Deubiquitinases as potential anti-cancer targets for gold(iii) complexes

A dual cytotoxic and anti-angiogenic water-soluble gold(iii) complex induces endoplasmic reticulum damage in HeLa cells

(2012) Jing-Jing Zhang et al.   CHEMICAL COMMUNICATIONS

Noble metal-dithiocarbamates precious allies in the fight against cancer

(2012) Eszter Márta Nagy et al.   MINI-REVIEWS IN MEDICINAL CHEMISTRY

Anticancer dirhodium(ii,ii) carboxylates as potent inhibitors of ubiquitin-proteasome system

(2012) Fung-Ming Siu et al.   Chemical Science

DUBs and cancer: The role of deubiquitinating enzymes as oncogenes, non-oncogenes and tumor suppressors

(2011) Sajjad Hussain et al.   CELL CYCLE

Therapeutic applications of gold complexes: lipophilic gold(iii) cations and gold(i) complexes for anti-cancer treatment

(2011) Chi-Ming Che et al.   CHEMICAL COMMUNICATIONS

Inhibition of proteasome deubiquitinating activity as a new cancer therapy

(2011) Pádraig D'Arcy et al.   NATURE MEDICINE

Deubiquitinases in cancer: new functions and therapeutic options

(2011) J M Fraile et al.   ONCOGENE

CYLD regulates angiogenesis by mediating vascular endothelial cell migration

(2010) J. Gao et al.   BLOOD

Deubiquitinase Inhibition by Small-Molecule WP1130 Triggers Aggresome Formation and Tumor Cell Apoptosis

(2010) V. Kapuria et al.   CANCER RESEARCH

Cyclometalated gold(iii) complexes with N-heterocyclic carbene ligands as topoisomerase I poisons

(2010) Jessie Jing Yan et al.   CHEMICAL COMMUNICATIONS

Ubiquitin-like protein conjugation and the ubiquitin–proteasome system as drug targets

(2010) Lynn Bedford et al.   NATURE REVIEWS DRUG DISCOVERY

Ubiquitin vinyl methyl ester binding orients the misaligned active site of the ubiquitin hydrolase UCHL1 into productive conformation

(2010) D. A. Boudreaux et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulation and Cellular Roles of Ubiquitin-Specific Deubiquitinating Enzymes

(2009) Francisca E. Reyes-Turcu et al.   Annual Review of Biochemistry

A Gold(III) Porphyrin Complex with Antitumor Properties Targets the Wnt/ -catenin Pathway

(2009) K. H.-M. Chow et al.   CANCER RESEARCH

Thioredoxin reductase: A target for gold compounds acting as potential anticancer drugs

(2009) Alberto Bindoli et al.   COORDINATION CHEMISTRY REVIEWS

Current applications and future potential for bioinorganic chemistry in the development of anticancer drugs

(2009) Sabine H. van Rijt et al.   DRUG DISCOVERY TODAY

Breaking the chains: structure and function of the deubiquitinases

(2009) David Komander et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY