Dual Activators of Protein Kinase R (PKR) and Protein Kinase R-Like Kinase (PERK) Identify Common and Divergent Catalytic Targets

Tumor suppression by small molecule inhibitors of translation initiation

(2015) Limo Chen et al.   Oncotarget

Uncoupling Proteostasis and Developmentin Vitrowith a Small Molecule Inhibitor of the Pancreatic Endoplasmic Reticulum Kinase, PERK

(2012) Heather P. Harding et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Discovery of 7-Methyl-5-(1-{[3-(trifluoromethyl)phenyl]acetyl}-2,3-dihydro-1H-indol-5-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine (GSK2606414), a Potent and Selective First-in-Class Inhibitor of Protein Kinase R (PKR)-like Endoplasmic Reticulum Kinase (PERK)

(2012) Jeffrey M. Axten et al.   JOURNAL OF MEDICINAL CHEMISTRY

Stress Granule Formation Induced by Measles Virus Is Protein Kinase PKR Dependent and Impaired by RNA Adenosine Deaminase ADAR1

(2012) K. M. Okonski et al.   JOURNAL OF VIROLOGY

In vitro inhibition of translation initiation by N,N′-diarylureas—potential anti-cancer agents

(2011) Séverine Denoyelle et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

PERK and PKR: Old kinases learn new tricks

(2011) Jennifer F. Raven et al.   CELL CYCLE

The Early Interferon Response to Rotavirus Is Regulated by PKR and Depends on MAVS/IPS-1, RIG-I, MDA-5, and IRF3

(2011) A. Sen et al.   JOURNAL OF VIROLOGY

Chemical genetics identify eIF2α kinase heme-regulated inhibitor as an anticancer target

(2011) Ting Chen et al.   Nature Chemical Biology

Inhibition of RNA-dependent protein kinase (PKR) leads to cancer cell death and increases chemosensitivity

(2010) Abujiang Pataer et al.   CANCER BIOLOGY & THERAPY

Double-Stranded RNA-Dependent Protein Kinase Links Pathogen Sensing with Stress and Metabolic Homeostasis

(2010) Takahisa Nakamura et al.   CELL

Structural Determinants of PERK Inhibitor Potency and Selectivity

(2010) Hong Wang et al.   Chemical Biology & Drug Design

Regulation of innate immunity through RNA structure and the protein kinase PKR

(2010) Subba Rao Nallagatla et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Embryonic Lethal Abnormal Vision-like HuR-dependent mRNA Stability Regulates Post-transcriptional Expression of Cyclin-dependent Kinase Inhibitor p27Kip1

(2010) Gudrun Ziegeler et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

PERK promotes cancer cell proliferation and tumor growth by limiting oxidative DNA damage

(2010) E Bobrovnikova-Marjon et al.   ONCOGENE

Wolcott-Rallison syndrome

(2010) Cécile Julier et al.   Orphanet Journal of Rare Diseases

Multiple levels of PKR inhibition during HIV-1 replication

(2010) Guerline Clerzius et al.   REVIEWS IN MEDICAL VIROLOGY

Acute ablation of PERK results in ER dysfunctions followed by reduced insulin secretion and cell proliferation

(2009) Daorong Feng et al.   BMC CELL BIOLOGY

Interaction of Double-stranded RNA-dependent Protein Kinase (PKR) with the Death Receptor Signaling Pathway in Amyloid β (Aβ)-treated Cells and in APPSLPS1 Knock-in Mice

(2009) Julien Couturier et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

PKR, a p53 target gene, plays a crucial role in the tumor-suppressor function of p53

(2009) C.-H. Yoon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tumor Suppression by PTEN Requires the Activation of the PKR-eIF2  Phosphorylation Pathway

(2009) Z. Mounir et al.   Science Signaling

PKR protein kinase is activated by hepatitis C virus and inhibits viral replication through translational control

(2009) Ju-Il Kang et al.   VIRUS RESEARCH

Inhibition of activation of dsRNA-dependent protein kinase and tumour growth inhibition

(2008) Helen L. Eley et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

PKR is activated in MDS patients and its subcellular localization depends on disease severity

(2008) M Y Follo et al.   LEUKEMIA

Rapid evolution of protein kinase PKR alters sensitivity to viral inhibitors

(2008) Stefan Rothenburg et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Double stranded RNA activated EIF2 α kinase (EIF2AK2; PKR) is associated with Alzheimer's disease

(2007) María J. Bullido et al.   NEUROBIOLOGY OF AGING