Article
Chemistry, Analytical
Mengren Wu, Yuan Gao, Amirreza Ghaznavi, Weiqi Zhao, Jie Xu
Summary: Efficient mixing of fluids is crucial for various biomedical and biochemical applications in lab-on-a-chip devices. This study explores electroosmosis micromixing in a lab-on-a-foil microfluidic device, achieving efficient micromixing using tooth-shaped planar electrodes. The study evaluates the mixing performance through intensity measurement and investigates the effects of frequency, flow rate, voltage amplitude, and number of electrode tooth pairs. The research demonstrates the potential for optimizing mixing performance in EOF-based micromixers and the fabrication of low-cost flexible electric microfluidic devices.
SENSORS AND ACTUATORS B-CHEMICAL
(2022)
Review
Chemistry, Analytical
Sri Manikandan Saravanakumar, Paul-Vahe Cicek
Summary: This review paper provides a comprehensive understanding of the intricate physics of microfluidics and their applications in micromixing techniques. The paper explores various methods for enhancing mixing in microchannels, with a focus on the underlying fluid dynamics principles. Understanding the physics of fluid behavior and rationalizing these techniques is essential for tailoring the most suitable micromixing solution for specific microfluidic mixing needs.
Review
Pharmacology & Pharmacy
Renata Maia, Violeta Carvalho, Rui Lima, Graca Minas, Raquel O. Rodrigues
Summary: This systematic review summarizes the recent progress in the use of microneedles (MNs) in biomedical applications, including drug delivery, biomarker detection, and their potential integration with microfluidic devices. Although MNs have been extensively utilized in lab-on-a-chip platforms, recent studies have also explored their applicability in organ-on-a-chip models. Overall, the presence of MNs in advanced microfluidic devices offers simplified drug delivery, microinjection, and biomarker detection through integrated biosensors, enabling real-time monitoring of various biomarkers in lab- and organ-on-a-chip platforms.
Article
Engineering, Chemical
Yue Qiu, Yuyang Hou, Leizhen Lu, Shiyu Zhang, Hao Wu, Jun Zhou, Jishuang Chen
Summary: The use of Ca(OH)2 slurry to absorb and remove CO2 can achieve a carbon-free biogas purification process and is an effective method for preparing CaCO3.
SEPARATION AND PURIFICATION TECHNOLOGY
(2023)
Review
Pharmacology & Pharmacy
Ghazal Shabestani Monfared, Peter Ertl, Mario Rothbauer
Summary: Cutaneous wound healing is a complex process involving cell communication events and cell migration to achieve wound closure. Microfluidic and lab-on-a-chip technologies have improved in vitro wound healing assays to create more reliable models resembling the in vivo wound microenvironment.
Article
Chemistry, Physical
Huichao Lin, Yang Liu, Chonghui Yang, Gaozhen Zhao, Jiaao Song, Taiyi Zhang, Xiaowen Huang
Summary: Artificial photosynthesis is an effective method to convert solar energy into chemical energy, and it plays an important role in the regeneration of coenzymes and synthesis of organic matter. However, traditional photocatalytic materials and oxidoreductases have problems such as poor stability and inability to be reused. This study presents an efficient and stable microfluidic artificial photosynthetic system for reduced nicotinamide adenine dinucleotide (NADH) regeneration and l-glutamate synthesis, with advantages of high efficiency, low cost, and sustainability.
CATALYSIS SCIENCE & TECHNOLOGY
(2022)
Article
Chemistry, Analytical
Harry Dawson, Jinane Elias, Pascal Etienne, Sylvie Calas-Etienne
Summary: The integration of optical circuits with microfluidic lab-on-chip devices has brought about new possibilities for sample manipulation and detection at the micro-scale, particularly in bio-chemical applications. However, challenges remain due to the complexity of combining photonics with micro-fabricated systems, which limits the industrial scaling of this technology.
Article
Chemistry, Analytical
Yu-Shih Chen, Tzu-Wei Lo, Hong-Yuan Huang, Lien-Min Li, Yi-Wen Wang, Da-Jeng Yao, Wen-Syang Hsu, Cheng-Hsien Liu
Summary: The combination of In Vitro Fertilization (IVF) and microfluidic technology offers a promising solution to infertility by enhancing the success rate of IVF and accelerating embryo growth and development. By utilizing a microfluidic embryo lab chip for co-cultivation, researchers observed faster embryo growth rates and higher blastocyst development rates compared to traditional culture methods.
SENSORS AND ACTUATORS B-CHEMICAL
(2021)
Review
Chemistry, Analytical
Federico Sala, Carlotta Ficorella, Roberto Osellame, Josef A. Kaes, Rebeca Martinez Vazquez
Summary: Understanding cell migration is crucial for unraveling physiological phenomena and predicting pathologies like cancer metastasis. Microfluidic devices have been used to investigate cellular migration response by engineering mechanical and spatial stimuli. This review discusses the existing technologies, such as soft lithography and femtosecond laser micromachining, used in microfluidic cellular migration assays. It highlights the different geometrical configurations employed and envisions future developments in in vitro migration studies under spatial confinement in microfluidic devices.
Article
Computer Science, Theory & Methods
Xing Huang, Tsung-Yi Ho, Wenzhong Guo, Bing Li, Krishnendu Chakrabarty, Ulf Schlichtmann
Summary: Flow-based microfluidic biochips are increasingly utilized in biology and biochemistry for laboratory procedures, with advancements in manufacturing technology allowing for integration of thousands of microvalves into a small platform. Computer-aided design (CAD) in the past decade has attracted research interest for automation of biochip design, enabling designers to explore new chip architectures and simplify complex tasks. Key trends and directions for future research focus on maximizing the potential of microfluidics to advance the industry.
ACM COMPUTING SURVEYS
(2021)
Article
Engineering, Electrical & Electronic
Samith Hettiarachchi, Gehan Melroy, Amith Mudugamuwa, Peshan Sampath, Charith Premachandra, Ranjith Amarasinghe, Van Dau
Summary: This paper discusses the modeling, simulation, and experimentation of an active droplet generator used in LOC devices, focusing on the key factor of droplet generation. The study found that optimized droplet contraction width and flow rate ratios are crucial for effective droplet generation. Experimental results show that droplet formation occurs within a certain range of flow rate ratios, with droplet diameter decreasing as the flow rate ratio decreases.
SENSORS AND ACTUATORS A-PHYSICAL
(2021)
Article
Engineering, Multidisciplinary
Tong Hou, Hui Chang, Haoliang Jiang, Pengcheng Wang, Na Li, Yongxin Song, Dongqing Li
Summary: The smartphone integrated microfluidic lab-on-chip device enables real-time detection, counting, and sizing of living algae in ship's ballast water, achieving high accuracy and convenience in operation.
Article
Engineering, Electrical & Electronic
Sarah E. Lu, Andrew Morris, Geraldine Clinton-Bailey, Medya Namiq, Paul C. Gow, Antony Birchill, Sebastian Steigenberger, James Wyatt, Reuben Forrester, Matthew C. Mowlem, Phillip E. Warwick
Summary: Nuclear reactor process control often relies on manual sampling and laboratory analysis for monitoring pure β-emitting radionuclides, leading to delays in data availability and response times. The development of an in situ microfluidic Lab on Chip (LoC) system with integrated detection offers a promising solution, reducing occupational exposure and monitoring costs while providing improved temporal resolution through near real-time data acquisition.
SENSORS AND ACTUATORS A-PHYSICAL
(2023)
Article
Engineering, Electrical & Electronic
Yitong Xu, Weisheng Wu, Zhongyi Zhou, Qiyi Su, Xinghui Liu, Weiwei Li, Kai Wang
Summary: We present a fully-integrated lab on a chip (LOC) that combines a digital microfluidic array, on-chip resistive heater and temperature sensor, on-chip optical sensor, and transimpedance preamplifier. The LOC is manufactured on a thin-film transistor (TFT) glass substrate, making it cost-effective and suitable for disposable point-of-care testing (POCT) applications.
IEEE ELECTRON DEVICE LETTERS
(2023)
Article
Engineering, Multidisciplinary
Agnieszka Krakos (Podwin), Anna Janicka, Justyna Molska, Maciej Zawis, Danylo Lizanets, Tomasz Bialecki, Bartosz Gawron, Tomasz Suchocki
Summary: This paper presents a lab-on-a-chip (LOC) for cellular studies and verifies its performance through numerical simulations and biological experiments. The toxicity of jet fuels on cells was evaluated using Euglena gracilis as a bioindicator. Exhaust gas chromatography analysis showed that the concentration of the most toxic BTEX group increased about two times with the addition of HEFAtype hydrocarbons.
Article
Ecology
Dana Kuersten, Frances Moeller, Gregor Alexander Gross, Claudia Lenk, Nikunjkumar Visaveliya, Tim Schueler, Johann Michael Koehler
METHODS IN ECOLOGY AND EVOLUTION
(2015)
Article
Engineering, Environmental
J. M. Koehler, F. Moeller, S. Schneider, P. M. Guenther, A. Albrecht, G. A. Gross
CHEMICAL ENGINEERING JOURNAL
(2011)
Article
Engineering, Environmental
Lahbib Abahmane, Andrea Knauer, J. Michael Koehler, G. Alexander Gross
CHEMICAL ENGINEERING JOURNAL
(2011)
Article
Engineering, Environmental
S. Li, G. A. Gross, P. M. Guenther, J. M. Koehler
CHEMICAL ENGINEERING JOURNAL
(2011)
Article
Engineering, Environmental
M. Budden, S. Schneider, G. A. Gross, M. Kielpinski, T. Henkel, J. M. Koehler
CHEMICAL ENGINEERING JOURNAL
(2013)
Article
Biotechnology & Applied Microbiology
G. Alexander Gross, Sukhdeep Singh, Gregor Schlingloff, Andreas Schwienhorst, Daniel Riester, Dennis Wegener, Hanns Wurziger, Andreas Schober
ENGINEERING IN LIFE SCIENCES
(2013)
Article
Engineering, Electrical & Electronic
Matthias Budden, Steffen Schneider, G. Alexander Gross, Mark Kielpinski, Thomas Henkel, Brian Cahill, J. Michael Koehler
SENSORS AND ACTUATORS A-PHYSICAL
(2013)
Article
Chemistry, Organic
Sukhdeep Singh, Andreas Schober, G. Alexander Gross
TETRAHEDRON LETTERS
(2014)
Article
Materials Science, Characterization & Testing
Antonella Hadzich, G. Alexander Gross, Martin Leimbach, Adriana Ispas, Andreas Bund, Santiago Flores
Article
Chemistry, Analytical
Mark Kielpinski, Oliver Walther, Jialan Cao, Thomas Henkel, J. Michael Koehler, G. Alexander Gross
Article
Chemistry, Applied
Antonella Hadzich, G. Alexander Gross, Martin Leimbach, Adriana Ispas, Andreas Bund, Santiago Flores
PROGRESS IN ORGANIC COATINGS
(2020)
Article
Chemistry, Analytical
Jialan Cao, Felix Richter, Michael Kastl, Jonny Erdmann, Christian Burgold, David Dittrich, Steffen Schneider, J. Michael Koehler, G. Alexander Gross
Article
Chemistry, Analytical
Thomas Henkel, Guenter Mayer, Joerg Hampl, Jialan Cao, Linda Ehrhardt, Andreas Schober, Gregor Alexander Gross
Summary: Droplet-based microfluidic screening techniques can be connected to established microtiter plate-based screening and sample management workflows through interfacing tools. A bidirectional sampling interface for sample transfer from wells into droplets and vice versa droplets into wells is achieved using Digital Microfluidic Pipetting Tips (DMPT) and a robotic system.
Article
Biotechnology & Applied Microbiology
Martin Baca, Dana Brauer, Maren Klett, Uta Fernekorn, Sukhdeep Singh, Jorg Hampl, G. Alexander Gross, Patrick Mai, Karin Friedel, Andreas Schober
Summary: This study reports the design and function of a 3D automated culture and analysis device that can monitor and analyze the condition of cell culture in real-time. The results show that the application of the hepatotoxic drug-like APAP leads to decreased albumin secretion in HepaRG cells in this device. The system demonstrates higher sensitivity to APAP compared to conventional culture methods.
BIOENGINEERING-BASEL
(2022)
Article
Engineering, Environmental
Xiang Li, Nikunjkumar Visaveliya, Lars Hafermann, G. Alexander Gross, Andrea Knauer, J. Michael Koehler
CHEMICAL ENGINEERING JOURNAL
(2017)
Article
Engineering, Chemical
Qing Han, Mengqing Shi, Linkai Han, Di Liu, Mingwei Tong, Yuxin Xie, Zhonghua Xiang
Summary: Developing highly efficient bifunctional oxygen electrocatalysts is crucial for zinc-air flow batteries. Metal-organic frameworks (MOFs) and covalent organic polymers (COPs) have emerged as promising alternatives due to their designable and controllable atomic-level structures. However, their catalytic performances are limited by conductivity and catalytic activity. In this study, nanosheet FeNi-MOF and iron phthalocyanine rich COP hybrid materials are assembled through the pi-pi stacking effect to create highly efficient bifunctional electrocatalysts. The resulting catalyst exhibits superior catalytic performance and stability, making it a promising candidate for zinc-air flow batteries.
CHEMICAL ENGINEERING SCIENCE
(2024)
Article
Engineering, Chemical
Daria Grigorash, Dmytro Mihrin, Rene Wugt Larsen, Erling H. Stenby, Wei Yan
Summary: The article introduces a new approach to describe the cross-association between molecules, allowing for the simulation of weakly bound molecular complexes with different conformations in mixtures. By incorporating this approach into the equation of state, accurate predictions of vapor-liquid equilibrium and liquid-liquid equilibrium can be made. The new method is validated through experiments on alcohol and acid mixtures, with the results compared to experimental data, demonstrating its accuracy and reliability.
CHEMICAL ENGINEERING SCIENCE
(2024)
Article
Engineering, Chemical
Mohammed Al-Sharabi, Daniel Markl, Vincenzino Vivacqua, Prince Bawuah, Natalie Maclean, Andrew P. E. York, Axel Zeitler
Summary: This study used terahertz pulsed imaging to investigate the transport process of different solvents into ceramic catalytic materials. The results showed that the heating rate of the samples influenced the water transport rate, while the viscosity of 1-octanol slowed down its transport.
CHEMICAL ENGINEERING SCIENCE
(2024)
Article
Engineering, Chemical
Chukwunonso Anyaoku, Sati Bhattacharya, Rajarathinam Parthasarathy
Summary: This study aimed to enhance understanding of settling dynamics in viscoelastic fluids by developing a semi-empirical correlation and a dimensionless ratio, which accurately described the characteristics of settling suspensions.
CHEMICAL ENGINEERING SCIENCE
(2024)
Article
Engineering, Chemical
Antti I. Koponen, Janika Viitala, Atsushi Tanaka, Baranivignesh Prakash, Olli-Ville Laukkanen, Ari Jasberg
Summary: This study focuses on the development of foam application chemicals for the paper and board industry. The research explores the rheology of the polyvinyl alcohol foam used in the process. Measurements were conducted to determine the foam viscosity and slip flow. The results suggest that slip flow contributes significantly to the total flow rate, and the obtained viscosity and slip models provide a solid foundation for industrial processes.
CHEMICAL ENGINEERING SCIENCE
(2024)
Article
Engineering, Chemical
Dalei Sun, Jinghui Cai, Yating Yang, Zhiwu Liang
Summary: In this study, Fe-doped alpha-Bi2O3 catalysts with different Fe/Bi molar ratios were synthesized and utilized in the carbonylation of isobutyl amine with CO2. The results showed that Fe doping significantly enhanced the catalytic abilities of alpha-Bi2O3.
CHEMICAL ENGINEERING SCIENCE
(2024)
Article
Engineering, Chemical
Yuan Tian, Xinxin Wang, Yanrong Liu, Wenping Hu
Summary: This paper predicts the solubility of nitrogen gas in ionic liquids (ILs) using two quantitative structure-property relationship (QSPR) models. By combining machine learning methods and ionic fragments contribution method, the accuracy and reliability of the prediction models are improved.
CHEMICAL ENGINEERING SCIENCE
(2024)
Article
Engineering, Chemical
Liwang Wang, Wei Liu, Pan Yang, Yulong Chang, Xiaoxu Duan, Lingyu Xiao, Yaoming Hu, Jiwei Wu, Liang Ma, Hualin Wang
Summary: This study investigates the effective phase interfacial area (ae) of hydro-jet cyclones at different injection angles. The results show that a 45 degrees upward incidence angle yields the most favorable flow field characteristics for efficient mass transfer. The significant enhancement in ae of the hydro-jet cyclones offers the advantage of reducing equipment volume and cost savings.
CHEMICAL ENGINEERING SCIENCE
(2024)
Article
Engineering, Chemical
Chuanjun Wu, Jiangzhi Chen, Jiyue Sun, I-Ming Chou, Shenghua Mei, Juezhi Lin, Lei Jiang
Summary: In this study, the solubility of H2S hydrate in water was measured using Raman spectroscopy. The results showed that the solubility increases with temperature under certain equilibrium conditions, and the solubility also depends on pressure and temperature under different equilibrium conditions. A thermodynamic model based on the van der Waals-Platteeuw theory was developed to predict the solubility, demonstrating its accuracy.
CHEMICAL ENGINEERING SCIENCE
(2024)
Article
Engineering, Chemical
Lorenzo Brivio, Serena Meini, Mattia Sponchioni, Davide Moscatelli
Summary: This study investigates the influence of three main parameters and proposes a kinetic model to predict the optimal operating conditions for high yield of dimethyl terephthalate (DMT) in the chemical recycling process of polyethylene terephthalate (PET).
CHEMICAL ENGINEERING SCIENCE
(2024)
Article
Engineering, Chemical
Hongju Lin, Fanhui Liao, Yanchang Chu, Mingyu Xie, Lun Pan, Yuanyuan Wang, Lijian Leng, Donghai Xu, Le Yang, Gangfeng Ouyang
Summary: A honeycomb NiCo/C-Na catalyst with a micro-meso-macroporous structure has been fabricated and shown to have significantly higher catalytic activity for the decarboxylation of fatty acids. It also proves to be efficient in upgrading sludge HTL bio-crude, resulting in a biofuel with decreased viscosity and increased density.
CHEMICAL ENGINEERING SCIENCE
(2024)
Article
Engineering, Chemical
Xiaoxian Li, Rui Li, Min Lin, Mingde Yang, Yulong Wu
Summary: A series of coated non-noble metal porous carbon catalysts were synthesized and applied to the aqueous-phase deoxygenation of algal bio-oil. One of the catalysts showed excellent deoxygenation selectivity and catalytic activity at 250 degrees C. The catalyst exhibited good hydrothermal stability and the reaction mechanism was proposed based on product analysis and active site analysis.
CHEMICAL ENGINEERING SCIENCE
(2024)
Article
Engineering, Chemical
M. V. Chudakova, M. V. Popov, P. A. Korovchenko, E. O. Pentsak, A. R. Latypova, P. B. Kurmashov, A. A. Pimenov, E. A. Tsilimbaeva, I. S. Levin, A. G. Bannov, A. V. Kleymenov
Summary: A series of catalysts with different potassium contents were prepared using solution combustion synthesis and characterized using various techniques. The results showed that the potassium content affected the phase composition and texture of the catalysts. The addition of a small amount of potassium resulted in a change in particle size distribution, leading to higher hydrogen yield. The Ni-1%K2O/Al2O3 catalyst exhibited the highest hydrogen yield at temperatures of 675 and 750 degrees Celsius.
CHEMICAL ENGINEERING SCIENCE
(2024)
Article
Engineering, Chemical
Aliakbar Roosta, Nima Rezaei
Summary: In this study, we modified the electrolyte cubic plus association equation of state (e-CPA EoS) and integrated it with two electrical conductivity models to estimate the electrical conductivity of 11 monovalent electrolyte solutions in water. The modified e-CPA model demonstrated better performance and the hybridization with electrical conductivity models resulted in two predictive models for estimating the electrical conduction of dilute and concentrated electrolyte solutions. These predictive models showed relative average percentage deviations (AARD) of 11.15% and 13.87% over wide ranges of temperature and electrolyte concentration.
CHEMICAL ENGINEERING SCIENCE
(2024)
Article
Engineering, Chemical
Haoren Niu, Jianzheng Wang, Qingzhu Jia, Qiang Wang, Jin Zhao, Fangyou Yan
Summary: A study developed two quantitative structure-property relationship models for the complexation performance of alpha- and beta-cyclodextrins and validated their stability and predictive ability through internal and external validation. The models showed robustness and satisfactory performance, as demonstrated by the experimental results and model validations. These models can effectively predict the binding constants between cyclodextrins and various types of molecules, providing valuable tools for cyclodextrin design.
CHEMICAL ENGINEERING SCIENCE
(2024)