Advances in nucleophilic phosphine catalysis of alkenes, allenes, alkynes, and MBHADs

PHOSPHINE-CATALYZED [4+2] ANNULATION: SYNTHESIS OF ETHYL 6-PHENYL-1-TOSYL-1,2,5,6-TETRAHYDROPYRIDINE-3-CARBOXYLATE

(2014)   ORGANIC SYNTHESES

Catalytic Asymmetric CN Bond Formation: Phosphine-Catalyzed Intra- and Intermolecular γ-Addition of Nitrogen Nucleophiles to Allenoates and Alkynoates

(2013) Rylan J. Lundgren et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

In vitro and in vivo effects of geranylgeranyltransferase I inhibitor P61A6 on non-small cell lung cancer cells

(2013) Drazen B Zimonjic et al.   BMC CANCER

Recent Advances in Organocatalytic Asymmetric Morita–Baylis–Hillman/aza-Morita–Baylis–Hillman Reactions

(2013) Yin Wei et al.   CHEMICAL REVIEWS

Domino Cyclization Initiated by Cross-Rauhut-Currier Reactions

(2013) Peizhong Xie et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Enantioselective Synthesis of Highly Functionalized Trifluoromethyl-Bearing Cyclopentenes: Asymmetric [3+2] Annulation of Morita-Baylis-Hillman Carbonates with Trifluoroethylidenemalonates Catalyzed by Multifunctional Thiourea-Phosphines

(2012) Hong-Ping Deng et al.   ADVANCED SYNTHESIS & CATALYSIS

Chiral Phosphine Catalyzed Asymmetric Michael Addition of Oxindoles

(2012) Fangrui Zhong et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Phosphine Organocatalysis in the Synthesis of Natural Products and Bioactive Compounds

(2012) Catherine Gomez et al.   ChemCatChem

Phosphine-catalyzed intramolecular γ-umpolung addition of α-aminoalkylallenic esters: facile synthesis of 3-carbethoxy-2-alkyl-3-pyrrolines

(2012) Ian P. Andrews et al.   CHEMICAL COMMUNICATIONS

One-Pot Phosphine-Catalyzed Syntheses of Quinolines

(2012) San Khong et al.   JOURNAL OF ORGANIC CHEMISTRY

Highly Enantioselective Regiodivergent Allylic Alkylations of MBH Carbonates with Phthalides

(2012) Fangrui Zhong et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Chiral phosphine-catalyzed asymmetric allylic alkylation of 3-substituted benzofuran-2(3H)-ones or oxindoles with Morita–Baylis–Hillman carbonates

(2012) De Wang et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Highly enantioselective [4 + 2] cycloadditions of allenoates and dual activated olefins catalyzed by N-acyl aminophosphines

(2012) Hua Xiao et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Total Synthesis of (±)-Hirsutine: Application of Phosphine-Catalyzed Imine–Allene [4 + 2] Annulation

(2012) Reymundo A. Villa et al.   ORGANIC LETTERS

Phosphine/Palladium-Catalyzed Syntheses of Alkylidene Phthalans, 3-Deoxyisoochracinic Acid, Isoochracinic Acid, and Isoochracinol

(2012) Yi Chiao Fan et al.   ORGANIC LETTERS

BINAPHANE-Catalyzed Asymmetric Synthesis of trans-β-Lactams from Disubstituted Ketenes and N-Tosyl Arylimines

(2012) Shi Chen et al.   ORGANIC LETTERS

A Torquoselective 6π Electrocyclization Approach to Reserpine Alkaloids

(2012) Gregg A. Barcan et al.   ORGANIC LETTERS

Highly enantioselective [4 + 2] annulations catalyzed by amino acid-based phosphines: Synthesis of functionalized cyclohexenes and 3-spirocyclohexene-2-oxindoles

(2012) Fangrui Zhong et al.   Chemical Science

Enantioselective total synthesis of (+)-ibophyllidine via an asymmetric phosphine-catalyzed [3 + 2] annulation

(2012) Ian P. Andrews et al.   Chemical Science

Versatile Enantioselective [3+2] Cyclization between Imines and Allenoates Catalyzed by Dipeptide-Based Phosphines

(2011) Xiaoyu Han et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Highly Enantioselective [3+2] Annulation of Morita-Baylis-Hillman Adducts Mediated by L-Threonine-Derived Phosphines: Synthesis of 3-Spirocyclopentene-2-oxindoles having Two Contiguous Quaternary Centers

(2011) Fangrui Zhong et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Quantum Mechanical Investigations of Organocatalysis: Mechanisms, Reactivities, and Selectivities

(2011) Paul Ha-Yeon Cheong et al.   CHEMICAL REVIEWS

The Baylis–Hillman reaction: a novel concept for creativity in chemistry

(2011) Deevi Basavaiah et al.   CHEMICAL SOCIETY REVIEWS

Bifunctional N-Acyl-Aminophosphine-Catalyzed Asymmetric [4+2] Cycloadditions of Allenoates and Imines

(2011) Hua Xiao et al.   CHEMISTRY-A EUROPEAN JOURNAL

Aplexone targets the HMG-CoA reductase pathway and differentially regulates arteriovenous angiogenesis

(2011) J. Choi et al.   DEVELOPMENT

Chiral Bifunctional Thiourea-Phosphane Organocatalysts in Asymmetric Allylic Amination of Morita-Baylis-Hillman Acetates

(2011) Hong-Ping Deng et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Phosphane-Catalyzed Umpolung Addition Reaction of Nucleophiles to Ethyl 2-Methyl-2,3-butadienoate

(2011) Xiao-Yang Guan et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Diastereo- and Enantioselective Construction of γ-Butenolides through Chiral Phosphane-Catalyzed Allylic Alkylation of Morita-Baylis-Hillman Acetates

(2011) Yin Wei et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Core-Structure-Motivated Design of a Phosphine-Catalyzed [3 + 2] Cycloaddition Reaction: Enantioselective Syntheses of Spirocyclopenteneoxindoles

(2011) Bin Tan et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Enantioselective [3 + 2] Cycloaddition of Allenes to Acrylates Catalyzed by Dipeptide-Derived Phosphines: Facile Creation of Functionalized Cyclopentenes Containing Quaternary Stereogenic Centers

(2011) Xiaoyu Han et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Phosphine-Catalyzed Annulations of Azomethine Imines: Allene-Dependent [3 + 2], [3 + 3], [4 + 3], and [3 + 2 + 3] Pathways

(2011) Risong Na et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Diversity-Oriented Synthesis Based on the DPPP-Catalyzed Mixed Double-Michael Reactions of Electron-Deficient Acetylenes and β-Amino Alcohols

(2011) Yi Chiao Fan et al.   MOLECULES

Multifunctional chiral phosphines-catalyzed highly diastereoselective and enantioselective substitution of Morita–Baylis–Hillman adducts with oxazolones

(2011) Yuan-Liang Yang et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Phosphine-Initiated General Base Catalysis: Facile Access to Benzannulated 1,3-Diheteroatom Five-Membered Rings via Double-Michael Reactions of Allenes

(2011) Judy Szeto et al.   ORGANIC LETTERS

Phosphine-Catalyzed β′-Umpolung Addition of Nucleophiles to Activated α-Alkyl Allenes

(2011) Tioga J. Martin et al.   ORGANIC LETTERS

Identification and Characterization of Mechanism of Action of P61-E7, a Novel Phosphine Catalysis-Based Inhibitor of Geranylgeranyltransferase-I

(2011) Lai N. Chan et al.   PLoS One

Diversity through phosphine catalysis identifies octahydro-1,6-naphthyridin-4-ones as activators of endothelium-driven immunity

(2011) D. Cruz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Phosphine-catalyzed one-pot isomerization of 3-alkynoates and [2 + 3]-cycloaddition with imines: formal synthesis of Securinega alkaloid (±)-allosecurinine

(2011) Magesh Sampath et al.   Chemical Science

Enantioselective carbon–sulfur bond formation: γ additions of aryl thiols to allenoates catalyzed by a chiral phosphepine

(2011) Yuji Fujiwara et al.   Chemical Science

Multifunctional Chiral Phosphine Organocatalysts in Catalytic Asymmetric Morita−Baylis−Hillman and Related Reactions

(2010) Yin Wei et al.   ACCOUNTS OF CHEMICAL RESEARCH

Reversal of Enantioselectivity by Tuning the Conformational Flexibility of Phase-Transfer Catalysts

(2010) Ming-Qing Hua et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Recent Contributions from the Baylis−Hillman Reaction to Organic Chemistry

(2010) Deevi Basavaiah et al.   CHEMICAL REVIEWS

Diversity Through a Branched Reaction Pathway: Generation of Multicyclic Scaffolds and Identification of Antimigratory Agents

(2010) Zhiming Wang et al.   CHEMISTRY-A EUROPEAN JOURNAL

Josiphos-Catalyzed Asymmetric Homodimerization of Ketoketenes

(2010) Ahmad A. Ibrahim et al.   JOURNAL OF ORGANIC CHEMISTRY

2-(Acetoxymethyl)buta-2,3-dienoate, a Versatile 1,4-Biselectrophile for Phosphine-Catalyzed (4 +n) Annulations with 1,n-Bisnucleophiles (n= 1, 2)

(2010) Qiongmei Zhang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Phosphine-Catalyzed Formation of Carbon−Sulfur Bonds: Catalytic Asymmetric Synthesis of γ-Thioesters

(2010) Jianwei Sun et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Synthesis of Functionalized Chromans by PnBu3-Catalyzed Reactions of Salicylaldimines and Salicylaldehydes with Allenic Ester

(2010) Yin-Wei Sun et al.   ORGANIC LETTERS

Diastereoselective Synthesis of 6-Trifluoromethyl-5,6-dihydropyrans via Phosphine-Catalyzed [4 + 2] Annulation of α-Benzylallenoates with Ketones

(2010) Tong Wang et al.   ORGANIC LETTERS

Diphosphine-Catalyzed Mixed Double-Michael Reaction: A Unified Synthesis of Indolines, Dihydropyrrolopyridines, Benzimidazolines, Tetrahydroquinolines, Tetrahydroisoquinolines, Dihydrobenzo-1,4-oxazines, and Dihydrobenzo-3,1-oxazines

(2010) Vardhineedi Sriramurthy et al.   ORGANIC LETTERS

Phosphine-Catalyzed Domino Reaction: Highly Stereoselective Synthesis oftrans-2,3-Dihydrobenzofurans from SalicylN-Thiophosphinyl Imines and Allylic Carbonates

(2010) Peizhong Xie et al.   ORGANIC LETTERS

Phosphine-catalyzed asymmetric additions of malonate esters to  -substituted allenoates and allenamides

(2010) R. Sinisi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Phosphine-mediated diverse reactivity of γ-substituted allenoates with aldehydes: syntheses of highly functionalized chromans and (E,E)-1,3-dienes

(2010) Renqin Ma et al.   TETRAHEDRON

Highly enantio-, regio- and diastereo-selective one-pot [2 + 3]-cycloaddition reaction via isomerization of 3-butynoates to allenoates,

(2010) Magesh Sampath et al.   Chemical Science

Phosphine-Catalyzed Enantioselective Synthesis of Oxygen Heterocycles

(2009) Ying Kit Chung et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Silicon as a directing group in the phosphine-catalyzed [2 + 3]-cycloaddition of aryl allenones with electron-deficient olefins

(2009) Magesh Sampath et al.   CHEMICAL COMMUNICATIONS

aza-Baylis−Hillman Reaction

(2009) Valérie Declerck et al.   CHEMICAL REVIEWS

Phosphine-Mediated [3+2] Cycloaddition Reactions of Ethyl 5,5-Diarylpenta-2,3,4-trienoates with Arylmethylidenemalononitriles andN-Tosylimines

(2009) Xiao-Yang Guan et al.   JOURNAL OF ORGANIC CHEMISTRY

Asymmetric Carbon−Carbon Bond Formation γ to a Carbonyl Group: Phosphine-Catalyzed Addition of Nitromethane to Allenes

(2009) Sean W. Smith et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

In vivo antitumor effect of a novel inhibitor of protein geranylgeranyltransferase-I

(2009) J. Lu et al.   MOLECULAR CANCER THERAPEUTICS

Asymmetric Total Synthesis of the Iridoid β-Glucoside (+)-Geniposide via Phosphine Organocatalysis

(2009) Regan A. Jones et al.   ORGANIC LETTERS

PPh3-Catalyzed Domino Reaction: A Facile Method for the Synthesis of Chroman Derivatives

(2009) Xiangtai Meng et al.   ORGANIC LETTERS

New Access to Trisubstituted 3-Pyrrolines under Phosphine Catalysis

(2009) Marie Schuler et al.   ORGANIC LETTERS

The Rauhut–Currier reaction: a history and its synthetic application

(2009) Carrie E. Aroyan et al.   TETRAHEDRON

Chiral phosphine-catalyzed regio- and enantioselective allylic amination of Morita–Baylis–Hillman acetates

(2009) Guang-Ning Ma et al.   TETRAHEDRON-ASYMMETRY

Mechanism, Regioselectivity, and the Kinetics of Phosphine-Catalyzed [3+2] Cycloaddition Reactions of Allenoates and Electron-Deficient Alkenes

(2008) Yong Liang et al.   CHEMISTRY-A EUROPEAN JOURNAL

Use of Allenylphosphonates as New Substrates for Phosphane-Catalyzed [3+2] and [4+2] Annulations

(2008) Armen Panossian et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Inhibitors of Protein Geranylgeranyltransferase I and Rab Geranylgeranyltransferase Identified from a Library of Allenoate-derived Compounds

(2008) Masaru Watanabe et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cycloaddition of Alkynyl Ketones withN-Tosylimines Catalyzed by Bu3P and DMAP: Synthesis of Highly Functionalized Pyrrolidines and Azetidines

(2008) Ling-Guo Meng et al.   JOURNAL OF ORGANIC CHEMISTRY

Chiral Phosphine-Catalyzed Enantioselective Construction of γ-Butenolides Through Substitution of Morita−Baylis−Hillman Acetates with 2-Trimethylsilyloxy Furan

(2008) Ying-Qing Jiang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

2-Phospha[3]ferrocenophanes with Planar Chirality: Synthesis and Use in Enantioselective Organocatalytic [3 + 2] Cyclizations

(2008) Arnaud Voituriez et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Cooperative, Highly Enantioselective Phosphinothiourea Catalysis of Imine−Allene [3 + 2] Cycloadditions

(2008) Yuan-Qing Fang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A Phosphine-Catalyzed [3 + 2] Annulation Reaction of Modified Allylic Compounds andN-Tosylimines

(2008) Suqing Zheng et al.   ORGANIC LETTERS

Alcohol-Assisted Phosphine Catalysis:  One-Step Syntheses of Dihydropyrones from Aldehydes and Allenoates

(2008) Gardner S. Creech et al.   ORGANIC LETTERS

Bifunctional Phosphine-Catalyzed Domino Reaction: Highly Stereoselective Synthesis ofcis-2,3-Dihydrobenzofurans from SalicylN-Thiophosphinyl Imines and Allenes

(2008) Xiangtai Meng et al.   ORGANIC LETTERS

Advances in the Baylis–Hillman reaction-assisted synthesis of cyclic frameworks

(2008) Vijay Singh et al.   TETRAHEDRON

Theory-guided design of Brønsted acid-assisted phosphine catalysis: synthesis of dihydropyrones from aldehydes and allenoates

(2008) Gardner S. Creech et al.   TETRAHEDRON

One-pot synthesis of highly substituted tetrahydrofurans from activated propargyl alcohols using Bu3P

(2008) Yakambram Pedduri et al.   TETRAHEDRON LETTERS