Article
Chemistry, Physical
Jugal Suthar, Alberto Alvarez-Fernandez, Esther Osarfo-Mensah, Stefano Angioletti-Uberti, Gareth R. Williams, Stefan Guldin
Summary: Extracellular vesicles (EVs) are released from various cell types and contain biomolecular content for health and disease identification. However, the heterogeneity of EVs and complexity of biofluids pose challenges to current analytical approaches. This study explores nanostructuring the sensor electrode surface to enhance detection capabilities and achieves significant improvement.
NANOSCALE HORIZONS
(2023)
Article
Nanoscience & Nanotechnology
Hua Chai, Wenbo Cheng, Dayong Jin, Peng Miao
Summary: This article summarizes the assembly principles and applications of hybridization chain reaction (HCR) in DNA nanotechnology. HCR has excellent assembly kinetics and ease of operation, making it suitable for ultra-sensitive detection of various targets. Future advancements in overcoming challenges are needed for further development in this field.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Chemistry, Physical
Jing Su, Yuqing Ke, Nokuzola Maboyi, Xiao Zhi, Sijia Yan, Fuwu Li, Bo Zhao, Xiaolong Jia, Shiping Song, Xianting Ding
Summary: The authors developed a CRISPR/Cas12a-powered DNA framework-supported electrochemical biosensing platform for ultrasensitive nucleic acid analysis without pre-amplification, showing incredible capability for sequence-specific targeting and detection.
Article
Chemistry, Multidisciplinary
Pu Zhang, Yu Ouyang, Itamar Willner
Summary: In this study, dye-loaded UiO-66 metal-organic framework nanoparticles modified with catalytic hemin/G-quadruplex DNAzyme labels were utilized for chemiluminescence resonance energy transfer (CRET) analysis of miRNAs and genes. The engineered hairpin probes, caged G-quadruplex domains, and self-assembly of hemin/G-quadruplex DNAzyme labels allowed for sensitive detection of specific miRNAs and genes. The DNA hairpin-functionalized dye-loaded NMOF sensing modules were also applied for amplified miRNA or gene CRET-based sensing platforms, demonstrating multiplexed detection capabilities.
Article
Chemistry, Physical
Minoru Yoshimoto, Shigeru Kurosawa, Mutsuo Tanaka
Summary: The study found that under different temperatures and oscillation frequencies, the nanoscale dynamics of soft materials can be described linearly by the relationship between resonant length or molecular weight and the logarithm of QCM angular frequency, and converged to a single point independently of temperature within a certain temperature range.
JOURNAL OF PHYSICAL CHEMISTRY C
(2021)
Article
Biophysics
Yu Xue, Haopu Xie, Yu Wang, Sinuo Feng, Jian Sun, Jianshe Huang, Xiurong Yang
Summary: In this study, a novel electrochemical/fluorescent dual-mode biosensor was developed for sensitive and accurate detection of target nucleic acids. The biosensor utilized functional nucleic acids to achieve self-assembly and cascaded amplification, significantly improving the sensitivity and accuracy. The research showed promising applications in bioanalysis and early disease diagnosis.
BIOSENSORS & BIOELECTRONICS
(2022)
Article
Chemistry, Multidisciplinary
Yacine Mazouzi, Fadoua Sallem, Francesca Farina, Alexis Loiseau, Natayme Rocha Tartaglia, Morgane Fontaine, Atul Parikh, Michele Salmain, Christian Neri, Souhir Boujday
Summary: This study combines quartz crystal microbalance with dissipation (QCM-D) and nanoplasmonic sensing (NPS) to provide a facile method for tracking the viscoelastic properties of small EVs, analyzing EVs related to the Huntington's disease gene. The results suggest that the mass and viscoelastic dissipation of EVs can serve as potent biomarkers.
Review
Engineering, Electrical & Electronic
P. J. Jandas, K. Prabakaran, Jingting Luo, M. G. Derry Holaday
Summary: The combination of novel sensitive materials with effective instrumentation technology has led to significant growth in fabrication methods of various practical biosensors. Quartz crystal microbalance (QCM) has become one of the most popular biosensing devices in the past 10-15 years, with well-crafted research. This article systematically reviews the recent developments in QCM research as a biosensing tool, and explains its application in biomolecule identification, estimation, and interfacial interaction analysis, as well as immunosensing characteristics against various microorganisms.
SENSORS AND ACTUATORS A-PHYSICAL
(2021)
Article
Chemistry, Analytical
Yibin Lu, Xueyu Lu, Shiting Gu, Xiao-Mei Shi, Gao-Chao Fan
Summary: A novel and robust two-electrode photoelectrochemical biosensing platform amplified by bilirubin oxidase labeling was reported, showing high sensitivity and good selectivity. By separating biorecognition with the photoanode, the platform presents a promising path for applying in complex biological samples.
SENSORS AND ACTUATORS B-CHEMICAL
(2021)
Article
Chemistry, Analytical
Hongkun Li, Yuqi Zhang, Guifen Jie
Summary: A DNA reticular nanostructure was assembled using hairpin DNA probes via a target-induced circular amplification strategy for the fluorescence biosensing of miRNA-21. This method allows sensitive detection of miRNA-21 and holds great application potential in biosensors and functional nanomaterials.
SENSORS AND ACTUATORS B-CHEMICAL
(2021)
Article
Chemistry, Applied
Chonnipa Palasingh, Rupert Kargl, Karin Stana Kleinschek, Jana Schaubeder, Stefan Spirk, Anna Strom, Tiina Nypelo
Summary: Polysaccharides, including xylans from wood, can be processed into films. The solubility of xylans can be improved through oxidative cleavage of the saccharide ring. The degree of oxidation (DO) of xylans affects their solubility, film formation, and stability. High DO xylans showed the smallest hydrodynamic diameter and formed continuous films with significant moisture uptake.
CARBOHYDRATE POLYMERS
(2023)
Article
Biochemical Research Methods
Taoran Tian, Tao Zhang, Sirong Shi, Yang Gao, Xiaoxiao Cai, Yunfeng Lin
Summary: An active targeting strategy-enabled DNA tetrahedron delivery vehicle has been developed for stable drug encapsulation and stimuli-responsive on-demand release, providing a universal platform for various drug delivery requirements.
Article
Chemistry, Multidisciplinary
Kunihiko Morihiro, Yasuhiro Tomida, Daisuke Fukui, Manami Hasegawa, Akimitsu Okamoto
Summary: Many miRNAs are commonly found in cancer cells, making them promising biomarkers for cancer diagnosis and treatment. However, it is challenging to convert nucleic acid sequence information into functional molecules. To overcome this challenge, hairpin DNA circuits were used to convert nucleic acid input into small molecule output. The circuits responded to oncogenic miR-21 and released fluorophore, dye, and anticancer agent, enabling efficient detection and chemotherapy based on nucleic acid expression profiles.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Biophysics
Daniel Pereiraa, Andreas Santamaria, Nisha Pawar, Javier Carrascosa-Tejedor, Mariana Sardo, Luis Mafra, Eduardo Guzman, David J. Owen, Nathan R. Zaccai, Armando Maestro, Ildefonso Marin-Montesinos
Summary: The combination of solid-supported lipid bilayer (SLB) models and surface sensitive techniques provides quantitative information about molecular interactions and lipid distributions. This study designed complex SLBs to mimic cellular plasma membranes, and incorporated phosphatidylinositol 4,5-bisphosphate (PtdIns4,5P2) lipids and synthetic lipo-peptides. Results showed that the adsorption and fusion kinetics of PtdIns4,5P2 were influenced by Mg2+ and higher concentrations of PtdIns4,5P2 led to more homogeneous SLBs. The presence of PtdIns4,5P2 clusters was observed using AFM, while NR provided insights into the structural organization of the SLBs and the role of CD4-derived cargo peptides.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2023)
Article
Biochemistry & Molecular Biology
Negin Gooran, Bo Kyeong Yoon, Joshua A. Jackman
Summary: This study comparatively evaluated the membrane-disruptive properties of TX-100 and potential replacement SL-11W using a supported lipid bilayer (SLB) platform. The results showed that TX-100 exhibited higher potency and caused rapid and irreversible membrane solubilization, while SL-11W induced more gradual and reversible membrane budding. The study also revealed that both TX-100 and SL-11W showed concentration-dependent interaction behaviors and were only active at or above their critical micelle concentration (CMC) values.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Materials Science, Biomaterials
Huaming Wang, Wei Tang, Hejia Wei, Yan Zhao, Shichao Hu, Yan Guan, Wei Pan, Bin Xia, Na Li, Feng Liu
Journal of Materials Chemistry B
(2015)
Article
Chemistry, Multidisciplinary
Shichao Hu, Wei Tang, Yan Zhao, Na Li, Feng Liu
Article
Chemistry, Multidisciplinary
Wei Tang, Shichao Hu, Huaming Wang, Yan Zhao, Na Li, Feng Liu
CHEMICAL COMMUNICATIONS
(2014)
Article
Chemistry, Multidisciplinary
Wei Tang, Huaming Wang, Dingzhong Wang, Yan Zhao, Na Li, Feng Liu
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2013)
Article
Biochemical Research Methods
Yi Xu, Jeong-Heon Lee, Zhaoyu Li, Liguo Wang, Tamas Ordog, Ryan C. Bailey
Article
Chemistry, Multidisciplinary
Wei Tang, Mengxi Cheng, Danling Dai, Zhonghua Xiong, Feng Liu
Article
Biophysics
Xiaolong Wang, Rui Zeng, Shengnan Chu, Wei Tang, Na Lin, Jun Fu, Jiangrong Yang, Bo Gao
BIOSENSORS & BIOELECTRONICS
(2019)
Article
Chemistry, Analytical
Yi Xu, Steven R. Doonan, Tamas Ordog, Ryan C. Bailey
ANALYTICAL CHEMISTRY
(2020)
Article
Chemistry, Analytical
Jian Chu, Chun Chen, Xijian Li, Libing Yu, Wenjing Li, Mengxi Cheng, Wei Tang, Zhonghua Xiong
Summary: A one-step preparation method for Pb2+-responsive pure DNA hydrogel material was developed in this study to achieve a new label-free strategy for Pb2+ biosensing.
ANALYTICA CHIMICA ACTA
(2021)
Article
Environmental Sciences
Libing Yu, Wenjing Li, Jian Chu, Chun Chen, Xijian Li, Wei Tang, Binyuan Xia, Zhonghua Xiong
Summary: Uranium as an emerging pollutant presents serious threats to ecological and human health, with the kidney identified as a major deposition site and sensitive target organ for its toxicity, which is associated with oxidative stress and mitochondrial respiration. This study found that cytochrome c oxidase and ATP synthase play key roles in uranium-induced toxicity by inhibiting their activities in the mitochondrial respiration pathway. These inhibitory effects could explain the generation of reactive oxygen species and mitochondrial alterations observed in uranium poisoning.
ENVIRONMENTAL POLLUTION
(2021)
Article
Engineering, Environmental
Libing Yu, Zhaozhu Lin, Xuedan Cheng, Jian Chu, Xijian Li, Chun Chen, Tinghua Zhu, Wenjing Li, Wei Lin, Wei Tang
Summary: Thorium, a radioactive heavy metal, inhibits cytochrome c oxidase in mitochondria, leading to cellular toxicity by altering mitochondrial membrane potential and generating reactive oxygen species. This suggests cytochrome c oxidase as a key molecular target underlying thorium-induced toxicological effects.
JOURNAL OF HAZARDOUS MATERIALS
(2022)
Article
Biochemistry & Molecular Biology
Wenjing Li, Libing Yu, Bo Fu, Jian Chu, Chun Chen, Xijian Li, Jiahua Ma, Wei Tang
Summary: The study found that Polygonatum kingianum (PK) can effectively detoxify and prevent uranium-induced nephrotoxicity. Polysaccharides and aqueous extract of PK can enhance metabolic activity, alleviate cell damage and apoptosis. The study also found that PK alleviates uranium-induced cytotoxicity by regulating mitochondria-mediated apoptosis and the GSK-3 beta/Fyn/Nrf2 pathway.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Pharmacology & Pharmacy
Xuedan Cheng, Jian Chu, Liandong Zhang, Zhirong Suo, Wei Tang
Summary: This study used metabolomics to analyze the effects of uranium exposure on human kidney cells and identified an oxidative stress mechanism caused by uranium exposure, providing new evidence for the study of uranium poisoning.
Review
Environmental Sciences
Liandong Zhang, Jian Chu, Binyuan Xia, Zhonghua Xiong, Shaoyu Zhang, Wei Tang
Summary: Uranium contamination is a significant global health issue, particularly through inhalation of particulate uranium. Studies have shown a possible association between lung cancer risk and uranium exposure, but evidence for other tumors is limited. Animal experiments have demonstrated respiratory and central nervous system damage from particulate uranium exposure. However, understanding of the health risks and toxicological mechanisms of particulate uranium contamination is still preliminary.
Review
Chemistry, Multidisciplinary
Dan He, Yawen Li, Fuwen Zhao, Yuze Lin
Summary: High trap density in organic solar cells leads to localized charge carriers and reduced carrier lifetime, limiting device efficiency. This feature article summarizes the recent advances of trap suppression by material design and device engineering.
CHEMICAL COMMUNICATIONS
(2024)
Review
Chemistry, Multidisciplinary
Olivier Monfort, Arshitha Madhusudhan, Martin Motola
Summary: This article presents the advantages of coupling photocatalysis and Fenton-based processes for environmental remediation and discusses their synergy. It critically examines the simultaneous triggering of these two processes and provides insights into research approaches. The study aims to enhance understanding of this complex process and highlight the potential integration of new catalysts in current wastewater treatment technology.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Manideepa Dhar, Chittaranjan Mishra, Avijit Das, Uttam Manna
Summary: An approach of 'polymerization of monomers in its aggregated form' has been introduced to tailor the water wettability of fibrous and porous substrates, achieving hydrophobicity to superhydrophobicity transition, as well as patterned wettability. This facile chemical method provides a durable coating with adjustable and patterned wettability for various potential applications.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Saswat Ranjan Bhoi, Chhanda Debnath, Shikha Gandhi
Summary: In this article, a novel catalytic reaction using Pd(0) and Bronsted acid is reported for the synthesis of biologically important imidazolidinone-fused N-heterocycles through redox-neutral intramolecular N-allylation of indoles and pyrroles with alkynes. This atom-economical method is applicable to a wide range of substrates and eliminates the need for leaving groups or oxidizing agents commonly used in traditional allylation reactions.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Longkun Chen, Mingshuai Zhang, Meichen Liu, Zhuoyuan Liu, Yuetong Qiu, Zhilai Zhang, Fuchao Yu, Jiuzhong Huang
Summary: In this study, an efficient Rh(III)-catalyzed selective mono- and dual-C-H bond functionalization/cyclization with iodonium ylide as the sole coupling partner was demonstrated. Fused benzodiazepine skeletons were obtained in excellent yields, providing an improved approach to dual C-H unsymmetrical functionalization.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Alice Kennett, Sven Epple, Gabriella van der Valk, Irene Georgiou, Evelyne Gout, Romain R. Vives, Angela J. Russell
Summary: This study presents the design and synthesis of sulfated disaccharide inhibitors based on IdoA(2S)-GlcNS(6S), which showed potent inhibition of Sulf-2. The results suggest that IdoA(2S)-GlcNS(6S) is the shortest fragment size required for effective inhibition of Sulfs, and a trisulfated disaccharide is identified as the minimal fragment size of heparan sulfate for effective endosulfatase inhibition.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Mauro Garbini, Andrea Brunetti, Riccardo Pedrazzani, Magda Monari, Massimo Marcaccio, Giulio Bertuzzi, Marco Bandini
Summary: The self-adaptability of galvanostatic electrolysis was found to be helpful in a multistage chemo- and diastereoselective electrochemically promoted cyclodimerization of chalcones. Through a series of reductive events, densely functionalized cyclopentanes with five contiguous stereocenters were obtained (25 examples, yields up to 95%, dr values up to >20:1). Further experimental and electrochemical investigations indicated the crucial role of dynamic kinetic resolution of the aldol intermediate in the reaction mechanism.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Dhananjay S. Nipate, Neha Meena, Prakash N. Swami, Krishnan Rangan, Anil Kumar
Summary: In this study, the synthesis of functionalized benzo[a]phenazines and indazolo[2,3-a]quinolines was achieved through Rh(III)-catalyzed oxidative annulation of 2-arylquinoxalines and 2-aryl-2H-indazoles with allyl alcohols. The method showed a wide substrate scope, excellent functional group tolerance, good to high yields of annulated products, and the capability for scaled-up synthesis. A tentative mechanism of the annulation reaction was proposed based on a preliminary mechanistic investigation.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Ruonan Zhang, Abudukadi Tudi, Xia Yang, Xuping Wang, Zhihua Yang, Shujuan Han, Shilie Pan
Summary: A new lead tellurium borate material with a unique fundamental building block [B4O10] was synthesized and found to exhibit high birefringence. The structure-property relationship was discussed using first-principles calculations.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Amresh Kumar Singh, Baishali Thakurta, Anupam Giri, Monalisa Pal
Summary: This study introduces three key concepts for the quick synthesis of large-scale high-quality 2D materials films and their utilization in device fabrication.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Reina Hagiwara, Shun Nishimura, Kosuke Okeyoshi
Summary: A copolymer-conjugated nanocatalytic system has been developed to improve electron transfer and enhance photoinduced H2 generation.
CHEMICAL COMMUNICATIONS
(2024)
