Article
Clinical Neurology
Han Zhang, Yu Zhao, Yun Qu, Yunyun Huang, Zhu Chen, Hong Lan, Yi Peng, Hongying Ren
Summary: Cognitive impairment is a serious complication of traumatic brain injury (TBI) that impacts patients' quality of life. This study aims to investigate whether repetitive transcranial magnetic stimulation (rTMS) can improve memory and executive function in TBI patients. A randomized controlled trial will be conducted with 36 participants, and neuropsychological assessments will be performed. The preliminary results suggest positive effects of rTMS on memory and executive function in TBI patients.
FRONTIERS IN NEUROLOGY
(2022)
Article
Immunology
Lulin Li, Lakshmi Yerra, Betty Chang, Vidhu Mathur, Andy Nguyen, Jian Luo
Summary: CSF1 treatment can attenuate long-term cognitive impairment in both acute and delayed TBI, and also improve pathological outcomes related to brain injuries.
BRAIN BEHAVIOR AND IMMUNITY
(2021)
Article
Rehabilitation
Eduardo Cisneros, Veronique Beausejour, Elaine de Guise, Sylvie Belleville, Michelle McKerral
Summary: This study evaluated the impact of a 12-week, 24-session multimodal group cognitive rehabilitation intervention on executive functioning and resumption of daily activities after traumatic brain injury in older individuals compared to an active control group receiving usual care. Results showed significant improvement in executive functioning for the experimental group, with positive impact on daily activities, indicating the effectiveness of the Cognitive Enrichment Program.
ANNALS OF PHYSICAL AND REHABILITATION MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Jiang Fang, Qiang Yuan, Zhuoying Du, Quan Zhang, Lei Yang, Meihua Wang, Weijian Yang, Cong Yuan, Jian Yu, Gang Wu, Jin Hu
Summary: We found that a distinct ferroptotic signature was detected in the injured hippocampus at the early stage of traumatic brain injury (TBI). Elevated levels of arachidonic acid (AA), ACLS4, and ALXO15, and deficiency of GPX4 were observed in the hippocampus after TBI, creating a pro-ferroptosis environment. Gpx4 overexpression alleviated TBI-induced cognitive deficits and reversed hippocampal ferroptosis and synaptic damage.
FREE RADICAL BIOLOGY AND MEDICINE
(2023)
Article
Immunology
Karen Krukowski, Amber Nolan, McKenna Becker, Katherine Picard, Nathalie Vernoux, Elma S. Frias, Xi Feng, Marie-Eve Tremblay, Susanna Rosi
Summary: The study revealed that one week after brain injury, microglia exhibit increased phagocytic activity, synaptic engulfment, and neuronal contact, which may contribute to cognitive deficits. By utilizing state-of-the-art techniques, novel microglia-mediated mechanisms that impact neuronal function after TBI were uncovered.
BRAIN BEHAVIOR AND IMMUNITY
(2021)
Article
Medicine, General & Internal
Jun-Quan Chen, Shuang-Qi Gao, Lun Luo, Zong-Yuan Jiang, Chao-Feng Liang, Hai-Yong He, Ying Guo
Summary: This study investigates the role of redox states of HMGB1 in neurite outgrowth and regeneration, finding that nonoxid-HMGB1 promotes this process through upregulated expression of SH3RF2. The results suggest that nonoxid-HMGB1 may be a potential therapeutic candidate for the treatment of TBI.
FRONTIERS IN MEDICINE
(2022)
Article
Immunology
Si-Wei Tan, Yan Zhao, Ping Li, Ya-Lei Ning, Zhi-Zhong Huang, Nan Yang, Dong Liu, Yuan-Guo Zhou
Summary: The study found that the continuous activation of the NLRP3 inflammasome and release of HMGB1 are closely related to cognitive impairment in the late stage of traumatic brain injury (TBI). Inhibition of HMGB1 improved long-term potentiation reduction and cognitive function by reducing NLRP3 inflammasome activation. This provides insights into the mechanism of cognitive dysfunction progression in TBI.
JOURNAL OF NEUROINFLAMMATION
(2021)
Article
Medicine, General & Internal
Chaonan Zhang, Cheng Wei, Xingqi Huang, Changxin Hou, Chuan Liu, Shu Zhang, Zilong Zhao, Yafan Liu, Ruiguang Zhang, Lei Zhou, Ying Li, Xubo Yuan, Jianning Zhang
Summary: Contact sports athletes and military personnel who suffered rmTBI are at high risk of neurodegenerative diseases. However, the diagnosis and treatment of rmTBI are limited due to the lack of specific biological indicators. In this study, MPC-capsuled immunoglobulins (MPC-n (IgG)) were used to alleviate cognitive impairment and other symptoms in rmTBI mice, showing promising results in the treatment of rmTBI-related cognitive impairment.
Article
Rehabilitation
Rotem Eliav, Yael Lugassy, Rachel Kizony
Summary: This study aimed to validate the Assessment of Participation and Executive Functions (A-PEX) tool for evaluating executive function deficits in post-traumatic brain injury (TBI) patients during the subacute phase of rehabilitation. The results showed that the A-PEX had good internal consistency and reliability, and can be used as an effective measure for assessing executive functions in TBI patients.
EUROPEAN JOURNAL OF PHYSICAL AND REHABILITATION MEDICINE
(2023)
Article
Critical Care Medicine
Chantal M. Sanchez, David J. Titus, Nicole M. Wilson, Julie E. Freund, Coleen M. Atkins
Summary: Early life stress may contribute to persistent cognitive deficits in individuals with mild traumatic brain injury, including impaired learning and memory function, as well as worsened cortical pathology.
JOURNAL OF NEUROTRAUMA
(2021)
Article
Oncology
Lijuan Quan, Yue Zhao, Chengfeng Ouyang, Dexia Ying, Zhichao Xiong, Xunxin Li, Ziqin Liao, Jun Luo, Howe Liu
Summary: Objective: This study aimed to investigate the role of chemokine receptor ACKR2 in cognitive impairment in young rats with traumatic brain injury. Methods: Various techniques were employed to examine the effects of ACKR2 in young rats, including water maze test, electron microscope, staining, ELISA, RT-PCR, and Western blotting. Results: The study found that the expression of ACKR2 was decreased in TBI rats, resulting in decreased learning and memory abilities, increased inflammatory factors levels, and elevated expressions of Tau and NG2. Conclusion: Overexpression of ACKR2 combined with sensory integration improved the cognitive abilities of TBI rats, suggesting that ACKR2 may be an effective method for improving outcomes in young rats with traumatic brain injury.
AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH
(2023)
Article
Clinical Neurology
Iori Ozono, Fusao Ikawa, Toshikazu Hidaka, Michitsura Yoshiyama, Masashi Kuwabara, Shingo Matsuda, Yuji Yamamori, Tomoko Nagata, Hidekazu Tomimoto, Michiyasu Suzuki, Shuhei Yamaguchi, Kaoru Kurisu, Nobutaka Horie
Summary: As the global population ages, the impact of mild TBI on the cognitive function of the elderly has become a focus. This study found that older patients with hypertension are at a significantly higher risk of cognitive impairment after experiencing even mild TBI. Careful management is needed for these patients following mild TBI.
WORLD NEUROSURGERY
(2022)
Article
Clinical Neurology
Elaine de Guise, Catherine Degre, Oceane Beaujean, Jessica Julien, Maude Lague-Beauvais, Jehane Dagher, Judith Marcoux
Summary: This preliminary study aimed to assess the impact of traumatic brain injury (TBI) in older age on executive functioning and functional outcome, as well as the influence of cognitive reserve (CR) and estimated premorbid cognitive functioning (EPCF) on these components. The results showed that patients with TBI performed worse on certain tests and had worse functional outcome scores compared to the control group. Higher level of education and higher estimated premorbid cognitive functioning were associated with better performance and functional outcome post TBI.
APPLIED NEUROPSYCHOLOGY-ADULT
(2022)
Review
Critical Care Medicine
Nikolett Szarka, Dora Szellar, Szabolcs Kiss, Nelli Farkas, Zsolt Szakacs, Andras Czigler, Zoltan Ungvari, Peter Hegyi, Andras Buki, Peter Toth
Summary: Through literature review and meta-analysis, it was found that GH replacement therapy after TBI can moderately improve cognitive function and quality of life, as well as alleviate the severity of depressive symptoms.
JOURNAL OF NEUROTRAUMA
(2021)
Article
Medicine, General & Internal
Natascha Ekdahl, Alison K. Godbolt, Catharina Nygren Deboussard, Marianne Lannsjo, Britt-Marie Stalnacke, Maud Stenberg, Trandur Ulfarsson, Marika C. Moller
Summary: The study investigates the relationship between early global cognitive functioning and cognitive flexibility in severe traumatic brain injury patients. The results show a significant correlation between early global cognitive functioning, cognitive flexibility, and long-term outcome.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Rehabilitation
Alba Aza, Miguel Angel Verdugo, Maria Begona Orgaz, Nada Andelic, Maria Fernandez, Marit Vindal Forslund
Summary: This study explores the differences in self- and proxy-reported quality of life (QoL) among individuals with acquired brain injury (ABI) and identifies predictors of QoL. The results show that professionals have the lowest QoL scores, followed by family members and individuals with ABI. Significant differences were found for almost all QoL domains, with the highest correlations observed between family and professional proxy measures. Sociodemographic, clinical, rehabilitation, personal, and social variables were identified as significant predictors of QoL.
DISABILITY AND REHABILITATION
(2022)
Article
Audiology & Speech-Language Pathology
M. Ali, A. Lifshitz Ben Basat, M. Berthier, M. Blom Johansson, C. Breitenstein, D. A. Cadilhac, F. Constantinidou, M. Cruice, G. Davila, M. Gandolfi, M. Gil, R. Grima, E. Godecke, L. Jesus, L. Martinez Jiminez, M. Kambanaros, T. Kukkonen, A. Laska, I Mavis, R. Mc Menamin, C. Mendez-Orellana, H. Obrig, P. Ostberg, H. Robson, K. Sage, M. Van De Sandt-koenderman, K. Sprecht, E. Visch-Brink, E. Wehling, S. Wielaert, S. J. Wallace, L. J. Williams, M. C. Brady
Summary: This study aims to document and inform international delivery of post-stroke aphasia treatment to optimize recovery and reintegration of people with aphasia. It is a prospective, multi-center open study focusing on participants with post-stroke aphasia, assessing outcomes at baseline, discharge, 6 months, and 12 months post-stroke. The research will explore associations between demographics, therapy, medication use, and outcomes to identify cost-effective approaches for optimizing rehabilitation and benefiting people with aphasia.
Article
Psychology, Clinical
Daniel Loke, Marianne Lovstad, Nada Andelic, Stein Andersson, Eivind Ystrom, Olav Vassend
Summary: The study aimed to investigate the relationship between fatigue, pain, and distress, and to determine the extent to which genetic and environmental factors contribute to this relationship. The findings suggest that a significant proportion of the association between fatigue, pain, and distress is due to genetic and environmental confounding. However, pain and distress still have a direct effect on fatigue even when controlling for genetic and stable environmental contributions. The study highlights the complex interplay between symptoms in various illnesses.
HEALTH PSYCHOLOGY AND BEHAVIORAL MEDICINE
(2022)
Article
Medicine, General & Internal
Daniel Loke, Nada Andelic, Eirik Helseth, Olav Vassend, Stein Andersson, Jennie L. Ponsford, Cathrine Tverdal, Cathrine Brunborg, Marianne Lovstad
Summary: This study explores factors relevant to identification and rehabilitation of fatigue following traumatic brain injuries (TBI) using a biopsychosocial approach. The results reveal that psychosocial robustness, somatic vulnerability, and injury severity are significantly associated with fatigue, explaining 44.2% of the variance.
JOURNAL OF CLINICAL MEDICINE
(2022)
Correction
Health Care Sciences & Services
Helene Lundgaard Soberg, Hakon Ogreid Moksnes, Audny Anke, Olav Roise, Cecilie Roe, Eline Aas, Unni Sveen, Christine Gaarder, Pal Aksel Naess, Eirik Helseth, Hilde Margrete Dahl, Frank Becker, Marianne Lovstad, Kristian Bartnes, Christoph Schafer, Mari S. Rasmusssen, Paul Perrin, Juan Lu, Torgeir Hellstrom, Nada Andelic
JMIR RESEARCH PROTOCOLS
(2022)
Article
Rehabilitation
Kjersti Sagstad, Emilie Isager Howe, Silje C. R. Fure, Marianne Lovstad, Heidi Enehaug, Helene Ugelstad, Marte Feiring, Nada Andelic, Unni Sveen
Summary: This study explored the experiences of persons with MTBI returning to ordinary competitive work after a prolonged period of sickness absence. Participants experienced a crisis when starting work and emphasized the importance of making the decision to return to work. Challenges related to time perception and capacity restrictions were identified during the process of increased workload. The importance of being seen and valued was highlighted.
SCANDINAVIAN JOURNAL OF OCCUPATIONAL THERAPY
(2023)
Article
Health Care Sciences & Services
Henriette Michalsen, Silje C. Wangberg, Gunnar Hartvigsen, Andre Henriksen, Gunn Pettersen, Letizia Jaccheri, Reidun Birgitta Jahnsen, Gyrd Thrane, Cathrine Arntzen, Audny Anke
Summary: This study aims to evaluate the feasibility and acceptability of intervention procedures for a future randomized controlled trial on mobile health (mHealth) to support physical activity for individuals with intellectual disabilities (IDs). The study will also explore how the use of technology can influence motivation for physical activity among participants, caregivers, and staff members. A mixed methods pilot study will be conducted, involving 10 participants with ID and their caregivers or staff members. Assessments will include questionnaires and activity trackers, and qualitative methods will be used to assess acceptability.
JMIR RESEARCH PROTOCOLS
(2022)
Article
Education, Special
Monica Isabel Olsen, Erik Sondenaa, Ellen Melbye Langballe, Marianne Berg Halvorsen, Per Wilhelmsen, Erik Bautz-Holter, Audny Anke
Summary: This study investigates the utilization of health and dental care services in adults with intellectual disability in the past year based on Norwegian recommendations. The results show that the frequency of health checks and contact with doctors decreases with the severity of intellectual disability. Few women undergo cancer screening, and dental health is poor.
JOURNAL OF INTELLECTUAL & DEVELOPMENTAL DISABILITY
(2023)
Article
Rehabilitation
Anniken Bogstrand, Astrid Gramstad, Audny Anke, Henriette Holm Stabel, Cathrine Arntzen
Summary: The study highlights the neglected group of patients with mild to moderate cognitive impairment after stroke in rehabilitation services, pointing to structural and professional issues as contributing factors. It emphasizes the need to increase knowledge about cognitive rehabilitation and organize rehabilitation services to meet the long-term needs of stroke survivors and caregivers.
REHABILITATION RESEARCH AND PRACTICE
(2022)
Article
Medicine, General & Internal
Juan Lu, Mari S. Rasmussen, Solrun Sigurdardottir, Marit V. Forslund, Emilie I. Howe, Silje C. R. Fure, Marianne Lovstad, Reagan Overeem, Cecilie Roe, Nada Andelic
Summary: This study examined the impact of injury characteristics and one-year functional level on the community integration outcomes of patients with moderate-to-severe traumatic brain injury over a 10-year period. The results showed improved community integration over time, with age, cognitive function, and bodily pain being significant predictors of long-term outcomes.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, General & Internal
Nicole von Steinbuechel, Stefanie Hahm, Holger Muehlan, Juan Carlos Arango-Lasprilla, Fabian Bockhop, Amra Covic, Silke W. Schmidt, Ewout Steyerberg, Andrew I. R. Maas, David Menon, Nada Andelic, Marina Zeldovich, CTR TBI Participants Investigators
Summary: Traumatic brain injury (TBI) is a major cause of death and disability worldwide. This study aims to understand the impact of TBI on various outcome domains, evaluating factors contributing to worsening or improving outcomes. The study used patient-reported outcome measures and identified different trajectory classes for outcome after TBI, including stable good health, persistent impairments, improving health, and deteriorating health. Individuals with persistent impairments and deterioration need special attention and long-term clinical monitoring and therapy.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, General & Internal
Hakon Ogreid Moksnes, Christoph Schafer, Mari Storli Rasmussen, Helene Lundgaard Soberg, Olav Roise, Audny Anke, Cecilie Roe, Pal Aksel Naess, Christine Gaarder, Eirik Helseth, Hilde Margrete Dahl, Morten Hestnes, Cathrine Brunborg, Nada Andelic, Torgeir Hellstrom
Summary: This study evaluates the global functional outcomes at 6 and 12 months after moderate-to-severe traumatic injury and identifies the factors that predict these outcomes. The results show that half of the patients experience persistent disability at 12 months post-injury.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, General & Internal
Solveig L. Hauger, Ida M. H. Borgen, Marit V. Forslund, Ingerid Kleffelgard, Nada Andelic, Marianne Lovstad, Paul B. Perrin, Cecilie Roe, Silje C. R. Fure
Summary: This study evaluates participation over a period of one year among persons with traumatic brain injury (TBI) in the chronic phase and explores predictors of levels and trajectories of participation. The results suggest that marital status, education, and global functioning are associated with higher levels of participation. Age, marital status, and education are predictors of specific domains of participation.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, General & Internal
Benedikte a. Madsen, Silje C. R. Fure, Nada Andelic, Daniel Loke, Marianne Lovstad, Cecilie Roe, Emilie Isager Howe
Summary: Approximately 30% of individuals with mild traumatic brain injury (mTBI) experience persistent post-concussion symptoms (PPCS). Personality traits such as neuroticism, openness to experience, and conscientiousness are associated with more severe PPCS and lower return to work (RTW) in patients with mild-to-moderate TBI. However, after controlling for PPCS, personality traits are no longer significantly associated with RTW.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, General & Internal
Ingerid Kleffelgard, Nada Andelic, Kari Anette Bruusgaard, Birgitta Langhammer, Anne-Lise Tamber, Helene Lundgaard Soberg
Summary: Persistent dizziness and balance problems after mmTBI can lead to significant disability. This study aimed to identify factors associated with dizziness-related disability one year after injury. The findings showed that pre-injury comorbidity, neck pain, increased post-concussion symptom burden, increased dizziness symptom severity, and reduced balance and mobility were all associated with dizziness-related disability at one year.
JOURNAL OF CLINICAL MEDICINE
(2023)
