Article
Engineering, Environmental
Jozef Kovacik, Slawomir Dresler, Maciej Strzemski, Ireneusz Sowa, Petr Babula, Magdalena Wojciak-Kosior
Summary: The study found that in the medicinal plant Hypericum perforatum L., strontium can be mitigated by organic nitrogen forms, and even have a stimulatory effect. Additionally, the effects of strontium on the plant mainly manifest in changes in primary and secondary metabolites, as well as in mineral elements.
JOURNAL OF HAZARDOUS MATERIALS
(2022)
Article
Plant Sciences
Hongyan Su, Ling Jin, Mengfei Li, Paul W. Pare
Summary: Plants of St John's wort grown at cooler temperatures exhibit changes in leaf anatomy and gene expression, which support the plant's ability to accumulate enhanced levels of the anti-depression compound hypericin at low temperatures.
FRONTIERS IN PLANT SCIENCE
(2022)
Article
Agricultural Engineering
Masumeh Karimi, Nima Ahmadi, Morteza Ebrahimi
Summary: The study revealed that increasing the red light fraction in LED light had a positive effect on the growth, flowering, and secondary metabolite accumulation in Hypericum perforatum plants, while higher levels of blue light showed poorer growth and flowering traits. Additionally, antioxidant enzymes activities, total phenolic and flavonoid content were higher in plants exposed to a mixture of red and blue light compared to those grown under white LED light.
INDUSTRIAL CROPS AND PRODUCTS
(2022)
Article
Biochemistry & Molecular Biology
Hongyan Su, Jie Li, Sijin Chen, Ping Sun, Hua Xing, Delong Yang, Xiaona Zhang, Mengfei Li, Jianhe Wei
Summary: Through physiological and transcriptomic analysis of Hypericum perforatum grown at different temperatures, it was found that the stomatal density, opening percentage, and Hyp content were significantly higher at lower temperatures compared to higher temperatures. A total of 150 genes were associated with Hyp biosynthesis, plant growth, and stress response processes, providing insight into the regulation mechanisms of low temperature enhancing Hyp biosynthesis in Hypericum perforatum.
Article
Biochemical Research Methods
Borivoj Adnadjevic, Biljana Koturevic, Jelena Jovanovic
Summary: This study aimed to investigate the kinetics of extracting total hypericin from Hypericum perforatum flowers, finding that the Jander three-dimensional diffusion model best described the extraction process. The calculation of kinetic parameters and identification of the controlling step provide important insights for the extraction process.
PHYTOCHEMICAL ANALYSIS
(2021)
Article
Biochemical Research Methods
Maryam Saffariha, Ali Jahani, Reza Jahani, Sajid Latif
Summary: The MLP model (R-2=0.87) was found to be more accurate in predicting hypericin content in H. perforatum compared to RBF (R-2=0.8) and SVM (R-2=0.54) models. Sensitivity analysis revealed that phenological stages, hill aspects, total nitrogen, altitude, and organic carbon are the most influential factors affecting hypericin content in the plant.
Article
Biochemistry & Molecular Biology
Jie Zhang, Chunrong Feng, Pu Ge, Qingqing Wang, Yanling Liu, Hui Xu, Xing Zhou
Summary: The study demonstrated a facile strategy for the separation and purification of hypericin from Hypericum perforatum L. extract using MRCC and PLC techniques. Various parameters of MRCC were investigated to optimize the separation efficiency of hypericin, while PLC parameters were determined to achieve high purity hypericin with a high recovery ratio.
PROCESS BIOCHEMISTRY
(2021)
Article
Engineering, Biomedical
Rosmeire Aparecida Barroso, Ricardo Navarro, Carla Roberta Tim, Lucas de Paula Ramos, Luciane Dias de Oliveira, Angela Toshie Araki, Karina Gonzales Camara Fernandes, Daniela Macedo, Livia Assis
Summary: Acne vulgaris is a common skin condition that can be effectively reduced by antimicrobial photodynamic therapy, particularly when using 15 μg/mL of hypericin combined with 3 and 5 J of low-level laser irradiation. This combination showed a significant reduction in the P. acnes biofilms, demonstrating effective antimicrobial action.
LASERS IN MEDICAL SCIENCE
(2021)
Article
Pharmacology & Pharmacy
Ilioara Oniga, Anca Toiu, Daniela Benedec, Laurian Vlase
Summary: The present research compared the phytochemical composition of Hypericum perforatum and H. hirsutum from different areas. The results showed that H. perforatum had higher levels of bioactive compounds compared to H. hirsutum, and there were significant chemical differences between the two species.
Article
Biotechnology & Applied Microbiology
Shamshad Ahmad Khan, Priyanka Verma, Varsha A. Parasharami
Summary: Overexpression of the HpPKS2 gene in H. perforatum leads to higher hypericin content in the native system, while its expression in the heterologous system B. monnieri also improves bacopaside I, bacopaside II, and bacopasaponin C production.
PLANT CELL TISSUE AND ORGAN CULTURE
(2022)
Article
Chemistry, Medicinal
Fakry F. Mohamed, Darisuren Anhlan, Michael Schoefbaenker, Andre Schreiber, Nica Classen, Andreas Hensel, Georg Hempel, Wolfgang Scholz, Joachim Kuehn, Eike R. Hrincius, Stephan Ludwig
Summary: A study found that the extract of Hypericum perforatum possesses potent antiviral activity against SARS-CoV-2, with naphtodianthrones hypericin and pseudohypericin playing a crucial role. This research highlights the potential value of Hypericum perforatum and its active ingredients in combating SARS-CoV-2 infections.
Article
Plant Sciences
F. Seyrekoglu, H. Temiz, F. Eser, C. Yildirim
Summary: The study investigated the total phenolic content, antioxidant activity, and main constituents of three Hypericum species from Turkey. The results showed that these plants have high total phenolic content, hypericin, and pseudohypericin content, as well as strong antioxidant activity.
SOUTH AFRICAN JOURNAL OF BOTANY
(2022)
Article
Biochemistry & Molecular Biology
Surbhi Kapoor, Rajat Chandel, Ramandeep Kaur, Satish Kumar, Raj Kumar, Sandeep Janghu, Amarjeet Kaur, Vikas Kumar
Summary: In recent years, globalization has led to the growth of the food processing industry to meet the increasing demand for various food products. This has also renewed interest in medicinal plants, with Hypericum perforatum L. being one of them. The flower of this plant species contains bioactive compounds that have potential uses in the nutraceutical and pharmaceutical sectors. Research has shown that it possesses various health-promoting properties, such as antidepressant, antioxidant, and anti-inflammatory effects, making it a potential ingredient in food and pharmaceutical products.
BIOCHEMICAL SYSTEMATICS AND ECOLOGY
(2023)
Article
Pharmacology & Pharmacy
E. Hamurtekin, Y. Hamurtekin, R. Matucci, S. Dei, E. Baris, H. Kazdagli
Summary: This study investigated the cholinergic receptor affinities of Hypericum perforatum L (HP) extract and its active constituents. The results showed that HP extract inhibited the muscarinic receptors hM2 and hM5, while the active constituents had lower affinity for muscarinic receptors at higher concentrations and did not produce any inhibition of nicotinic receptors.
INTERNATIONAL JOURNAL OF PHARMACOLOGY
(2022)
Article
Medicine, Research & Experimental
Seyedeh Zahra Nobakht, Maryam Akaberi, Amir Hooshang Mohammadpour, Ali Tafazoli Moghadam, Seyed Ahmad Emami
Summary: This study provides a comprehensive review of clinical trials on Saint John's wort (SJW) and evaluates its efficacy and safety in traditional medicine. The results indicate that SJW is valuable for psychiatric disorders.
IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES
(2022)
Article
Chemistry, Physical
Halil Koyu, Aslihan Kazan, Taylan Kurtulus Ozturk, Ozlem Yesil-Celiktas, Mehmet Zeki Haznedaroglu
JOURNAL OF SUPERCRITICAL FLUIDS
(2017)
Article
Integrative & Complementary Medicine
Gizem Bulut, Mehmet Zeki Haznedaroglu, Ahmet Dogan, Halil Koyu, Ertan Tuzlaci
JOURNAL OF HERBAL MEDICINE
(2017)
Article
Chemistry, Applied
Halil Koyu, Aslihan Kazan, Serdar Demir, Mehmet Zeki Haznedaroglu, Ozlem Yesil-Celiktas
Article
Chemistry, Physical
Aslihan Kazan, Halil Koyu, Irem Cemre Turu, Ozlem Yesil-Celiktas
JOURNAL OF SUPERCRITICAL FLUIDS
(2014)
Article
Biochemistry & Molecular Biology
Halil Koyu, Aslihan Kazan, Ayse Nalbantsoy, Husniye Tansel Yalcin, Ozlem Yesil-Celiktas
MOLECULAR BIOLOGY REPORTS
(2020)
Article
Biochemistry & Molecular Biology
Gokay Albayrak, Serdar Demir, Halil Koyu, Sura Baykan
Summary: This study reports the anticholinesterase effects of extracts and isolated compounds from the roots of Prangos uechtritzii, and identifies a novel polyacetylenic compound, along with known polyacetylenes and coumarin derivatives. The isolated compounds showed inhibitory activities against AChE and BChE enzymes, with (+)-8-O-methyloplopantriol A, (+)-falcarindiol, 6-formylumbelliferone, tamarin, and imperatorin exhibiting specific inhibitory activities against BChE. These findings suggest that (+)-falcarindiol and imperatorin could be promising candidates for the development of new BChE inhibitors for the treatment of Alzheimer's disease.
CHEMISTRY & BIODIVERSITY
(2022)
Article
Pharmacology & Pharmacy
Gokay Albayrak, Serdar Demir, Halil Koyu, Sura Baykan
Summary: The study found that Prangos heyniae root extracts have inhibitory effects on tyrosinase and acetylcholinesterase. Among the different extracts, chloroform extract showed the most promising inhibitory activity against acetylcholinesterase.
ISTANBUL JOURNAL OF PHARMACY
(2023)
Article
Food Science & Technology
Halil Koyu, Huseyin Istanbullu, Sinem Ezgi Turunc Ozoglu, Tijen Kaya Temiz
Summary: In this study, the inhibitory activity of turmeric extracts and isolated fractions on HDAC 1 was investigated. The results showed that curcumin, a major curcuminoid in turmeric, exhibited remarkable potency in inhibiting HDAC 1. This comparative study provides a foundation for future development of curcuminoid-rich products for HDAC-related diseases.
EUROPEAN FOOD RESEARCH AND TECHNOLOGY
(2023)
Article
Pharmacology & Pharmacy
Huseyin Istanbullu, Ezgi Turunc, Sami Hamdoun, Merve Saylam, Halil Koyu, Tijen Kaya Temiz
Summary: In this study, the HDAC1 inhibitory effects of ipratropium bromide, metoprolol, leflunomide, nateglinide, and levothyroxine were investigated using in silico and in vitro methods. The results show potential therapeutic targets for cancer and neurodegenerative diseases.
ISTANBUL JOURNAL OF PHARMACY
(2023)
Article
Pharmacology & Pharmacy
Mehmet Z. Haznedaroglu, Aysu Yurdasiper, Halil Koyu, Gorkem Yalcin, Ismail Ozturk, Evren H. Gokce
LATIN AMERICAN JOURNAL OF PHARMACY
(2013)
Meeting Abstract
Plant Sciences
H. Koyu, M. Haznedaroglu