4.7 Article

Synthesis of β-cyclodextrin conjugated superparamagnetic iron oxide nanoparticles for selective binding and detection of cholesterol crystals

Journal

CHEMICAL COMMUNICATIONS
Volume 48, Issue 28, Pages 3385-3387

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c2cc17852d

Keywords

-

Funding

  1. NSF
  2. National Cancer Institute [R01-CA149451]
  3. Division Of Chemistry
  4. Direct For Mathematical & Physical Scien [0852308] Funding Source: National Science Foundation

Ask authors/readers for more resources

Water-soluble, beta-cyclodextrin conjugated superparamagnetic nanoparticles have been constructed. These particles showed selective binding to cholesterol crystals, which opens the door for the detection of cholesterol crystal-related diseases such as atherosclerosis by magnetic resonance imaging (MRI).

Authors

I am an author on this paper
Click your name to claim this paper and add it to your profile.

Reviews

Primary Rating

4.7
Not enough ratings

Secondary Ratings

Novelty
-
Significance
-
Scientific rigor
-
Rate this paper

Recommended

Article Chemistry, Multidisciplinary

Synthesis of a Systematic 64-Membered Heparan Sulfate Tetrasaccharide Library

Kedar N. Baryal, Sherif Ramadan, Guowei Su, Changxin Huo, Yuetao Zhao, Jian Liu, Linda C. Hsieh-Wilson, Xuefei Huang

Summary: A divergent approach was used to synthesize a library of HS tetrasaccharides that covered all possible sulfation structures. This library helped identify the structural requirements for HS sequences to bind to fibroblast growth factor-2 and showed weak affinity for platelet factor-4. This could lead to the development of new HS-based therapeutics without the adverse effect of heparin-induced thrombocytopenia.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2023)

Article Biochemical Research Methods

Super-resolution and segmentation deep learning for breast cancer histopathology image analysis

Aniwat Juhong, Bo Li, Cheng-You Yao, Chia-Wei Yang, Dalen W. Agnew, Yu Leo Lei, Xuefei Huang, Wibool Piyawattanametha, Zhen Qiu

Summary: Traditionally, high-performance microscopes are required for high-resolution imaging, but the resulting images are typically large and not easily managed or stored. This study demonstrates custom convolution neural networks (CNNs) for super-resolution image enhancement and characterization of breast cancer histopathological images. The results show improved image quality and segmentation compared to other methods.

BIOMEDICAL OPTICS EXPRESS (2023)

Article Chemistry, Multidisciplinary

Rational Design and Synthesis of D-galactosyl Lysophospholipids as Selective Substrates and non-ATP-competitive Inhibitors of Phosphatidylinositol Phosphate Kinases

Mengxia Sun, Chi Zhang, Dexin Sui, Canchai Yang, Dohun Pyeon, Xuefei Huang, Jian Hu

Summary: Phosphatidylinositol phosphate kinases (PIPKs) are enzymes that produce lipid signaling molecules and have become attractive drug targets for various diseases. Researchers have designed and synthesized D-galactosyl lysophospholipids, which can selectively target phosphatidylinositol 4-phosphate 5-kinase. This study also discovered a human PIKfyve inhibitor that enhances the inhibition of Apilimod, an ATP-competitive PIKfyve inhibitor, in clinical trials for SARS-CoV-2 infection and amyotrophic lateral sclerosis. These findings demonstrate the potential of D-galactose-based phosphoinositide mimetics as artificial substrates and inhibitors of PIPKs.

CHEMISTRY-A EUROPEAN JOURNAL (2023)

Article Biology

Identification and analysis of C17orf53 as a prognostic signature for hepatocellular carcinoma

Yalei Zhao, Lingjian Zhang, Qingqing Hu, Danhua Zhu, Zhongyang Xie

Summary: In this study, the role of C17orf53 in hepatocellular carcinoma (HCC) was analyzed using public datasets. The findings suggest that C17orf53 is highly expressed and predicts poor survival in HCC patients. It also correlates positively with the abundance of B cells, macrophages, and dendritic cells. Functional analysis revealed that C17orf53 is involved in cell cycle, DNA replication, and Fanconi anemia pathways. Knockdown of C17orf53 inhibited cell proliferation and decreased the expression of MCM8, cyclin D1, and PCNA. Overall, C17orf53 is a novel prognostic signature for HCC.

COMPUTERS IN BIOLOGY AND MEDICINE (2023)

Article Plant Sciences

Cold stress induces malformed tomato fruits by breaking the feedback loops of stem cell regulation in floral meristem

Junqing Wu, Wenru Sun, Chao Sun, Chunmiao Xu, Shuang Li, Pengxue Li, Huimin Xu, Danyang Zhu, Meng Li, Liling Yang, Jinbo Wei, Aya Hanzawa, Sumaiya Jannat Tapati, Reiko Uenoyama, Masao Miyazaki, Abidur Rahman, Shuang Wu

Summary: Fruit malformation is a widespread issue in fruit production, causing significant economic losses. Although farmers have long observed the association between chilling temperature before blooming and malformed fruits, the molecular mechanism behind this phenomenon remains unclear. In this study, we investigated how tomato fruit development responded to cold stress and found that short-term cold stress led to increased callose accumulation in both shoot apical and floral meristems. This caused symplastic isolation and altered intercellular movement of WUS, resulting in expanded stem cell population and malformed fruits. Our findings suggest that the callose dynamics during short-term cold stress involve the interplay of abscisic acid and gibberellin, similar to bud dormancy mechanisms. This study provides new insights into the regulation of fruit malformation under cold stress.

NEW PHYTOLOGIST (2023)

Article Materials Science, Multidisciplinary

Fabrication of Gd2O2S:Tb scintillation ceramics using water-bath method: The influence of initial reaction temperature

Junlin Wu, Jiyang Ding, Xinyou Huang, Zhengfa Dai, Xiaoying Li, Danyang Zhu, Dong Huang, TengFei Xie, Jianrong Zhou, Xingfen Jiang, Zhijia Sun, Dariusz Hreniak, Jiang Li

Summary: Gd2O2S:Tb nanopowders were synthesized by hot water-bath method using Gd2O3 and H2SO4 as raw materials. The properties of precursors and powders were influenced by the initial bathing temperature. The size and thickness of flakes in the precursors and powders increased with the increase of initial temperature. Gd2O2S:Tb scintillation ceramics were fabricated using the obtained powders and showed different properties based on the initial temperature of synthesis.

OPTICAL MATERIALS (2023)

Article Physics, Multidisciplinary

Investigating emission characteristics and plasma properties in a long-pulse magnetically insulated coaxial diode with different cathode materials

Danni Zhu, Yancheng Cui, Jin Meng, Yuzhang Yuan, Haitao Wang, Jiangfeng Han

Summary: Magnetically insulated coaxial diodes are commonly used in high power microwave devices for generating intense annular electron beams. This study conducted electrical and optical measurements on a long-pulse magnetically insulated coaxial diode to observe the emission characteristics and plasma properties. The impact of cathode material, blade angle, diode voltage, and guiding magnetic field on the emission characteristics and plasma properties of six types of annular cathodes was investigated. The metal-dielectric cathode showed excellent emission characteristics and plasma properties, achieving impressive diode performance. Additionally, high voltage and small blade angle were found to enhance the emission capability and uniformity, while a strong magnetic field or large diode voltage reduced the axial and radial expansion velocities.

PHYSICA SCRIPTA (2023)

Article Chemistry, Multidisciplinary

Developing Next-Generation Protein-Based Vaccines Using High-Affinity Glycan Ligand-Decorated Glyconanoparticles

Yanan Gao, Wei Wang, Yunru Yang, Qingyu Zhao, Chendong Yang, Xiaoying Jia, Yang Liu, Minmin Zhou, Weihong Zeng, Xuefei Huang, Sandra Chiu, Tengchuan Jin, Xuanjun Wu

Summary: Researchers have developed functionalized nanoparticles as a universal vaccine design platform for major diseases such as cancer and COVID-19. The nanoparticles induce potent immune responses and provide effective protection against tumors and the SARS-CoV-2 virus.

ADVANCED SCIENCE (2023)

Article Toxicology

Lysosomal dysfunction in Schwann cells is involved in bortezomib-induced peripheral neurotoxicity

Zhanxun Wu, Wenping Yan, Ke Wang, Genghua Xu, Danyan Zhu, Xuyun Li, Huafeng Wang, Min Yang, Xiangnan Zhang, Jiaying Wu

Summary: Bortezomib (BTZ) is an effective drug for multiple myeloma treatment, but it often leads to BTZ-induced peripheral neuropathy (BIPN). In this study, it was found that BTZ caused demyelination in sciatic nerves, leading to mechanical hyperalgesia and impaired nerve conduction. The mechanism was identified as the dysfunction of lysosomes and autophagy blockage in Schwann cells. However, the use of the lysosomal activator Torin1 reversed the autophagy blockage and improved the BIPN pathology.

ARCHIVES OF TOXICOLOGY (2023)

Article Plant Sciences

Khellin as a selective monoamine oxidase B inhibitor ameliorated paclitaxel-induced peripheral neuropathy in mice

Xingnan Ouyang, Danyang Zhu, Yujie Huang, Xuejian Zhao, Rui Xu, Jiaying Wang, Wenjun Li, Xu Shen

Summary: This study found that MAOB was highly overexpressed in the spinal cord and DRG tissues of PIPN mice, rather than MAOA, and Khellin as a selective MAOB inhibitor could improve PIPN-like pathology. Moreover, Khellin promoted neurite outgrowth, alleviated apoptosis, and improved mitochondrial dysfunction of DRG neurons by targeting MAOB, while inhibiting spinal astrocytes activation and suppressing neuroinflammation through the MAOB/NF-kappa B/NLRP3/ASC/Caspase1/IL-1 beta pathway. These findings provide potential therapeutic approaches for treating the side effects of PTX-induced neuropathy using selective MAOB inhibitors.

PHYTOMEDICINE (2023)

Article Engineering, Environmental

The effect of repeated energy inputs on the release profiles of extracellular organic substances in sewage sludge

Rui Liu, Ying Xu, Liang Song, Shiyu Liu, Zixuan Liang, Danyang Zhu, Xiaohu Dai

Summary: This study investigated the influence of binding strength (BS) of extracellular organic substances (EOS) on organic matter (OM) recovery from sewage sludge. The results revealed the effects of multivalent metals, floc structures, and rheological properties on the release of EOS. The power-law distribution of BS was found to determine the state of organic molecules, stability of floc structures, and rheological properties. Hierarchical cluster analysis identified three levels of BS in EOS, indicating three stages of OM release or recovery from sludge. This study provides a theoretical basis for developing methods for OM release and recovery from sludge.

WATER RESEARCH (2023)

Review Oncology

A promising new cancer marker: Long noncoding RNA EGFR-AS1

Danhua Zhu, Xiaoxi Ouyang, Yanhong Zhang, Xiaopeng Yu, Kunkai Su, Lanjuan Li

Summary: Long noncoding RNAs (lncRNAs) are noncoding RNAs with a length of more than 200 nucleotides. Dysregulation of lncRNAs is involved in various diseases, and is closely associated with patient clinical features. EGFR-AS1, a lncRNA, is aberrantly expressed in many types of cancers and is associated with multiple clinical characteristics. It regulates various cellular activities, making it a promising marker for cancer management.

FRONTIERS IN ONCOLOGY (2023)

Article Materials Science, Biomaterials

Development of a novel sialic acid-conjugated camptothecin prodrug for enhanced cancer chemotherapy

Huiling Dong, Xuefei Huang, Xuanjun Wu

Summary: 9-SH-Sia is coupled to CPT to form a novel CPT prodrug (CPT-ss-Sia) that self-assembles into nanostructures in an aqueous solution. CPT-ss-Sia exhibits enhanced water solubility, GSH-triggered CPT release, and increased E-lactone ring stability, with comparable cancer cell-killing ability to CPT. Intravenous administration of CPT-ss-Sia inhibits tumor growth and reduces lesions without adverse effects on body weight in mice. This is the first report of the 9-SH-Sia conjugate-based prodrug, with broad clinical application prospects.

BIOMATERIALS SCIENCE (2023)

Article Biology

Lysate-to-grid: Rapid Isolation of Native Complexes from Budding Yeast for Cryo-EM Imaging

Ian Cooney, Deirdre C. Mack, Aaron J. Ferrell, Michael G. Stewart, Shuxin Wang, Helen M. Donelick, Daniela Tamayo-Jaramillo, Dakota L. Greer, Danyang Zhu, Wenyan Li, Peter S. Shen

Summary: Single-particle electron cryo-microscopy (cryo-EM) is an effective method for determining high-resolution structures of macromolecular complexes. This study presents a protocol using budding yeast to isolate tagged proteins and their associated complexes within three hours, prioritizing speed to recover intact, low-abundant complexes for cryo-EM specimen preparation. The protocol is applicable to soluble yeast proteins that tolerate C-terminal epitope tags.

BIO-PROTOCOL (2023)

Article Physics, Nuclear

Measurement of the 236,238U(n,f) cross sections from the threshold to 200 MeV at CSNS Back-n

Zhizhou Ren, Yiwei Yang, Rong Liu, Bangjiao Ye, Zhongwei Wen, Jie Wen, Hairui Guo, Yonghao Chen, Han Yi, Weili Sun, Jie Yan, Zijie Han, Xingyan Liu, Qiping Chen, Tao Ye, Jiangbo Bai, Qi An, Huaiyong Bai, Jie Bao, Ping Cao, Pinjing Cheng, Zengqi Cui, Ruirui Fan, Changqing Feng, Minhao Gu, Fengqin Guo, Changcai Han, Guozhu He, Yongcheng He, Yuefeng He, Hanxiong Huang, Weiling Huang, Xiru Huang, Xiaolu Ji, Xuyang Ji, Haoyu Jiang, Wei Jiang, Hantao Jing, Ling Kang, Mingtao Kang, Bo Li, Lun Li, Qiang Li, Xiao Li, Yang Li, Shubin Liu, Guangyuan Luan, Yinglin Ma, Changjun Ning, Binbin Qi, Jie Ren, Xichao Ruan, Zhaohui Song, Hong Sun, Xiaoyang Sun, Zhijia Sun, Zhixin Tan, Hongqing Tang, Jingyu Tang, Pengcheng Wang, Qi Wang, Taofeng Wang, Yanfeng Wang, Zhaohui Wang, Zheng Wang, Qingbiao Wu, Xiaoguang Wu, Xuan Wu, Likun Xie, Li Yu, Tao Yu, Yongji Yu, Guohui Zhang, Jing Zhang, Linhao Zhang, Liying Zhang, Qingmin Zhang, Qiwei Zhang, Xianpeng Zhang, Yuliang Zhang, Zhiyong Zhang, Yingtan Zhao, Liang Zhou, Zuying Zhou, Danyang Zhu, Kejun Zhu, Peng Zhu

Summary: The neutron-induced uranium fission reactions have significant implications in advanced nuclear energy research and nuclear science. Using the time-of-flight method, the fission cross sections of U-236 and U-238 relative to U-235 were measured, providing valuable experimental data for further research and nuclear data evaluations.

EUROPEAN PHYSICAL JOURNAL A (2023)

Review Chemistry, Multidisciplinary

Trap suppression in ordered organic photovoltaic heterojunctions

Dan He, Yawen Li, Fuwen Zhao, Yuze Lin

Summary: High trap density in organic solar cells leads to localized charge carriers and reduced carrier lifetime, limiting device efficiency. This feature article summarizes the recent advances of trap suppression by material design and device engineering.

CHEMICAL COMMUNICATIONS (2024)

Review Chemistry, Multidisciplinary

Controversial mechanism of simultaneous photocatalysis and Fenton-based processes: additional effect or synergy?

Olivier Monfort, Arshitha Madhusudhan, Martin Motola

Summary: This article presents the advantages of coupling photocatalysis and Fenton-based processes for environmental remediation and discusses their synergy. It critically examines the simultaneous triggering of these two processes and provides insights into research approaches. The study aims to enhance understanding of this complex process and highlight the potential integration of new catalysts in current wastewater treatment technology.

CHEMICAL COMMUNICATIONS (2024)

Article Chemistry, Multidisciplinary

Polymerization of monomer aggregates for tailoring and patterning water wettability

Manideepa Dhar, Chittaranjan Mishra, Avijit Das, Uttam Manna

Summary: An approach of 'polymerization of monomers in its aggregated form' has been introduced to tailor the water wettability of fibrous and porous substrates, achieving hydrophobicity to superhydrophobicity transition, as well as patterned wettability. This facile chemical method provides a durable coating with adjustable and patterned wettability for various potential applications.

CHEMICAL COMMUNICATIONS (2024)

Article Chemistry, Multidisciplinary

Pd/Brønsted acid catalysed intramolecular N-allylation of indoles and pyrroles with alkynes for the synthesis of N-fused heterocycles

Saswat Ranjan Bhoi, Chhanda Debnath, Shikha Gandhi

Summary: In this article, a novel catalytic reaction using Pd(0) and Bronsted acid is reported for the synthesis of biologically important imidazolidinone-fused N-heterocycles through redox-neutral intramolecular N-allylation of indoles and pyrroles with alkynes. This atom-economical method is applicable to a wide range of substrates and eliminates the need for leaving groups or oxidizing agents commonly used in traditional allylation reactions.

CHEMICAL COMMUNICATIONS (2024)

Article Chemistry, Multidisciplinary

Rh(III)-catalyzed selective mono- and dual-functionalization/cyclization of 1-aryl-5-aminopyrazoles with iodonium ylides

Longkun Chen, Mingshuai Zhang, Meichen Liu, Zhuoyuan Liu, Yuetong Qiu, Zhilai Zhang, Fuchao Yu, Jiuzhong Huang

Summary: In this study, an efficient Rh(III)-catalyzed selective mono- and dual-C-H bond functionalization/cyclization with iodonium ylide as the sole coupling partner was demonstrated. Fused benzodiazepine skeletons were obtained in excellent yields, providing an improved approach to dual C-H unsymmetrical functionalization.

CHEMICAL COMMUNICATIONS (2024)

Article Chemistry, Multidisciplinary

Modified minimal-size fragments of heparan sulfate as inhibitors of endosulfatase-2 (Sulf-2)

Alice Kennett, Sven Epple, Gabriella van der Valk, Irene Georgiou, Evelyne Gout, Romain R. Vives, Angela J. Russell

Summary: This study presents the design and synthesis of sulfated disaccharide inhibitors based on IdoA(2S)-GlcNS(6S), which showed potent inhibition of Sulf-2. The results suggest that IdoA(2S)-GlcNS(6S) is the shortest fragment size required for effective inhibition of Sulfs, and a trisulfated disaccharide is identified as the minimal fragment size of heparan sulfate for effective endosulfatase inhibition.

CHEMICAL COMMUNICATIONS (2024)

Article Chemistry, Multidisciplinary

Reductive cyclodimerization of chalcones: exploring the self-adaptability of galvanostatic electrosynthesis

Mauro Garbini, Andrea Brunetti, Riccardo Pedrazzani, Magda Monari, Massimo Marcaccio, Giulio Bertuzzi, Marco Bandini

Summary: The self-adaptability of galvanostatic electrolysis was found to be helpful in a multistage chemo- and diastereoselective electrochemically promoted cyclodimerization of chalcones. Through a series of reductive events, densely functionalized cyclopentanes with five contiguous stereocenters were obtained (25 examples, yields up to 95%, dr values up to >20:1). Further experimental and electrochemical investigations indicated the crucial role of dynamic kinetic resolution of the aldol intermediate in the reaction mechanism.

CHEMICAL COMMUNICATIONS (2024)

Article Chemistry, Multidisciplinary

Rh(III)-catalyzed oxidative [4+2] annulation of 2-arylquinoxalines and 2-aryl-2H-indazoles with allyl alcohols

Dhananjay S. Nipate, Neha Meena, Prakash N. Swami, Krishnan Rangan, Anil Kumar

Summary: In this study, the synthesis of functionalized benzo[a]phenazines and indazolo[2,3-a]quinolines was achieved through Rh(III)-catalyzed oxidative annulation of 2-arylquinoxalines and 2-aryl-2H-indazoles with allyl alcohols. The method showed a wide substrate scope, excellent functional group tolerance, good to high yields of annulated products, and the capability for scaled-up synthesis. A tentative mechanism of the annulation reaction was proposed based on a preliminary mechanistic investigation.

CHEMICAL COMMUNICATIONS (2024)

Article Chemistry, Multidisciplinary

PbTeB4O9: a lead tellurium borate with unprecedented fundamental building block [B4O10] and large birefringence

Ruonan Zhang, Abudukadi Tudi, Xia Yang, Xuping Wang, Zhihua Yang, Shujuan Han, Shilie Pan

Summary: A new lead tellurium borate material with a unique fundamental building block [B4O10] was synthesized and found to exhibit high birefringence. The structure-property relationship was discussed using first-principles calculations.

CHEMICAL COMMUNICATIONS (2024)

Article Chemistry, Multidisciplinary

Wafer-scale synthesis of two-dimensional ultrathin films

Amresh Kumar Singh, Baishali Thakurta, Anupam Giri, Monalisa Pal

Summary: This study introduces three key concepts for the quick synthesis of large-scale high-quality 2D materials films and their utilization in device fabrication.

CHEMICAL COMMUNICATIONS (2024)

Article Chemistry, Multidisciplinary

Precise design of copolymer-conjugated nanocatalysts for active electron transfer

Reina Hagiwara, Shun Nishimura, Kosuke Okeyoshi

Summary: A copolymer-conjugated nanocatalytic system has been developed to improve electron transfer and enhance photoinduced H2 generation.

CHEMICAL COMMUNICATIONS (2024)