Article
Microbiology
Lucie Paloque, Romain Coppee, Barbara H. Stokes, Nina F. Gnadig, Karamoko Niare, Jean-Michel Augereau, David A. Fidock, Jerome Clain, Francoise Benoit-Vical
Summary: This study demonstrates that the propeller domain is not the sole mediator of PfK13-mediated artemisinin resistance, highlighting the importance of monitoring for mutations throughout PfK13. The P413A mutation in the BTB/POZ domain upstream of the propeller domain is sufficient to confer in vitro artemisinin resistance.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2022)
Article
Biochemistry & Molecular Biology
Mengwei Zhao, Yu Ge, Zhangyan Xu, Xue Ouyang, Yuling Jia, Jiangtao Liu, Meixiang Zhang, Yuyan An
Summary: This study identifies a negative regulator, NbBTB, which negatively modulates both plant basal defense and effector-triggered immunity (ETI) in response to the oomycete pathogen Phytophthora parasitica. It is specifically involved in the defense against oomycete pathogen and does not affect resistance to bacterial pathogens. NbBTB negatively regulates the hypersensitive response triggered by avirulence proteins and affects effector protein accumulation.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Chemistry, Medicinal
Haijun Gu, Jia He, Yuzhan Li, Dazhao Mi, Tian Guan, Weikai Guo, Bo Liu, Yihua Chen
Summary: B-cell lymphoma 6 (BCL6) is a transcriptional repressor that is highly expressed in malignant cells and drives tumorigenesis. Targeting BCL6 may be a promising therapeutic strategy for treating lymphomas. This review comprehensively discusses the latest development of BCL6 inhibitors in diffuse large B-cell lymphoma, including their pharmacophores and efficacies.
JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Article
Immunology
Yayi Gao, Monica Zamisch, Melanie Vacchio, Laura Chopp, Thomas Ciucci, Elliott L. Paine, Gaelyn C. Lyons, Jia Nie, Qi Xiao, Ekaterina Zvezdova, Paul E. Love, Charles R. Vinson, Lisa M. Jenkins, Remy Bosselut
Summary: The NuRD complex is identified as a critical cofactor for Thpok, a BTB-ZF transcription factor that controls T cell development. NuRD is involved in the repression of CD8(+) lineage genes by Thpok, but is dispensable for Cd4 expression. This study reveals the importance of cofactor binding in the functional specificity of BTB-ZF factors.
SCIENCE IMMUNOLOGY
(2022)
Article
Plant Sciences
Spela Tomaz, Marko Petek, Tjasa Lukan, Karmen Pogacar, Katja Stare, Erica Teixeira Prates, Daniel A. Jacobson, Jan Zrimec, Gregor Bajc, Matej Butala, Marusa Pompe Novak, Quentin Dudley, Nicola Patron, Ajda Taler-Vercic, Aleksandra Usenik, Dusan Turk, Salome Prat, Anna Coll, Kristina Gruden
Summary: This study identified a novel potato transcription factor, StTGA2.1, which plays a crucial role in hormone-mediated immune responses by interacting with other transcription factors. The study also revealed the molecular mechanisms of StTGA2.1 and its regulation of key genes involved in plant immune response.
Article
Multidisciplinary Sciences
Swarupa Nanda Mandal, Jacobo Sanchez, Rakesh Bhowmick, Oluwatobi R. Bello, Coenraad R. Van-Beek, Benildo G. de los Reyes
Summary: This study analyzed 110 BTB/POZ encoding gene loci in the genome of O. rufipogon and identified nine novel BTB/POZ genes with orthologs in other Poaceae species. The study sheds light on the evolution and functional divergence of this gene family.
SCIENTIFIC REPORTS
(2023)
Article
Medicine, Research & Experimental
Nunghathai Sawasdee, Kanyaluck Jantakee, Methi Wathikthinnakon, Suthida Panwong, Jeeraporn Pekkoh, Kritsana Duangjan, Pa-thai Yenchitsomanus, Aussara Panya
Summary: The ethanolic extract from Chlorella sp. was found to inhibit the growth of five types of cancer cells and promote cancer cell death by inhibiting the AKT/mTOR pathway.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Biochemistry & Molecular Biology
Xinhao Zhang, Hongyan Shen, Binbin Wen, Sen Li, Chen Xu, Yu Gai, Xiangguang Meng, Huajie He, Ning Wang, Dongmei Li, Xiude Chen, Wei Xiao, Xiling Fu, Qiuping Tan, Ling Li
Summary: The study shows that PpBT3 regulates peach bud endodormancy by interacting with PpDAM5, with the expression pattern of PpBT3 opposite to that of PpDAM5, revealing a new mechanism for regulating bud dormancy of perennial deciduous trees.
Article
Multidisciplinary Sciences
Neil L. Ingham, Navid Banafshe, Clarisse A. Panganiban, Julia P. Crunden, Jing Chen, Morag Lewis, Karen Steel
Summary: Mutations in the Klhl18 gene result in progressive low-frequency hearing impairment in mice, affecting inner hair cell stereocilia while cochlear outer hair cell function remains normal. This indicates the importance of Klhl18 in maintaining inner hair cell function at low frequencies.
Article
Multidisciplinary Sciences
Neil J. Ingham, Navid Banafshe, Clarisse Panganiban, Julia L. Crunden, Jing Chen, Morag A. Lewis, Karen P. Steel
Summary: Progressive low-frequency recessive hearing impairment was observed in mutant mouse lines carrying different mutant alleles of the Klhl18 gene, with ABR thresholds increasing progressively from 4 weeks old onwards, while DPOAE sensitivity and amplitudes remained normal.
Article
Oncology
Tuo Tang, Shengnan Wang, Tianyu Cai, Zhenyu Cheng, Yu Meng, Shimei Qi, Yao Zhang, Zhilin Qi
Summary: This study found that HMGB1 promotes proliferation and migration of gastric cancer cells through the RAGE-mediated signaling pathways, involving multiple molecular mechanisms. It highlights HMGB1 as a potential therapeutic target for GC, providing important evidence for future research and treatment strategies.
Article
Veterinary Sciences
Jingsong Liu, Xueming Zhang, Shengnan Yue, Jingcheng Fu, Jin Chen, Ruochao Huang, Pengyuan Shang, Kai Zhong, Shuang Guo, Xianqin Jiao, Guangming Zha, Liqiang Han, Guoyu Yang, Heping Li, Yueying Wang
Summary: The study demonstrates that EPO promotes proliferation of MAC-T cells and has a better anti-inflammatory effect in cells treated with LPS, showing anti-apoptotic and anti-autophagic effects as well. These beneficial effects are dependent on the regulation of the PI3K/Akt/mTOR signaling pathway.
RESEARCH IN VETERINARY SCIENCE
(2022)
Article
Pharmacology & Pharmacy
Chao Ren, Ren-qi Yao, Li-xue Wang, Jun-cong Li, Kun-wei Chen, Yao Wu, Ning Dong, Yong-wen Feng, Yong-ming Yao
Summary: This study found that HMGB1 plays a critical role in dysregulating immune response in sepsis, with the relationship between cerebral HMGB1 and splenic DC dysfunction being dependent on cholinergic system activity. The findings shed light on the mechanisms of immune dysfunction in sepsis and the potential therapeutic targets involving HMGB1 and cholinergic pathways.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Wataru Takaki, Hirotaka Konishi, Daiki Matsubara, Katsutoshi Shoda, Tomohiro Arita, Satoshi Kataoka, Jun Shibamoto, Hirotaka Furuke, Kazuya Takabatake, Hiroki Shimizu, Shuhei Komatsu, Atsushi Shiozaki, Takeshi Kubota, Kazuma Okamoto, Eigo Otsuji
Summary: This study reveals that extracellular HMGB1 promotes the progression and metastasis of gastric cancer, and plasma HMGB1 concentrations can serve as a prognostic marker in gastric cancer patients. Recombinant human soluble thrombomodulin (rTM) targeting HMGB1 shows potential therapeutic effects in gastric cancer treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Immunology
William A. Banks, Kim M. Hansen, Michelle A. Erickson, Fulton T. Crews
Summary: High-mobility group box 1 (HMGB1) is a protein that regulates transcription in the cell nucleus and activates the innate immune system. It can cross the blood-brain barrier (BBB) and affect neuroimmune signaling in the brain and periphery. In this study, the ability of radioactively labeled HMGB1 to cross the BBB was examined. The results showed that HMGB1 could bidirectionally cross the BBB and its transport rates were enhanced by inflammation. This finding suggests that HMGB1 levels have an impact on neuroimmune signaling in various conditions.
BRAIN BEHAVIOR AND IMMUNITY
(2023)
Article
Cell Biology
Ke Mi, Lizhong Zeng, Yang Chen, Jingya Ning, Siyuan Zhang, Peilin Zhao, Shuanying Yang
Summary: In this study, the researchers explored the role of DHX38 in NSCLC and its underlying molecular mechanism. They found that DHX38 was overexpressed in NSCLC and patients with high DHX38 expression had poor prognosis. DHX38 promoted cell proliferation, migration, and invasion in NSCLC and activated the MAPK pathway. The researchers also identified G3BP1 as a target protein that interacted with DHX38 and showed that DHX38 regulated the expression of G3BP1. Silencing G3BP1 reversed the effects of DHX38 overexpression on tumor cell proliferation, migration, and invasion and inhibited the MAPK pathway activation.
CELLULAR SIGNALLING
(2024)
Article
Cell Biology
Tiina A. Jokela, Mark A. Dane, Rebecca L. Smith, Kaylyn L. Devlin, Sundus Shalabi, Jennifer C. Lopez, Masaru Miyano, Martha R. Stampfer, James E. Korkola, Joe W. Gray, Laura M. Heiser, Mark A. Labarge
Summary: Microenvironment signals have a significant impact on cell fate and tissue homeostasis. Understanding how different microenvironment factors regulate cellular phenotype has been challenging. In this study, a high-throughput microenvironment microarray was used to identify factors that support the proliferation and maintenance of primary human mammary luminal epithelial cells. Multiple factors that modulate luminal cell number were identified and their effects were confirmed using RNA sequencing and cell-based functional studies. Hepatocyte growth factor (HGF) was found to be robust to individual variation and played a role in expanding luminal cells. Our approach demonstrates the power of high-dimensional cell-based approaches in dissecting microenvironmental signals.
CELLULAR SIGNALLING
(2024)
Article
Cell Biology
Chao He, Yongfeng Ding, Yan Yang, Gang Che, Fei Teng, Haohao Wang, Jing Zhang, Donghui Zhou, Yanyan Chen, Zhan Zhou, Haiyong Wang, Lisong Teng
Summary: This study categorized gastric cancer patients into three stemness subtypes, each demonstrating distinct prognoses, components of tumor microenvironment (TME) infiltration, and varying sensitivity or resistance to treatment. A stemness risk model was constructed to predict treatment response and prognosis.
CELLULAR SIGNALLING
(2024)
Article
Cell Biology
Haile Zhao, Lijuan Feng, Rui Cheng, Man Wu, Xiaozhou Bai, Lifei Fan, Yaping Liu
Summary: miR-29c-3p is overexpressed in benign and malignant ovarian carcinoma and is associated with poor prognosis. Its overexpression modulates tumorigenesis in ovarian cancer cells, including epithelial-mesenchymal transition, proliferation, migration, and invasion, through the regulation of DNMT3A, TET1, and HBP1. miR-29c-3p may serve as a potential biomarker for clinical diagnosis or co-diagnosis of ovarian carcinoma.
CELLULAR SIGNALLING
(2024)
Article
Cell Biology
Haiyan Zhao, Fangfang Bi, Mengyuan Li, Yuhan Diao, Chen Zhang
Summary: This study confirmed the tumor suppressor effect of RNF180 on ovarian cancer, elucidated the mechanism of the molecule network related to RNF180 and IPO4 in ovarian cancer, and identified a new therapeutic target for ovarian cancer.
CELLULAR SIGNALLING
(2024)
Article
Cell Biology
Chu Chen, Guanhua Xu, Jiajia Chen, Chunshuai Wu, Jinlong Zhang, Jiawei Jiang, Hongxiang Hong, Zhiming Cui
Summary: This study investigated the role of transcription factor FoxO1 in facet joint osteoarthritis (FJOA) and found that FoxO1 deletion led to severe osteoarthritic changes. Transcriptome sequencing and bioinformatics analysis identified differentially expressed genes (DEGs) and potential key contributors to FJOA. Additionally, over-expression of certain genes and inhibition of others were shown to counteract the impairments caused by FoxO1 deletion in chondrocyte migration and extracellular matrix synthesis. These findings help unravel the molecular mechanisms underlying FJOA and open up promising therapeutic avenues for its treatment.
CELLULAR SIGNALLING
(2024)
Article
Cell Biology
Wen Deng, Ru Chen, Situ Xiong, Jianqiang Nie, Hailang Yang, Ming Jiang, Bing Hu, Xiaoqiang Liu, Bin Fu
Summary: This study demonstrates that circFSCN1 is upregulated in bladder cancer and associated with cancer-specific survival. CircFSCN1 promotes tumor progression and epithelial-mesenchymal transition in bladder cancer through enhancing MDM2-mediated silencing of p53 by sponging miR-145-5p.
CELLULAR SIGNALLING
(2024)
Article
Cell Biology
Jun Wu, Weibin Hu, Wenhui Yang, Yihao Long, Kaizhao Chen, Fugui Li, Xiaodong Ma, Xun Li
Summary: Cholesterol biosynthesis and metabolism play critical roles in tumor development and microenvironmental conditions. Squalene Epoxidase (SQLE), the second rate-limiting enzyme in cholesterol synthesis, is found to be uniquely expressed in various cancers, and its expression level is closely associated with tumor mutation burden and microsatellite instability. SQLE expression is negatively correlated with immune cell infiltration. Inhibition of SQLE alters the immune response in the tumor microenvironment. Furthermore, protein metabolism and translation are identified as main binding factors with SQLE.
CELLULAR SIGNALLING
(2024)
Article
Cell Biology
Zhihong Zhang, Mingyue Li, Yi Tai, Yue Xing, Hongxiang Zuo, Xuejun Jin, Juan Ma
Summary: ZNF70 plays an important role in colitis-associated colorectal cancer (CAC) by regulating macrophages IL-1 beta secretion to promote HCT116 proliferation. It may serve as a promising target for treating CAC.
CELLULAR SIGNALLING
(2024)
Article
Cell Biology
Zenghong Wu, Gangping Li, Weijun Wang, Kun Zhang, Mengke Fan, Yu Jin, Rong Lin
Summary: This study comprehensively explored the role of immune checkpoints and tumor microenvironment in gastric cancer patients based on genomic data. It constructed an ICIs signature and ICI score to evaluate patient prognosis and heterogeneity.
CELLULAR SIGNALLING
(2024)
Article
Cell Biology
Yantong Wan, Jieshu Zhou, Panpan Zhang, Xuemei Lin, Hao Li
Summary: This study found that Rac1 plays a role in astrocyte activation and attenuates chronic inflammatory pain by blocking the phosphorylation of NLRP3 inflammasome and NF-kappa B.
CELLULAR SIGNALLING
(2024)
Article
Cell Biology
Zhen Wang, Diankun She, Lei Liu, Xianming Hua, Hao Zhu, Lingfeng Yu, Han Wang, Yan Zhu, Gentao Fan, Yicun Wang, Meng Xu, Guangxin Zhou
Summary: Circular RNAs (circRNAs) are non-coding RNAs that play a role in the regulation of various cancers, including osteosarcoma (OS). This study identified circSATB2 as a highly expressed circRNA in OS tissues and cell lines, and demonstrated its involvement in promoting OS proliferation and migration. Mechanistically, circSATB2 was found to regulate the progression of OS by sponging miR-661 and FUS to regulate ZNFX1 mRNA. These findings suggest that circSATB2 could serve as a prognostic marker and therapeutic target for osteosarcoma.
CELLULAR SIGNALLING
(2024)
Article
Cell Biology
Kenichi Ogata, Masafumi Moriyama, Tatsuya Kawado, Hiroki Yoshioka, Aiko Yano, Mayu Matsumura-Kawashima, Seiji Nakamura, Shintaro Kawano
Summary: This study found that extracellular vesicles released by induced pluripotent stem cells can reduce inflammatory cell infiltration, increase saliva volume, and decrease the production of antibodies associated with Sjogren's syndrome in a mouse model. The let-7 family in these vesicles may suppress the expression of TLR4 and NF-kappa B, which leads to the inhibition of pro-inflammatory cytokine production through the MAPK pathway.
CELLULAR SIGNALLING
(2024)
Article
Cell Biology
Mikayla R. Erdelsky, Sarah A. Groves, Charmi Shah, Samantha B. Delios, M. Bibiana Umana, Donald H. Maurice
Summary: Recent evidence suggests that cAMP signaling within the primary cilium plays a crucial role in promoting adipogenic differentiation of 3T3-L1 preadipocytes. In this study, the researchers identified the specific cAMP phosphodiesterases expressed by these cells and found that inhibition of PDE4 promotes FFAR4-mediated adipogenesis. This work could potentially lead to the discovery of more targeted therapeutic approaches for controlling adipogenesis and differentiation of other stem cells.
CELLULAR SIGNALLING
(2024)
Article
Cell Biology
Chun-Hui Liu, Jun-Jie Zhang, Qian-Jin Zhang, Yang Dong, Zhen-Duo Shi, Si-Hao Hong, Hou-Guang He, Wei Wu, Cong-Hui Han, Lin Hao
Summary: Bladder cancer, the most common malignant tumor in the urinary system, is associated with significantly up-regulated expression of P3H4, which is regulated by METTL3 and plays a crucial role in the proliferation, metastasis, and EMT progression of bladder cancer. Targeting this METTL3-P3H4 pathway may serve as a potential therapeutic strategy for bladder cancer.
CELLULAR SIGNALLING
(2024)
