Anchoring β-CD on simvastatin-loaded rHDL for selective cholesterol crystals dissolution and enhanced anti-inflammatory effects in macrophage/foam cells

Affinity-Driven Design of Cargo-Switching Nanoparticles to Leverage a Cholesterol-Rich Microenvironment for Atherosclerosis Therapy

(2020) Heegon Kim et al.   ACS Nano

Size-adaptable and ligand (biotin)-sheddable nanocarriers equipped with avidin scavenging technology for deep tumor penetration and reduced toxicity

(2020) Ya Jin et al.   JOURNAL OF CONTROLLED RELEASE

Immunity and Inflammation in Atherosclerosis

(2019) Dennis Wolf et al.   CIRCULATION RESEARCH

Dynamically enhancing plaque targeting via a positive feedback loop using multifunctional biomimetic nanoparticles for plaque regression

(2019) Cuiping Jiang et al.   JOURNAL OF CONTROLLED RELEASE

Macrophages in Atherosclerosis Regression

(2019) Tessa J. Barrett   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Biofunctionalization of β-cyclodextrin nanosponges using cholesterol

(2018) Parbeen Singh et al.   CARBOHYDRATE POLYMERS

Co-delivery of LOX-1 siRNA and statin to endothelial cells and macrophages in the atherosclerotic lesions by a dual-targeting core-shell nanoplatform: A dual cell therapy to regress plaques

(2018) Yi Zhao et al.   JOURNAL OF CONTROLLED RELEASE

Evaluation of the Combined Effect of Recombinant High-Density Lipoprotein Carrier and the Encapsulated Lovastatin in RAW264.7 Macrophage Cells Based on the Median-Effect Principle

(2018) Cuiping Jiang et al.   MOLECULAR PHARMACEUTICS

Cyclodextrin-based delivery systems for cancer treatment

(2018) Dongjing Zhang et al.   Materials Science & Engineering C-Materials for Biological Applications

A systematic comparison of clinically viable nanomedicines targeting HMG-CoA reductase in inflammatory atherosclerosis

(2017) Amr Alaarg et al.   JOURNAL OF CONTROLLED RELEASE

Atherosclerosis

(2016) Peter Libby et al.   CIRCULATION RESEARCH

High-density lipoprotein reduces inflammation from cholesterol crystals by inhibiting inflammasome activation

(2016) Seth G. Thacker et al.   IMMUNOLOGY

Vitamin E TPGS modified liposomes enhance cellular uptake and targeted delivery of luteolin: An in vivo/in vitro evaluation

(2016) Jinli Li et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Cyclodextrin promotes atherosclerosis regression via macrophage reprogramming

(2016) Sebastian Zimmer et al.   Science Translational Medicine

Mechanism and Physiologic Significance of the Suppression of Cholesterol Esterification in Human Interstitial Fluid

(2016) Norman E. Miller et al.   Frontiers in Pharmacology

A Simple Method to Extract Whole Apolipoproteins for the Preparation of Discoidal Recombined High Density Lipoproteins as Bionic Nanocarriers for Drug Delivery

(2015) Wenli Zhang et al.   JOURNAL OF PHARMACY AND PHARMACEUTICAL SCIENCES

Suppression of Remodeling Behaviors with Arachidonic Acid Modification for Enhanced in vivo Antiatherogenic Efficacies of Lovastatin-loaded Discoidal Recombinant High Density Lipoprotein

(2015) Hongliang He et al.   PHARMACEUTICAL RESEARCH

Neutrophil extracellular traps license macrophages for cytokine production in atherosclerosis

(2015) A. Warnatsch et al.   SCIENCE

Inhibiting macrophage proliferation suppresses atherosclerotic plaque inflammation

(2015) J. Tang et al.   Science Advances

Hyaluronic acid-decorated reconstituted high density lipoprotein targeting atherosclerotic lesions

(2014) Lisha Liu et al.   BIOMATERIALS

Arachidonic Acid-Modified Lovastatin Discoidal Reconstituted High Density Lipoprotein Markedly Decreases the Drug Leakage during the Remodeling Behaviors Induced by Lecithin Cholesterol Acyltransferase

(2014) Hongliang He et al.   PHARMACEUTICAL RESEARCH

Serum albumin acts as a shuttle to enhance cholesterol efflux from cells

(2013) Sandhya Sankaranarayanan et al.   JOURNAL OF LIPID RESEARCH

Chitosan-g-TPGS Nanoparticles for Anticancer Drug Delivery and Overcoming Multidrug Resistance

(2013) Yuanyuan Guo et al.   MOLECULAR PHARMACEUTICS

High-density lipoprotein mediates anti-inflammatory reprogramming of macrophages via the transcriptional regulator ATF3

(2013) Dominic De Nardo et al.   NATURE IMMUNOLOGY

Pharmacokinetics and atherosclerotic lesions targeting effects of tanshinone IIA discoidal and spherical biomimetic high density lipoproteins

(2012) Wenli Zhang et al.   BIOMATERIALS

Synthesis of β-cyclodextrin conjugated superparamagnetic iron oxide nanoparticles for selective binding and detection of cholesterol crystals

(2012) Hongguang Li et al.   CHEMICAL COMMUNICATIONS

Macrophages in the Pathogenesis of Atherosclerosis

(2011) Kathryn J. Moore et al.   CELL

Structure and remodeling behavior of drug-loaded high density lipoproteins and their atherosclerotic plaque targeting mechanism in foam cell model

(2011) Wen-Li Zhang et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Identification of cholesterol crystals in plaques of atherosclerotic mice using hyperspectral CARS imaging

(2011) Ryan S. Lim et al.   JOURNAL OF LIPID RESEARCH

Evaluation of foam cell formation in cultured macrophages: an improved method with Oil Red O staining and DiI-oxLDL uptake

(2010) Suowen Xu et al.   CYTOTECHNOLOGY

Cholesterol crystals piercing the arterial plaque and intima trigger local and systemic inflammation

(2010) George S. Abela   Journal of Clinical Lipidology

NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals

(2010) Peter Duewell et al.   NATURE

Physical factors that trigger cholesterol crystallization leading to plaque rupture

(2008) Ameeth Vedre et al.   ATHEROSCLEROSIS

Doxorubicin conjugated to d-α-tocopheryl polyethylene glycol 1000 succinate (TPGS): Conjugation chemistry, characterization, in vitro and in vivo evaluation

(2008) Na Cao et al.   BIOMATERIALS

An ApoA-I Mimetic Peptide High-Density-Lipoprotein-Based MRI Contrast Agent for Atherosclerotic Plaque Composition Detection

(2008) David P. Cormode et al.   Small