A Modified Epigenetics Toolbox to Study Histone Modifications on the Nucleosome Core

Adding New Chemistries to the Genetic Code

(2010) Chang C. Liu et al.   Annual Review of Biochemistry

Biological Applications of Protein Splicing

(2010) Miquel Vila-Perelló et al.   CELL

Quantitative Interaction Proteomics and Genome-wide Profiling of Epigenetic Histone Marks and Their Readers

(2010) Michiel Vermeulen et al.   CELL

A Genetically Encoded ε-N-Methyl Lysine in Mammalian Cells

(2010) Dan Groff  et al.   CHEMBIOCHEM

A method to site-specifically introduce methyllysine into proteins in E. coli

(2010) Hui-wang Ai et al.   CHEMICAL COMMUNICATIONS

Targeting DOT1L action and interactions in leukemia: the role of DOT1L in transformation and development

(2010) Evan R Barry et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Linking H3K79 trimethylation to Wnt signaling through a novel Dot1-containing complex (DotCom)

(2010) M. Mohan et al.   GENES & DEVELOPMENT

Chemical Approaches for Studying Histone Modifications

(2010) Champak Chatterjee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Allele-Specific H3K79 Di- versus Trimethylation Distinguishes Opposite Parental Alleles at Imprinted Regions

(2010) Purnima Singh et al.   MOLECULAR AND CELLULAR BIOLOGY

The Histone Chaperone Nap1 Promotes Nucleosome Assembly by Eliminating Nonnucleosomal Histone DNA Interactions

(2010) Andrew J. Andrews et al.   MOLECULAR CELL

Disulfide-directed histone ubiquitylation reveals plasticity in hDot1L activation

(2010) Champak Chatterjee et al.   Nature Chemical Biology

Structure–Activity Analysis of Semisynthetic Nucleosomes: Mechanistic Insights into the Stimulation of Dot1L by Ubiquitylated Histone H2B

(2009) Robert K. McGinty et al.   ACS Chemical Biology

AF17 Competes with AF9 for Binding to Dot1a to Up-regulate Transcription of Epithelial Na+Channel α

(2009) Mary Rose Reisenauer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Genetically EncodingNϵ-Methyl-l-lysine in Recombinant Histones

(2009) Duy P. Nguyen et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Linking Cell Cycle to Histone Modifications: SBF and H2B Monoubiquitination Machinery and Cell-Cycle Regulation of H3K79 Dimethylation

(2009) Julia M. Schulze et al.   MOLECULAR CELL

Reconstitution of Yeast Silent Chromatin: Multiple Contact Sites and O-AADPR Binding Load SIR Complexes onto Nucleosomes In Vitro

(2009) Fabrizio Martino et al.   MOLECULAR CELL

A Method for Genetically Installing Site-Specific Acetylation in Recombinant Histones Defines the Effects of H3 K56 Acetylation

(2009) Heinz Neumann et al.   MOLECULAR CELL

ES Cell Cycle Progression and Differentiation Require the Action of the Histone Methyltransferase Dot1L

(2009) Evan R. Barry et al.   STEM CELLS

H3K79 Methylation Profiles Define Murine and Human MLL-AF4 Leukemias

(2008) Andrei V. Krivtsov et al.   CANCER CELL

UV sensitive mutations in histone H3 in Saccharomyces cerevisiae that alter specific K79 methylation states genetically act through distinct DNA repair pathways

(2008) Margery L. Evans et al.   CURRENT GENETICS

DOT1L/KMT4 Recruitment and H3K79 Methylation Are Ubiquitously Coupled with Gene Transcription in Mammalian Cells

(2008) D. J. Steger et al.   MOLECULAR AND CELLULAR BIOLOGY

Synthetic Lethal Screens Identify Gene Silencing Processes in Yeast and Implicate the Acetylated Amino Terminus of Sir3 in Recognition of the Nucleosome Core

(2008) T. van Welsem et al.   MOLECULAR AND CELLULAR BIOLOGY

Chemically ubiquitylated histone H2B stimulates hDot1L-mediated intranucleosomal methylation

(2008) Robert K. McGinty et al.   NATURE

The effect of H3K79 dimethylation and H4K20 trimethylation on nucleosome and chromatin structure

(2008) Xu Lu et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Nonprocessive methylation by Dot1 leads to functional redundancy of histone H3K79 methylation states

(2008) Floor Frederiks et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

A Histone Methyltransferase Modulates Antigenic Variation in African Trypanosomes

(2008) Luisa M Figueiredo et al.   PLOS BIOLOGY

Antigenic Variation in Trypanosoma brucei: Joining the DOTs

(2008) Chris Stockdale et al.   PLOS BIOLOGY

The Histone H3K79 Methyltransferase Dot1L Is Essential for Mammalian Development and Heterochromatin Structure

(2008) Brendan Jones et al.   PLoS Genetics