Potential Therapeutic Benefit of Low Dose Naltrexone in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: Role of Transient Receptor Potential Melastatin 3 Ion Channels in Pathophysiology and Treatment

Systematic review and meta-analysis of the prevalence of chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME)

(2020) Eun-Jin Lim et al.   Journal of Translational Medicine

Opioid Receptors in Immune and Glial Cells—Implications for Pain Control

(2020) Halina Machelska et al.   Frontiers in Immunology

Validation of impaired Transient Receptor Potential Melastatin 3 ion channel activity in natural killer cells from Chronic Fatigue Syndrome/ Myalgic Encephalomyelitis patients

(2019) H. Cabanas et al.   MOLECULAR MEDICINE

Promiscuous G-Protein-Coupled Receptor Inhibition of Transient Receptor Potential Melastatin 3 Ion Channels by Gβγ Subunits

(2019) Omar Alkhatib et al.   JOURNAL OF NEUROSCIENCE

Naltrexone Restores Impaired Transient Receptor Potential Melastatin 3 Ion Channel Function in Natural Killer Cells From Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Patients

(2019) Helene Cabanas et al.   Frontiers in Immunology

Loss of Transient Receptor Potential Melastatin 3 ion channel function in natural killer cells from Chronic Fatigue Syndrome/Myalgic Encephalomyelitis patients

(2018) Hélène Cabanas et al.   MOLECULAR MEDICINE

Featured Article: Serum [Met5]-enkephalin levels are reduced in multiple sclerosis and restored by low-dose naltrexone

(2017) Michael D Ludwig et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

G protein βγ subunits inhibit TRPM3 ion channels in sensory neurons

(2017) Talisia Quallo et al.   eLife

Inhibition of Transient Receptor Potential Melastatin 3 ion channels by G-protein βγ subunits

(2017) Doreen Badheka et al.   eLife

Anti-nociceptive action of peripheral mu-opioid receptors by G-beta-gamma protein-mediated inhibition of TRPM3 channels

(2017) Sandeep Dembla et al.   eLife

The Neuroinflammatory Etiopathology of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS)

(2017) Julian A. G. Glassford   Frontiers in Physiology

Naltrexone Inhibits IL-6 and TNFα Production in Human Immune Cell Subsets following Stimulation with Ligands for Intracellular Toll-Like Receptors

(2017) Rachel Cant et al.   Frontiers in Immunology

Opioid Receptors

(2016) Christoph Stein   Annual Review of Medicine

Leukocyte opioid receptors mediate analgesia via Ca 2+ -regulated release of opioid peptides

(2016) Melih Ö. Celik et al.   BRAIN BEHAVIOR AND IMMUNITY

Impaired calcium mobilization in natural killer cells from chronic fatigue syndrome/myalgic encephalomyelitis patients is associated with transient receptor potential melastatin 3 ion channels

(2016) T. Nguyen et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Treatment of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: A Systematic Review for a National Institutes of Health Pathways to Prevention Workshop

(2015) M.E. Beth Smith et al.   ANNALS OF INTERNAL MEDICINE

Central pathways causing fatigue in neuro-inflammatory and autoimmune illnesses

(2015) Gerwyn Morris et al.   BMC Medicine

The use of low-dose naltrexone (LDN) as a novel anti-inflammatory treatment for chronic pain

(2014) Jarred Younger et al.   CLINICAL RHEUMATOLOGY

Treatment of Complex Regional Pain Syndrome (CRPS) Using Low Dose Naltrexone (LDN)

(2013) Pradeep Chopra et al.   Journal of Neuroimmune Pharmacology

Calcium signalling remodelling and disease

(2012) Michael J. Berridge   BIOCHEMICAL SOCIETY TRANSACTIONS

Calcium, cancer and killing: The role of calcium in killing cancer cells by cytotoxic T lymphocytes and natural killer cells

(2012) Eva C. Schwarz et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Citrus fruit and fabacea secondary metabolites potently and selectively block TRPM3

(2012) I Straub et al.   BRITISH JOURNAL OF PHARMACOLOGY

Role of the mu-opioid receptor in opioid modulation of immune function

(2011) Jana Ninković et al.   AMINO ACIDS

Molecular Mechanisms of Opioid Receptor-dependent Signaling and Behavior

(2011) Ream Al-Hasani et al.   ANESTHESIOLOGY

Myalgic encephalomyelitis: International Consensus Criteria

(2011) B. M. Carruthers et al.   JOURNAL OF INTERNAL MEDICINE

Immunological abnormalities as potential biomarkers in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis

(2011) Ekua W Brenu et al.   Journal of Translational Medicine

TRPM3 Is a Nociceptor Channel Involved in the Detection of Noxious Heat

(2011) Joris Vriens et al.   NEURON

Pilot trial of low-dose naltrexone and quality of life in multiple sclerosis

(2010) Bruce A. C. Cree et al.   ANNALS OF NEUROLOGY

Interactions between the immune and nervous systems in pain

(2010) Ke Ren et al.   NATURE MEDICINE

TRPM3 channels provide a regulated influx pathway for zinc in pancreatic beta cells

(2010) Thomas F. J. Wagner et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Opioid-Like Activity of Naltrexone on Natural Killer Cell Cytolytic Activity and Cytokine Production in Splenocytes: Effects of Alcohol

(2009) Nadka I. Boyadjieva et al.   JOURNAL OF INTERFERON AND CYTOKINE RESEARCH

Effects of Naltrexone on Pain Sensitivity and Mood in Fibromyalgia: No Evidence for Endogenous Opioid Pathophysiology

(2009) Jarred W. Younger et al.   PLoS One

Normative Data for the 12 Item WHO Disability Assessment Schedule 2.0

(2009) Gavin Andrews et al.   PLoS One