Article
Clinical Neurology
Theodoros S. Constantinidis, Chryssa Arvaniti, Nikolaos Fakas, Jobst Rudolf, Evangelos Kouremenos, Ermioni Giannouli, Dimos D. Mitsikostas
Summary: This study estimated the prevalence, burden, and treatment of disabling primary headaches in a large sample of the Greek population aged 18-70 years old. The results showed that more than 10% of Greek adults experience disabling headaches, with over 80% never having taken pharmacological prophylaxis and a preference for oral medication for treatment.
Article
Biology
Jacob Genizi, Morya Shnaider, Liat Yaniv, Nogah C. Kerem, Keren Nathan, Irina Chistyakov
Summary: Medication overuse headaches are common in children with chronic headaches, particularly those with tension-type headaches (TTH). They appear to be more pronounced in TTH patients compared to migraine sufferers, and have a higher prevalence among females.
Article
Clinical Neurology
Sara Z. Mehrhof, Lisa M. Fiksenbaum, Ariel M. Bettridge, Benjamin I. Goldstein
Summary: There is a high prevalence of migraines among adolescents with BD compared to healthy controls, with similar correlates to those found in adults, including the association with the depressive polarity of BD. Future prospective studies are needed to evaluate the temporal associations between migraines and mood symptoms, as well as the neurobiological and cardiovascular underpinnings of these associations.
Article
Clinical Neurology
Theodoros Constantinidis, Chryssa Arvaniti, Nikolaos Fakas, Jobst Rudolf, Evangelos Kouremenos, Ermioni D. Giannouli, Dimos Mitsikostas, Hellenic Headache Society
Summary: This study aimed to estimate the prevalence and burden of medication overuse headache in a representative sample of the Greek population. Results showed that the prevalence of medication overuse headache in Greece was 0.7%, with a higher proportion in females. The impact on work performance and productivity was significant. Medication overuse headache is a serious socio-economic health problem that requires immediate health policy planning.
Article
Medicine, Research & Experimental
Antanas Vaitkus, Ovidijus Laucius, Zemyna Kurnickaite, Simona Gylyte
Summary: Tension-type headache is the most common type of headache, but its classification as a primary headache is questionable. Existing studies lack evidence connecting it to other primary headaches, and there are phenotypical differences compared to other primary headaches. Due to the uncertainty of its origin and pathophysiology, treatment options for tension-type headache are limited.
MEDICAL HYPOTHESES
(2022)
Article
Clinical Neurology
Inna E. Tchivileva, Richard Ohrbach, Roger B. Fillingim, Feng-Chang Lin, Pei Feng Lim, Samuel J. Arbes, Gary D. Slade
Summary: Headache attributed to Temporomandibular Disorder (HATMD) is a common secondary headache among patients with chronic myogenous TMD and primary headaches, often presenting as migraine. Unlike primary headaches, HATMD is associated with higher headache frequency and examination-evoked masticatory muscle pain, but surprisingly few measures of facial pain, general health, and psychological distress. Understanding these differences is important for developing targeted strategies for HATMD management.
JOURNAL OF HEADACHE AND PAIN
(2021)
Review
Food Science & Technology
Katarzyna Kepczynska, Izabela Domitrz
Summary: This article presents the common types of headaches and the effects of botulinum toxin in their treatment. Tension-type headache and migraine are the most common types of headaches, and botulinum toxin has shown significant benefits in treating chronic headaches. However, there is still a lack of evidence for its use in other types of headaches.
Review
Nutrition & Dietetics
Anna Zdunska, Joanna Cegielska, Sebastian Zdunski, Izabela Domitrz
Summary: The consumption of caffeine in the diet has a significant impact on the nervous system and can both relieve and trigger headaches. Caffeine affects headaches, particularly migraine, through mechanisms that have yet to be fully understood. It is also an important therapeutic agent for certain types of headaches and can cause caffeine withdrawal headaches when abruptly discontinued.
Review
Clinical Neurology
Bartlomiej Blaszczyk, Marcin Straburzynski, Mieszko Wieckiewicz, Slawomir Budrewicz, Piotr Niemiec, Martyna Staszkiewicz, Marta Waliszewska-Prosol
Summary: This study explores the relationship between alcohol consumption and primary headaches. The findings from systematic review and meta-analysis suggest an inverse correlation between alcohol consumption and migraine, while tension-type headache (TTH) is not associated with drinking. The observation that migraine patients avoid alcohol may explain this relationship, rather than alcohol having a protective role against migraine. Further studies with low risk of bias are needed to investigate the relationship between primary headaches and alcohol consumption.
JOURNAL OF HEADACHE AND PAIN
(2023)
Review
Clinical Neurology
Gabriela F. Carvalho, Alena R. Becnel, Carolin Miske, Tibor M. Szikszay, Waclaw M. Adamczyk, Kerstin Luedtke
Summary: This study summarized the evidence of static and dynamic balance alterations among patients with headache. Patients with migraine showed greater sway area in static posturography and performed worse in the tandem walk test and limits of stability (LOS) test. However, there was no evidence of altered sway velocity and length in static posturography among patients with migraine. The level of evidence for balance alteration among patients with tension-type and cervicogenic headache was very low due to limited studies and high heterogeneity.
Article
Medicine, General & Internal
Melissa McNeil
Summary: Headaches are common in primary care practices, with tension-type headaches and migraine headaches being the most prevalent. Imaging is generally unnecessary unless concerning findings are identified. The principles of acute treatment include early initiation of therapy and adequate dosing to avoid medication overuse headaches.
MEDICAL CLINICS OF NORTH AMERICA
(2021)
Article
Clinical Neurology
Marco Antonio Arruda, Renato Arruda, J. Landeira-Fernandez, Luis Anunciacao, Marcelo Eduardo Bigal
Summary: The study found that a higher frequency of headache was associated with lower RRs and higher VR, while headache diagnosis did not significantly influence the risk of low RRs or high VR. Females and individuals with psychosocial adjustment problems were predictors of low RRs, and prenatal exposure to tobacco was a predictor of high VR in adolescents with primary headache.
Article
Emergency Medicine
Kasra Morad Soltani, Hassan Motamed, Kaveh Eslami, Nastaran Majdinasab, Leila Kouti
Summary: This study compared the pain-relieving effects of metoclopramide and ketorolac in acute primary headaches patients, finding no significant difference between the two drugs in pain outcomes with no serious adverse events reported.
AMERICAN JOURNAL OF EMERGENCY MEDICINE
(2021)
Review
Orthopedics
Mohammadreza Pourahmadi, Jan Dommerholt, Cesar Fernandez-de-Las-Penas, Bart Willem Koes, Mohammad Ali Mohseni-Bandpei, Mohammad Ali Mansournia, Somayeh Delavari, Abbasali Keshtkar, Mehrdad Bahramian
Summary: Dry needling does not show significant advantages in short-term relief of headache pain intensity for patients with TTH and CGH, but is more effective in improving related disabilities. Further high-quality studies are needed.
Article
Clinical Neurology
Michela Tinelli, Matilde Leonardi, Koen Paemeleire, Alberto Raggi, Dimos Mitsikostas, Elena Ruiz de la Torre, Timothy J. Steiner
Summary: This study proposed a healthcare solution for headache in the form of structured headache services and economically evaluated it in multiple settings across Europe. The findings demonstrated that structured headache services not only increased effectiveness but also saved costs across different types of headaches and over time. Lost productivity had a significant impact on the estimates, but sensitivity analyses showed that the intervention remained cost-effective even when assuming only 20% of lost productivity could be recovered by remedying disability.
JOURNAL OF HEADACHE AND PAIN
(2021)
Article
Clinical Neurology
Claudia Altamura, R. Ornello, F. Ahmed, A. Negro, A. M. Miscio, A. Santoro, A. Alpuente, A. Russo, M. Silvestro, S. Cevoli, N. Brunelli, L. Grazzi, C. Baraldi, S. Guerzoni, A. P. Andreou, G. Lambru, I Frattale, K. Kamm, R. Ruscheweyh, M. Russo, P. Torelli, E. Filatova, N. Latysheva, A. Gryglas-Dworak, M. Straburzynski, C. Butera, B. Colombo, M. Filippi, P. Pozo-Rosich, P. Martelletti, S. Sacco, F. Vernieri
Summary: This study aimed to investigate the outcome of OnabotulinumtoxinA (OBT-A) as preventative therapy in elderly chronic migraine (CM) patients. The results showed that there were no differences in the primary and secondary endpoints between elderly and non-elderly patients in the first three treatment cycles.
JOURNAL OF NEUROLOGY
(2023)
Article
Clinical Neurology
Jean Paul Medina Carrion, Mario Stanziano, Ludovico D'Incerti, Davide Sattin, Sara Palermo, Stefania Ferraro, Davide Rossi Sebastiano, Matilde Leonardi, Maria Grazia Bruzzone, Cristina Rosazza, Anna Nigri
Summary: When studying brain networks in patients with Disorders of Consciousness (DoC), it is important to evaluate both the structural integrity and functional activity of the networks. This study investigated the usefulness of structural MRI and clinical variables for diagnosis in chronic DoC patients and found that qualitative analysis of MRI data is more effective than quantitative analysis. The results showed that the structural integrity of HighOrder networks had better diagnostic accuracy than LowOrder networks, especially when clinical variables were included in the analysis. The integrity of the left hemisphere was associated with a better clinical status.
ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY
(2023)
Article
Psychology, Multidisciplinary
Chiara Castelletti, Elvira Lara, Beata Tobiasz-Adamczyk, Seppo Koskinen, Beatriz Olaya, Josep Maria Haro, Matilde Leonardi, Paul Kowal, Somnath Chatterji, Jose Luis Ayuso-Mateos, Marta Miret
Summary: This study aimed to explore the distribution of positive and negative emotions across nine low-, middle- and high-income countries and the association between social factors and these emotions. Data from 52,553 participants were drawn from the SAGE and the COURAGE studies. Emotions were assessed using the day reconstruction method, and sociodemographic characteristics and social factors were measured. The findings showed variation in the extent of each emotion across countries, but suggested an association between social factors and emotions.
INTERNATIONAL JOURNAL OF PSYCHOLOGY
(2023)
Article
Geriatrics & Gerontology
Dilara Onan, William David Wells-Gatnik, Enrico Bentivegna, Christian Lampl, Paolo Martelletti
Summary: Migraine is a prevalent and burdensome disease, affecting around 14% of the global population. Recent randomized controlled trials (RCTs) of new migraine drugs have included participants aged over 65 years, providing clinicians with safety and efficacy data for treating older patients. However, the inclusion criteria of RCTs often exclude patients with multiple comorbidities, reducing the clinical applicability of the new drugs for older patients.
Article
Clinical Neurology
Mayowa O. Owolabi, Matilde Leonardi, Claudio Bassetti, Joke Jaarsma, Tadeusz Hawrot, Akintomiwa I. Makanjuola, Rajinder K. Dhamija, Wuwei Feng, Volker Straub, Jennifer Camaradou, David W. Dodick, Rosita Sunna, Bindu Menon, Claire Wright, Chris Lynch, Antonella Santuccione Chadha, Maria Teresa Ferretti, Anna De, Coriene E. Catsman-Berrevoets, Muthoni Gichu, Cristina Tassorelli, David Oliver, Walter Paulus, Ramla K. Mohammed, Augustina Charway-Felli, Kevin Rostasy, Valery Feigin, Audrey Craven, Elizabeth Cunningham, Orla Galvin, Alexandra Heumber Perry, Ericka L. Fink, Peer Baneke, Anne Helme, Joanna Laurson-Doube, Marco T. Medina, Juan David Roa, Birgit Hogl, Allan O'Bryan, Claudia Trenkwalder, Jo Wilmshurst, Rufus O. Akinyemi, Joseph O. Yaria, David C. Good, Volker Hoemberg, Paul Boon, Samuel Wiebe, J. Helen Cross, Magali Haas, Inez Jabalpurwala, Marijeta Mojasevic, Monica DiLuca, Paola Barbarino, Stephanie Clarke, Sameer M. Zuberi, Paul Olowoyo, Ayomide Owolabi, Nelson Oyesiku, Pia C. Maly-Sundgren, Bo Norrving, Surjo R. Soekadar, Pieter A. van Doorn, Richard Lewis, Tom Solomon, Franco Servadei
Summary: The global burden of neurological disorders is substantial, especially in low-resource settings. The World Health Organization's new global action plan on epilepsy and other neurological disorders provides an opportunity to rethink the delivery of neurological services and propose pragmatic solutions to enhance neurological health. The neurological quadrangle, consisting of surveillance, prevention, acute care, and rehabilitation, is a new framework that aims to provide equitable and effective services for neurological disorders worldwide.
NATURE REVIEWS NEUROLOGY
(2023)
Article
Clinical Neurology
Stefania Bianchi Marzoli, Lisa Melzi, Paola Ciasca, Alberto Raggi, Anna Bersano, Carlotta Casati, Nadia Bolognini
Summary: This study aimed to quantify the degree of ganglion cell degeneration using SD-OCT in adult patients with post-stroke homonymous visual field defect. The results showed that there were significant differences in pRNFL-AVG, GCC-AVG, GLV, and FLV between stroke patients and controls regardless of stroke type and involved vascular territories. Age and elapsed time from stroke had a significant effect on pRNFL-AVG and GCC-AVG, while visual field defect size was unrelated to SD-OCT measurements.
NEUROLOGICAL SCIENCES
(2023)
Editorial Material
Health Care Sciences & Services
Christina Deligianni, Paolo Martelletti, Dimos D. Mitsikostas
JOURNAL OF COMPARATIVE EFFECTIVENESS RESEARCH
(2023)
Article
Medicine, General & Internal
Martina Cacciatore, Francesca Giulia Magnani, Camilla Ippoliti, Filippo Barbadoro, Paola Anversa, Lara Portincaso, Elisa Visani, Jorge Navarro, Guya Devalle, Maurizio Lanfranchi, Valeria Pingue, Sara Marelli, Luigi Ferini Strambi, Francesca Lunardini, Simona Ferrante, Marco Tremolati, Matilde Leonardi, Davide Rossi Sebastiano, Davide Sattin
Summary: In this study, 22 prolonged or chronic disorders of consciousness (DOC) patients were evaluated using long-lasting polygraphic recordings. The presence of non-functional jaw muscle activity (NFJMA) was observed in 5 patients, with electromyographic patterns similar to bruxism, suggesting a disinhibition of masticatory motor nuclei from the cortical control. Additionally, 2 patients showed electromyographic patterns indicating the presence of myorhythmia, suggesting brainstem/diencephalic involvement. Functional, non-invasive tools like long-lasting polygraphic recordings are important in revealing potentially severe disorders impacting the quality of life of DOC patients.
Article
Clinical Neurology
Elena Gross, Elena Ruiz de la Torre, Paolo Martelletti
Summary: Despite the evidence on the epidemiology of migraine and its impact on patients in terms of disability, burden, and cost, the stigma of migraine has not been fully acknowledged as a key factor in the chronicity of the disease and social isolation of patients. In this commentary, a European advocacy body and a clinician specializing in migraine present different perspectives, highlighting the need for actions to improve community perception and propose treatment and rehabilitation paths for the reintegration of migraine sufferers into social contexts.
NEUROLOGY AND THERAPY
(2023)
Article
Psychology, Clinical
Fabiola Silvaggi, Arianna Mariniello, Matilde Leonardi, Antonio Silvani, Elena Lamperti, Serena Di Cosimo, Secondo Folli, Anna Trapani, Silvia Schiavolin
Summary: This study aimed to evaluate the work ability and its associated factors in patients with glioma (II, III) and breast cancer after 6 and 12 months from surgery. A total of 99 patients were evaluated with self-reported questionnaires, and the results showed that work ability was associated with various psychosocial factors in both groups at different time points. The findings suggest that further investigation of these factors is needed to facilitate the patients' return to work.
JOURNAL OF HEALTH PSYCHOLOGY
(2023)
Review
Clinical Neurology
Chiara Riccietti, Silvia Schiavolin, Valentina Caldiera, Giuseppe Ganci, Annalisa Sgoifo, Giorgia Camarda, Matilde Leonardi, Elisa Ciceri
Summary: This article reviews the literature on cognitive and psychological domains in patients undergoing interventional neuroradiology procedures and highlights the need for clinicians to include cognitive and psychological assessments in clinical practice. The research suggests that early psychological consultations and nonpharmacologic strategies can positively impact the anxiety and depression of patients, while endovascular treatment is safe and generates similar or even fewer cognitive deficits compared with surgical procedures.
AMERICAN JOURNAL OF NEURORADIOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Tsubasa Takizawa, Keiko Ihara, Shunsuke Uno, Seiya Ohtani, Narumi Watanabe, Noboru Imai, Jin Nakahara, Satoko Hori, David Garcia-Azorin, Paolo Martelletti
EXPERT OPINION ON DRUG METABOLISM & TOXICOLOGY
(2023)
Article
Pharmacology & Pharmacy
William Wells-Gatnik, Paolo Martelletti
Summary: A recent study has found an increased risk of neurodevelopmental disorders in individuals exposed to valproate or topiramate. Regulatory bodies are reviewing the safety of topiramate during pregnancy. This review highlights the concerns regarding the use of valproate and topiramate in women of childbearing potential.
EXPERT OPINION ON DRUG SAFETY
(2023)
Review
Pharmacology & Pharmacy
William David Wells-Gatnik, Tiffany Yazmin Wences Chirino, Fatma Nur Onan, Dilara Onan, Paolo Martelletti
Summary: This article introduces new drugs for the treatment of migraine and discusses their clinical trial outcomes. As approximately 50% of patients do not respond to calcitonin gene-related peptide therapies, there is significant value in future drug innovation. Overall, these emerging drugs are largely developed based on important targets of migraine pathogenesis, but the clinical value of individual drugs needs further research to appropriately target the relevant pathways.
EXPERT OPINION ON INVESTIGATIONAL DRUGS
(2023)
Article
Clinical Neurology
Arife Cimen Atalar, Ayse Nur Ozdag Acarli, Betuel Baykan, Paolo Martelletti, Hayrunnisa Bolay, Mustafa Ertas, Esme Ekizoglu, Omer Karadas, Burcu Polat, Isil Yazici Gencdal, David Garcia Azorin, Dimos Mitsikostas, Loukia Apostolakopoulou, Hamit Genc, Pinar Yalinay Dikmen, Esra Aciman Demirel, Elif Ilgaz Aydinlar, Rabia Gokcen Gozubatik-Celik, Javid Shafiyev, Bahar Tasdelen, Aynur Ozge
Summary: This multinational observational study aimed to investigate prolonged or worsened headaches associated with COVID-19 vaccination. Questionnaires were used to assess the vaccination-related headaches at three time points. Repeated K-means cluster analysis identified patient profiles with prolonged or worsened headaches related to COVID-19 vaccination.
JOURNAL OF HEADACHE AND PAIN
(2023)
