Article
Chemistry, Multidisciplinary
Rui Tang, Yu-Hao Fu, Bo Gong, Ying-Ying Fan, Hong-Hui Wang, Yan Huang, Zhou Nie, Ping Wei
Summary: The study introduces an intelligent molecular platform to engineer T-cell recognition for selective activation and potent cancer cell killing. By incorporating multiple aptameric antigen recognitions, combinatorial recognition of triple antigens on cancer cells is achieved for selective T-cell activation.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Optics
Zhongtao Cheng, Lihong Wang
Summary: A technique called ultrasound-induced field perturbation optical focusing (UFP) is introduced as a more efficient method for achieving noninvasive and addressable optical focusing in scattering media. Compared to conventional methods, UFP leverages brighter zeroth-order photons and can easily be developed into double-shot or single-shot realization for high-speed wavefront shaping. This new approach broadens the horizon of light control in scattering media and provides a flexible mechanism for implementing ultrasound-guided wavefront shaping.
LIGHT-SCIENCE & APPLICATIONS
(2021)
Article
Chemistry, Multidisciplinary
Zhengxiao Zhang, Eiji Nakata, Huyen Dinh, Masayuki Saimura, Arivazhagan Rajendran, Kazunari Matsuda, Takashi Morii
Summary: By designing new substrates, sequence-selective rapid crosslinking reactions of protein modular adaptors (MAs) with SNAP-tag can be achieved, improving the selectivity and efficiency of the reaction.
CHEMISTRY-A EUROPEAN JOURNAL
(2021)
Article
Multidisciplinary Sciences
Simon Klingler, Jason P. Holland
Summary: This study introduces a fully automated synthesis box for the production of Zr-89-radiolabeled antibodies. The automated method eliminates the need for manual synthesis and improves the yield and purity of the radiolabeled antibodies. This will benefit the Nuclear Medicine and research institutions in accessing state-of-the-art Zr-89-radiolabeled antibodies.
SCIENTIFIC REPORTS
(2022)
Article
Chemistry, Multidisciplinary
Joschka Hellmeier, Rene Platzer, Vanessa Muehlgrabner, Magdalena C. Schneider, Elke Kurz, Gerhard J. Schuetz, Johannes B. Huppa, Eva Sevcsik
Summary: DNA origami structures provide flexible scaffolds for organizing biomolecules with nanometer precision, but functionalizing them with proteins while maintaining stoichiometry and protein functionality remains challenging. This study systematically evaluated different strategies for site-specific decoration of DNA origami structures, with a focus on efficiency, stoichiometry, and protein functionality. The study found that using charge-neutral peptide nucleic acid emerged as the best strategy for achieving high yield and preserving protein functionality.
Review
Nanoscience & Nanotechnology
Kun Chen, Ming Jiang, Jin Liu, Deli Huang, Yuhe R. R. Yang
Summary: Nanoparticle-based vaccines offer a multivalent approach for antigen display, efficiently activating T and B cells in the lymph nodes. DNA nanotechnology provides an innovative alternative platform, featuring high modularity, spatial addressing, nanoscale regulation, high functional group density, and lower self-antigenicity. This review explores the potential of DNA nanostructures as biomolecular scaffolds for antigen display, discussing immunological mechanisms, characterization techniques, advancements in DNA nanotechnology, strategies for precise antigen presentation, and current applications and future possibilities.
WILEY INTERDISCIPLINARY REVIEWS-NANOMEDICINE AND NANOBIOTECHNOLOGY
(2023)
Article
Physics, Applied
Shiyun Tang, Wenjiang Tan, Jinhai Si, Jing Li, Yang Yang, Xun Hou
Summary: The article introduces a light intensity-dependent feedback-based wavefront shaping method using a genetic algorithm, which can achieve the desired wavefront shaping faster than the conventional method. By dividing the phase mask into multiple regions and allocating different phase modulation units based on light intensity distribution, the efficiency of wavefront shaping can be significantly improved.
JOURNAL OF APPLIED PHYSICS
(2021)
Article
Biochemistry & Molecular Biology
Yi Zhang, Yiao Wang, Safak Uslu, Sneha Venkatachalapathy, Mohammad Rashidian, Jonas Schaefer, Andreas Pluckthun, Mark D. Distefano
Summary: A novel method for the conjugation of genetically modified proteins with fluorescent dyes or cell-killing agents.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Multidisciplinary
Kyoung-Ran Kim, Junghyun Kim, Ji Hyun Back, Ji Eun Lee, Dae-Ro Ahn
Summary: The protein corona, formed on the surface of nanoparticles, plays a significant role in determining their fate in vivo. By controlling protein adsorption, nanoparticles can be targeted to specific tissues and cells. This study explores the use of a DNA tetrahedron conjugated with cholesterol to interact with lipoproteins, generating a lipoprotein-associated protein corona that targets hepatocytes and myofibroblasts. The tetrahedron is also used for targeted delivery of antisense oligonucleotide, showing potential as a therapeutic delivery system. Controlled seeding of the protein corona on nanomaterials can guide nanoparticles to their target area.
Article
Chemistry, Multidisciplinary
Anders Marcher, Minke A. D. Nijenhuis, Kurt V. Gothelf
Summary: An antibody DNA wireframe cube conjugate has been developed for precise control of the drug-to-antibody ratio (DAR) in ADCs for cancer treatment. This method utilizes DNA functionalization to tightly control DAR, with gel electrophoresis and atomic force microscopy used for investigation, and successful application in targeted drug delivery in vitro.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Polymer Science
Lirong He, Hui Zhao, Patrick Theato
Summary: The study demonstrates the use of UV irradiation to control polymer conjugation reactions, providing spatial and temporal control over polymeric building blocks.
JOURNAL OF POLYMER SCIENCE
(2022)
Article
Chemistry, Physical
Marta Dudek, Marco Deiana, Kinga Szkaradek, Mikolaj J. Janicki, Ziemowit Pokladek, Robert W. Gora, Katarzyna Matczyszyn
Summary: This study presents a light-responsive G-quadruplex (G4)-based assembly, in which chirality enrichment is induced, tuned, and fueled by molecular switches. Through experimental and computational analysis, compelling evidence is provided on the binding mode of the photochromes on G4s, and the origin of the chirality effect associated with the complexation event is rationalized.
JOURNAL OF PHYSICAL CHEMISTRY LETTERS
(2021)
Article
Chemistry, Multidisciplinary
Tianrui Li, Hao Zhang, Jinling Miao, Chunyue Xu, Yong Nie, Guangning Liu, Guoxin Sun, Xuchuan Jiang
Summary: This study investigates the synthesis and properties of o-carborane-tetraphenylethene compounds. The results demonstrate that the carborane and linker have significant effects on the solid state structures and luminescence properties of the compounds. Additionally, the compounds exhibit mechano-and thermofluorochromic properties.
NEW JOURNAL OF CHEMISTRY
(2023)
Review
Chemistry, Multidisciplinary
Liangcan He, Jing Mu, Oleg Gang, Xiaoyuan Chen
Summary: DNA serves as a versatile tool for engineering and self-assembling nanostructures, enhancing scalability, programmability, and functionality. This has opened doors for various biomedical applications such as biosensing, bioimaging, drug delivery, and disease therapy. Recent advancements in DNA nanostructure design and construction, including conjugated nanoparticle systems, DNA-based clusters, and DNA origami-templated assemblies, have further expanded its potential in the field.
Article
Biochemical Research Methods
Carolina T. Orozco, Matthew J. Edgeworth, Paul W. A. Devine, Alistair R. Hines, Owen Cornwell, Christopher Thompson, Xiangyang Wang, Jonathan J. Phillips, Peter Ravn, Sophie E. Jackson, Nicholas J. Bond
Summary: Antibody-drug conjugates have emerged as one of the most actively developed drug classes, combining the specificity of antibodies with the potency of cytotoxic compounds. Recent advancements in engineering antibody-drug conjugate scaffolds focus on achieving controlled drug to antibody ratios by inserting cysteines. A study found that an engineered antibody scaffold with an inserted cysteine unexpectedly formed a disulfide bridge during the manufacturing process, leading to significant changes in stability and structural dynamics.
BIOCONJUGATE CHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
N. Maximilian Bojanowski, Aleksandra Vranic, Vincent Hahn, Pascal Rietz, Tobias Messer, Julian Brueckel, Christopher Barner-Kowollik, Eva Blasco, Stefan Braese, Martin Wegener
Summary: Recent studies have introduced a new generation of photoinitiators for 3D laser nanoprinting, replacing two-photon absorption with two-step absorption. This can now be achieved using inexpensive blue laser diodes instead of expensive femtosecond laser systems. Additionally, researchers are exploring alternative photoinitiators that can be excited by one-color two-step absorption and be de-excited by a different laser color.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Jochen A. Kammerer, Florian Feist, Daniel Ryklin, Abhishek Sarkar, Christopher Barner-Kowollik, Rasmus R. Schroder
Summary: It is shown that the postfunctionalization of solid polymeric microspheres can produce fully and extensively functionalized materials instead of core-shell structures. The complete functionalization is exemplified by photochemically generated microspheres, which are subsequently converted into polyradical systems. By directly visualizing the chemical distribution inside the postfunctionalized microspheres using characteristic electron energy loss signals in transmission electron microscopy (TEM), this study pioneers characterization methods with high sensitivity and resolution for all-organic low-contrast soft-matter material structures. The successful combination of ultrasonic ultramicrotomy and electron energy loss spectroscopy (EELS) and electron spectroscopic imaging (ESI) in TEM opens up a new avenue for analyzing such structures.
ADVANCED MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Steven C. Gauci, Katharina Ehrmann, Marvin Gernhardt, Bryan Tuten, Eva Blasco, Hendrik Frisch, Vishakya Jayalatharachchi, James P. Blinco, Hannes A. Houck, Christopher Barner-Kowollik
Summary: A photoresist-based on a light-stabilized dynamic material driven by an out-of-equilibrium photo-Diels-Alder reaction is introduced for 3D laser lithography. By adjusting the laser intensity, the postprinting degradation ability can be tuned. The resist's ability to form stable networks that degrade in the dark is transformed into a tunable degradable 3D printing material platform.
ADVANCED MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Kai Mundsinger, Bryan T. Tuten, Lily Wang, Kira Neubauer, Christian Kropf, Megan L. O'Mara, Christopher Barner-Kowollik
Summary: We present a single-chain nanoparticle (SCNP) system that exhibits three times higher catalytic efficiency for the photooxidation of nonpolar alkenes compared to an equivalent concentration of small-molecule photosensitizer. The SCNP is constructed using poly(ethylene glycol) methyl ether methacrylate and glycidyl methacrylate, compacted through multifunctional thiol-epoxide ligation, and functionalized with Rose Bengal (RB). The confined RB within the SCNP achieves enhanced photocatalysis for nonpolar alkenes due to spatial proximity in the hydrophobic region.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Polymer Science
Cameron M. Cole, Susanna V. Kunz, Thomas Baumann, James P. Blinco, Prashant Sonar, Christopher Barner-Kowollik, Soniya D. Yambem
Summary: Thermally activated delayed fluorescent (TADF) emitters are the leading materials for efficient OLEDs. A simple OLED with fully solution-processed organic layers is introduced, where the TADF emissive layer is ink-jet printed. The self-hosted TADF polymer shows potential for flexible ink-jet printed OLEDs, enabling a more scalable fabrication process.
MACROMOLECULAR RAPID COMMUNICATIONS
(2023)
Article
Multidisciplinary Sciences
Liang Yang, Hongrong Hu, Alexander Scholz, Florian Feist, Gabriel Cadilha Marques, Steven Kraus, Niklas Maximilian Bojanowski, Eva Blasco, Christopher Barner-Kowollik, Jasmin Aghassi-Hagmann, Martin Wegener
Summary: The authors propose laser printing as a facile process for fabricating printed electronics with minimum feature sizes below 1μm and demonstrate functional diodes, memristors, and physically unclonable functions. Laser printing with different inks, for the semiconductor ZnO and the metals Pt and Ag, is introduced for fabricating printed functional electronic devices with minimum feature sizes below 1μm. The versatility of this approach is demonstrated by showing functional diodes, memristors, and a physically unclonable function.
NATURE COMMUNICATIONS
(2023)
Article
Polymer Science
Philipp Neidinger, Dominik Voll, Sarah L. Walden, Andreas-Neil Unterreiner, Christopher Barner-Kowollik
Summary: This paper introduces the 800 nm two-photon pulsed laser polymerization (PLP) and demonstrates its working principle through biological tissue. The reliability of 2P PLP in determining propagation rate coefficients is shown using the example of the free radical polymerization of methyl methacrylate (MMA) at frequencies ranging from 10 to 100 Hz.
Article
Chemistry, Multidisciplinary
Linh Duy Thai, Thiago R. Guimaraes, Lewis C. Chambers, Jochen A. Kammerer, Dmitri Golberg, Hatice Mutlu, Christopher Barner-Kowollik
Summary: This study investigates the impact of macromolecular architecture on the isomerization efficiency of main-chain-incorporated chromophores in both solution and solid state. It is found that branched architectures deliver the highest isomerization efficiency in the solid state, reaching up to 70% compared to solution. The macromolecular design principles established in this study can serve as a blueprint for enhancing the solid-state isomerization efficiency in other polymer systems.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2023)
Article
Chemistry, Multidisciplinary
Ishrath Mohamed Irshadeen, Vinh X. Truong, Hendrik Frisch, Christopher Barner-Kowollik
Summary: By observing the changes in absorptivity of two chromophores upon light exposure and constructing a dual action plot, we can fold distinct polymer chains into single chain nanoparticles (SCNPs) from the same reaction mixture regardless of pathlength and wavelength-dependency.
CHEMICAL COMMUNICATIONS
(2023)
Article
Chemistry, Multidisciplinary
Sebastian Gillhuber, Joshua O. Holloway, Hendrik Frisch, Florian Feist, Florian Weigend, Christopher Barner-Kowollik, Peter W. Roesky
Summary: We present a method for folding single-chain nanoparticles (SCNPs) using covalently bonded ferrocene units. In particular, we demonstrate the ability of 2-ferrocenyl-1,10-phenanthroline to induce single-chain collapse and introduce a donor functionality, allowing for the incorporation of a Pd-catalytic site. This results in the synthesis of the first heterobimetallic ferrocene-functionalized SCNP.
CHEMICAL COMMUNICATIONS
(2023)
Article
Polymer Science
Philipp Neidinger, Dominik Voll, Sarah L. Walden, Christopher Barner-Kowollik, Andreas-Neil Unterreiner
Summary: This article introduces a two-photon pulsed laser polymerization method that can penetrate through biological tissue, and demonstrates its reliability through the example of free radical polymerization of methyl methacrylate at different frequencies.
Article
Chemistry, Multidisciplinary
Rita T. Michenfelder, Laura Delafresnaye, Vinh X. Truong, Christopher Barner-Kowollik, Hans-Achim Wagenknecht
Summary: We present a visible light-driven (lambda(max) = 451 nm) photo-chemical approach for labeling DNA in living HeLa cells using the [2+2] cycloaddition reaction of a styrylquinoxaline moiety, which is incorporated into both DNA and the fluorescent label. Our methodology provides a sophisticated platform for mild remote DNA labeling in water, without the need for UV light activation.
CHEMICAL COMMUNICATIONS
(2023)
Article
Polymer Science
Alyssa J. J. Ghielmetti, Christopher Barner-Kowollik, Filip E. E. Du Prez, Hannes A. A. Houck
Summary: The molecular network connectivity in dynamic polymer networks significantly affects material properties and reprocessing conditions. The influence of regioisomerism in light-stabilized dynamic materials has been highlighted. Interchanging regioisomer fractions of substituted naphthalenes with triazolinediones (TADs) in a photo-driven cycloaddition reaction has been demonstrated to affect the cycloreversion kinetics and is important for the design of dynamic covalent materials. The development of completely regioselective TAD/naphthalene systems and the control of cycloreversion kinetics through naphthalene substitution offer new opportunities for the advancement and applications of light-stabilized dynamic materials.
Article
Polymer Science
Philipp Neidinger, Joshua Davis, Joshua A. Carroll, Jochen Kammerer, Esa Jaatinen, Sarah L. Walden, Andreas-Neil Unterreiner, Christopher Barner-Kowollik
Summary: A near infrared action plot from 620 to 950 nm for gold nanorod (AuNR) mediated free-radical polymerization is reported, probing the wavelength-by-wavelength monomer to polymer conversion with an identical number of photons at each wavelength.
Article
Chemistry, Multidisciplinary
Sarah Walden, Joshua Carroll, Andreas-Neil Unterreiner, Christopher Barner-Kowollik
Summary: This article reveals a fundamental mismatch between the absorption spectrum of a chromophore and its photochemical reactivity, highlighting the limitations of the assumption that effective photochemical reactions require strong overlap between the absorption spectrum and the excitation wavelength. The article proposes future directions for understanding action plots and explores the importance of action plots in designing precise photochemical applications.
Review
Chemistry, Multidisciplinary
Dan He, Yawen Li, Fuwen Zhao, Yuze Lin
Summary: High trap density in organic solar cells leads to localized charge carriers and reduced carrier lifetime, limiting device efficiency. This feature article summarizes the recent advances of trap suppression by material design and device engineering.
CHEMICAL COMMUNICATIONS
(2024)
Review
Chemistry, Multidisciplinary
Olivier Monfort, Arshitha Madhusudhan, Martin Motola
Summary: This article presents the advantages of coupling photocatalysis and Fenton-based processes for environmental remediation and discusses their synergy. It critically examines the simultaneous triggering of these two processes and provides insights into research approaches. The study aims to enhance understanding of this complex process and highlight the potential integration of new catalysts in current wastewater treatment technology.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Manideepa Dhar, Chittaranjan Mishra, Avijit Das, Uttam Manna
Summary: An approach of 'polymerization of monomers in its aggregated form' has been introduced to tailor the water wettability of fibrous and porous substrates, achieving hydrophobicity to superhydrophobicity transition, as well as patterned wettability. This facile chemical method provides a durable coating with adjustable and patterned wettability for various potential applications.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Saswat Ranjan Bhoi, Chhanda Debnath, Shikha Gandhi
Summary: In this article, a novel catalytic reaction using Pd(0) and Bronsted acid is reported for the synthesis of biologically important imidazolidinone-fused N-heterocycles through redox-neutral intramolecular N-allylation of indoles and pyrroles with alkynes. This atom-economical method is applicable to a wide range of substrates and eliminates the need for leaving groups or oxidizing agents commonly used in traditional allylation reactions.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Longkun Chen, Mingshuai Zhang, Meichen Liu, Zhuoyuan Liu, Yuetong Qiu, Zhilai Zhang, Fuchao Yu, Jiuzhong Huang
Summary: In this study, an efficient Rh(III)-catalyzed selective mono- and dual-C-H bond functionalization/cyclization with iodonium ylide as the sole coupling partner was demonstrated. Fused benzodiazepine skeletons were obtained in excellent yields, providing an improved approach to dual C-H unsymmetrical functionalization.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Alice Kennett, Sven Epple, Gabriella van der Valk, Irene Georgiou, Evelyne Gout, Romain R. Vives, Angela J. Russell
Summary: This study presents the design and synthesis of sulfated disaccharide inhibitors based on IdoA(2S)-GlcNS(6S), which showed potent inhibition of Sulf-2. The results suggest that IdoA(2S)-GlcNS(6S) is the shortest fragment size required for effective inhibition of Sulfs, and a trisulfated disaccharide is identified as the minimal fragment size of heparan sulfate for effective endosulfatase inhibition.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Mauro Garbini, Andrea Brunetti, Riccardo Pedrazzani, Magda Monari, Massimo Marcaccio, Giulio Bertuzzi, Marco Bandini
Summary: The self-adaptability of galvanostatic electrolysis was found to be helpful in a multistage chemo- and diastereoselective electrochemically promoted cyclodimerization of chalcones. Through a series of reductive events, densely functionalized cyclopentanes with five contiguous stereocenters were obtained (25 examples, yields up to 95%, dr values up to >20:1). Further experimental and electrochemical investigations indicated the crucial role of dynamic kinetic resolution of the aldol intermediate in the reaction mechanism.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Dhananjay S. Nipate, Neha Meena, Prakash N. Swami, Krishnan Rangan, Anil Kumar
Summary: In this study, the synthesis of functionalized benzo[a]phenazines and indazolo[2,3-a]quinolines was achieved through Rh(III)-catalyzed oxidative annulation of 2-arylquinoxalines and 2-aryl-2H-indazoles with allyl alcohols. The method showed a wide substrate scope, excellent functional group tolerance, good to high yields of annulated products, and the capability for scaled-up synthesis. A tentative mechanism of the annulation reaction was proposed based on a preliminary mechanistic investigation.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Ruonan Zhang, Abudukadi Tudi, Xia Yang, Xuping Wang, Zhihua Yang, Shujuan Han, Shilie Pan
Summary: A new lead tellurium borate material with a unique fundamental building block [B4O10] was synthesized and found to exhibit high birefringence. The structure-property relationship was discussed using first-principles calculations.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Amresh Kumar Singh, Baishali Thakurta, Anupam Giri, Monalisa Pal
Summary: This study introduces three key concepts for the quick synthesis of large-scale high-quality 2D materials films and their utilization in device fabrication.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Reina Hagiwara, Shun Nishimura, Kosuke Okeyoshi
Summary: A copolymer-conjugated nanocatalytic system has been developed to improve electron transfer and enhance photoinduced H2 generation.
CHEMICAL COMMUNICATIONS
(2024)
