Article
Biochemistry & Molecular Biology
Luqing Song, Tao Wu, Li Zhang, Jin Wan, Zheng Ruan
Summary: The phenolic acid CGA can protect the intestinal barrier by inhibiting ROCK/MLCK signaling pathways and relieving ER stress. Three other substances were also found to stabilize intestinal homeostasis.
Review
Genetics & Heredity
Guangzhao Guan, Richard D. D. Cannon, Dawn E. E. Coates, Li Mei
Summary: The mechanical properties of cells play an important role in tissue homeostasis and various cellular processes. These properties are determined by the cytoskeleton, which is a complex and dynamic network of microfilaments, intermediate filaments, and microtubules. The Rho-kinase/ROCK signaling pathway regulates the architecture of this cytoskeletal network, influencing cell behavior.
Review
Behavioral Sciences
RuoLan Cai, YangYang Wang, ZhenTing Huang, Qian Zou, YinShuang Pu, Changyin Yu, Zhiyou Cai
Summary: ROCK activation can promote the occurrence of Alzheimer's disease and may involve a positive feedback loop between Aβ and ROCK. Additionally, ROCK can also promote the formation of neurofibrillary tangles and exacerbate neuroinflammatory responses.
BEHAVIOURAL BRAIN RESEARCH
(2021)
Article
Pharmacology & Pharmacy
Mohd Hanifa, Mohini Singh, Puneet Kaur Randhawa, Amteshwar Singh Jaggi, Anjana Bali
Summary: Depression is a common mental health disorder, and its cellular and molecular mechanisms are still unclear. Activation of the Rho/ROCK signaling pathway in response to chronic stress leads to neuronal apoptosis and loss of synapses. Inhibition of the Rho/ROCK signaling pathway has shown potential in treating depression by enhancing synaptogenesis and improving behavior. This review highlights the role of the Rho/ROCK signaling pathway in depression and the possibility of using ROCK inhibitors as disease-modifying treatments.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Article
Multidisciplinary Sciences
Mengwei Li, Limei Zhang, Xinyan Liu, Guoqiang Wang, Jian Lu, Jifeng Guo, Hongjie Wang, Jinpeng Xu, Yi Zhang, Na Li, You Zhou
Summary: This study found that low-intensity exercise training can improve the heart function and structure of spontaneously hypertensive rats by inhibiting the RhoA/ROCK signaling pathway, providing further evidence for this protective effect.
SCIENTIFIC REPORTS
(2022)
Article
Behavioral Sciences
Aluri Bhavya Sree, Mohd Hanifa, Anjana Bali
Summary: This study aimed to explore the role of the Rho/ROCK inhibitor fasudil in the treatment of PTSD. The results showed that fasudil can inhibit freezing behavior in response to situational reminders, thus reducing the formation of aversive memory in PTSD mice. Furthermore, fasudil, like the standard drug sertraline, can restore behavioral changes and normalize corticosterone levels.
BEHAVIOURAL BRAIN RESEARCH
(2023)
Article
Cell Biology
Yuliya Filina, Aida Gabdoulkhakova, Albert Rizvanov, Valentina Safronova
Summary: Phagocytes' functional activity and inflammation's development and resolution are determined by formylpeptide receptors (FPRs) signaling. Research has shown that different types of formylpeptide receptors, FPR1 and FPR2, activate distinct patterns of MAP kinase activity, with JNK involved in both Fpr1 and Fpr2 mediated activation of ROS production, while p38 MAPK and ERK are only involved in Fpr1 induced ROS generation.
CELLULAR SIGNALLING
(2022)
Article
Mining & Mineral Processing
Manchao He, Qi Wang
Summary: This study aims to establish a theoretical system and control technologies for rock mass dynamics disasters in deep mines. By classifying and defining different types of dynamic disasters, a compensation control method is proposed, along with three key technologies. The method has been successfully applied in a high-stress deep coal mine with validated results.
INTERNATIONAL JOURNAL OF MINING SCIENCE AND TECHNOLOGY
(2023)
Article
Oncology
Yongtao Yang, Lianyong Li, Huan He, Mengyang Shi, Lanying He, Shuwen Liang, Jun Qi, Weiqing Chen
Summary: Numb regulates cell proliferation, differentiation, migration, and apoptosis through the RhoA/ROCK signaling pathway in colorectal cancer. Its expression is correlated with prognosis and provides a new theoretical molecular basis for understanding the pathogenesis of colorectal cancer.
EXPERIMENTAL CELL RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Qinghua Di, Yansu Li, Shuzhen Li, Aokun Shi, Mengdi Zhou, Huazhong Ren, Yan Yan, Chaoxing He, Jun Wang, Mintao Sun, Xianchang Yu
Summary: This study reveals the signaling mechanisms involved in cold acclimation memory and highlights the essential role of photosynthesis mediated by RBOH-dependent signaling in cold acclimation memory.
Article
Biochemistry & Molecular Biology
Lu Liu, Xuejiao Yang, Jingjing Zhang, Wenlan Jiang, Tianyu Hou, Yao Zong, Haiqing Bai, Kun Yang, Xian Yang
Summary: In this study, it was found that long non-coding RNA small nucleolar RNA host gene 11 (SNHG11) regulates the Wnt/β-catenin signaling pathway in trabecular meshwork (TM) cells through the Rho/ROCK pathway and β-catenin phosphorylation, affecting cell proliferation, migration, apoptosis, and autophagy. These findings suggest that SNHG11 plays a crucial role in the pathogenesis of glaucoma and could be a potential therapeutic target.
Article
Pharmacology & Pharmacy
C. Liu, Y. Li
Summary: Propofol alleviates myocardial ischemia-reperfusion injury (MIRI) in rats by inhibiting the Rho/Rock signaling pathway activity, leading to reduced inflammation, oxidative stress, and myocardial cell apoptosis.
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
(2021)
Article
Engineering, Environmental
Xin Cai, Chuanqing Cheng, Zilong Zhou, Heinz Konietzky, Zhengyang Song, Shaofeng Wang
Summary: Water spraying or injection into rock mass is an effective method for preventing rock bursts in deeply buried hard rock engineering projects. Experimental results indicate that the presence of water significantly weakens the strength and energy storage capacity of rocks, leading to gentler failure patterns and reduced dynamicity. Additionally, a simple mechanical model was established to illustrate the local stress regulation by water penetration.
BULLETIN OF ENGINEERING GEOLOGY AND THE ENVIRONMENT
(2021)
Article
Medicine, Research & Experimental
Xiaorui Li, Xiao Li, Rong Sun, Mei Gao, Hui Wang
Summary: Cadmium exposure enhances the expression of VE-cadherin in vascular endothelial cells via suppression of ROCK signaling.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2022)
Article
Environmental Sciences
Lianxin Li, Jinge Xin, Hesong Wang, Yadong Wang, Weiqi Peng, Ning Sun, Haonan Huang, Yanxi Zhou, Xingmei Liu, Yu Lin, Jing Fang, Bo Jing, Kangcheng Pan, Yan Zeng, Dong Zeng, Xiang Qin, Yang Bai, Xueqin Ni
Summary: Fluoride is a common contaminant that poses challenges to animal and human health. This study investigates the role of the cytoskeleton in fluoride-induced barrier dysfunction and provides potential therapeutic targets for fluoride-induced intestinal injury.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)
Article
Multidisciplinary Sciences
Vladimir Riazanski, Aida G. Gabdoulkhakova, Lin S. Boynton, Raphael R. Eguchi, Ludmila V. Deriy, D. Kyle Hogarth, Nadege Loaec, Nassima Oumata, Herve Galons, Mary E. Brown, Pavel Shevchenko, Alexander J. Gallan, Sang Gune Yoo, Anjaparavanda P. Naren, Mitchel L. Villereal, Daniel W. Beacham, Vytautas P. Bindokas, Lutz Birnbaumer, Laurent Meijer, Deborah J. Nelson
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2015)
Review
Immunology
Laurent Meijer, Deborah J. Nelson, Vladimir Riazanski, Aida G. Gabdoulkhakova, Genevieve Hery-Arnaud, Rozenn Le Berre, Nadege Loaec, Nassima Oumata, Herve Galons, Emmanuel Nowak, Laetitia Gueganton, Guillaume Dorothee, Michaela Prochazkova, Bradford Hall, Ashok B. Kulkarni, Robert D. Gray, Adriano G. Rossi, Veronique Witko-Sarsat, Caroline Norez, Frederic Becq, Denis Ravel, Dominique Mottier, Gilles Rault
JOURNAL OF INNATE IMMUNITY
(2016)
Article
Immunology
Marina I. Arleevskaya, Albina Z. Shafigullina, Yulia V. Filina, Julie Lemerle, Yves Renaudineau
FRONTIERS IN IMMUNOLOGY
(2017)
Article
Medicine, Research & Experimental
M. I. Arleevskaya, A. I. Zabotin, A. G. Gabdulkhakova, O. M. Semenova, A. P. Tsibulkin
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE
(2013)
Article
Immunology
Marina I. Arleevskaya, Shafigullina Albina, Regina V. Larionova, Aida G. Gabdoulkhakova, Julie Lemerle, Yves Renaudineau
FRONTIERS IN IMMUNOLOGY
(2018)
Article
Cell Biology
Yuliya Filina, Aida Gabdoulkhakova, Albert Rizvanov, Valentina Safronova
Summary: Phagocytes' functional activity and inflammation's development and resolution are determined by formylpeptide receptors (FPRs) signaling. Research has shown that different types of formylpeptide receptors, FPR1 and FPR2, activate distinct patterns of MAP kinase activity, with JNK involved in both Fpr1 and Fpr2 mediated activation of ROS production, while p38 MAPK and ERK are only involved in Fpr1 induced ROS generation.
CELLULAR SIGNALLING
(2022)
Article
Biochemistry & Molecular Biology
Yu. V. Filina, I. V. Tikhonova, A. G. Gabdoulkhakova, A. A. Rizvanov, V. G. Safronova
Summary: The study highlights the importance of FPR2 and its signaling pathways in understanding the activity of immune cells, particularly in the phosphorylation and activation of ERK1/2. The research also reveals the significant role of ROS in regulating ERK activity.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
(2022)
Meeting Abstract
Biotechnology & Applied Microbiology
G. R. Tarasova, A. G. Gabdoulkhakova, G. V. Cherepnev, N. V. Kalacheva
HUMAN GENE THERAPY
(2019)
Review
Biochemistry & Molecular Biology
S. S. Skvortsov, A. G. Gabdoulkhakova
BIOCHEMISTRY-MOSCOW
(2017)
Meeting Abstract
Pediatrics
N. W. Keiser, A. Gabdoulkhakova, V Riazanski, D. J. Nelson, J. Engelhardt
PEDIATRIC PULMONOLOGY
(2014)
Meeting Abstract
Oncology
Regina R. Miftakhova, Almaz Akhunzyanov, Julia V. Filina, Svetlana F. Khaiboullina, Albert A. Rizvanov
JOURNAL OF CLINICAL ONCOLOGY
(2017)
Article
Cell Biology
Ke Mi, Lizhong Zeng, Yang Chen, Jingya Ning, Siyuan Zhang, Peilin Zhao, Shuanying Yang
Summary: In this study, the researchers explored the role of DHX38 in NSCLC and its underlying molecular mechanism. They found that DHX38 was overexpressed in NSCLC and patients with high DHX38 expression had poor prognosis. DHX38 promoted cell proliferation, migration, and invasion in NSCLC and activated the MAPK pathway. The researchers also identified G3BP1 as a target protein that interacted with DHX38 and showed that DHX38 regulated the expression of G3BP1. Silencing G3BP1 reversed the effects of DHX38 overexpression on tumor cell proliferation, migration, and invasion and inhibited the MAPK pathway activation.
CELLULAR SIGNALLING
(2024)
Article
Cell Biology
Tiina A. Jokela, Mark A. Dane, Rebecca L. Smith, Kaylyn L. Devlin, Sundus Shalabi, Jennifer C. Lopez, Masaru Miyano, Martha R. Stampfer, James E. Korkola, Joe W. Gray, Laura M. Heiser, Mark A. Labarge
Summary: Microenvironment signals have a significant impact on cell fate and tissue homeostasis. Understanding how different microenvironment factors regulate cellular phenotype has been challenging. In this study, a high-throughput microenvironment microarray was used to identify factors that support the proliferation and maintenance of primary human mammary luminal epithelial cells. Multiple factors that modulate luminal cell number were identified and their effects were confirmed using RNA sequencing and cell-based functional studies. Hepatocyte growth factor (HGF) was found to be robust to individual variation and played a role in expanding luminal cells. Our approach demonstrates the power of high-dimensional cell-based approaches in dissecting microenvironmental signals.
CELLULAR SIGNALLING
(2024)
Article
Cell Biology
Chao He, Yongfeng Ding, Yan Yang, Gang Che, Fei Teng, Haohao Wang, Jing Zhang, Donghui Zhou, Yanyan Chen, Zhan Zhou, Haiyong Wang, Lisong Teng
Summary: This study categorized gastric cancer patients into three stemness subtypes, each demonstrating distinct prognoses, components of tumor microenvironment (TME) infiltration, and varying sensitivity or resistance to treatment. A stemness risk model was constructed to predict treatment response and prognosis.
CELLULAR SIGNALLING
(2024)
Article
Cell Biology
Haile Zhao, Lijuan Feng, Rui Cheng, Man Wu, Xiaozhou Bai, Lifei Fan, Yaping Liu
Summary: miR-29c-3p is overexpressed in benign and malignant ovarian carcinoma and is associated with poor prognosis. Its overexpression modulates tumorigenesis in ovarian cancer cells, including epithelial-mesenchymal transition, proliferation, migration, and invasion, through the regulation of DNMT3A, TET1, and HBP1. miR-29c-3p may serve as a potential biomarker for clinical diagnosis or co-diagnosis of ovarian carcinoma.
CELLULAR SIGNALLING
(2024)
Article
Cell Biology
Haiyan Zhao, Fangfang Bi, Mengyuan Li, Yuhan Diao, Chen Zhang
Summary: This study confirmed the tumor suppressor effect of RNF180 on ovarian cancer, elucidated the mechanism of the molecule network related to RNF180 and IPO4 in ovarian cancer, and identified a new therapeutic target for ovarian cancer.
CELLULAR SIGNALLING
(2024)
Article
Cell Biology
Chu Chen, Guanhua Xu, Jiajia Chen, Chunshuai Wu, Jinlong Zhang, Jiawei Jiang, Hongxiang Hong, Zhiming Cui
Summary: This study investigated the role of transcription factor FoxO1 in facet joint osteoarthritis (FJOA) and found that FoxO1 deletion led to severe osteoarthritic changes. Transcriptome sequencing and bioinformatics analysis identified differentially expressed genes (DEGs) and potential key contributors to FJOA. Additionally, over-expression of certain genes and inhibition of others were shown to counteract the impairments caused by FoxO1 deletion in chondrocyte migration and extracellular matrix synthesis. These findings help unravel the molecular mechanisms underlying FJOA and open up promising therapeutic avenues for its treatment.
CELLULAR SIGNALLING
(2024)
Article
Cell Biology
Wen Deng, Ru Chen, Situ Xiong, Jianqiang Nie, Hailang Yang, Ming Jiang, Bing Hu, Xiaoqiang Liu, Bin Fu
Summary: This study demonstrates that circFSCN1 is upregulated in bladder cancer and associated with cancer-specific survival. CircFSCN1 promotes tumor progression and epithelial-mesenchymal transition in bladder cancer through enhancing MDM2-mediated silencing of p53 by sponging miR-145-5p.
CELLULAR SIGNALLING
(2024)
Article
Cell Biology
Jun Wu, Weibin Hu, Wenhui Yang, Yihao Long, Kaizhao Chen, Fugui Li, Xiaodong Ma, Xun Li
Summary: Cholesterol biosynthesis and metabolism play critical roles in tumor development and microenvironmental conditions. Squalene Epoxidase (SQLE), the second rate-limiting enzyme in cholesterol synthesis, is found to be uniquely expressed in various cancers, and its expression level is closely associated with tumor mutation burden and microsatellite instability. SQLE expression is negatively correlated with immune cell infiltration. Inhibition of SQLE alters the immune response in the tumor microenvironment. Furthermore, protein metabolism and translation are identified as main binding factors with SQLE.
CELLULAR SIGNALLING
(2024)
Article
Cell Biology
Zhihong Zhang, Mingyue Li, Yi Tai, Yue Xing, Hongxiang Zuo, Xuejun Jin, Juan Ma
Summary: ZNF70 plays an important role in colitis-associated colorectal cancer (CAC) by regulating macrophages IL-1 beta secretion to promote HCT116 proliferation. It may serve as a promising target for treating CAC.
CELLULAR SIGNALLING
(2024)
Article
Cell Biology
Zenghong Wu, Gangping Li, Weijun Wang, Kun Zhang, Mengke Fan, Yu Jin, Rong Lin
Summary: This study comprehensively explored the role of immune checkpoints and tumor microenvironment in gastric cancer patients based on genomic data. It constructed an ICIs signature and ICI score to evaluate patient prognosis and heterogeneity.
CELLULAR SIGNALLING
(2024)
Article
Cell Biology
Yantong Wan, Jieshu Zhou, Panpan Zhang, Xuemei Lin, Hao Li
Summary: This study found that Rac1 plays a role in astrocyte activation and attenuates chronic inflammatory pain by blocking the phosphorylation of NLRP3 inflammasome and NF-kappa B.
CELLULAR SIGNALLING
(2024)
Article
Cell Biology
Zhen Wang, Diankun She, Lei Liu, Xianming Hua, Hao Zhu, Lingfeng Yu, Han Wang, Yan Zhu, Gentao Fan, Yicun Wang, Meng Xu, Guangxin Zhou
Summary: Circular RNAs (circRNAs) are non-coding RNAs that play a role in the regulation of various cancers, including osteosarcoma (OS). This study identified circSATB2 as a highly expressed circRNA in OS tissues and cell lines, and demonstrated its involvement in promoting OS proliferation and migration. Mechanistically, circSATB2 was found to regulate the progression of OS by sponging miR-661 and FUS to regulate ZNFX1 mRNA. These findings suggest that circSATB2 could serve as a prognostic marker and therapeutic target for osteosarcoma.
CELLULAR SIGNALLING
(2024)
Article
Cell Biology
Kenichi Ogata, Masafumi Moriyama, Tatsuya Kawado, Hiroki Yoshioka, Aiko Yano, Mayu Matsumura-Kawashima, Seiji Nakamura, Shintaro Kawano
Summary: This study found that extracellular vesicles released by induced pluripotent stem cells can reduce inflammatory cell infiltration, increase saliva volume, and decrease the production of antibodies associated with Sjogren's syndrome in a mouse model. The let-7 family in these vesicles may suppress the expression of TLR4 and NF-kappa B, which leads to the inhibition of pro-inflammatory cytokine production through the MAPK pathway.
CELLULAR SIGNALLING
(2024)
Article
Cell Biology
Mikayla R. Erdelsky, Sarah A. Groves, Charmi Shah, Samantha B. Delios, M. Bibiana Umana, Donald H. Maurice
Summary: Recent evidence suggests that cAMP signaling within the primary cilium plays a crucial role in promoting adipogenic differentiation of 3T3-L1 preadipocytes. In this study, the researchers identified the specific cAMP phosphodiesterases expressed by these cells and found that inhibition of PDE4 promotes FFAR4-mediated adipogenesis. This work could potentially lead to the discovery of more targeted therapeutic approaches for controlling adipogenesis and differentiation of other stem cells.
CELLULAR SIGNALLING
(2024)
Article
Cell Biology
Chun-Hui Liu, Jun-Jie Zhang, Qian-Jin Zhang, Yang Dong, Zhen-Duo Shi, Si-Hao Hong, Hou-Guang He, Wei Wu, Cong-Hui Han, Lin Hao
Summary: Bladder cancer, the most common malignant tumor in the urinary system, is associated with significantly up-regulated expression of P3H4, which is regulated by METTL3 and plays a crucial role in the proliferation, metastasis, and EMT progression of bladder cancer. Targeting this METTL3-P3H4 pathway may serve as a potential therapeutic strategy for bladder cancer.
CELLULAR SIGNALLING
(2024)