Vitexin isolated from Prosopis cineraria leaves induce apoptosis in K-562 leukemia cells via inhibition of the BCR-ABL-Ras-Raf pathway

Investigation of phytochemical constituents of anti-leukemic herbal drugs used by the traditional healers of Purulia, Birbhum and Bankura districts of West Bengal

(2019) Monaj Kumar Sarkar et al.   NATURAL PRODUCT RESEARCH

KRAS, NRAS, and BRAF mutations are highly enriched in trisomy 12 chronic lymphocytic leukemia and are associated with shorter treatment-free survival

(2019) Elena Vendramini et al.   LEUKEMIA

Improving cellular uptake of therapeutic entities through interaction with components of cell membrane

(2019) Renshuai Zhang et al.   DRUG DELIVERY

Synthesis of potent neuroprotective butenolides based on plant smoke derived 3,4,5-Trimethylfuran-2(5H)-one and 3-methyl-2H-furo[2,3-c]pyrone-2-one

(2019) Devashan Naidoo et al.   PHYTOCHEMISTRY

Sanguinarine Induces Apoptosis Pathway in Multiple Myeloma Cell Lines via Inhibition of the JaK2/STAT3 Signaling

(2019) Sabah Akhtar et al.   Frontiers in Oncology

Green barley mitigates cytotoxicity in human lymphocytes undergoing aggressive oxidative stress, via activation of both the Lyn/PI3K/Akt and MAPK/ERK pathways

(2019) Blanca E. Ruiz-Medina et al.   Scientific Reports

Platyphylloside Isolated from Betula platyphylla is Antiproliferative and Induces Apoptosis in Colon Cancer and Leukemic Cells

(2019) Joo-Eun Lee et al.   MOLECULES

Induction of autophagy, apoptosis and aquisition of resistance in response to piceatannol toxicity in MOLT-4 human leukemia cells

(2019) Kamila Siedlecka-Kroplewska et al.   TOXICOLOGY IN VITRO

Oxidative stress mediated cytotoxicity in leukemia cells induced by active phyto-constituents isolated from traditional herbal drugs of West Bengal

(2019) Monaj Kumar Sarkar et al.   JOURNAL OF ETHNOPHARMACOLOGY

Chronic myeloid leukemia: 2018 update on diagnosis, therapy and monitoring

(2018) Elias Jabbour et al.   AMERICAN JOURNAL OF HEMATOLOGY

Mitochondrial membrane potential

(2018) Ljubava D. Zorova et al.   ANALYTICAL BIOCHEMISTRY

Computational study of molecular electrostatic potential, docking and dynamics simulations of gallic acid derivatives as ABL inhibitors

(2018) K.R. Raghi et al.   COMPUTATIONAL BIOLOGY AND CHEMISTRY

Viscum articulatum Burm. f. aqueous extract exerts antiproliferative effect and induces cell cycle arrest and apoptosis in leukemia cells

(2018) Ruchi Mishra et al.   JOURNAL OF ETHNOPHARMACOLOGY

Chronic Lymphocytic Leukemia: Diagnosis and Treatment

(2018) Paolo Strati et al.   MAYO CLINIC PROCEEDINGS

An overview of apoptosis assays detecting DNA fragmentation

(2018) Pavlína Majtnerová et al.   MOLECULAR BIOLOGY REPORTS

Molecular modeling, dynamics simulations, and binding efficiency of berberine derivatives: A new group of RAF inhibitors for cancer treatment

(2018) Parham Jabbarzadeh Kaboli et al.   PLoS One

Scoulerine affects microtubule structure, inhibits proliferation, arrests cell cycle and thus culminates in the apoptotic death of cancer cells

(2018) Klara Habartova et al.   Scientific Reports

Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

(2018) Freddie Bray et al.   CA-A CANCER JOURNAL FOR CLINICIANS

ROS and the DNA damage response in cancer

(2018) Upadhyayula Sai Srinivas et al.   Redox Biology

Uptake of phenolic compounds from plant foods in human intestinal Caco-2 cells

(2017) Gavirangappa Hithamani et al.   JOURNAL OF BIOSCIENCES

Vitexin induces apoptosis by suppressing autophagy in multi-drug resistant colorectal cancer cells

(2017) Monika Bhardwaj et al.   Oncotarget

An iterative compound screening contest method for identifying target protein inhibitors using the tyrosine-protein kinase Yes

(2017) Shuntaro Chiba et al.   Scientific Reports

A Selenium-Modified Ginseng Polysaccharide Promotes the Apoptosis in Human Promyelocytic Leukemia (HL-60) Cells via a Mitochondrial-Mediated Pathway

(2016) Kainan Liao et al.   BIOLOGICAL TRACE ELEMENT RESEARCH

Selective toxicity of persian gulf sea cucumber holothuria parva on human chronic lymphocytic leukemia b lymphocytes by direct mitochondrial targeting

(2016) Ahmad Salimi et al.   ENVIRONMENTAL TOXICOLOGY

Biological evaluation of dimethylpyridine–platinum complexes with potent antiproliferative activity

(2016) Robert Czarnomysy et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

In vitro antitumor activity of the ethyl acetate extract of Potentilla chinensis in osteosarcoma cancer cells

(2016) Guang Wan et al.   Molecular Medicine Reports

Design, synthesis and “in vitro” anti-leukemic evaluation of ferulic acid analogues as BCR-Abl inhibitors

(2016) Narendran Rajendran et al.   RSC Advances

Self assembled nano fibers of betulinic acid: A selective inducer for ROS/TNF-alpha pathway mediated leukemic cell death

(2015) Sandeep Kumar Dash et al.   BIOORGANIC CHEMISTRY

Differentiation and apoptosis induction by lovastatin and γ-tocotrienol in HL-60 cells via Ras/ERK/NF-κB and Ras/Akt/NF-κB signaling dependent down-regulation of glyoxalase 1 and HMG-CoA reductase

(2015) Chun-Chia Chen et al.   CELLULAR SIGNALLING

Membrane Interactions of Phytochemicals as Their Molecular Mechanism Applicable to the Discovery of Drug Leads from Plants

(2015) Hironori Tsuchiya   MOLECULES

Structure-Based Virtual Screening for Drug Discovery: Principles, Applications and Recent Advances

(2014) Evanthia Lionta et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Simvastatin interacts synergistically with tipifarnib to induce apoptosis in leukemia cells through the disruption of RAS membrane localization and ERK pathway inhibition

(2014) Tamer A. Ahmed et al.   LEUKEMIA RESEARCH

Hepatic, gastric, and intestinal first-pass effects of vitexin in rats

(2014) He-Fei Xue et al.   PHARMACEUTICAL BIOLOGY

Searching in Mother Nature for Anti-Cancer Activity: Anti-Proliferative and Pro-Apoptotic Effect Elicited by Green Barley on Leukemia/Lymphoma Cells

(2013) Elisa Robles-Escajeda et al.   PLoS One

The Bcl-2/Bax and Ras/Raf/MEK/ERK signaling pathways: implications in pediatric leukemia pathogenesis and new prospects for therapeutic approaches

(2013) Orsola Vitagliano et al.   Expert Review of Hematology

Bioavailability of bioactive food compounds: a challenging journey to bioefficacy

(2012) Maarit J. Rein et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Purified Vitexin Compound 1 Suppresses Tumor Growth and Induces Cell Apoptosis in a Mouse Model of Human Choriocarcinoma

(2012) Zhihui Tan et al.   INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER

The Novel p53-Dependent Metastatic and Apoptotic Pathway Induced by Vitexin in Human Oral Cancer OC2 Cells

(2012) Shih-Huang Yang et al.   PHYTOTHERAPY RESEARCH

The Effect of Bioactive Compounds on In Vitro and In Vivo Antioxidant Activity of Different Berry Juices

(2012) Ana Slatnar et al.   PLoS One

Dihydroartemisinin induces autophagy and inhibits the growth of iron-loaded human myeloid leukemia K562 cells via ROS toxicity

(2012) Zeng Wang et al.   FEBS Open Bio

Arsenic trioxide and radiation enhance apoptotic effects in HL-60 cells through increased ROS generation and regulation of JNK and p38 MAPK signaling pathways

(2011) Sheng-Yow Ho et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Roles of the Ras/Raf/MEK/ERK pathway in leukemia therapy

(2011) L S Steelman et al.   LEUKEMIA

Ikarugamycin induces DNA damage, intracellular calcium increase, p38 MAP kinase activation and apoptosis in HL-60 human promyelocytic leukemia cells

(2011) Ruxandra Popescu et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

Panaxydol induces apoptosis through an increased intracellular calcium level, activation of JNK and p38 MAPK and NADPH oxidase-dependent generation of reactive oxygen species

(2010) Joo Young Kim et al.   APOPTOSIS

3,6-Dihydroxyflavone induces apoptosis in leukemia HL-60 cell via reactive oxygen species-mediated p38 MAPK/JNK pathway

(2010) Hui Chang et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Role of Ras/Raf/MEK/ERK signaling in physiological hematopoiesis and leukemia development

(2010) Eva Chung et al.   IMMUNOLOGIC RESEARCH

Prostaglandin A2 activates intrinsic apoptotic pathway by direct interaction with mitochondria in HL-60 cells

(2010) Sun-Young Lee et al.   PROSTAGLANDINS & OTHER LIPID MEDIATORS

Encapsulation of polyphenols – a review

(2010) Zhongxiang Fang et al.   TRENDS IN FOOD SCIENCE & TECHNOLOGY