Article
Oncology
Paula Gonzalez-Lopez, Marta Alvarez-Villarreal, Ruben Ruiz-Simon, Andrea R. Lopez-Pastor, Melina Vega de Ceniga, Leticia Esparza, Jose L. Martin-Ventura, Oscar Escribano, Almudena Gomez-Hernandez
Summary: MicroRNAs miR-15a-5p and miR-199a-3p are significantly decreased in aortic and carotid samples from atherosclerosis patients and mice. Overexpression of these miRNAs can reduce inflammation and progression of atherosclerosis. MiR-15a-5p may serve as a novel diagnostic biomarker for advanced atherosclerosis.
CLINICAL AND TRANSLATIONAL MEDICINE
(2023)
Article
Chemistry, Multidisciplinary
Zhu-Qi Huang, Wu Luo, Wei-Xin Li, Pan Chen, Zhe Wang, Rui-Jie Chen, Yi Wang, Wei-Jian Huang, Guang Liang
Summary: Costunolide (CTD) has anti-atherosclerotic effects by reducing inflammatory responses and oxLDL uptake, and its mechanism involves the inhibition of NF-kappa B signaling pathway through covalent binding to IKKβ.
ACTA PHARMACOLOGICA SINICA
(2023)
Article
Biotechnology & Applied Microbiology
Hui Kang, Hui Yu, Jingxiu Fan, Ge Cao
Summary: Rotigotine shows beneficial effects on Ox-LDL-induced endothelial cell damage, including inhibition of cholesterol accumulation, improvement of monocyte adhesion, reduction of oxidative stress and inflammation. Its potential therapeutic role in cardiovascular diseases is highlighted through these effects.
Article
Cell Biology
Jun Ma, Xiangyu Yang, Xiaoping Chen
Summary: Our study reveals that ox-LDL stimulation enhances C/EBP beta-regulated transcription in THP-1 cells, leading to increased release of IL-18, IL-1 beta, and IL-6 through direct gene binding. Knockdown of C/EBP beta inhibits the secretion of CXCL8, TNFSF11, CSF3, and CCL2 induced by ox-LDL in THP-1 cells.
INFLAMMATION RESEARCH
(2021)
Article
Integrative & Complementary Medicine
Gyorgyi Horvath, Adrienn Horvath, Greta Reichert, Andrea Boszormenyi, Katalin Sipos, Edina Pandur
Summary: Essential oils from thyme are effective in preventing neuroinflammation and related neurodegeneration, with different chemotypes and main compounds showing varying degrees of anti-inflammatory effects. Pretreatment with essential oils can significantly reduce the secretion of inflammatory cytokines, while main compounds exhibit strong inhibitory effects on specific cell signalling components related to proinflammatory cytokine expression.
BMC COMPLEMENTARY MEDICINE AND THERAPIES
(2021)
Article
Cell Biology
Chao Zhu, Wei Chen, Haiming Cui, Zhigang Huang, Ru Ding, Na Li, Qinqin Wang, Feng Wu, Yanmin Zhao, Xiaoliang Cong
Summary: Oxidized low-density lipoprotein (ox-LDL) promotes the expression of TRIM64, enhancing the activation of NLRP3 inflammasomes and the expression of downstream molecules. TRIM64 interacts with I kappa B alpha, promoting I kappa B alpha ubiquitination to activate the NF-kappa B signaling pathway. TRIM64 and NF-kappa B form a positive feedback mechanism in the development of atherosclerosis.
CELL BIOLOGY AND TOXICOLOGY
(2023)
Article
Medicine, Research & Experimental
Ya-Xian Liu, Xi-Wang Liu, Ya-Jun Yang, Shi-Hong Li, Li-Xia Bai, Wen-Bo Ge, Xiao Xu, Cun Li, Jian-Yong Li, Zhe Qin
Summary: AEE can reduce cholesterol levels, inhibit plaque formation, and prevent atherosclerosis by promoting cholesterol efflux and reducing inflammation factors.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Environmental Sciences
Jing Zhang, Xiaojing Yang, Yushan Yang, Min Xiong, Ning Li, Lan Ma, Jiaqi Tian, Haoyu Yin, Lin Zhang, Yulan Jin
Summary: Long-term exposure to respirable silica particles can cause pulmonary inflammation and fibrosis, primarily promoted by cytokines released from alveolar macrophages. This study explored the mechanism of IL-1 beta biosynthesis and release from the perspective of nuclear factor kappa B (NE-kappa B). The results showed that silica nanoparticles (SiNPs) were internalized by macrophages, leading to cell damage. SiNPs exposure enhanced the expression of IL-1 beta and NE-kappa B, but this effect could be suppressed by BAY 11-7082, an NF-kappa B specific inhibitor. Animal experiments confirmed that silica exposure caused pulmonary inflammation and fibrosis, along with pathological changes in lung tissue.
ENVIRONMENTAL TOXICOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Denuja Karunakaran, My-Anh Nguyen, Michele Geoffrion, Dianne Vreeken, Zachary Lister, Henry S. Cheng, Nicola Otte, Patricia Essebier, Hailey Wyatt, Joshua W. Kandiah, Richard Jung, Francis J. Alenghat, Ana Mompeon, Richard Lee, Calvin Pan, Emma Gordon, Adil Rasheed, Aldons J. Lusis, Peter Liu, Ljubica Perisic Matic, Ulf Hedin, Jason E. Fish, Liang Guo, Frank Kolodgie, Renu Virmani, Janine M. van Gils, Katey J. Rayner
Summary: The study indicates that RIPK1 plays a central role in driving inflammation in atherosclerosis by activating the NF-kappa B pathway and promoting the release of inflammatory cytokines. Knockdown of RIPK1 reduces inflammatory cell activation and protects against the progression of atherosclerosis. These findings suggest RIPK1 as a potential therapeutic target to reduce residual inflammation in patients at high risk of coronary artery disease.
Article
Cell Biology
Xuan Li, Wanlu Xie, Qiong Pan, Xiaoxun Zhang, Liangjun Zhang, Nan Zhao, Qiaoling Xie, Jingjing Ding, Jin Chai
Summary: This study found that both SEMA7A mutation and overexpression can activate the NF-κB p50/p65 pathway through integrin beta 1 and play a crucial role in inflammatory responses.
CELL COMMUNICATION AND SIGNALING
(2023)
Article
Cell Biology
Rusan Catar, Lei Chen, Hongfan Zhao, Dashan Wu, Julian Kamhieh-Milz, Christian Luecht, Daniel Zickler, Alexander W. Krug, Christian G. Ziegler, Henning Morawietz, Janusz Witowski
Summary: Atherosclerotic artery disease is a major global cause of death and healthcare burden. This study analyzes the effects of native LDL and oxidized LDL on the expression of their receptors in endothelial cells. The results show that native LDL mainly signals through LDLR receptors, while oxidized LDL mainly signals through LOX-1 receptors, and both engage different signaling pathways involving ERK1/2, p38, AP-1, and NF-kappa B transcription factors.
Article
Pharmacology & Pharmacy
Lipeng Tang, Tong Li, Bowen Zhang, Zihao Zhang, Xiaoyi Sun, Ying Zhu, Bing Feng, Zuqing Su, Laijun Yang, Hongxia Li, Huazhen Liu, Yuchao Chen, Zhenhua Dai, Xirun Zheng, Mingxian Li, Chutian Li, Jie Zhao, Xinmin Qiu, Shuyan Ye, Han Liu, Guangjuan Zheng, Ben Li, Chuanjian Lu
Summary: Punicalagin (PUN) shows therapeutic potential for psoriasis by inhibiting inflammatory response and cell signaling pathways.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Jiashan Li, Jiaru Liu, Ying Yu, Yuee Liu, Xiuru Guan
Summary: The NF-kappa B pathway plays a crucial role in the development of atherosclerosis by mediating cell pyroptosis and cholesterol efflux.
MOLECULAR BIOLOGY REPORTS
(2022)
Article
Plant Sciences
Yixi Yang, Yujin Zhang, Xun Chen, Zhou Su, Yu Deng, Qi Zhao
Summary: This study explored the bioactivity of Khasianine and showed that it possessed highly anti-inflammatory bioactivity which rapidly alleviated psoriasis-like mice skin inflammation.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Medicine, Research & Experimental
Weiwei Lu, Zhaojie Meng, Rebecca Hernandez, Changcheng Zhou
Summary: The study demonstrates the crucial role of IKK-beta in regulating fibroblast functions and cardiac remodeling, showing that fibroblast-specific IKK-beta deficiency can protect mice from hypertension-induced adverse cardiac remodeling, including hypertrophy, fibrosis, and macrophage infiltration. Ablation of fibroblast IKK-beta inhibits proinflammatory and profibrogenic responses, leading to improved cardiac remodeling and function.
Review
Biochemistry & Molecular Biology
Jun Ma, Ken Chen
Summary: Physical exercise is effective for improving human health, with irisin as a muscle factor secreted after exercise that can protect multiple organs with different mechanisms. The role of irisin in multiorgan protection is gradually being revealed through research on its underlying molecular mechanisms.
MOLECULAR BIOLOGY REPORTS
(2021)
Article
Cardiac & Cardiovascular Systems
Chunyan He, Chuan Liu, Shiyong Yu, Jie Yang, Xiaohan Ding, Shizhu Bian, Jihang Zhang, Jie Yu, Hu Tan, Jun Jin, Mingdong Hu, Guoming Wu, Chen Zhang, Rongsheng Rao, Lan Huang
Summary: Short-term exposure to high altitude was found to impair bi-atrial function in healthy men, with a more pronounced effect observed in the right atrium.
INTERNATIONAL JOURNAL OF CARDIOVASCULAR IMAGING
(2021)
Article
Multidisciplinary Sciences
Chunyan He, Hedong Xiang, Chuan Liu, Shiyong Yu, Jie Yang, Xiaohan Ding, Shizhu Bian, Jihang Zhang, Hu Tan, Jun Jin, Mingdong Hu, Chen Zhang, Rongsheng Rao, Lan Huang
Summary: The study showed that high altitude exposure leads to right atrial mechanical dyssynchrony in healthy young men, possibly due to increased pulmonary arterial pressure. Subjects with higher right atrial dyssynchrony exhibited worse right atrial contractile function and right ventricular performance.
Article
Physiology
Ran Cheng, Chuan Liu, Jie Yang, Yuanqi Yang, Renzheng Chen, Xiaohan Ding, Xubin Gao, Jingbin Ke, Fangzhengyuan Yuan, Chunyan He, Yang Shen, Limin Zhang, Ping Li, Hu Tan, Lan Huang
Summary: The study found that male COVID-19 patients have higher incidence of myocardial injury compared to females, and men exhibit more severe inflammation and coagulation disorders. Risk factors for myocardial injury in males include hypertension, coronary artery disease, leucocyte counts, hs-CRP, and D-dimer. The correlations of hs-CRP and D-dimer with hs-cTnI and BNP were stronger in men.
FRONTIERS IN PHYSIOLOGY
(2021)
Review
Cardiac & Cardiovascular Systems
Jun Ma, Xiaoping Chen
Summary: Anti-inflammatory treatments for coronary atherosclerotic heart disease have shown promising results with interleukin 1 beta antibodies, interleukin 6 receptor antagonists, and colchicine. However, there are still questions that need to be addressed.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Medicine, Research & Experimental
Renzheng Chen, Yong Wang, Jie Yang, Xiaofeng Cheng, Jiang Wang, Lan Huang
Summary: This case report describes the clinical outcome of using the anticoagulant dabigatran to treat left ventricular thrombosis in a rare case of recurrent pheochromocytoma. The patient had previously undergone surgery twice to remove the tumor, which had recurred for the second time. Additionally, there was resolution of the thrombus in the left ventricle after anticoagulation therapy.
JOURNAL OF INTERNATIONAL MEDICAL RESEARCH
(2021)
Article
Physiology
Renzheng Chen, Jie Yang, Chuan Liu, Mengjia Sun, Jingbin Ke, Yuanqi Yang, Yang Shen, Fangzhengyuan Yuan, Chunyan He, Ran Cheng, Hailin Lv, Hu Tan, Xubin Gao, Jihang Zhang, Lan Huang
Summary: The study shows that females are more likely to suffer from AMS than males, and elevated morning blood pressure is closely associated with AMS occurrence. Headache severity is closely correlated with the severity of elevated morning blood pressure.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Physiology
Fangzhengyuan Yuan, Chuan Liu, Shiyong Yu, Shizhu Bian, Jie Yang, Xiaohan Ding, Jihang Zhang, Hu Tan, Jingbin Ke, Yuanqi Yang, Chunyan He, Chen Zhang, Rongsheng Rao, Zhaojun Liu, Jun Yang, Lan Huang
Summary: Exposure to high altitude can lead to the formation of RVOT notch in some subjects, which is associated with impaired RV function. Subjects with RVOT notch showed significantly increased SPAP, mPAP, PVR, and decreased SpO(2), RV GLS, TAPSE/SPAP compared to those without RVOT notch.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Engineering, Mechanical
Xiang Liu, Chunqi Wang, Yumin Zhang, Lixi Huang
Summary: An investigation into a smart micro-perforated panel aims to enhance the sound absorption performance of MPP absorbers at low frequencies, utilizing a combination of mechanical damping, electrical shunt damping, and Helmholtz resonance. Different multimode shunt design methods are explored to intensify panel vibration and improve sound absorption, with absorption peaks induced by electromechanical coupling found at frequencies lower than the MPP's Helmholtz resonance frequency.
INTERNATIONAL JOURNAL OF MECHANICAL SCIENCES
(2021)
Article
Cell Biology
Jun Ma, Xiangyu Yang, Xiaoping Chen
Summary: Our study reveals that ox-LDL stimulation enhances C/EBP beta-regulated transcription in THP-1 cells, leading to increased release of IL-18, IL-1 beta, and IL-6 through direct gene binding. Knockdown of C/EBP beta inhibits the secretion of CXCL8, TNFSF11, CSF3, and CCL2 induced by ox-LDL in THP-1 cells.
INFLAMMATION RESEARCH
(2021)
Review
Endocrinology & Metabolism
Ping Wang, Jun Ma, Ru Zhang
Summary: This review discusses the role and mechanisms of inflammasomes in atherosclerotic disease and explores the new approach of targeting inflammasomes to reduce residual inflammation for the treatment of atherosclerosis.
ENDOCRINE METABOLIC & IMMUNE DISORDERS-DRUG TARGETS
(2022)
Review
Cardiac & Cardiovascular Systems
Jun Ma, Xiaoping Chen
Summary: Hypertension is a significant risk factor for cardiovascular and cerebrovascular diseases and the leading cause of premature death worldwide. The pathogenesis of essential hypertension, especially, is complex and requires further studies. Recent findings in the field have the potential to provide important theoretical bases and therapeutic tools to overcome the existing limitations of essential hypertension.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Pharmacology & Pharmacy
Ping Wang, Guihua Liao, Xi Wu, Rentao Yu, Jun Ma
Summary: Brachial-ankle pulse wave velocity (baPWV) is a clinical indicator of aortic stiffness and a risk predictor of cardiovascular disease. In this study, we examined the correlation of baPWV with body fat-related indicators and assessed whether baPWV can predict these indicators.
CLINICAL AND EXPERIMENTAL HYPERTENSION
(2023)
Review
Biochemistry & Molecular Biology
Jun Ma, Yanan Li, Xiangyu Yang, Kai Liu, Xin Zhang, Xianghao Zuo, Runyu Ye, Ziqiong Wang, Rufeng Shi, Qingtao Meng, Xiaoping Chen
Summary: Hypertension is a complex condition that affects vascular function and is difficult to cure due to its complex mechanisms involving multiple interactive factors. This article comprehensively reviews the signaling pathways involved in vascular function regulation and hypertension progression, including calcium pathway, NO-NOsGC-cGMP pathway, various vascular remodeling pathways, and important upstream pathways. The article also discusses the treatment methods targeting vascular function regulation and the possibility of applying these signaling pathways to clinical work.
SIGNAL TRANSDUCTION AND TARGETED THERAPY
(2023)
Article
Biophysics
Fangzhengyuan Yuan, Zhexue Qin, Chuan Liu, Shiyong Yu, Jie Yang, Jun Jin, Shizhu Bian, Xubin Gao, Jihang Zhang, Chen Zhang, Mingdong Hu, Jingbin Ke, Yuanqi Yang, Jingdu Tian, Chunyan He, Wenzhu Gu, Chun Li, Rongsheng Rao, Lan Huang
Summary: The study suggests that high-altitude exposure may lead to right ventricular outflow tract notching, which is associated with the occurrence of acute mountain sickness. RVOT notching is related to the incidence of AMS, with individuals experiencing notching more likely to have symptoms like headache and fatigue.
HIGH ALTITUDE MEDICINE & BIOLOGY
(2021)
