Article
Medicine, Research & Experimental
Chuanlin Zhang, MeiJuan Xiao, Nan Cao, Lei Zhang, Qiong He, Jianing Wang, Rui Wang, Lu Wang, Lei Zhao, Junqiang Si
Summary: The study aimed to investigate the mechanical and electrophysiological effects of emodin on BK channels in rat interlobar renal artery smooth muscle cells (IRASMCs). The results showed that emodin induced vasorelaxation and enhanced outward currents in a concentration-dependent manner. These effects were mediated through the activation of BK channels.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Multidisciplinary Sciences
Wataru Okumura, Takuma Kozono, Hiroyuki Sato, Hitomi Matsui, Tsubasa Takagi, Takashi Tonozuka, Atsushi Nishikawa
Summary: This study demonstrates that Jaw1 increases calcium influx by changing the oscillation pattern and enhancing calcium release activity of ITPR subtypes upon GPCR stimulation. The findings provide insights into the relationship between heterogeneous calcium dynamics and specific ITPR and Jaw1 expression patterns.
SCIENTIFIC REPORTS
(2022)
Article
Chemistry, Applied
Pengzhan Liu, Zhao Yin, Min Chen, Caihuan Huang, Zhihui Wu, Junqing Huang, Shiyi Ou, Jie Zheng
Summary: The study found that adducts formed by the combination of quercetin and MGO in food can exhibit higher cytotoxicity than their precursors, inducing apoptosis and mitochondrial dysfunction through various pathways. Additionally, these adducts were shown to induce neurodegeneration apoptosis through mitochondria-mediated signaling pathways.
Article
Biochemistry & Molecular Biology
Jong-Heon Kim, Hyun-Gug Jung, Ajung Kim, Hyun Soo Shim, Seung Jae Hyeon, Young-Sun Lee, Jin Han, Jong Hoon Jung, Jaekwang Lee, Hoon Ryu, Jae-Yong Park, Eun Mi Hwang, Kyoungho Suk
Summary: The study demonstrates the crucial role of the interaction between the neuronal protein hevin and the vesicular protein calcyon in synaptic reorganization after brain injury. The regulated expression and interaction between hevin and calcyon were confirmed in mouse models of traumatic brain injury and patients with chronic traumatic encephalopathy, providing direct evidence for their causal relationship in synaptic reorganization. Neuron-glia interactions between hevin and calcyon can be utilized to modulate synaptic reorganization in various neurological conditions.
CELL DEATH AND DIFFERENTIATION
(2021)
Article
Biochemistry & Molecular Biology
Robin Irvine
Summary: The text shares some personal memories from a significant adventure I had with Mike.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
(2021)
Article
Endocrinology & Metabolism
Patrick A. Fletcher, Ben Thompson, Chante Liu, Richard Bertram, Leslie S. Satin, Arthur S. Sherman
Summary: The standard model for Ca2+ oscillations in insulin-secreting pancreatic 13 cells relies on voltage-activated Ca2+ channels for Ca2+ entry. These channels work together with ATP-dependent K+ channels to regulate the secretion of insulin in response to the metabolic state of the cells. However, an alternative model proposes that calcium-induced calcium release from the endoplasmic reticulum is the key driver of islet oscillations. This study shows that the alternative model is incompatible with established experimental data and that the standard model provides a better explanation for the new observations.
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
(2023)
Review
Biochemistry & Molecular Biology
Roberto Docampo, Guozhong Huang
Summary: Trypanosoma cruzi and the T. brucei group of parasites are neglected diseases affecting millions of people globally. These microorganisms have complex life cycles involving insect vectors and mammalian hosts, and possess unique signaling pathways and receptor adaptations that differentiate them from their mammalian counterparts.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Luisa Galla, Nicola Vajente, Diana Pendin, Paola Pizzo, Tullio Pozzan, Elisa Greotti
Summary: Calcium (Ca2+) plays a crucial role in controlling both physiological and pathological cellular processes, with a new nuclear-targeted calcium probe developed for more accurate quantitative measurements. This study successfully demonstrated similar levels of calcium in cytoplasm and nucleoplasm in resting and stimulated cells, highlighting the importance of localized calcium monitoring for cell function.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Physiology
Adan Dagnino-Acosta, Agustin Guerrero-Hernandez
Summary: PKC inhibitors stimulate Ca2+ release from internal stores by increasing SR Ca2+ leak mediated by translocon activation. This increased leak does not deplete the Ca2+ store, but rather compensates by increasing SERCA pump activity, leading to a new steady-state level. This change also results in increased activity of high conductance, Ca2+-sensitive potassium channels.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Neurosciences
Pamela J. Urrutia, Christian Gonzalez-Billault
Summary: Neuronal polarization is a complex process regulated by various intrinsic and extrinsic mechanisms. The review summarizes the role of second messengers, such as Ca21, IP3, cAMP, cGMP, and hydrogen peroxide, in controlling different aspects of neuronal polarization. It also highlights the remaining challenges in fully understanding the cellular processes involved in axodendritic polarization.
JOURNAL OF NEUROSCIENCE
(2023)
Review
Neurosciences
Mark W. Sherwood, Misa Arizono, Aude Panatier, Katsuhiko Mikoshiba, Stephane H. R. Oliet
Summary: Astrocytes modulate neuronal functions by releasing gliotransmitters in response to ongoing neuronal activities, with IP3R-Ca2+ signaling playing a crucial role at the network and behavioral level. Multiple astrocytic IP3R isoforms exist, each with unique physiological roles, enriching calcium dynamics and influencing astrocyte-neuron communication.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2021)
Review
Endocrinology & Metabolism
Candela R. Gonzalez, Betina Gonzalez
Summary: Spermatogenesis is regulated by unique epigenetic programs, which can be influenced by paternal lifestyle stressors and affect the development and behavior of offspring. Understanding the impact of environmental perturbations on sperm epigenetics is crucial for unraveling the mechanisms of stress transmission between generations.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Environmental Sciences
Huiling Guo, Bingyan Huang, Ting Cui, Xuesheng Chu, Wenjing Pu, Gang Huang, Chenghong Xing, Caiying Zhang
Summary: Cadmium exposure in duck renal tubular cells leads to calcium overload and autophagy through the PLC-IP3-IP3R pathway.
ENVIRONMENTAL TOXICOLOGY
(2022)
Article
Developmental Biology
Rishav Mitra, Shlesha Richhariya, Siddharth Jayakumar, Dimple Notani, Gaiti Hasan
Summary: In fruit fly larvae, the IP3/Ca2+ signals in specific interneurons drive the expression of Set2 gene, essential for pupariation in the absence of dietary protein. This signal-controlled expression of Set2 upregulates key Ca2+-signaling genes through a positive-feedback loop, regulating gene expression for the transition from larval to pupal stages.
Review
Materials Science, Ceramics
Lamiya Noor, Atolo Tuinukuafe, Jason H. Ideker
Summary: Ettringite-accelerated binders, composed of CAC-PC-C$ and CSA-PC-C$, are widely used for indoor applications due to their rapid setting, early strength gain, and shrinkage compensation properties. However, their stability in outdoor exposure conditions remains uncertain. This critical review aims to analyze current research and identify knowledge gaps in order to determine factors that promote or deter ettringite stability.
JOURNAL OF THE AMERICAN CERAMIC SOCIETY
(2023)
Article
Cell Biology
Ke Mi, Lizhong Zeng, Yang Chen, Jingya Ning, Siyuan Zhang, Peilin Zhao, Shuanying Yang
Summary: In this study, the researchers explored the role of DHX38 in NSCLC and its underlying molecular mechanism. They found that DHX38 was overexpressed in NSCLC and patients with high DHX38 expression had poor prognosis. DHX38 promoted cell proliferation, migration, and invasion in NSCLC and activated the MAPK pathway. The researchers also identified G3BP1 as a target protein that interacted with DHX38 and showed that DHX38 regulated the expression of G3BP1. Silencing G3BP1 reversed the effects of DHX38 overexpression on tumor cell proliferation, migration, and invasion and inhibited the MAPK pathway activation.
CELLULAR SIGNALLING
(2024)
Article
Cell Biology
Tiina A. Jokela, Mark A. Dane, Rebecca L. Smith, Kaylyn L. Devlin, Sundus Shalabi, Jennifer C. Lopez, Masaru Miyano, Martha R. Stampfer, James E. Korkola, Joe W. Gray, Laura M. Heiser, Mark A. Labarge
Summary: Microenvironment signals have a significant impact on cell fate and tissue homeostasis. Understanding how different microenvironment factors regulate cellular phenotype has been challenging. In this study, a high-throughput microenvironment microarray was used to identify factors that support the proliferation and maintenance of primary human mammary luminal epithelial cells. Multiple factors that modulate luminal cell number were identified and their effects were confirmed using RNA sequencing and cell-based functional studies. Hepatocyte growth factor (HGF) was found to be robust to individual variation and played a role in expanding luminal cells. Our approach demonstrates the power of high-dimensional cell-based approaches in dissecting microenvironmental signals.
CELLULAR SIGNALLING
(2024)
Article
Cell Biology
Chao He, Yongfeng Ding, Yan Yang, Gang Che, Fei Teng, Haohao Wang, Jing Zhang, Donghui Zhou, Yanyan Chen, Zhan Zhou, Haiyong Wang, Lisong Teng
Summary: This study categorized gastric cancer patients into three stemness subtypes, each demonstrating distinct prognoses, components of tumor microenvironment (TME) infiltration, and varying sensitivity or resistance to treatment. A stemness risk model was constructed to predict treatment response and prognosis.
CELLULAR SIGNALLING
(2024)
Article
Cell Biology
Haile Zhao, Lijuan Feng, Rui Cheng, Man Wu, Xiaozhou Bai, Lifei Fan, Yaping Liu
Summary: miR-29c-3p is overexpressed in benign and malignant ovarian carcinoma and is associated with poor prognosis. Its overexpression modulates tumorigenesis in ovarian cancer cells, including epithelial-mesenchymal transition, proliferation, migration, and invasion, through the regulation of DNMT3A, TET1, and HBP1. miR-29c-3p may serve as a potential biomarker for clinical diagnosis or co-diagnosis of ovarian carcinoma.
CELLULAR SIGNALLING
(2024)
Article
Cell Biology
Haiyan Zhao, Fangfang Bi, Mengyuan Li, Yuhan Diao, Chen Zhang
Summary: This study confirmed the tumor suppressor effect of RNF180 on ovarian cancer, elucidated the mechanism of the molecule network related to RNF180 and IPO4 in ovarian cancer, and identified a new therapeutic target for ovarian cancer.
CELLULAR SIGNALLING
(2024)
Article
Cell Biology
Chu Chen, Guanhua Xu, Jiajia Chen, Chunshuai Wu, Jinlong Zhang, Jiawei Jiang, Hongxiang Hong, Zhiming Cui
Summary: This study investigated the role of transcription factor FoxO1 in facet joint osteoarthritis (FJOA) and found that FoxO1 deletion led to severe osteoarthritic changes. Transcriptome sequencing and bioinformatics analysis identified differentially expressed genes (DEGs) and potential key contributors to FJOA. Additionally, over-expression of certain genes and inhibition of others were shown to counteract the impairments caused by FoxO1 deletion in chondrocyte migration and extracellular matrix synthesis. These findings help unravel the molecular mechanisms underlying FJOA and open up promising therapeutic avenues for its treatment.
CELLULAR SIGNALLING
(2024)
Article
Cell Biology
Wen Deng, Ru Chen, Situ Xiong, Jianqiang Nie, Hailang Yang, Ming Jiang, Bing Hu, Xiaoqiang Liu, Bin Fu
Summary: This study demonstrates that circFSCN1 is upregulated in bladder cancer and associated with cancer-specific survival. CircFSCN1 promotes tumor progression and epithelial-mesenchymal transition in bladder cancer through enhancing MDM2-mediated silencing of p53 by sponging miR-145-5p.
CELLULAR SIGNALLING
(2024)
Article
Cell Biology
Jun Wu, Weibin Hu, Wenhui Yang, Yihao Long, Kaizhao Chen, Fugui Li, Xiaodong Ma, Xun Li
Summary: Cholesterol biosynthesis and metabolism play critical roles in tumor development and microenvironmental conditions. Squalene Epoxidase (SQLE), the second rate-limiting enzyme in cholesterol synthesis, is found to be uniquely expressed in various cancers, and its expression level is closely associated with tumor mutation burden and microsatellite instability. SQLE expression is negatively correlated with immune cell infiltration. Inhibition of SQLE alters the immune response in the tumor microenvironment. Furthermore, protein metabolism and translation are identified as main binding factors with SQLE.
CELLULAR SIGNALLING
(2024)
Article
Cell Biology
Zhihong Zhang, Mingyue Li, Yi Tai, Yue Xing, Hongxiang Zuo, Xuejun Jin, Juan Ma
Summary: ZNF70 plays an important role in colitis-associated colorectal cancer (CAC) by regulating macrophages IL-1 beta secretion to promote HCT116 proliferation. It may serve as a promising target for treating CAC.
CELLULAR SIGNALLING
(2024)
Article
Cell Biology
Zenghong Wu, Gangping Li, Weijun Wang, Kun Zhang, Mengke Fan, Yu Jin, Rong Lin
Summary: This study comprehensively explored the role of immune checkpoints and tumor microenvironment in gastric cancer patients based on genomic data. It constructed an ICIs signature and ICI score to evaluate patient prognosis and heterogeneity.
CELLULAR SIGNALLING
(2024)
Article
Cell Biology
Yantong Wan, Jieshu Zhou, Panpan Zhang, Xuemei Lin, Hao Li
Summary: This study found that Rac1 plays a role in astrocyte activation and attenuates chronic inflammatory pain by blocking the phosphorylation of NLRP3 inflammasome and NF-kappa B.
CELLULAR SIGNALLING
(2024)
Article
Cell Biology
Zhen Wang, Diankun She, Lei Liu, Xianming Hua, Hao Zhu, Lingfeng Yu, Han Wang, Yan Zhu, Gentao Fan, Yicun Wang, Meng Xu, Guangxin Zhou
Summary: Circular RNAs (circRNAs) are non-coding RNAs that play a role in the regulation of various cancers, including osteosarcoma (OS). This study identified circSATB2 as a highly expressed circRNA in OS tissues and cell lines, and demonstrated its involvement in promoting OS proliferation and migration. Mechanistically, circSATB2 was found to regulate the progression of OS by sponging miR-661 and FUS to regulate ZNFX1 mRNA. These findings suggest that circSATB2 could serve as a prognostic marker and therapeutic target for osteosarcoma.
CELLULAR SIGNALLING
(2024)
Article
Cell Biology
Kenichi Ogata, Masafumi Moriyama, Tatsuya Kawado, Hiroki Yoshioka, Aiko Yano, Mayu Matsumura-Kawashima, Seiji Nakamura, Shintaro Kawano
Summary: This study found that extracellular vesicles released by induced pluripotent stem cells can reduce inflammatory cell infiltration, increase saliva volume, and decrease the production of antibodies associated with Sjogren's syndrome in a mouse model. The let-7 family in these vesicles may suppress the expression of TLR4 and NF-kappa B, which leads to the inhibition of pro-inflammatory cytokine production through the MAPK pathway.
CELLULAR SIGNALLING
(2024)
Article
Cell Biology
Mikayla R. Erdelsky, Sarah A. Groves, Charmi Shah, Samantha B. Delios, M. Bibiana Umana, Donald H. Maurice
Summary: Recent evidence suggests that cAMP signaling within the primary cilium plays a crucial role in promoting adipogenic differentiation of 3T3-L1 preadipocytes. In this study, the researchers identified the specific cAMP phosphodiesterases expressed by these cells and found that inhibition of PDE4 promotes FFAR4-mediated adipogenesis. This work could potentially lead to the discovery of more targeted therapeutic approaches for controlling adipogenesis and differentiation of other stem cells.
CELLULAR SIGNALLING
(2024)
Article
Cell Biology
Chun-Hui Liu, Jun-Jie Zhang, Qian-Jin Zhang, Yang Dong, Zhen-Duo Shi, Si-Hao Hong, Hou-Guang He, Wei Wu, Cong-Hui Han, Lin Hao
Summary: Bladder cancer, the most common malignant tumor in the urinary system, is associated with significantly up-regulated expression of P3H4, which is regulated by METTL3 and plays a crucial role in the proliferation, metastasis, and EMT progression of bladder cancer. Targeting this METTL3-P3H4 pathway may serve as a potential therapeutic strategy for bladder cancer.
CELLULAR SIGNALLING
(2024)
