First synthesis of an aziridinyl fused pyrrolo[1,2-a]benzimidazole and toxicity evaluation towards normal and breast cancer cell lines

Synthesis and toxicity towards normal and cancer cell lines of benzimidazolequinones containing fused aromatic rings and 2-aromatic ring substituents

(2010) Eoin Moriarty et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

The influence of the aziridinyl substituent of benzimidazoles and benzimidazolequinones on toxicity towards normal and Fanconi anaemia cells

(2010) Karen Fahey et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Triple molecular target approach to selective melanoma cytotoxicity

(2010) Edward B. Skibo et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

One-pot double intramolecular homolytic aromatic substitution routes to dialicyclic ring fused imidazobenzimidazolequinones and preliminary analysis of anticancer activity

(2010) Vincent Fagan et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Mitomycins syntheses: a recent update

(2009) Jean-Christophe Andrez   Beilstein Journal of Organic Chemistry

Premature senescence is a major response to DNA cross-linking agents in BRCA1-defective cells: implication for tailored treatments of BRCA1 mutation carriers

(2009) M. Santarosa et al.   MOLECULAR CANCER THERAPEUTICS

First synthesis of N-[(aziridin-2-yl)methyl]benzimidazolequinone and analysis of toxicity towards normal and Fanconi anemia cells

(2008) Liz O’Donovan et al.   CHEMICAL COMMUNICATIONS

Design of anticancer prodrugs for reductive activation

(2008) Yu Chen et al.   MEDICINAL RESEARCH REVIEWS

Synthesis of dimethyl substituted benzimidazoles containing cyclopropane fused onto five to eight membered [1,2-a]alicyclic rings and influence of methyl group substituents on cytotoxicity of benzimidazolequinones

(2008) Sarah Hehir et al.   TETRAHEDRON

Natural and synthetic quinones and their reduction by the quinone reductase enzyme NQO1: from synthetic organic chemistry to compounds with anticancer potential

(2007) Marie A. Colucci et al.   ORGANIC & BIOMOLECULAR CHEMISTRY