Understanding Small-Molecule Binding to MDM2: Insights into Structural Effects of Isoindolinone Inhibitors from NMR Spectroscopy

Inhibitors of MDM2 and MDMX: a structural perspective

(2009) Christiane Riedinger et al.   Future Medicinal Chemistry

Discovery and Optimization of Chromenotriazolopyrimidines as Potent Inhibitors of the Mouse Double Minute 2−Tumor Protein 53 Protein−Protein Interaction

(2009) John G. Allen et al.   JOURNAL OF MEDICINAL CHEMISTRY

Isoquinolin‐1‐one Inhibitors of the MDM2–p53 Interaction

(2008) Ulli Rothweiler et al.   ChemMedChem

Small molecular weight protein–protein interaction antagonists—an insurmountable challenge?

(2008) Alexander Dömling   CURRENT OPINION IN CHEMICAL BIOLOGY

Quantitative Lid Dynamics of MDM2 Reveals Differential Ligand Binding Modes of the p53-Binding Cleft

(2008) Scott A. Showalter et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Analysis of Chemical Shift Changes Reveals the Binding Modes of Isoindolinone Inhibitors of the MDM2-p53 Interaction

(2008) Christiane Riedinger et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Temporal activation of p53 by a specific MDM2 inhibitor is selectively toxic to tumors and leads to complete tumor growth inhibition

(2008) S. Shangary et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA