A Novel Immunocompetent Mouse Model of Pancreatic Cancer with Robust Stroma: a Valuable Tool for Preclinical Evaluation of New Therapies

Triptolide inhibits human breast cancer MCF-7 cell growth via downregulation of the ERα-mediated signaling pathway

(2015) Han Li et al.   ACTA PHARMACOLOGICA SINICA

Cancer statistics, 2015

(2015) Rebecca L. Siegel et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Triptolide abrogates growth of colon cancer and induces cell cycle arrest by inhibiting transcriptional activation of E2F

(2015) Amanda R Oliveira et al.   LABORATORY INVESTIGATION

Primary and Liver Metastasis–Derived Cell Lines From KrasG12D; Trp53R172H; Pdx-1 Cre Animals Undergo Apoptosis in Response to Triptolide

(2015) Veena Sangwan et al.   PANCREAS

Pancreatic Adenocarcinoma

(2015) David P. Ryan et al.   NEW ENGLAND JOURNAL OF MEDICINE

Inhibition of epithelial ovarian cancer by Minnelide, a water-soluble pro-drug

(2014) Colleen Rivard et al.   GYNECOLOGIC ONCOLOGY

MUC1 Enhances Tumor Progression and Contributes Toward Immunosuppression in a Mouse Model of Spontaneous Pancreatic Adenocarcinoma

(2014) T. L. Tinder et al.   JOURNAL OF IMMUNOLOGY

Triptolide induces apoptosis of gastric cancer cells via inhibiting the overexpression of MDM2

(2014) Bo-Yong Wang et al.   MEDICAL ONCOLOGY

Wild-type p53 reactivation by small-molecule Minnelide™ in human papillomavirus (HPV)-positive head and neck squamous cell carcinoma

(2014) Emiro Caicedo-Granados et al.   ORAL ONCOLOGY

Minnelide reduces tumor burden in preclinical models of osteosarcoma

(2013) Sulagna Banerjee et al.   CANCER LETTERS

Patient-Derived Tumor Xenografts: Transforming Clinical Samples into Mouse Models

(2013) D. Siolas et al.   CANCER RESEARCH

Role of the immune system in pancreatic cancer progression and immune modulating treatment strategies

(2013) K. Sideras et al.   CANCER TREATMENT REVIEWS

Inflammatory networks and immune surveillance of pancreatic carcinoma

(2013) Robert H Vonderheide et al.   CURRENT OPINION IN IMMUNOLOGY

Relevance of Animal Models of Pancreatic Cancer and Pancreatitis to Human Disease

(2013) Ashok K. Saluja et al.   GASTROENTEROLOGY

Enzymatic Targeting of the Stroma Ablates Physical Barriers to Treatment of Pancreatic Ductal Adenocarcinoma

(2012) Paolo P. Provenzano et al.   CANCER CELL

Tumor-Derived Granulocyte-Macrophage Colony-Stimulating Factor Regulates Myeloid Inflammation and T Cell Immunity in Pancreatic Cancer

(2012) Lauren J. Bayne et al.   CANCER CELL

Oncogenic Kras-Induced GM-CSF Production Promotes the Development of Pancreatic Neoplasia

(2012) Yuliya Pylayeva-Gupta et al.   CANCER CELL

Pancreatic adenocarcinoma induces bone marrow mobilization of myeloid-derived suppressor cells which promote primary tumor growth

(2012) Matthew R. Porembka et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Genetically Engineered Mouse Models of Pancreatic Cancer

(2012) Christoph Benedikt Westphalen et al.   CANCER JOURNAL

Mesenchymal stem cells regulate epithelial-mesenchymal transition and tumor progression of pancreatic cancer cells

(2012) Ayano Kabashima-Niibe et al.   CANCER SCIENCE

The Pancreas Cancer Microenvironment

(2012) C. Feig et al.   CLINICAL CANCER RESEARCH

A Preclinical Evaluation of Minnelide as a Therapeutic Agent Against Pancreatic Cancer

(2012) R. Chugh et al.   Science Translational Medicine

Prosurvival role of heat shock factor 1 in the pathogenesis of pancreatobiliary tumors

(2011) Vikas Dudeja et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Heat Shock Protein 70 Inhibits Apoptosis in Cancer Cells Through Simultaneous and Independent Mechanisms

(2009) Vikas Dudeja et al.   GASTROENTEROLOGY

Inhibition of Hedgehog Signaling Enhances Delivery of Chemotherapy in a Mouse Model of Pancreatic Cancer

(2009) K. P. Olive et al.   SCIENCE

Triptolide therapy for neuroblastoma decreases cell viability in vitro and inhibits tumor growth in vivo

(2009) Mara B. Antonoff et al.   SURGERY

Cancer-Associated Stromal Fibroblasts Promote Pancreatic Tumor Progression

(2008) R. F. Hwang et al.   CANCER RESEARCH