Article
Biochemical Research Methods
Gustavo Ochoa-Vazquez, Boris Kharisov, Ana Arizmendi-Morquecho, Anais Cario, Cyril Aymonier, Samuel Marre, Israel Lopez
Summary: A simple and low-cost continuous segmented-flow process for the synthesis of Ag and Au spherical-shaped nanoparticles is presented. The flow conditions have opposite effects on the synthesis of Ag and Au nanoparticles, with low residence times improving Ag nanoparticle production and high residence times improving Au nanoparticle synthesis yield and quality.
IEEE TRANSACTIONS ON NANOBIOSCIENCE
(2022)
Article
Chemistry, Multidisciplinary
Vindula Basnayake Pussepitiyalage, Shohreh Hemmati
Summary: This study explores the synthesis of Pd nanorods using a sustainable reducing agent in a segmented millifluidic flow reactor. The results show that the initial reduction rate is about 66% faster in the first 45 minutes compared to the rest of the reaction.
Article
Polymer Science
Jordan Thomas Lovegrove, Radhika Raveendran, Patrick Spicer, Stephan Foerster, Christopher J. Garvey, Martina H. Stenzel
Summary: Margination refers to the movement of particles towards the endothelial wall within blood vessels. This study focused on 2D platelet particles as a potential drug delivery system and quantified their margination propensity. The results showed that 2D platelet particles exhibited increased margination compared to spherical particles, with higher margination observed at higher shear rates.
Article
Chemistry, Multidisciplinary
Chenghao Zhang, Xiaonan Duan, Jiabin Yin, Fengyan Lou, Jisong Zhang
Summary: Aerobic oxidation of alcohols to aldehydes and ketones is a green and sustainable method for the pharmaceutical and fragrance industries. Micro-reactors provide a solution to safety and mass transfer limitations in industrial applications of aerobic oxidations. This study demonstrates a highly efficient micro-packed bed reactor for Cu/TEMPO-catalyzed aerobic alcohol oxidation, and establishes a pivotal kinetic model. Additionally, the micro-packed bed allows for higher oxidation rates for various alcohols, making it a more efficient and safer option for aerobic alcohol oxidation.
REACTION CHEMISTRY & ENGINEERING
(2022)
Article
Biochemistry & Molecular Biology
Mohannad T. Aljarrah, Ala'a M. Alboull, Mohammad S. Alharahsheh, Azad Ashraf, Amith Khandakar
Summary: This study reports the synthesis of gold nanoparticles using chemical reduction in batch and microreactor methods. A parametric study was conducted to analyze the effect of several factors on the size of the nanoparticles, and the best conditions obtained were used to synthesize gold nanoparticles in a glass chip microreactor. The results show that the microreactor method consistently produces smaller nanoparticles in a shorter reaction time.
Article
Engineering, Environmental
Yosuke Muranaka, Taisuke Maki, Daiki Nakayoshi, Shusaku Asano, Katsuya Ikebata, Aiichiro Nagaki, Yosuke Ashikari, Kyoko Mandai, Kazuhiro Mae
Summary: The study demonstrated the chiral separation of a water-soluble amino acid derivative using a multiphase segmented flow technique. By utilizing simultaneous extraction and back-extraction with multiple phases, the accumulation of target material was prevented in the extraction phase and efficiently removed in the recovery phase, resulting in extraction performance beyond equilibrium.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Chemistry, Applied
Rohit Duvadie, Alexander Pomberger, Yiming Mo, Erhan Altinoglu, Hsiao-Wu Hsieh, Kakasaheb Y. Nandiwale, Victor L. Schultz, Klavs F. Jensen, Richard Robinson
Summary: This study focuses on optimizing organic reactions, particularly the photoredox iridium-nickel dual catalyzed cross-electrophile coupling, to achieve typical scale-up goals by developing homogeneous starting conditions. Initial screening was conducted via a 15 μL automated segmented flow reactor, followed by multigram continuous flow synthesis demonstration in a 5 mL photo-continuous stirred-tank reactor (CSTR) cascade.
ORGANIC PROCESS RESEARCH & DEVELOPMENT
(2021)
Article
Chemistry, Multidisciplinary
Jyotirban Dey, Alisha Virdi, Manabendra Chandra
Summary: Understanding the role of each plasmon decay channel is crucial for studying the plasmon-exciton interaction in nanoscale plexciton hybrids. In this study, we investigate the influence of chemical interface damping (CID) on the plasmon-exciton coupling by using single-particle spectroscopy. Our findings show that CID reduces the plasmon-exciton coupling strength and can be controlled by modifying the nanoparticle's surface.
Article
Engineering, Environmental
Chenghao Zhang, Jing Luo, Binqi Xie, Wei Liu, Jisong Zhang
Summary: A continuous micro-packed bed reactor platform is developed to determine the kinetics of aerobic ethylbenzene oxidation in the presence of N-hydroxyphthalimide. The reactor system offers enhanced gas-liquid mass transfer, leading to a significant increase in the space-time yield of ethylbenzene oxidation compared to traditional batch reactors. Furthermore, the organic catalyst NHPI is covalently anchored on commercial activated carbon through an imidization reaction. The synthesized heterogeneous catalysts exhibit excellent performance in terms of acetophenone yield and turnover frequency (TOF).
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Chemistry, Multidisciplinary
Amanda A. Volk, Robert W. Epps, Daniel Yonemoto, Felix N. Castellano, Milad Abolhasani
Summary: A quaternary segmented flow regime was introduced and characterized for continuous biphasic chemical processes, with over 1500 experiments conducted to verify its stability and dynamic properties. This flow format was then utilized for ligand exchange of cadmium selenide quantum dots, resulting in improved photoluminescence quantum yield under high intensity ultraviolet illumination.
REACTION CHEMISTRY & ENGINEERING
(2021)
Article
Chemistry, Physical
Ritesh Singh Maurya, Swetha Jayanthi, Ch Gupta Chandaluri, T. P. Radhakrishnan
Summary: The impact of the mode of assembly of molecules on the properties and functions of molecular materials is a fundamental problem that was investigated through a novel diaminodicyanoquinodimethane derivative in this study. The compound exhibited enhanced fluorescence in the crystalline state, with a noticeable weak and red-shifted fluorescence in the amorphous state. The transformation from amorphous to crystalline state was monitored through imaging techniques and confirmed by diffraction methods.
CHEMISTRY OF MATERIALS
(2022)
Article
Multidisciplinary Sciences
Malek Y. S. Ibrahim, Milad Abolhasani
Summary: In this study, a rapid and reusable catalyst was developed for the selective production of hindered amines in a flow reactor. Online reaction optimization and solvent tuning enabled the switch between amine and enamine production without changing the ligand. Furthermore, a robust recovery strategy for the rhodium catalyst was demonstrated using its ionic nature.
NATURE COMMUNICATIONS
(2022)
Article
Engineering, Environmental
Xiaoyang Jiang, Sihui Li, Ken-Ichiro Sotowa, Osamu Tonomura, Tae Hoon Oh
Summary: In this study, continuous synthesis of nanoFe3O4 was achieved within a microchannel using the coprecipitation method in segmented flow. The results, analyzed through X-ray diffraction, scanning electron microscopy, and transmission electron microscopy, showed that the segmented flow synthesis strategy was capable of fabricating approximately 6 nm nanoFe3O4. Moreover, by increasing the high-speed valve frequency and reducing the segment length, uniform nanoparticles were synthesized and the size distribution range was reduced. The developed continuous synthesis method offers significant advantages over existing technologies in terms of productivity and manufacturing cost, providing a promising pathway for industrial-scale continuous synthesis of nanoFe3O4.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Chemistry, Multidisciplinary
Kittipat Suwanpitak, Pornsak Sriamornsak, Inderbir Singh, Tanikan Sangnim, Kampanart Huanbutta
Summary: Polyglycolic acid (PGA) nanoparticles were continuously synthesized using a 3D-printed vortex tube reactor. The reactor design was optimized using computer-aided design (CAD) and design of experiments (DoE), and the mixing efficiency was evaluated using computational fluid dynamics simulations (CFD). The results showed that the optimized reactor design achieved homogeneous mixing and improved productivity compared to traditional tubular reactors. The study also identified the impact of flow parameters on PGA nanoparticle size and polydispersity index.
Article
Physics, Fluids & Plasmas
Florent Fessler, Vaibhav Sharma, Pierre Muller, Antonio Stocco
Summary: Entry of micro- or nanosized objects into cells or vesicles is a common phenomenon in various processes. In this study, the penetration of microparticles into giant unilamellar vesicles is investigated, without strong binding interactions. It is found that the particles can enter the vesicles when an external force is applied and the membrane tension is low. The role of the membrane area reservoir is identified, and a force minimum is observed when the particle size is comparable to the bendocapillary length.
Article
Chemistry, Applied
Claudia Lenk, Carlos Mattea, Siegfried Stapf, J. Michael Koheler
JOURNAL OF POROUS MATERIALS
(2017)
Article
Polymer Science
Nikunjkumar Visaveliya, Andrea Knauer, Johann Michael Koehler
MACROMOLECULAR CHEMISTRY AND PHYSICS
(2017)
Article
Biotechnology & Applied Microbiology
Jialan Cao, Lars Hafermann, J. Michael Koehler
ENGINEERING IN LIFE SCIENCES
(2017)
Article
Biochemical Research Methods
Matthias Thiele, Andrea Knauer, Daniell Malsch, Andrea Csaki, Thomas Henkel, J. Michael Koehler, Wolfgang Fritzsche
Article
Environmental Sciences
Johann Michael Koehler, Franziska Kalensee, Peter Mike Guenther, Tim Schueler, Jialan Cao
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH
(2018)
Article
Nanoscience & Nanotechnology
J. Michael Koehler, Danja Kuhfuss, Phillip Witthoeft, Martina Hentschel, Andrea Knauer
JOURNAL OF NANOMATERIALS
(2018)
Article
Chemistry, Multidisciplinary
Johann Michael Koehler, Andrea Knauer
APPLIED SCIENCES-BASEL
(2018)
Article
Materials Science, Characterization & Testing
Antonella Hadzich, G. Alexander Gross, Martin Leimbach, Adriana Ispas, Andreas Bund, Santiago Flores
Article
Chemistry, Analytical
Mark Kielpinski, Oliver Walther, Jialan Cao, Thomas Henkel, J. Michael Koehler, G. Alexander Gross
Article
Chemistry, Applied
Antonella Hadzich, G. Alexander Gross, Martin Leimbach, Adriana Ispas, Andreas Bund, Santiago Flores
PROGRESS IN ORGANIC COATINGS
(2020)
Article
Chemistry, Analytical
Jialan Cao, Felix Richter, Michael Kastl, Jonny Erdmann, Christian Burgold, David Dittrich, Steffen Schneider, J. Michael Koehler, G. Alexander Gross
Article
Chemistry, Analytical
Thomas Henkel, Guenter Mayer, Joerg Hampl, Jialan Cao, Linda Ehrhardt, Andreas Schober, Gregor Alexander Gross
Summary: Droplet-based microfluidic screening techniques can be connected to established microtiter plate-based screening and sample management workflows through interfacing tools. A bidirectional sampling interface for sample transfer from wells into droplets and vice versa droplets into wells is achieved using Digital Microfluidic Pipetting Tips (DMPT) and a robotic system.
Article
Biotechnology & Applied Microbiology
Martin Baca, Dana Brauer, Maren Klett, Uta Fernekorn, Sukhdeep Singh, Jorg Hampl, G. Alexander Gross, Patrick Mai, Karin Friedel, Andreas Schober
Summary: This study reports the design and function of a 3D automated culture and analysis device that can monitor and analyze the condition of cell culture in real-time. The results show that the application of the hepatotoxic drug-like APAP leads to decreased albumin secretion in HepaRG cells in this device. The system demonstrates higher sensitivity to APAP compared to conventional culture methods.
BIOENGINEERING-BASEL
(2022)
Article
Nanoscience & Nanotechnology
Xiang Li, Nikunjkumar R. Visaveliya, Lars Hafermann, Andrea Knauer, Steffen Schneider, J. Michael Koehler
ACS APPLIED NANO MATERIALS
(2018)
Article
Engineering, Environmental
Xiang Li, Nikunjkumar Visaveliya, Lars Hafermann, G. Alexander Gross, Andrea Knauer, J. Michael Koehler
CHEMICAL ENGINEERING JOURNAL
(2017)
Article
Engineering, Environmental
Xinping Zhang, Yuxin Guo, Xiaoyang Liu, Shun-Yu Wu, Ya-Xuan Zhu, Shao-Zhe Wang, Qiu-Yi Duan, Ke-Fei Xu, Zi-Heng Li, Xiao-Yu Zhu, Guang-Yu Pan, Fu-Gen Wu
Summary: This study develops a nanotrigger HCFT for simultaneous photodynamic therapy and light-triggered ferroptosis therapy. The nanotrigger can relieve tumor hypoxia, induce enhanced photodynamic reaction, and facilitate the continuation of Fenton reaction, ultimately leading to lethal ferroptosis in tumor cells.
CHEMICAL ENGINEERING JOURNAL
(2024)
Article
Engineering, Environmental
Olumide Bolarinwa Ayodele, Toyin Daniel Shittu, Olayinka S. Togunwa, Dan Yu, Zhen-Yu Tian
Summary: This study focused on the semihydrogenation of acetylene in an ethylene-rich stream using two alloyed Pt catalysts PtCu and PtCo. The PtCu catalyst showed higher activity and ethylene yield compared to PtCo due to its higher unoccupied Pt d-orbital density. This indicates that alloying Pt with Cu is more promising for industrial relevant SHA catalyst.
CHEMICAL ENGINEERING JOURNAL
(2024)
Article
Engineering, Environmental
Guowei Chen, Wen-Cheng Chen, Yaozu Su, Ruicheng Wang, Jia-Ming Jin, Hui Liang, Bingxue Tan, Dehua Hu, Shaomin Ji, Hao-Li Zhang, Yanping Huo, Yuguang Ma
Summary: This study proposes an intramolecular dual-locking design for organic luminescent materials, achieving high luminescence efficiency and performance for deep-blue organic light-emitting diodes. The material also exhibits unique mechanochromic luminescence behavior and strong fatigue resistance.
CHEMICAL ENGINEERING JOURNAL
(2024)
Article
Engineering, Environmental
Joren van Stee, Gregory Hermans, Jinu Joseph John, Koen Binnemans, Tom Van Gerven
Summary: This work presents a continuous solvent extraction method for the separation of cobalt and nickel in a millifluidic system using Cyphos IL 101 (C101) as the extractant. The optimal conditions for extraction performance and solvent properties were determined by investigating the effects of channel length, flow rate, and temperature. The performance of a developed manifold structure was compared to a single-channel system, and excellent separation results were achieved. The continuous separation process using the manifold structure resulted in high purity cobalt and nickel products.
CHEMICAL ENGINEERING JOURNAL
(2024)
Article
Engineering, Environmental
Yan Xu, Jingai Jiang, Xinyi Lv, Hui Li, Dongliang Yang, Wenjun Wang, Yanling Hu, Longcai Liu, Xiaochen Dong, Yu Cai
Summary: A programmed gas release nanoparticle was developed to address the challenges in treating diabetic infected wounds. It effectively removes drug-resistant pathogens and remodels the wound microenvironment using NO and H2S. The nanoparticle can eliminate bacteria and promote wound healing through antibacterial and anti-inflammatory effects.
CHEMICAL ENGINEERING JOURNAL
(2024)
Article
Engineering, Environmental
Tong Xia, Zhilin Xi, Lianquan Suo, Chen Wang
Summary: This study investigated a highly efficient coal dust suppressant with low initial viscosity and high adhesion-solidification properties. The results demonstrated that the dust suppressant formed a network of multiple hydrogen bonding cross-linking and achieved effective adhesion and solidification of coal dust through various chemical reactions.
CHEMICAL ENGINEERING JOURNAL
(2024)
Article
Engineering, Environmental
Jinzhi Cai, Zhenshan Li
Summary: A density functional theory-based rate equation was developed to predict the gas-solid reaction kinetics of CaO carbonation with CO2 in calcium looping. The negative activation energy of CaO carbonation close to equilibrium was accurately predicted through experimental validation.
CHEMICAL ENGINEERING JOURNAL
(2024)
Article
Engineering, Environmental
Jianxiong Chen, Fuhao Ren, Ningning Yin, Jie Mao
Summary: This study presents an economically efficient and easily implementable surface modification approach to enhance the high-temperature electrical insulation and energy storage performance of polymer dielectrics. The self-assembly of high-insulation-performance boron nitride nanosheets (BNNS) on the film surface through electrostatic interactions effectively impedes charge injection from electrodes while promoting charge dissipation and heat transfer.
CHEMICAL ENGINEERING JOURNAL
(2024)
Article
Engineering, Environmental
Zijian Li, Zhaohui Yang, Shao Wang, Hongxia Luo, Zhimin Xue, Zhenghui Liu, Tiancheng Mu
Summary: This study reports a strategy for upgrading polyester plastics into value-added chemicals using electrocatalytic methods. By inducing the targeted transfer of *OH species, polyethylene terephthalate was successfully upgraded into potassium diformate with high purity. This work not only develops an excellent electrocatalyst, but also provides guidance for the design of medium entropy metal oxides.
CHEMICAL ENGINEERING JOURNAL
(2024)
Article
Engineering, Environmental
Navneet Singh Shekhawat, Surendra Kumar Patra, Ashok Kumar Patra, Bamaprasad Bag
Summary: This study primarily focuses on developing a sulphur dyeing process at room temperature using bacterial Lysate, which is environmentally friendly, energy and cost effective, and sustainable. The process shows promising improvements in dye uptake and fastness properties.
CHEMICAL ENGINEERING JOURNAL
(2024)
Article
Engineering, Environmental
Dengjia Shen, Hongyang Ma, Madani Khan, Benjamin S. Hsiao
Summary: This study developed cationic PVC nanofibrous membranes with high filtration and adsorption capability for the removal of bacteria and hexavalent chromium ions from wastewater. The membranes demonstrated remarkable performance in terms of filtration efficiency and maximum adsorption capacity. Additionally, modified nanofibrous membranes were produced using recycled materials and showed excellent retention rates in dynamic adsorption processes.
CHEMICAL ENGINEERING JOURNAL
(2024)
Article
Engineering, Environmental
Xiaoyan Wang, Zhikun Wang, Ben Jia, Chunling Li, Shuangqing Sun, Songqing Hu
Summary: Inspired by photosystem II, self-supported Fe-doped NiCoP nanowire arrays modified with carboxylate were constructed to boost industrial-level overall water splitting by employing the concerted proton-coupled electron transfer mechanism. The introduction of Fe and carboxyl ligand led to improved catalytic activity for HER and OER, and NCFCP@NF exhibited long-term durability for overall water splitting.
CHEMICAL ENGINEERING JOURNAL
(2024)
Article
Engineering, Environmental
Pengyao Yu, Ge Yang, Yongming Chai, Lubomira Tosheva, Chunzheng Wang, Heqing Jiang, Chenguang Liu, Hailing Guo
Summary: Thin LTA zeolite membranes were prepared through secondary growth of nano LTA seeds in a highly reactive gel, resulting in membranes with superior permeability and selectivity in gas separation applications.
CHEMICAL ENGINEERING JOURNAL
(2024)
Article
Engineering, Environmental
Baiqin Zhou, Huiping Li, Ziyu Wang, Hui Huang, Yujun Wang, Ruichun Yang, Ranran Huo, Xiaoyan Xu, Ting Zhou, Xiaochen Dong
Summary: The use of machine learning to predict the performance of specific adsorbents in phosphate adsorption shows great promise in saving time and revealing underlying mechanisms. However, the small size of the dataset and insufficient detailed information limits the model training process and the accuracy of results. To address this, the study employs a fuzzing strategy that replaces detailed numeric information with descriptive text messages on the physiochemical properties of adsorbents. This strategy allows the recovery of discarded samples with limited information, leading to accurate prediction of adsorption amount, capacity, and kinetics. The study also finds that phosphate uptake by adsorbents is generally through physisorption, with some involvement of chemisorption. The framework established in this study provides a practical approach for quickly predicting phosphate adsorption performance in urgent scenarios, using easily accessible information.
CHEMICAL ENGINEERING JOURNAL
(2024)
Article
Engineering, Environmental
Paula Alejandra Lamprea Pineda, Joren Bruneel, Kristof Demeestere, Lisa Deraedt, Tex Goetschalckx, Herman Van Langenhove, Christophe Walgraeve
Summary: This study evaluates the use of four esterified fatty acids and three vegetable oils as absorption liquids for hydrophobic VOCs. The experimental results show that isopropyl myristate is the most efficient liquid for absorbing the target VOCs.
CHEMICAL ENGINEERING JOURNAL
(2024)