of Organoselenium Compounds: An In Vitro Study

(2010) B. Santhosh Kumar et al.   BIOLOGICAL TRACE ELEMENT RESEARCH

The choice of biomarkers determines the selenium status in young German vegans and vegetarians

(2010) Johanna Hoeflich et al.   BRITISH JOURNAL OF NUTRITION

Rapamycin suppresses ROS-dependent apoptosis caused by selenomethionine in A549 lung carcinoma cells

(2010) Maiko Suzuki et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Se-methylselenocysteine sensitizes hypoxic tumor cells to irinotecan by targeting hypoxia-inducible factor 1α

(2010) Sreenivasulu Chintala et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Selenium and Bladder Cancer Risk: a Meta-analysis

(2010) A. F. S. Amaral et al.   CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION

Antioxidant and Anticancer Properties and Mechanisms of Inorganic Selenium, Oxo-Sulfur, and Oxo-Selenium Compounds

(2010) Ria R. Ramoutar et al.   CELL BIOCHEMISTRY AND BIOPHYSICS

Distribution and Translocation of Selenium from Soil to Grain and Its Speciation in Paddy Rice (Oryza sativaL.)

(2010) Guo-Xin Sun et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

Direct quantitative speciation of selenium in selenium-enriched yeast and yeast-based products by X-ray absorption spectroscopy confirmed by HPLC-ICP-MS

(2010) Li Yu-Feng et al.   JOURNAL OF ANALYTICAL ATOMIC SPECTROMETRY

Selenium metabolism in hepatocytes incubated with selenite, selenate, selenomethionine, Se-methylselenocysteine and methylseleninc acid and analysed by LC-ICP-MS

(2010) Charlotte Gabel-Jensen et al.   JOURNAL OF ANALYTICAL ATOMIC SPECTROMETRY

Redox Signaling, Alkylation (Carbonylation) of Conserved Cysteines Inactivates Class I Histone Deacetylases 1, 2, and 3 and Antagonizes Their Transcriptional Repressor Function

(2010) Kelly Doyle et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Sodium selenate specifically activates PP2A phosphatase, dephosphorylates tau and reverses memory deficits in an Alzheimer’s disease model

(2010) Niall M. Corcoran et al.   JOURNAL OF CLINICAL NEUROSCIENCE

Investigation of the selenium metabolism in cancer cell lines

(2010) Kristoffer Lunøe et al.   Metallomics

Selenium status and cardiometabolic health: State of the evidence

(2010) S. Stranges et al.   NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES

Sodium selenate mitigates tau pathology, neurodegeneration, and functional deficits in Alzheimer's disease models

(2010) J. van Eersel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Methods of assessment of selenium status in humans: a systematic review

(2009) Kate Ashton et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Thioredoxin-1 and Endothelial Cell Aging: Role in Cardiovascular Diseases

(2009) Joachim Altschmied et al.   ANTIOXIDANTS & REDOX SIGNALING

Glutathione peroxidases in different stages of carcinogenesis

(2009) Regina Brigelius-Flohé et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Selenoproteins that function in cancer prevention and promotion

(2009) Dolph L. Hatfield et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Metabolism of selenium compounds catalyzed by the mammalian selenoprotein thioredoxin reductase

(2009) Jun Lu et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Selenoproteins and human health: Insights from epidemiological data

(2009) Margaret P. Rayman   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Protection against reactive oxygen species by selenoproteins

(2009) Holger Steinbrenner et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Selenium prevents cognitive decline and oxidative damage in rat model of streptozotocin-induced experimental dementia of Alzheimer's type

(2009) Tauheed Ishrat et al.   BRAIN RESEARCH

 -Keto Acid Metabolites of Naturally Occurring Organoselenium Compounds as Inhibitors of Histone Deacetylase in Human Prostate Cancer Cells

(2009) J.-I. Lee et al.   Cancer Prevention Research

Methyl-Selenium Compounds Inhibit Prostate Carcinogenesis in the Transgenic Adenocarcinoma of Mouse Prostate Model with Survival Benefit

(2009) L. Wang et al.   Cancer Prevention Research

Selenium modifies the osteoblast inflammatory stress response to bone metastatic breast cancer

(2009) Yu-Chi Chen et al.   CARCINOGENESIS

 -Keto acid metabolites of organoselenium compounds inhibit histone deacetylase activity in human colon cancer cells

(2009) H. Nian et al.   CARCINOGENESIS

Serum Selenium Concentrations and Hypertension in the US Population

(2009) Martin Laclaustra et al.  

Selenium Characterization in the Global Rice Supply Chain

(2009) Paul N. Williams et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

Organoselenium (Sel-Plex diet) decreases amyloid burden and RNA and DNA oxidative damage in APP/PS1 mice

(2009) Mark A. Lovell et al.   FREE RADICAL BIOLOGY AND MEDICINE

Selenium and Vitamin E Supplementation for Cancer Prevention

(2009) Margaret P. Rayman   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Oxidative stress and cardiovascular disease: Novel tools give (free) radical insight

(2009) Ian M. Fearon et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Supplementation of selenium reduces chemical hepatocarcinogenesis in male Sprague-Dawley rats

(2009) Nasar Alwahaibi et al.   JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY

Targeting selenium metabolism and selenoproteins: Novel avenues for drug discovery

(2009) Sarah Elizabeth Jackson-Rosario et al.   Metallomics

The Outcome of Selenium and Vitamin E Cancer Prevention Trial (SELECT) Reveals the Need for Better Understanding of Selenium Biology

(2009) D. L. Hatfield et al.   MOLECULAR INTERVENTIONS

Extracellular thiol-assisted selenium uptake dependent on the xc- cystine transporter explains the cancer-specific cytotoxicity of selenite

(2009) E. Olm et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

In vitro radioprotection studies of organoselenium compounds: differences between mono- and diselenides

(2009) B. Santhosh Kumar et al.   RADIATION AND ENVIRONMENTAL BIOPHYSICS

Selenium supplementation improves antioxidant capacity in vitro and in vivo in patients with coronary artery disease

(2008) Renate Schnabel et al.   AMERICAN HEART JOURNAL

Novel approaches for selenium speciation in foodstuffs and biological specimens: A review

(2008) Zoyne Pedrero et al.   ANALYTICA CHIMICA ACTA

Complementary use of molecular and element-specific mass spectrometry for identification of selenium compounds related to human selenium metabolism

(2008) Bente Gammelgaard et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Serum Selenium Levels and All-Cause, Cancer, and Cardiovascular Mortality Among US Adults

(2008) Joachim Bleys   ARCHIVES OF INTERNAL MEDICINE

Treatment of lung cancer cells with cytotoxic levels of sodium selenite: Effects on the thioredoxin system

(2008) Markus Selenius et al.   BIOCHEMICAL PHARMACOLOGY

Kinetics of Tyrosyl Radical Reduction by Selenocysteine

(2008) Daniel Steinmann et al.   BIOCHEMISTRY

Selenocystine induces reactive oxygen species–mediated apoptosis in human cancer cells

(2008) Tianfeng Chen et al.   BIOMEDICINE & PHARMACOTHERAPY

Combination of methylselenocysteine with tamoxifen inhibits MCF-7 breast cancer xenografts in nude mice through elevated apoptosis and reduced angiogenesis

(2008) Zengshan Li et al.   BREAST CANCER RESEARCH AND TREATMENT

Sodium selenite induces apoptosis by generation of superoxide via the mitochondrial-dependent pathway in human prostate cancer cells

(2008) Nong Xiang et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Antioxidant Activity of the Anti-Inflammatory Compound Ebselen: A Reversible Cyclization Pathway via Selenenic and Seleninic Acid Intermediates

(2008) Bani Kanta Sarma et al.   CHEMISTRY-A EUROPEAN JOURNAL

Selenium nanoparticles fabricated in Undaria pinnatifida polysaccharide solutions induce mitochondria-mediated apoptosis in A375 human melanoma cells

(2008) Tianfeng Chen et al.   COLLOIDS AND SURFACES B-BIOINTERFACES

Effect of Selenium and Vitamin E on Risk of Prostate Cancer and Other Cancers

(2008) Scott M. Lippman et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Locally Generated Methylseleninic Acid Induces Specific Inactivation of Protein Kinase C Isoenzymes

(2008) Usha Gundimeda et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mechanisms of inhibition of zinc-finger transcription factors by selenium compounds ebselen and selenite

(2008) Jason L. Larabee et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

Insights into the Chemical Biology of Selenium

(2008) Richard S. Glass et al.   PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS

Modulation of redox status in human lung cell lines by organoselenocompounds: Selenazolidines, selenomethionine, and methylseleninic acid

(2008) Robyn L. Poerschke et al.   TOXICOLOGY IN VITRO

Methylation and demethylation of intermediates selenide and methylselenol in the metabolism of selenium

(2007) Yuki Ohta et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY