Structural Basis of Furan-Amino Acid Recognition by a Polyspecific Aminoacyl-tRNA-Synthetase and its Genetic Encoding in Human Cells

Genetic Encoding of Photocaged Cysteine Allows Photoactivation of TEV Protease in Live Mammalian Cells

(2014) Duy P. Nguyen et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A Genetically Encoded Spin Label for Electron Paramagnetic Resonance Distance Measurements

(2014) Moritz J. Schmidt et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Red-Light-Controlled Protein-RNA Crosslinking with a Genetically Encoded Furan

(2013) Moritz J. Schmidt et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Toxicity Inspired Cross-Linking for Probing DNA–Peptide Interactions

(2013) Lieselot L.G. Carrette et al.   BIOCONJUGATE CHEMISTRY

Expanding the Library and Substrate Diversity of the Pyrrolysyl-tRNA Synthetase to Incorporate Unnatural Amino Acids Containing Conjugated Rings

(2013) Vanessa K. Lacey et al.   CHEMBIOCHEM

Structural Insights into Incorporation of Norbornene Amino Acids for Click Modification of Proteins

(2013) Sabine Schneider et al.   CHEMBIOCHEM

Exploiting furan's versatile reactivity in reversible and irreversible orthogonal peptide labeling

(2013) Kurt Hoogewijs et al.   CHEMICAL COMMUNICATIONS

Pyrrolysyl-tRNA synthetase variants reveal ancestral aminoacylation function

(2013) Jae-hyeong Ko et al.   FEBS LETTERS

A mildly inducible and selective cross-link methodology for RNA duplexes

(2013) L. L. G. Carrette et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Efficient viral delivery system for unnatural amino acid mutagenesis in mammalian cells

(2013) A. Chatterjee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Genetic Incorporation of Twelve meta-Substituted Phenylalanine Derivatives Using a Single Pyrrolysyl-tRNA Synthetase Mutant

(2012) Yane-Shih Wang et al.   ACS Chemical Biology

Towards automated crystallographic structure refinement withphenix.refine

(2012) Pavel V. Afonine et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Amino Acids for Diels-Alder Reactions in Living Cells

(2012) Tilman Plass et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A Need for Speed: Genetic Encoding of Rapid Cycloaddition Chemistries for Protein Labelling in Living Cells

(2012) Moritz J. Schmidt et al.   CHEMBIOCHEM

Genetic Encoding of a Bicyclo[6.1.0]nonyne-Charged Amino Acid Enables Fast Cellular Protein Imaging by Metal-Free Ligation

(2012) Annika Borrmann et al.   CHEMBIOCHEM

Photocontrol of Tyrosine Phosphorylation in Mammalian Cells via Genetic Encoding of Photocaged Tyrosine

(2012) Eyal Arbely et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Sequence Specific DNA Cross-Linking Triggered by Visible Light

(2012) Marieke Op de Beeck et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A Rationally Designed Pyrrolysyl-tRNA Synthetase Mutant with a Broad Substrate Spectrum

(2012) Yane-Shih Wang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Wide-range protein photo-crosslinking achieved by a genetically encoded Nε-(benzyloxycarbonyl)lysine derivative with a diazirinyl moiety

(2012) Tatsuo Yanagisawa et al.   Molecular BioSystems

Stereochemical Basis for Engineered Pyrrolysyl-tRNA Synthetase and the Efficientin VivoIncorporation of Structurally Divergent Non-native Amino Acids

(2011) Jeffrey K. Takimoto et al.   ACS Chemical Biology

Genetically Encoded Copper-Free Click Chemistry

(2011) Tilman Plass et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Probing Protein-Protein Interactions with a Genetically Encoded Photo-crosslinking Amino Acid

(2011) Hui-wang Ai et al.   CHEMBIOCHEM

Synthesis and incorporation of a furan-modified adenosine building block for DNA interstrand crosslinking

(2011) Anup M. Jawalekar et al.   CHEMICAL COMMUNICATIONS

Furan-Oxidation-Triggered Inducible DNA Cross-Linking: Acyclic Versus Cyclic Furan-Containing Building Blocks-On the Benefit of Restoring the Cyclic Sugar Backbone

(2011) Kristof Stevens et al.   CHEMISTRY-A EUROPEAN JOURNAL

Site-Specific Incorporation of Photo-Cross-Linker and Bioorthogonal Amino Acids into Enteric Bacterial Pathogens

(2011) Shixian Lin et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The de novo engineering of pyrrolysyl-tRNA synthetase for genetic incorporation of l-phenylalanine and its derivatives

(2011) Yane-Shih Wang et al.   Molecular BioSystems

A genetically incorporated crosslinker reveals chaperone cooperation in acid resistance

(2011) Meng Zhang et al.   Nature Chemical Biology

XDS

(2010) Wolfgang Kabsch   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Features and development ofCoot

(2010) P. Emsley et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

PHENIX: a comprehensive Python-based system for macromolecular structure solution

(2010) Paul D. Adams et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Adding New Chemistries to the Genetic Code

(2010) Chang C. Liu et al.   Annual Review of Biochemistry

Unprecedented C-Selective Interstrand Cross-Linking throughin SituOxidation of Furan-Modified Oligodeoxynucleotides

(2010) Marieke Op de Beeck et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Rapid chemical ligation of oligonucleotides by the Diels–Alder reaction

(2010) Afaf H. El-Sagheer et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Genetically encoding an aliphatic diazirine for protein photocrosslinking

(2010) Chungjung Chou et al.   Chemical Science

electronic Ligand Builder and Optimization Workbench(eLBOW): a tool for ligand coordinate and restraint generation

(2009) Nigel W. Moriarty et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

MolProbity: all-atom structure validation for macromolecular crystallography

(2009) Vincent B. Chen et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Expanding the Genetic Code for Biological Studies

(2009) Qian Wang et al.   CHEMISTRY & BIOLOGY

From DNA cross-linking to peptide labeling: on the versatility of the furan-oxidation–conjugation strategy

(2008) Annelies Deceuninck et al.   CHEMICAL COMMUNICATIONS

Multistep Engineering of Pyrrolysyl-tRNA Synthetase to Genetically Encode Nɛ-(o-Azidobenzyloxycarbonyl) lysine for Site-Specific Protein Modification

(2008) Tatsuo Yanagisawa et al.   CHEMISTRY & BIOLOGY

Crystallographic Studies on Multiple Conformational States of Active-site Loops in Pyrrolysyl-tRNA Synthetase

(2008) Tatsuo Yanagisawa et al.   JOURNAL OF MOLECULAR BIOLOGY