Genetically Engineered Mouse Models of Pancreatic Cancer

Enzymatic Targeting of the Stroma Ablates Physical Barriers to Treatment of Pancreatic Ductal Adenocarcinoma

(2012) Paolo P. Provenzano et al.   CANCER CELL

Tumor-Derived Granulocyte-Macrophage Colony-Stimulating Factor Regulates Myeloid Inflammation and T Cell Immunity in Pancreatic Cancer

(2012) Lauren J. Bayne et al.   CANCER CELL

Oncogenic Kras-Induced GM-CSF Production Promotes the Development of Pancreatic Neoplasia

(2012) Yuliya Pylayeva-Gupta et al.   CANCER CELL

Oncogenic Kras Maintains Pancreatic Tumors through Regulation of Anabolic Glucose Metabolism

(2012) Haoqiang Ying et al.   CELL

What We Have Learned About Pancreatic Cancer From Mouse Models

(2012) Pedro A. Pérez–Mancera et al.   GASTROENTEROLOGY

Oncogenic Kras is required for both the initiation and maintenance of pancreatic cancer in mice

(2012) Meredith A. Collins et al.   JOURNAL OF CLINICAL INVESTIGATION

Gamma secretase inhibition promotes hypoxic necrosis in mouse pancreatic ductal adenocarcinoma

(2012) Natalie Cook et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Changes in Connexin43 Expression and Localization During Pancreatic Cancer Progression

(2012) Joell L. Solan et al.   JOURNAL OF MEMBRANE BIOLOGY

Sleeping Beauty mutagenesis reveals cooperating mutations and pathways in pancreatic adenocarcinoma

(2012) K. M. Mann et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

nab -Paclitaxel Potentiates Gemcitabine Activity by Reducing Cytidine Deaminase Levels in a Mouse Model of Pancreatic Cancer

(2012) Kristopher K. Frese et al.   Cancer Discovery

RETRACTED: Notch-1 induces epithelial–mesenchymal transition consistent with cancer stem cell phenotype in pancreatic cancer cells

(2011) Bin Bao et al.   CANCER LETTERS

Sox9+ ductal cells are multipotent progenitors throughout development but do not produce new endocrine cells in the normal or injured adult pancreas

(2011) J. L. Kopp et al.   DEVELOPMENT

Ongoing Notch signaling maintains phenotypic fidelity in the adult exocrine pancreas

(2011) Daniel Kopinke et al.   DEVELOPMENTAL BIOLOGY

Pancreas organogenesis: From bud to plexus to gland

(2011) Fong Cheng Pan et al.   DEVELOPMENTAL DYNAMICS

Inhibition of Ras for cancer treatment: the search continues

(2011) Antonio T Baines et al.   Future Medicinal Chemistry

Deletion of Rb Accelerates Pancreatic Carcinogenesis by Oncogenic Kras and Impairs Senescence in Premalignant Lesions

(2011) Catherine Carrière et al.   GASTROENTEROLOGY

Crosstalk between the canonical NF-κB and Notch signaling pathways inhibits Pparγ expression and promotes pancreatic cancer progression in mice

(2011) Eleni Maniati et al.   JOURNAL OF CLINICAL INVESTIGATION

Gemcitabine Plusnab-Paclitaxel Is an Active Regimen in Patients With Advanced Pancreatic Cancer: A Phase I/II Trial

(2011) Daniel D. Von Hoff et al.   JOURNAL OF CLINICAL ONCOLOGY

Pancreatic cancer

(2011) Audrey Vincent et al.   LANCET

Subtypes of pancreatic ductal adenocarcinoma and their differing responses to therapy

(2011) Eric A Collisson et al.   NATURE MEDICINE

From tissue turnover to the cell of origin for pancreatic cancer

(2011) Bo Kong et al.   Nature Reviews Gastroenterology & Hepatology

Somatic Mutagenesis with a Sleeping Beauty Transposon System Leads to Solid Tumor Formation in Zebrafish

(2011) Maura McGrail et al.   PLoS One

Acute Pancreatitis Accelerates Initiation and Progression to Pancreatic Cancer in Mice Expressing Oncogenic Kras in the Nestin Cell Lineage

(2011) Catherine Carrière et al.   PLoS One

BRCA1 Tumor Suppression Depends on BRCT Phosphoprotein Binding, But Not Its E3 Ligase Activity

(2011) R. Shakya et al.   SCIENCE

CD40 Agonists Alter Tumor Stroma and Show Efficacy Against Pancreatic Carcinoma in Mice and Humans

(2011) G. L. Beatty et al.   SCIENCE

PTEN Is a Major Tumor Suppressor in Pancreatic Ductal Adenocarcinoma and Regulates an NF-κB–Cytokine Network

(2011) Haoqiang Ying et al.   Cancer Discovery

Germline Brca2 Heterozygosity Promotes KrasG12D -Driven Carcinogenesis in a Murine Model of Familial Pancreatic Cancer

(2010) Ferdinandos Skoulidis et al.   CANCER CELL

PTEN Loss Accelerates KrasG12D-Induced Pancreatic Cancer Development

(2010) R. Hill et al.   CANCER RESEARCH

β-catenin blocks Kras-dependent reprogramming of acini into pancreatic cancer precursor lesions in mice

(2010) John P. Morris et al.   JOURNAL OF CLINICAL INVESTIGATION

Assessing therapeutic responses in Kras mutant cancers using genetically engineered mouse models

(2010) Mallika Singh et al.   NATURE BIOTECHNOLOGY

Continuous cell supply from a Sox9-expressing progenitor zone in adult liver, exocrine pancreas and intestine

(2010) Kenichiro Furuyama et al.   NATURE GENETICS

Pancreatic Cancer

(2010) Manuel Hidalgo   NEW ENGLAND JOURNAL OF MEDICINE

Notch2 is required for progression of pancreatic intraepithelial neoplasia and development of pancreatic ductal adenocarcinoma

(2010) P. K. Mazur et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Animal transgenesis: an overview

(2009) Miguel A. Gama Sosa et al.   Brain Structure & Function

Context-Dependent Transformation of Adult Pancreatic Cells by Oncogenic K-Ras

(2009) Sharon Y. Gidekel Friedlander et al.   CANCER CELL

Mutant p53 Drives Invasion by Promoting Integrin Recycling

(2009) Patricia A.J. Muller et al.   CELL

Dre recombinase, like Cre, is a highly efficient site-specific recombinase in E. coli, mammalian cells and mice

(2009) K. Anastassiadis et al.   Disease Models & Mechanisms

GLI1 is regulated through Smoothened-independent mechanisms in neoplastic pancreatic ducts and mediates PDAC cell survival and transformation

(2009) O. Nolan-Stevaux et al.   GENES & DEVELOPMENT

Stem cells in gastroenterology and hepatology

(2009) Michael Quante et al.   Nature Reviews Gastroenterology & Hepatology

Sonic hedgehog paracrine signaling regulates metastasis and lymphangiogenesis in pancreatic cancer

(2009) J M Bailey et al.   ONCOGENE

Mutant p53 drives metastasis and overcomes growth arrest/senescence in pancreatic cancer

(2009) J. P. Morton et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hedgehog signaling is restricted to the stromal compartment during pancreatic carcinogenesis

(2009) H. Tian et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inhibition of Hedgehog Signaling Enhances Delivery of Chemotherapy in a Mouse Model of Pancreatic Cancer

(2009) K. P. Olive et al.   SCIENCE

Sonic Hedgehog Promotes Desmoplasia in Pancreatic Cancer

(2008) J. M. Bailey et al.   CLINICAL CANCER RESEARCH

Pancreatic Progenitor Cells—Recent Studies

(2008) Hsun Teresa Ku   ENDOCRINOLOGY

Stabilization of β-Catenin Induces Pancreas Tumor Formation

(2008) Patrick W. Heiser et al.   GASTROENTEROLOGY

RCAS-Mediated Retroviral Gene Delivery: A Versatile Tool for the Study of Gene Function in a Mouse Model of Pancreatic Cancer

(2008) Ulrich Mayr et al.   HUMAN GENE THERAPY

Pancreatic Lkb1 Deletion Leads to Acinar Polarity Defects and Cystic Neoplasms

(2008) A. F. Hezel et al.   MOLECULAR AND CELLULAR BIOLOGY

An orally bioavailable small-molecule inhibitor of Hedgehog signaling inhibits tumor initiation and metastasis in pancreatic cancer

(2008) G. Feldmann et al.   MOLECULAR CANCER THERAPEUTICS

A Cre-loxP-based mouse model for conditional somatic gene expression and knockdown in vivo by using avian retroviral vectors

(2008) B. Seidler et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Notch and Kras reprogram pancreatic acinar cells to ductal intraepithelial neoplasia

(2008) J.-P. De La O et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Core Signaling Pathways in Human Pancreatic Cancers Revealed by Global Genomic Analyses

(2008) S. Jones et al.   SCIENCE