Modification of the siRNA Passenger Strand by 5-Nitroindole Dramatically Reduces its Off-Target Effects

Improvement of RNAi Activity and Strand Selectivity of RISC Formation by Modified siRNA Involving Intercalators near 5′ Termini

(2011) Hiroshi Ito et al.   CHEMBIOCHEM

siRNA Repositioning for Guide Strand Selection by Human Dicer Complexes

(2011) Cameron L. Noland et al.   MOLECULAR CELL

Current prospects for RNA interference-based therapies

(2011) Beverly L. Davidson et al.   NATURE REVIEWS GENETICS

Modulation of thermal stability can enhance the potency of siRNA

(2010) H. Addepalli et al.   NUCLEIC ACIDS RESEARCH

A screen of chemical modifications identifies position-specific modification by UNA to most potently reduce siRNA off-target effects

(2010) Jesper B. Bramsen et al.   NUCLEIC ACIDS RESEARCH

Recognizing and avoiding siRNA off-target effects for target identification and therapeutic application

(2009) Aimee L. Jackson et al.   NATURE REVIEWS DRUG DISCOVERY

Profiling of mismatch discrimination in RNAi enabled rational design of allele-specific siRNAs

(2009) Huang Huang et al.   NUCLEIC ACIDS RESEARCH

A large-scale chemical modification screen identifies design rules to generate siRNAs with high activity, high stability and low toxicity

(2009) Jesper B. Bramsen et al.   NUCLEIC ACIDS RESEARCH

Enhancement of RNAi by a small molecule antibiotic enoxacin

(2008) Qiangzhe Zhang et al.   CELL RESEARCH

Steric Effects in RNA Interference: Probing the Influence of Nucleobase Size and Shape

(2008) Alvaro Somoza et al.   CHEMISTRY-A EUROPEAN JOURNAL

Structure of an argonaute silencing complex with a seed-containing guide DNA and target RNA duplex

(2008) Yanli Wang et al.   NATURE

Structure of the guide-strand-containing argonaute silencing complex

(2008) Yanli Wang et al.   NATURE

Functional dissection of siRNA sequence by systematic DNA substitution: modified siRNA with a DNA seed arm is a powerful tool for mammalian gene silencing with significantly reduced off-target effect

(2008) Kumiko Ui-Tei et al.   NUCLEIC ACIDS RESEARCH