Article
Chemistry, Multidisciplinary
Tuan D. Samdin, Chelsea R. Jones, Gretchen Guaglianone, Adam G. Kreutzer, J. Alfredo Freites, Michal Wierzbicki, James S. Nowick
Summary: This study investigates the arrangement, assembly, and function of beta-hairpins formed by the beta-amyloid peptide Aβ in oligomers. By synthesizing beta-hairpin peptides and conducting various experiments, the structure and function of the oligomers were revealed, and their relationship with membrane disruption and cell apoptosis was explored.
Article
Biochemistry & Molecular Biology
Tatsuhiro Ayabe, Chika Takahashi, Rena Ohya, Yasuhisa Ano
Summary: Beta-lactolin improves mitochondrial functions and prevents neuronal cell death in Alzheimer's disease-related neuronal cell models, demonstrating its advantage in maintaining neuronal health.
Article
Biochemistry & Molecular Biology
Siddhartha Banerjee, Divya Baghel, Ana Pacheco de Oliveira, Ayanjeet Ghosh
Summary: This study used nanoscale AFM-IR spectroscopy to investigate the structure of Aβ oligomers and fibrils. It found that the main effect of beta-carotene is not to inhibit fibril formation, but to alter the secondary structure of the fibrils and promote fibrils that lack the characteristic ordered beta structure.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cell Biology
Takuma Hotani, Kanako Nakagawa, Tomohito Tsukamoto, Hiroyuki Mizuguchi, Fuminori Sakurai
Summary: This study revealed that double-stranded RNA (dsRNA) decreased HIF-1a protein levels through a ubiquitin-proteasome pathway mediated by protein kinase R (PKR). These findings provide important clues for understanding the mechanism of dsRNA-mediated cellular toxicity and the therapeutic application of dsRNA.
Review
Medicine, Research & Experimental
Hao Yu, Jie Wu
Summary: Amyloid-beta accumulation is a key feature of Alzheimer's disease, with both neurotoxic and potentially protective effects. Understanding the role of Aβ in depth will provide a broader perspective on Alzheimer's disease treatment.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Cell Biology
Keliang Pang, Richeng Jiang, Wei Zhang, Zhengyi Yang, Lin-Lin Li, Makoto Shimozawa, Simone Tambaro, Johanna Mayer, Baogui Zhang, Man Li, Jiesi Wang, Hang Liu, Ailing Yang, Xi Chen, Jiazheng Liu, Bengt Winblad, Hua Han, Tianzi Jiang, Weiwen Wang, Per Nilsson, Wei Guo, Bai Lu
Summary: The lack of predictive and translatable animal models has been a major obstacle in Alzheimer's disease (AD) research. While transgenic mice overexpressing App gene do not reflect disease progression accurately, the App knock-in rat model with humanized A beta sequence shows promise in mimicking AD pathologies and progression, including A beta plaques, tau pathology, neuronal death, and cognitive deficits. This rat model may provide valuable insights for AD research and drug development.
Review
Biochemistry & Molecular Biology
Lucia Gallego Villarejo, Lisa Bachmann, David Marks, Maite Brachthaeuser, Alexander Geidies, Thorsten Mueller
Summary: Intracellular amyloid beta (iAβ) plays a crucial role in neurodegeneration and serves as a pathological marker. Modulating iAβ through pharmacological treatment has shown beneficial effects on cognitive properties. Future research should focus on the impact of viral infections on iAβ generation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Clinical Neurology
Jeremy F. Kellie, Bruce C. Campbell, Rosie Watson, Adrian J. Praeger, Girish Nair, Anand Murugasu, Christopher C. Rowe, Colin L. Masters, Steven Collins, Catriona McLean, Nawaf Yassi
Summary: Recent reports suggest the possibility of neurosurgical transmission of cerebral amyloid angiopathy (CAA), leading to intracerebral hemorrhage in young adults. However, such cases are rare in standard clinical practice.
Article
Environmental Sciences
Mostafa M. Elhady, Sara A. Adly, Husam A. Elshebiny, Said S. Moselhy
Summary: This study evaluated the levels of serum S100B and amyloid beta in patients with organophosphate (OP) intoxication to determine their sensitivity and specificity in assessing the severity of neurological damage. The results showed a positive correlation between S100B and amyloid beta levels, while there was a negative correlation between pseudocholinesterase activity and both markers. The levels of S100B and amyloid beta were significantly elevated in the patient group compared to the control group. The diagnostic accuracy of S100B was found to be higher than that of amyloid beta in distinguishing between moderate and severe OP intoxication. These findings suggest that changes in S100B and amyloid beta levels are directly related to the severity of OP intoxication.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Maria Grazia Morgese, Maria Bove, Matteo Francavilla, Stefania Schiavone, Stefania Dimonte, Anna Laura Colia, Matteo Bevilacqua, Luigia Trabace, Paolo Tucci
Summary: The study found that AKBA has protective effects on Aβ-induced depressive-like behavior, reducing latency to initiate self-care and total time spent on self-care in mice, as well as reducing immobility time. Additionally, AKBA can reverse the increase in GLU and KYN levels in the PFC and HIPP induced by Aβ injection, as well as the increase in GFAP and NF-κB levels.
Article
Multidisciplinary Sciences
Naoto Watamura, Kaori Sato, Gen Shiihashi, Ayami Iwasaki, Naoko Kamano, Mika Takahashi, Misaki Sekiguchi, Naomi Mihira, Ryo Fujioka, Kenichi Nagata, Shoko Hashimoto, Takashi Saito, Toshio Ohshima, Takaomi C. Saido, Hiroki Sasaguri
Summary: Devoid of the Swedish mutations, the newly generated App knock-in mice (App(G-F) mice) show characteristics suitable for preclinical studies of beta-secretase inhibition in Alzheimer's disease (AD). Comparison of isogenic App knock-in lines reveals the influence of factors like C-terminal fragment beta (CTF-beta) and humanization of A beta on endosomal alterations.
Article
Biochemistry & Molecular Biology
Fangyuan Duan, Ting Ju, Chen Song, Mengyao Liu, Yi Xiong, Xue Han, Weihong Lu
Summary: Alzheimer's disease is a complex neurodegenerative disorder and requires a combination of interventions for successful treatment. This study investigates the potential of combining beta-asarone and cannabidiol as a treatment for Alzheimer's disease. The results show that the combination of these two compounds can inhibit amyloid protein aggregation, toxicity, apoptosis, and gene expression, and also improve aging, paralysis, learning capacity, and autophagy activity. Further clinical trials are needed to determine the efficacy and safety of this combination treatment in humans.
COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL
(2023)
Article
Biochemistry & Molecular Biology
Zong-Ping Zhang, Xue Bai, Wen-Bo Cui, Xiao-Han Chen, Xu Liu, De-Juan Zhi, Zhan-Xin Zhang, Dong-Qing Fei, Dong-Sheng Wang
Summary: This study found that Caesalmin C can delay the progression of AD in the transgenic C. elegans model by inhibiting A beta deposition, upregulating the expression of genes associated with oxidative stress, inhibiting acetylcholinesterase activity, and upregulating proteasome activity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Clinical Neurology
Guozhen Qiu, Liming Cao, Yong-Jun Chen
Summary: This study demonstrates that the novel A2M p.N410T mutation may play a pathogenic role in Alzheimer's disease by altering the binding interactions between A2M and A beta.
FRONTIERS IN NEUROLOGY
(2023)
Article
Biochemistry & Molecular Biology
Naoto Watamura, Naomasa Kakiya, Per Nilsson, Satoshi Tsubuki, Naoko Kamano, Mika Takahashi, Shoko Hashimoto, Hiroki Sasaguri, Takashi Saito, Takaomi C. Saido
Summary: The study identified ENSA as a negative regulator of NEP downstream of SST signaling, with increased expression in AD and its mouse models. NEP directly contributes to the degradation of ENSA, creating a substrate-dependent feedback loop regulating NEP activity. Targeting a specific K-ATP channel subtype can attenuate A beta deposition and rescue impaired memory function in an AD mouse model through NEP activation.
MOLECULAR PSYCHIATRY
(2022)
Article
Geriatrics & Gerontology
Sophie Serriere, Clovis Tauber, Johnny Vercouillie, Celine Mothes, Christelle Pruckner, Denis Guilloteau, Michael Kassiou, Aurelie Domene, Lucette Garreau, Guylene Page, Sylvie Chalon
NEUROBIOLOGY OF AGING
(2015)
Article
Neurosciences
Laura Foucault-Fruchard, Aurelie Domene, Guylene Page, Marguerite Windsor, Patrick Emond, Nuno Rodrigues, Frederic Dolle, Annelaure Damont, Frederic Buron, Sylvain Routier, Sylvie Chalon, Daniel Antier
Article
Neurosciences
Adrien Julian, Agnes Rioux-Bilan, Stephanie Ragot, Pierre Krolak-Salmon, Gilles Berrut, Thierry Dantoine, Caroline Hommet, Olivier Hanon, Guylene Page, Marc Paccalin
JOURNAL OF ALZHEIMERS DISEASE
(2018)
Article
Immunology
J. Verite, T. Janet, D. Chassaing, B. Fauconneau, H. Rabeony, G. Page
JOURNAL OF NEUROINFLAMMATION
(2018)
Article
Neurosciences
Elodie Vion, Guylene Page, Eric Bourdeaud, Marc Paccalin, Jerome Guillard, Agnes Rioux Bilan
MOLECULAR AND CELLULAR NEUROSCIENCE
(2018)
Review
Cell Biology
Aline Freyssin, Guylene Page, Bernard Fauconneau, Agnes Rioux Bilan
NEURAL REGENERATION RESEARCH
(2018)
Article
Immunology
Arnaud Francois, Agnes Rioux Bilan, Nathalie Quellard, Beatrice Fernandez, Thierry Janet, Damien Chassaing, Marc Paccalin, Faraj Terro, Guylene Page
JOURNAL OF NEUROINFLAMMATION
(2014)
Article
Multidisciplinary Sciences
Arnaud Francois, Adrien Julian, Stephanie Ragot, Emilie Dugast, Ludovic Blanchard, Sonia Brishoual, Damien Chassaing, Guylene Page, Marc Paccalin
Correction
Multidisciplinary Sciences
Arnaud Francois, Adrien Julian, Stephanie Ragot, Emilie Dugast, Ludovic Blanchard, Sonia Brishoual, Faraj Terro, Damien Chassaing, Guylene Page, Marc Paccalin
Article
Multidisciplinary Sciences
Julie Verite, Guylene Page, Marc Paccalin, Adrien Julian, Thierry Janet
Article
Behavioral Sciences
Vincent Maleysson, Guylene Page, Thierry Janet, Ronald L. Klein, Obelia Haida, Anne Maurin, Serge Richard, Pascal Champeroux, Bernard Fauconneau
BEHAVIOURAL BRAIN RESEARCH
(2019)
Article
Multidisciplinary Sciences
Martial Caillaud, Jerome Guillard, Damien Richard, Serge Milin, Damien Chassaing, Marc Paccalin, Guylene Page, Agnes Rioux Bilan
Review
Medicine, General & Internal
R. Loera-Valencia, A. Cedazo-Minguez, P. A. Kenigsberg, G. Page, A. Duarte, P. Giusti, M. Zusso, P. Robert, G. B. Frisoni, A. Cattaneo, M. Zille, J. Boltze, N. Cartier, L. Buee, G. Johansson, B. Winblad
JOURNAL OF INTERNAL MEDICINE
(2019)
Article
Chemistry, Medicinal
Aziz Ouach, Johnny Vercouillie, Emilie Bertrand, Nuno Rodrigues, Frederic Pin, Sophie Serriere, Liliana Boiaryna, Agnes Chartier, Nathalie Percina, Pakorn Tangpong, Zuhal Gulhan, Celine Mothes, Jean-Bernard Deloye, Denis Guilloteau, Guylene Page, Franck Suzenet, Frederic Buron, Sylvie Chalon, Sylvain Routier
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2019)
Article
Geriatrics & Gerontology
Adrien Julian, Emilie Dugast, Stephanie Ragot, Pierre Krolak-Salmon, Gilles Berrut, Thierry Dantoine, Caroline Hommet, Olivier Hanon, Guylene Page, Marc Paccalin
AGING CLINICAL AND EXPERIMENTAL RESEARCH
(2015)