Peptides and Proteins as a Continuing Exciting Source of Inspiration for Peptidomimetics

“Triazole Bridge”: Disulfide-Bond Replacement by Ruthenium-Catalyzed Formation of 1,5-Disubstituted 1,2,3-Triazoles

(2011) Martin Empting et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Maintaining Biological Activity by Using Triazoles as Disufide Bond Mimetics

(2011) Kai Holland-Nell et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

On Resin Side-Chain Cyclization of Complex Peptides Using CuAAC

(2011) Sampat Ingale et al.   ORGANIC LETTERS

Systematic Analysis of Helical Protein Interfaces Reveals Targets for Synthetic Inhibitors

(2010) Andrea L. Jochim et al.   ACS Chemical Biology

“Click” synthesis of small molecule–peptide conjugates for organelle-specific delivery and inhibition of lysosomal cysteine proteases

(2010) Yuhui Loh et al.   CHEMICAL COMMUNICATIONS

Seamless Bead to Microarray Screening: Rapid Identification of the Highest Affinity Protein Ligands from Large Combinatorial Libraries

(2010) John M. Astle et al.   CHEMISTRY & BIOLOGY

Peptoid Macrocycles: Making the Rounds with Peptidomimetic Oligomers

(2010) Barney Yoo et al.   CHEMISTRY-A EUROPEAN JOURNAL

Methods for Enhancing Ring Closing Metathesis Yield in Peptides: Synthesis of a Dicarba Human Growth Hormone Fragment

(2010) Bianca J. van Lierop et al.   International Journal of Peptide Research and Therapeutics

Roche backs Aileron's stapled peptides

(2010) Cormac Sheridan   NATURE BIOTECHNOLOGY

Introduction of All-Hydrocarboni,i+3 Staples into α-Helices via Ring-Closing Olefin Metathesis

(2010) Young-Woo Kim et al.   ORGANIC LETTERS

Role of the intra-A-chain disulfide bond of insulin-like peptide 3 in binding and activation of its receptor, RXFP2

(2010) Suode Zhang et al.   PEPTIDES

Hydrocarbon double-stapling remedies the proteolytic instability of a lengthy peptide therapeutic

(2010) G. H. Bird et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Thermodynamic and Structural Effects of Macrocyclic Constraints in Protein−Ligand Interactions

(2010) John E. DeLorbe et al.   ACS Medicinal Chemistry Letters

To protect peptide pharmaceuticals against peptidases

(2010) R. Rink et al.   JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS

Rational and Modular Design of Potent Ligands Targeting the RNA That Causes Myotonic Dystrophy 2

(2009) Melissa M. Lee et al.   ACS Chemical Biology

The Canonical Helix of Urea Oligomers at Atomic Resolution: Insights Into Folding-Induced Axial Organization

(2009) Lucile Fischer et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Consequences of Isostructural Main-Chain Modifications for the Design of Antimicrobial Foldamers: Helical Mimics of Host-Defense Peptides Based on a Heterogeneous Amide/Urea Backbone

(2009) Paul Claudon et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Conformationally Homogeneous Heterocyclic Pseudotetrapeptides as Three-Dimensional Scaffolds for Rational Drug Design: Receptor-Selective Somatostatin Analogues

(2009) John M. Beierle et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Probing the Bioactive Conformation of an Archetypal Natural Product HDAC Inhibitor with Conformationally Homogeneous Triazole-Modified Cyclic Tetrapeptides

(2009) W. Seth Horne et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Peptoid-Peptide Hybrid Backbone Architectures

(2009) Christian A. Olsen   CHEMBIOCHEM

Regioselective formation of interlocked dicarba bridges in naturally occurring cyclic peptide toxins using olefin metathesis

(2009) Andrea J. Robinson et al.   CHEMICAL COMMUNICATIONS

A Semaphorin 3A Inhibitor Blocks Axonal Chemorepulsion and Enhances Axon Regeneration

(2009) Marisol Montolio et al.   CHEMISTRY & BIOLOGY

Peptidomimetics - A Versatile Route to Biologically Active Compounds

(2009) Andreas Grauer et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Identification of Shc Src Homology 2 Domain-Binding Peptoid−Peptide Hybrids

(2009) Won Jun Choi et al.   JOURNAL OF MEDICINAL CHEMISTRY

Design, Synthesis, and Pharmacological Activities of Dynorphin A Analogues Cyclized by Ring-Closing Metathesis

(2009) Wei-Jie Fang et al.   JOURNAL OF MEDICINAL CHEMISTRY

Structure and Activity of (2,8)-Dicarba-(3,12)-cystino α-ImI, an α-Conotoxin Containing a Nonreducible Cystine Analogue†

(2009) Christopher A. MacRaild et al.   JOURNAL OF MEDICINAL CHEMISTRY

Peptide Cyclization and Cyclodimerization by CuI-Mediated Azide−Alkyne Cycloaddition

(2009) Reshma Jagasia et al.   JOURNAL OF ORGANIC CHEMISTRY

Side chain-to-side chain cyclization by click reaction

(2009) Alexandra Le Chevalier Isaad et al.   JOURNAL OF PEPTIDE SCIENCE

New Strategies for the Design of Folded Peptoids Revealed by a Survey of Noncovalent Interactions in Model Systems

(2009) Benjamin C. Gorske et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

All-Atom Model for Stabilization of α-Helical Structure in Peptides by Hydrocarbon Staples

(2009) Peter S. Kutchukian et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A Preliminary Survey of the Peptoid Folding Landscape

(2009) Glenn L. Butterfoss et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Solid phase synthesis and structural analysis of novel A-chain dicarba analogs of human relaxin-3 (INSL7) that exhibit full biological activity

(2009) Mohammed Akhter Hossain et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Size-dependent cation transport by cyclic α-peptoid ion carriers

(2009) Chiara De Cola et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Microwave-assisted click polymerization for the synthesis of Aβ(16–22) cyclic oligomers and their self-assembly into polymorphous aggregates

(2009) Ronald C. Elgersma et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Structure–function relationships in peptoids: Recent advances toward deciphering the structural requirements for biological function

(2009) Sarah A. Fowler et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Improving Oral Bioavailability of Peptides by Multiple N-Methylation: Somatostatin Analogues

(2008) Eric Biron et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Inhibition of HIV-1 Fusion by Hydrogen-Bond-Surrogate-Based α Helices

(2008) Deyun Wang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Design of Potent Aspartic Protease Inhibitors to Treat Various Diseases

(2008) Jeffrey-Tri Nguyen et al.   ARCHIV DER PHARMAZIE

Synthesis and Characterization of Biodegradable Peptide-Based Polymers Prepared by Microwave-Assisted Click Chemistry

(2008) Maarten van Dijk et al.   BIOMACROMOLECULES

Synthesis, penetrability and intracellular targeting of fluorescein-tagged peptoids and peptide–peptoid hybrids

(2008) Asier Unciti-Broceta et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Conformational constraint in protein ligand design and the inconsistency of binding entropy

(2008) D. Gomika Udugamasooriya et al.   BIOPOLYMERS

Rapid identification of the pharmacophore in a peptoid inhibitor of the proteasome regulatory particle

(2008) Hyun-Suk Lim et al.   CHEMICAL COMMUNICATIONS

Synthesis, structures, and properties of nine-, twelve-, and eighteen-membered N-benzyloxyethyl cyclic α-peptoids

(2008) N. Maulucci et al.   CHEMICAL COMMUNICATIONS

Peptoid architectures: elaboration, actuation, and application

(2008) Barney Yoo et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Nα-Fmoc-Protected ω-Azido- and ω-Alkynyl-L-amino Acids as Building Blocks for the Synthesis of “Clickable” Peptides

(2008) Alexandra Le Chevalier Isaad et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Modulation of Cellular Apoptosis with Apoptotic Protease-Activating Factor 1 (Apaf-1) Inhibitors

(2008) L. Mondragón et al.   JOURNAL OF MEDICINAL CHEMISTRY

Peptoidic Amino- and Guanidinium-Carrier Systems: Targeted Drug Delivery into the Cell Cytosol or the Nucleus

(2008) Tina Schröder et al.   JOURNAL OF MEDICINAL CHEMISTRY

Synthesis and Conformational Analysis of a Cyclic Peptide Obtained viaitoi+4 Intramolecular Side-Chain to Side-Chain Azide−Alkyne 1,3-Dipolar Cycloaddition

(2008) Sonia Cantel et al.   JOURNAL OF ORGANIC CHEMISTRY

Angiotensin-(1-7) with Thioether Bridge: An Angiotensin-Converting Enzyme-Resistant, Potent Angiotensin-(1-7) Analog

(2008) L. D. Kluskens et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

A Peptoid “Antibody Surrogate” That Antagonizes VEGF Receptor 2 Activity

(2008) D. Gomika Udugamasooriya et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Oligo(N-aryl glycines): A New Twist on Structured Peptoids

(2008) Neel H. Shah et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Intranasal administration delivers peptoids to the rat central nervous system

(2008) Tinna M. Ross et al.   NEUROSCIENCE LETTERS

Peptoids that mimic the structure, function, and mechanism of helical antimicrobial peptides

(2008) N. P. Chongsiriwatana et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Design and Synthesis of Cyclic RGD Pentapeptoids by Consecutive Ugi Reactions

(2007) Otilie E. Vercillo et al.   ORGANIC LETTERS