Roles of the NH2-terminal Domains of Cardiac Ryanodine Receptor in Ca2+Release Activation and Termination

The CPVT-associated RyR2 mutation G230C enhances store overloadinduced Ca2+release and destabilizes the N-terminal domains

(2013) Yingjie Liu et al.   BIOCHEMICAL JOURNAL

Type 2 Ryanodine Receptor Domain A Contains a Unique and Dynamic α-Helix That Transitions to a β-Strand in a Mutant Linked with a Heritable Cardiomyopathy

(2013) Fernando J. Amador et al.   JOURNAL OF MOLECULAR BIOLOGY

Conformational Dynamics inside Amino-Terminal Disease Hotspot of Ryanodine Receptor

(2013) Xiaowei Zhong et al.   STRUCTURE

The Cardiac Ryanodine Receptor N-Terminal Region Contains an Anion Binding Site that Is Targeted by Disease Mutations

(2013) Lynn Kimlicka et al.   STRUCTURE

Disease mutations in the ryanodine receptor N-terminal region couple to a mobile intersubunit interface

(2013) Lynn Kimlicka et al.   Nature Communications

Abnormal Termination of Ca 2+ Release Is a Common Defect of RyR2 Mutations Associated With Cardiomyopathies

(2012) Yijun Tang et al.   CIRCULATION RESEARCH

Ligand-dependent Conformational Changes in the Clamp Region of the Cardiac Ryanodine Receptor

(2012) Xixi Tian et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ryanodine Receptors: Structure and Function

(2012) Filip Van Petegem   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural and functional conservation of key domains in InsP3 and ryanodine receptors

(2012) Min-Duk Seo et al.   NATURE

Cardiac Sarcoplasmic Reticulum Calcium Leak: Basis and Roles in Cardiac Dysfunction

(2011) Donald M. Bers   Annual Review of Physiology

Inherited Dysfunction of Sarcoplasmic Reticulum Ca 2+ Handling and Arrhythmogenesis

(2011) Silvia G. Priori et al.   CIRCULATION RESEARCH

Apo and InsP3-bound crystal structures of the ligand-binding domain of an InsP3 receptor

(2011) Chun-Chi Lin et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The Deletion of Exon 3 in the Cardiac Ryanodine Receptor Is Rescued by β Strand Switching

(2011) Paolo A. Lobo et al.   STRUCTURE

Mechanistic models for muscle diseases and disorders originating in the sarcoplasmic reticulum

(2010) David H. MacLennan et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Characterization of a novel mutation in the cardiac ryanodine receptor that results in catecholaminergic polymorphic ventricular tachycardia

(2010) Dawei Jiang et al.   Channels

The amino-terminal disease hotspot of ryanodine receptors forms a cytoplasmic vestibule

(2010) Ching-Chieh Tung et al.   NATURE

IP3 Receptors: Toward Understanding Their Activation

(2010) C. W. Taylor et al.   Cold Spring Harbor Perspectives in Biology

Crystal structure of type I ryanodine receptor amino-terminal  -trefoil domain reveals a disease-associated mutation "hot spot" loop

(2009) F. J. Amador et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Crystal Structures of the N-Terminal Domains of Cardiac and Skeletal Muscle Ryanodine Receptors: Insights into Disease Mutations

(2009) Paolo Antonio Lobo et al.   STRUCTURE

Coordinated Movement of Cytoplasmic and Transmembrane Domains of RyR1 upon Gating

(2009) Montserrat Samsó et al.   PLOS BIOLOGY

Endoplasmic reticulum Ca2+measurements reveal that the cardiac ryanodine receptor mutations linked to cardiac arrhythmia and sudden death alter the threshold for store-overload-induced Ca2+release

(2008) Peter P. Jones et al.   BIOCHEMICAL JOURNAL

Caffeine induces Ca2+release by reducing the threshold for luminal Ca2+activation of the ryanodine receptor

(2008) Huihui Kong et al.   BIOCHEMICAL JOURNAL