Long Residence Times Revealed by Aurora A Kinase-Targeting Fluorescent Probes Derived from Inhibitors MLN8237 and VX-689

Nima- and Aurora-related kinases of malaria parasites

(2013) Teresa Gil Carvalho et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

A Chemical Biology Strategy to Analyze Rheostat-like Protein Kinase-Dependent Regulation

(2013) Shigehiro A. Kawashima et al.   CHEMISTRY & BIOLOGY

A Novel Mechanism by Which Small Molecule Inhibitors Induce the DFG Flip in Aurora A

(2012) Mathew P. Martin et al.   ACS Chemical Biology

Aurora A kinase (AURKA) in normal and pathological cell division

(2012) Anna S. Nikonova et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Phase I Study of Aurora A Kinase Inhibitor MLN8237 in Advanced Solid Tumors: Safety, Pharmacokinetics, Pharmacodynamics, and Bioavailability of Two Oral Formulations

(2012) E. C. Dees et al.   CLINICAL CANCER RESEARCH

Aurora kinase inhibitors: Progress towards the clinic

(2012) Madhu Kollareddy et al.   INVESTIGATIONAL NEW DRUGS

Molecular dynamics and free energy studies on Aurora kinase A and its mutant bound with MLN8054: insight into molecular mechanism of subtype selectivity

(2012) Ying Yang et al.   Molecular BioSystems

On the molecular mechanisms of mitotic kinase activation

(2012) R. Bayliss et al.   Open Biology

Characterization of Alisertib (MLN8237), an Investigational Small-Molecule Inhibitor of Aurora A Kinase Using Novel In Vivo Pharmacodynamic Assays

(2011) M. G. Manfredi et al.   CLINICAL CANCER RESEARCH

Targeting Aurora Kinases in Cancer Treatment

(2011) Kevin R. Kelly et al.   CURRENT DRUG TARGETS

Conformational adaptation in drug–target interactions and residence time

(2011) Robert A Copeland   Future Medicinal Chemistry

Activation of Aurora-A Kinase by Protein Partner Binding and Phosphorylation Are Independent and Synergistic

(2011) Charlotte A. Dodson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Drug-Resistant Aurora A Mutants for Cellular Target Validation of the Small Molecule Kinase Inhibitors MLN8054 and MLN8237

(2010) Dominic A. Sloane et al.   ACS Chemical Biology

Crystal structure of an Aurora-A mutant that mimics Aurora-B bound to MLN8054: insights into selectivity and drug design

(2010) Charlotte A. Dodson et al.   BIOCHEMICAL JOURNAL

A novel Aurora-A kinase inhibitor MLN8237 induces cytotoxicity and cell-cycle arrest in multiple myeloma

(2010) G. Gorgun et al.   BLOOD

Uncovering new substrates for Aurora A kinase

(2010) Teresa Sardon et al.   EMBO REPORTS

Control of Aurora-A stability through interaction with TPX2

(2010) M. Giubettini et al.   JOURNAL OF CELL SCIENCE

MK-5108, a Highly Selective Aurora-A Kinase Inhibitor, Shows Antitumor Activity Alone and in Combination with Docetaxel

(2010) T. Shimomura et al.   MOLECULAR CANCER THERAPEUTICS

Biochemical characterization of GSK1070916, a potent and selective inhibitor of Aurora B and Aurora C kinases with an extremely long residence time1

(2009) Kelly Anderson et al.   BIOCHEMICAL JOURNAL

Bisubstrate Inhibitors of Protein Kinases: from Principle to Practical Applications

(2009) Darja Lavogina et al.   ChemMedChem

Discovery and Development of Aurora Kinase Inhibitors as Anticancer Agents

(2009) John R. Pollard et al.   JOURNAL OF MEDICINAL CHEMISTRY

Through the “Gatekeeper Door”: Exploiting the Active Kinase Conformation

(2009) Fabio Zuccotto et al.   JOURNAL OF MEDICINAL CHEMISTRY

The cell cycle as a therapeutic target againstTrypanosoma brucei: Hesperadin inhibits Aurora kinase-1 and blocks mitotic progression in bloodstream forms

(2009) Neal Jetton et al.   MOLECULAR MICROBIOLOGY

Discovery of Selective Aminothiazole Aurora Kinase Inhibitors

(2008) Carsten B. Andersen et al.   ACS Chemical Biology

High-affinity bisubstrate probe for fluorescence anisotropy binding/displacement assays with protein kinases PKA and ROCK

(2008) Angela Vaasa et al.   ANALYTICAL BIOCHEMISTRY

Modulation of kinase-inhibitor interactions by auxiliary protein binding: Crystallography studies on Aurora A interactions with VX-680 and with TPX2

(2008) Baoguang Zhao et al.   PROTEIN SCIENCE