Impact of Helix Irregularities on Sequence Alignment and Homology Modeling of G Protein-Coupled Receptors

The G-protein Coupled Receptor Family: Actors with Many Faces

(2012) George Liapakis et al.   CURRENT PHARMACEUTICAL DESIGN

Structure of the human M2 muscarinic acetylcholine receptor bound to an antagonist

(2012) Kazuko Haga et al.   NATURE

Crystal structure of the µ-opioid receptor bound to a morphinan antagonist

(2012) Aashish Manglik et al.   NATURE

Structure and dynamics of the M3 muscarinic acetylcholine receptor

(2012) Andrew C. Kruse et al.   NATURE

Crystal Structure of a Lipid G Protein-Coupled Receptor

(2012) M. A. Hanson et al.   SCIENCE

Molecular Mechanisms of Disease for Mutations at Gly-90 in Rhodopsin

(2011) Darwin Toledo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Identification of a Potent and Selective Free Fatty Acid Receptor 1 (FFA1/GPR40) Agonist with Favorable Physicochemical and in Vitro ADME Properties

(2011) Elisabeth Christiansen et al.   JOURNAL OF MEDICINAL CHEMISTRY

New Serotonin 5-HT1AReceptor Agonists with Neuroprotective Effect against Ischemic Cell Damage

(2011) Isabel Marco et al.   JOURNAL OF MEDICINAL CHEMISTRY

Structure of the human histamine H1 receptor complex with doxepin

(2011) Tatsuro Shimamura et al.   NATURE

Structure of a nanobody-stabilized active state of the β2 adrenoceptor

(2011) Søren G. F. Rasmussen et al.   NATURE

Crystal structure of the β2 adrenergic receptor–Gs protein complex

(2011) Søren G. F. Rasmussen et al.   NATURE

Molecular Basis of Ligand Dissociation in β-Adrenergic Receptors

(2011) Angel González et al.   PLoS One

Pathway and mechanism of drug binding to G-protein-coupled receptors

(2011) Ron O. Dror et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Diversity and modularity of G protein-coupled receptor structures

(2011) Vsevolod Katritch et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Evolutionary Origin of a Secondary Structure: π-Helices as Cryptic but Widespread Insertional Variations of α-Helices That Enhance Protein Functionality

(2010) Richard B. Cooley et al.   JOURNAL OF MOLECULAR BIOLOGY

A Structural Insight into the Reorientation of Transmembrane Domains 3 and 5 during Family A G Protein-Coupled Receptor Activation

(2010) K. Sansuk et al.   MOLECULAR PHARMACOLOGY

IUPHAR-DB: new receptors and tools for easy searching and visualization of pharmacological data

(2010) Joanna L. Sharman et al.   NUCLEIC ACIDS RESEARCH

Prediction of the human membrane proteome

(2010) Linn Fagerberg et al.   PROTEOMICS

Structures of the CXCR4 Chemokine GPCR with Small-Molecule and Cyclic Peptide Antagonists

(2010) B. Wu et al.   SCIENCE

Structure of the Human Dopamine D3 Receptor in Complex with a D2/D3 Selective Antagonist

(2010) E. Y. T. Chien et al.   SCIENCE

Importance of the extracellular loops in G protein-coupled receptors for ligand recognition and receptor activation

(2010) M.C. Peeters et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Modern Homology Modeling of G-Protein Coupled Receptors: Which Structural Template to Use?

(2009) Juan Carlos Mobarec et al.   JOURNAL OF MEDICINAL CHEMISTRY

Influence of the g− conformation of Ser and Thr on the structure of transmembrane helices

(2009) Xavier Deupi et al.   JOURNAL OF STRUCTURAL BIOLOGY

Conserved waters mediate structural and functional activation of family A (rhodopsin-like) G protein-coupled receptors

(2009) T. E. Angel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Wide Turn Diversity in Protein Transmembrane Helices Implications for G-Protein-Coupled Receptor and Other Polytopic Membrane Protein Structure and Function

(2008) R. P. Riek et al.   MOLECULAR PHARMACOLOGY

Structure of a β1-adrenergic G-protein-coupled receptor

(2008) Tony Warne et al.   NATURE

Crystal structure of squid rhodopsin

(2008) Midori Murakami et al.   NATURE

Crystal structure of the ligand-free G-protein-coupled receptor opsin

(2008) Jung Hee Park et al.   NATURE

Conformational thermostabilization of the  1-adrenergic receptor in a detergent-resistant form

(2008) M. J. Serrano-Vega et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The 2.6 Angstrom Crystal Structure of a Human A2A Adenosine Receptor Bound to an Antagonist

(2008) V.-P. Jaakola et al.   SCIENCE

Heterotrimeric G protein activation by G-protein-coupled receptors

(2007) William M. Oldham et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY