Targeting DOT1L action and interactions in leukemia: the role of DOT1L in transformation and development

Global reduction of the epigenetic H3K79 methylation mark and increased chromosomal instability in CALM-AF10-positive leukemias

(2009) Y.-H. Lin et al.   BLOOD

The molecular biology of mixed lineage leukemia

(2009) R. K. Slany   HAEMATOLOGICA

Overexpression ofgrappaencoding a histone methyltransferase enhances stress resistance inDrosophila

(2009) Olivier List et al.   HEREDITAS

Linking Cell Cycle to Histone Modifications: SBF and H2B Monoubiquitination Machinery and Cell-Cycle Regulation of H3K79 Dimethylation

(2009) Julia M. Schulze et al.   MOLECULAR CELL

Haematopoietic malignancies caused by dysregulation of a chromatin-binding PHD finger

(2009) Gang G. Wang et al.   NATURE

Protein methyltransferases as a target class for drug discovery

(2009) Robert A. Copeland et al.   NATURE REVIEWS DRUG DISCOVERY

Epigenetic dynamics of stem cells and cell lineage commitment: digging Waddington's canal

(2009) Myriam Hemberger et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Nuclear pore proteins and cancer

(2009) Songli Xu et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

ES Cell Cycle Progression and Differentiation Require the Action of the Histone Methyltransferase Dot1L

(2009) Evan R. Barry et al.   STEM CELLS

Epigenetic regulation: methylation of histone and non-histone proteins

(2009) Fei Lan et al.   Science in China. Series C, Life sciences / Chinese Academy of Sciences

Misguided Transcriptional Elongation Causes Mixed Lineage Leukemia

(2009) Dorothee Mueller et al.   PLOS BIOLOGY

Acute myeloid leukemia induced by MLL-ENL is cured by oncogene ablation despite acquisition of complex genetic abnormalities

(2008) S. J. Horton et al.   BLOOD

The recurrent SET-NUP214 fusion as a new HOXA activation mechanism in pediatric T-cell acute lymphoblastic leukemia

(2008) P. Van Vlierberghe et al.   BLOOD

Reconstructing the Disease Model and Epigenetic Networks for MLL-AF4 Leukemia

(2008) Bernd B. Zeisig et al.   CANCER CELL

H3K79 Methylation Profiles Define Murine and Human MLL-AF4 Leukemias

(2008) Andrei V. Krivtsov et al.   CANCER CELL

Stem Cells, the Molecular Circuitry of Pluripotency and Nuclear Reprogramming

(2008) Rudolf Jaenisch et al.   CELL

Coordinated regulation of transcriptional repression by the RBP2 H3K4 demethylase and Polycomb-Repressive Complex 2

(2008) D. Pasini et al.   GENES & DEVELOPMENT

Aberrant chromatin at genes encoding stem cell regulators in human mixed-lineage leukemia

(2008) M. G. Guenther et al.   GENES & DEVELOPMENT

Erasing the methyl mark: histone demethylases at the center of cellular differentiation and disease

(2008) P. A.C. Cloos et al.   GENES & DEVELOPMENT

DOT1L/KMT4 Recruitment and H3K79 Methylation Are Ubiquitously Coupled with Gene Transcription in Mammalian Cells

(2008) D. J. Steger et al.   MOLECULAR AND CELLULAR BIOLOGY

Chemical probes for histone-modifying enzymes

(2008) Philip A Cole   Nature Chemical Biology

Nonprocessive methylation by Dot1 leads to functional redundancy of histone H3K79 methylation states

(2008) Floor Frederiks et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Divergent Transcription from Active Promoters

(2008) Amy C. Seila et al.   SCIENCE

Mouse Hematopoietic Stem Cells, Unlike Human and Mouse Embryonic Stem Cells, Exhibit Checkpoint–Apoptosis Coupling

(2008) Sara Rohrabaugh et al.   STEM CELLS AND DEVELOPMENT

Genomewide Analysis of PRC1 and PRC2 Occupancy Identifies Two Classes of Bivalent Domains

(2008) Manching Ku et al.   PLoS Genetics

The Histone H3K79 Methyltransferase Dot1L Is Essential for Mammalian Development and Heterochromatin Structure

(2008) Brendan Jones et al.   PLoS Genetics

Changes in H3K79 Methylation During Preimplantation Development in Mice

(2007) Masatoshi Ooga et al.   BIOLOGY OF REPRODUCTION