Review
Clinical Neurology
Giovanni D'Andrea, Antonina Gucciardi, Alberta Leon
Summary: The pathogenesis of primary headaches, such as migraine and cluster headache, is still debated. This review discusses the possible role of tyrosine and tryptophan metabolism in these conditions, emphasizing neurotransmitter and neuromodulator abnormalities. The study finds important abnormalities in tyrosine-related metabolites in chronic migraine patients, and significantly lower plasma tryptamine levels in both chronic migraine and chronic tension-type headache patients.
NEUROLOGICAL SCIENCES
(2022)
Review
Entomology
Francesca Barbero, Giuseppe Mannino, Luca Pietro Casacci
Summary: Insects with highly structured societies rely on the coordination of individuals and the regulation of biogenic amines to achieve social behavior. This study reviews the potential role of biogenic amines in modulating insect social behavior, particularly in ants. It also provides an analysis of research trends and interests related to biogenic amines in social insects.
Article
Clinical Neurology
Giovanni D'Andrea, Antonina Gucciardi, Giuseppe Giordano, Gennaro Bussone, Alberta Leon
Summary: The study aimed to investigate the role of arginine metabolism in chronic migraine. Results revealed that chronic migraine patients had lower plasma levels of arginine, significantly elevated levels of ornithine, ADMA, and NMMA, while levels of citrulline and SDMA were within normal range.
NEUROLOGICAL SCIENCES
(2022)
Article
Neurosciences
Iris Hardege, Julia Morud, Amy Courtney, William R. Schafer
Summary: This study identifies multiple new inhibitory ion channels with diverse ligand activation properties in Caenorhabditis elegans. These channels have inhibitory effects on acetylcholine and also show both excitatory and inhibitory effects on other major neurotransmitters. The findings shed light on the important role of diverse ligand-gated ion channels in generating complexity in a compact anatomical nervous system.
JOURNAL OF NEUROSCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Christine Damrau, Julien Colomb, Bjoern Brembs
Summary: The study found differential dominance of the tβh gene in controlling behavioral processes in fruit flies, suggesting a complex interaction of aminergic systems and neuronal circuits.
Article
Medicine, Research & Experimental
Andy Hsien Wei Koh, Russ Chess-Williams, Anna Elizabeth Lohning
Summary: The study found that the trace amines p-tyramine, p-synephrine, and p-octopamine induced similar vasoconstrictor responses in porcine renal arteries, but their mechanisms of action appeared to differ. Tyramine seemed to mainly mediate constriction of the renal artery via an indirect sympathomimetic mechanism, while synephrine and octopamine exerted additional direct effects on a1-adrenoceptors.
Review
Entomology
Luca Finetti, Thomas Roeder, Girolamo Calo, Giovanni Bernacchia
Summary: This review comprehensively describes the molecular, structural characteristics, and functions of type 1 tyramine receptors (TAR1s) in insects, with a special focus on the important roles of TAR1 in physiology, behavior, and pharmacology. In addition, it explores the design of insecticides based on TAR1 and the development of pest management strategies for insect control.
Article
Biochemistry & Molecular Biology
Matheus C. Bianchini, Luiz F. W. Soares, Joao M. F. M. Sousa, Bruna P. Ramborger, Mateus C. Gayer, Jessika C. Bridi, Rafael Roehrs, Simone Pinton, Michael Aschner, Daiana S. Avila, Robson L. Puntel
Summary: This study found that exposure to methylmercury in fruit flies led to reduced survival rate, decreased levels of dopamine and octopamine, and changes in behavior. These effects were associated with inhibition of acetylcholinesterase and tyrosine hydroxylase, increased oxidative stress, and altered glutathione-S-transferase activity.
CHEMICO-BIOLOGICAL INTERACTIONS
(2022)
Article
Chemistry, Medicinal
Mehreen Arif, Khalid Rauf, Naeem Ur Rehman, Ahmed Tokhi, Muhammad Ikram, Robert Sewell
Summary: This study found that 6-MOF and donepezil have neuroprotective effects in chronic ethanol-induced cognitive impairment, improving cognitive performance and neurochemical markers in animals.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2022)
Article
Fisheries
Hsin-Wei Kuo
Summary: Stress has an impact on the immune systems, growth, and reproduction of aquatic organisms, which is related to the synthesis pathway of octopamine (OA). This study reveals the changes in the expression of tyramine beta hydroxylase (TBH), and its correlation with OA levels, in Litopenaeus vannamei under various stress conditions.
FISH & SHELLFISH IMMUNOLOGY
(2023)
Article
Biology
Laurent Duchatelet, Constance Coubris, Christopher Pels, Sam T. Dupont, Jerome Mallefet
Summary: Bioluminescence is an important ecological feature for many marine species. Recent research has discovered a mechanism in benthic anthozoans where neurotransmitters, particularly adrenaline, play a role in controlling light emission.
Review
Clinical Neurology
Paula Trujillo, Megan A. Aumann, Daniel O. Claassen
Summary: Neuromelanin-sensitive MRI is a non-invasive method that can be used for the diagnosis and quantification of various neurodegenerative and psychiatric disorders associated with disruptions in the dopaminergic and noradrenergic systems. This review focuses on the biological and physical contrast mechanisms of NM-MRI and discusses its potential clinical applications, as well as the challenges and limitations.
Article
Biochemistry & Molecular Biology
Sherry J. Cheriyamkunnel, Saloni Rose, Pedro F. Jacob, Lauren A. Blackburn, Shaleen Glasgow, Jacob Moorse, Mike Winstanley, Patrick J. Moynihan, Scott Waddell, Carolina Rezaval
Summary: This study describes how fruit flies make decisions between feeding and courtship behaviors, with nutritional status playing a key role in prioritizing these actions. The tyramine signaling pathway is identified as essential for mediating this decision-making process, with tyramine levels modulating the activity of neurons controlling food-seeking and courtship behaviors.
Article
Neurosciences
Hui Liu, Jing-Jing Wu, Rong Li, Ping-Zhou Wang, Jia-Hao Huang, Yu Xu, Jia-Lu Zhao, Piao-Ping Wu, Si-Jia Li, Zheng-Xing Wu
Summary: In this study, the researchers found that the interaction between ASH and ADL neurons enhances Caenorhabditis elegans' avoidance behavior towards mild and medium hyperosmolality. This interaction is mediated through a negative feedback circuit involving ASH, ADL, and RIM interneurons. Additionally, multiple sensory neurons, including ASH and ADL, are involved in hyperosmotic sensation and avoidance behavior.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2023)
Article
Microbiology
Patrick Vudriko, Rika Umemiya-Shirafuji, Dickson Stuart Tayebwa, Joseph Byaruhanga, Benedicto Byamukama, Maria Tumwebaze, Xuenan Xuan, Hiroshi Suzuki
Summary: This study characterized the OCT/Tyr receptor gene of amitraz-resistant and -susceptible R. (B.) decoloratus ticks from Uganda, revealing four novel amino acid mutations associated with amitraz resistance. However, the absence of mutations in the OCT/Tyr gene fragment for some resistant ticks suggests the presence of other resistance mechanisms.
Article
Clinical Neurology
Vincenzo Levi, Nicola Ernesto Di Laurenzio, Andrea Franzini, Irene Tramacere, Alessandra Erbetta, Luisa Chiapparini, Domenico D'Amico, Angelo Franzini, Giuseppe Messina
JOURNAL OF NEUROSURGERY
(2020)
Article
Clinical Neurology
Svetlana Lorenzano, Annarita Vestri, Paolo Bovi, Manuel Cappellari, Paolo Stanzione, Domenico Sama, Maddalena Bruscoli, Milena Cavazzuti, Andrea Zini, Maurizia Rasura, Mario Beccia, Giancarlo Comi, Maria Sessa, Carlo Gandolfo, Maurizio Balestrino, Giancarlo Agnelli, Valeria Caso, Piercarlo Gerbino Promis, Claudio Pozzessere, Sabrina Anticoli, Francesco Perini, Michela Marcon, Annalisa Vinattieri, Alba Caruso, Mauro Magoni, Mauro Furlan, Giovanni Orlandi, Vincenzo Di Lazzaro, Mariarosaria Valente, Patrizia Nencini, Danilo Toni
Summary: The TESPI trial aimed to evaluate the effects of alteplase treatment in patients over 80 with acute ischemic stroke and, based on previous randomized controlled trials, concluded that administering alteplase within 3 hours may be beneficial for this patient population.
INTERNATIONAL JOURNAL OF STROKE
(2021)
Editorial Material
Clinical Neurology
Martina Guglielmetti, Alberto Raggi, Raffaele Ornello, Simona Sacco, Domenico D'Amico, Matilde Leonardi, Paolo Martelletti
Article
Clinical Neurology
Emanuela Sansone, Licia Grazzi, Alberto Raggi, Matilde Leonardi, Domenico D'Amico
NEUROLOGICAL SCIENCES
(2020)
Article
Clinical Neurology
Domenico D'Amico, Susanna Usai, Luisa Chiapparini, Alessandra Erbetta, Andrea Gioppo, Giuseppe Messina, Alberto Astengo, Massimo Leone
NEUROLOGICAL SCIENCES
(2020)
Review
Clinical Neurology
Leonardo Varotto, Gianni Bregolin, Mariemma Paccanaro, Antonella De Boni, Carlo Bonanno, Francesco Perini
Summary: Systematic reviews suggest that PFO closure is effective in preventing strokes compared to medical therapy, but may increase the risk of atrial fibrillation.
NEUROLOGICAL SCIENCES
(2021)
Article
Environmental Sciences
Matilde Leonardi, Licia Grazzi, Domenico D'Amico, Paolo Martelletti, Erika Guastafierro, Claudia Toppo, Alberto Raggi
Summary: Headache disorders, including migraine and tension-type headache, are prevalent and have a substantial impact on people of all ages globally. The study based on Global Burden of Disease data shows an increase in prevalence rates of these headache types over the past decade, especially among females. Unequal availability of effective treatments across regions may contribute to regional differences in headache burden. Promoting public health policies and strategies, including proper diagnosis and treatments, is crucial in reducing the disability and burden associated with headaches among children and adolescents.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2021)
Review
Environmental Sciences
Domenico D'Amico, Stewart J. Tepper, Erika Guastafierro, Claudia Toppo, Matilde Leonardi, Licia Grazzi, Paolo Martelletti, Alberto Raggi
Summary: Assessment instruments addressing disability and quality of life in headache disorders have not been comprehensively addressed. Few instruments are commonly used across different types of headache disorders and further research is needed to expand the scope of impact on daily life activities and environmental factors.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2021)
Review
Environmental Sciences
Licia Grazzi, Claudia Toppo, Domenico D'Amico, Matilde Leonardi, Paolo Martelletti, Alberto Raggi, Erika Guastafierro
Summary: Non-pharmacological treatments such as non-invasive neuromodulation, nutraceuticals, and behavioral therapies are increasingly used in the management of headache disorders, especially for patients with medication overuse or contraindications to drug treatment. Further investigations are needed to consider the long-term effects of these approaches.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2021)
Article
Immunology
Luigi Zuliani, Sabrina Marangoni, Piera De Gaspari, Irene Rosellini, Margherita Nosadini, Joanne M. Fleming, Valentina De Riva, Elisabetta Galloni, Francesco Perini, Anna Chiara Frigo, Stefano Sartori, Marco Zoccarato, Bruno Giometto
Summary: This study reviewed 13 years of biobank data to assess the incidence of NSAE in two Italian provinces over a 5-year period, finding an estimated rate of 1.54 per 1,000,000 population. LGI1-E was the most common NSAE among adults.
JOURNAL OF NEUROIMMUNOLOGY
(2021)
Article
Clinical Neurology
Davide Pareyson, Chiara Pantaleoni, Roberto Eleopra, Giuseppe De Filippis, Isabella Moroni, Elena Freri, Federica Zibordi, Sara Bulgheroni, Emanuela Pagliano, Daniela Sarti, Antonio Silvani, Licia Grazzi, Pietro Tiraboschi, Giuseppe Didato, Elena Anghileri, Anna Bersano, Laura Valentini, Sylvie Piacentini, Cristina Muscio, Matilde Leonardi, Caterina Mariotti, Marica Eoli, Sara Nuzzo, Fabrizio Tagliavini, Paolo Confalonieri, Francesca De Giorgi
Summary: Lombardy in Italy experienced a rapid reorganization of its healthcare system due to the COVID-19 pandemic, leading to the implementation and success of neuro-telemedicine services and teleneurorehabilitation. The recognition and pricing of telehealth services in Italy have become a stable pillar of the health system as a result of the pandemic.
NEUROLOGICAL SCIENCES
(2021)
Article
Clinical Neurology
Domenico D'Amico, Licia Grazzi, Erika Guastafierro, Emanuela Sansone, Matilde Leonardi, Alberto Raggi
Summary: This study aimed to identify predictors of failure in patients with chronic migraine and medication overuse headache. The study found that failure predictors included day-hospital-based withdrawal, emergency room access before withdrawal, and baseline headache frequency exceeding 69 days/three months. Patients who failed withdrawal did not show improvement in medication use, prophylactic treatment, or symptoms of anxiety and depression.
ACTA NEUROLOGICA SCANDINAVICA
(2021)
Article
Clinical Neurology
Laura Antolini, Jacopo C. DiFrancesco, Marialuisa Zedde, Gianpaolo Basso, Andrea Arighi, Atsushi Shima, Annachiara Cagnin, Massimo Caulo, Roxana O. Carare, Andreas Charidimou, Mario Cirillo, Vincenzo Di Lazzaro, Carlo Ferrarese, Alessia Giossi, Domenico Inzitari, Michela Marcon, Roberto Marconi, Masafumi Ihara, Ricardo Nitrini, Berardino Orlandi, Alessandro Padovani, Rosario Pascarella, Francesco Perini, Giulia Perini, Maria Sessa, Elio Scarpini, Fabrizio Tagliavini, Raffaella Valenti, Juan Francisco Vazquez-Costa, Alberto Villarejo-Galende, Yuta Hagiwara, Nicole Ziliotto, Fabrizio Piazza
Summary: This study aimed to investigate the natural history and outcomes after treatment of spontaneous amyloid-related imaging abnormalities (ARIA)-like in cerebral amyloid angiopathy-related inflammation (CAA-ri). The results showed that most patients clinically and radiologically recovered within 3 to 12 months after the first-ever presentation of CAA-ri, but 38.3% experienced at least one recurrence within the following 24 months, with a higher likelihood of recurrence if IV high-dose corticosteroid pulse therapy was suddenly stopped.
Article
Clinical Neurology
Yongjun Wang, Yuesong Pan, Hao Li, Pierre Amarenco, Hans Denison, Scott R. Evans, Anders Himmelmann, Stefan James, Filip Birve, Per Ladenvall, Carlos A. Molina, S. Claiborne Johnston
Summary: This study evaluated the efficacy and safety of ticagrelor plus aspirin in patients with moderate ischemic stroke, showing that these patients had better outcomes compared to aspirin alone, with no further increase in the risk of intracranial bleeding or other severe bleeding events.
Article
Clinical Neurology
Piero Barbanti, Gabriella Egeo, Cinzia Aurilia, Giulia Fiorentini, Stefania Proietti, Carlo Tomino, Stefano Bonassi
Summary: The Italian Migraine Registry (I-GRAINE) is a research study aimed at providing big data on migraine. The study collects information on patients' sociodemographic characteristics, lifestyle, migraine features, patient's journey, and healthcare resource use. Preliminary results show that most patients are women with high-frequency and severe disability migraine. There is a difference in response rates to different treatments. Additionally, a significant number of patients have had specialist visits or diagnostic investigations in the past three years.
NEUROLOGICAL SCIENCES
(2022)