Anti-inflammatory Therapy for Coronary Atherosclerotic Heart Disease: Unanswered Questions Behind Existing Successes

Colchicine for Stroke Prevention in Patients with Coronary Artery Disease: A Systematic Review and Meta‐analysis

(2020) Aristeidis H. Katsanos et al.   EUROPEAN JOURNAL OF NEUROLOGY

Colchicine for acute and chronic coronary syndromes

(2020) Massimo Imazio et al.   HEART

Immunomodulation of the NLRP3 Inflammasome in Atherosclerosis, Coronary Artery Disease, and Acute Myocardial Infarction

(2020) Max J. M. Silvis et al.   Journal of Cardiovascular Translational Research

Targeting Inflammation After Myocardial Infarction

(2020) Dhruv Mahtta et al.   Current Cardiology Reports

Colchicine in Patients with Acute Coronary Syndrome: The Australian COPS Randomized Clinical Trial

(2020) David C. Tong et al.   CIRCULATION

Inhibition of Interleukin-1β and Reduction in Atherothrombotic Cardiovascular Events in the CANTOS Trial

(2020) Brendan M. Everett et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Colchicine in Patients with Chronic Coronary Disease

(2020) Stefan M. Nidorf et al.   NEW ENGLAND JOURNAL OF MEDICINE

Drug repurposing? Cardiovascular effect of colchicine on patients with coronary artery disease: A systematic review and meta-analysis

(2020) Yu-Yu Tien et al.   Journal of Cardiology

Meta-analysis Evaluating the Utility of Colchicine in Secondary Prevention of Coronary Artery Disease

(2020) Meng Xia et al.   AMERICAN JOURNAL OF CARDIOLOGY

Quantifying Importance of Major Risk Factors for Coronary Heart Disease

(2019) Michael J. Pencina et al.   CIRCULATION

Immunity and Inflammation in Atherosclerosis

(2019) Dennis Wolf et al.   CIRCULATION RESEARCH

2019 ACC/AHA Guideline on the Primary Prevention of Cardiovascular Disease

(2019) Donna K. Arnett et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Anticytokine Agents

(2019) Paul M Ridker   CIRCULATION RESEARCH

The Low Dose Colchicine after Myocardial Infarction (LoDoCo-MI) study: A pilot randomized placebo controlled trial of colchicine following acute myocardial infarction

(2019) Thomas Hennessy et al.   AMERICAN HEART JOURNAL

Residual inflammatory risk associated with interleukin-18 and interleukin-6 after successful interleukin-1β inhibition with canakinumab: further rationale for the development of targeted anti-cytokine therapies for the treatment of atherothrombosis

(2019) Paul M Ridker et al.   EUROPEAN HEART JOURNAL

2019 ESC Guidelines for the diagnosis and management of chronic coronary syndromes

(2019) Juhani Knuuti et al.   EUROPEAN HEART JOURNAL

Efficacy and Safety of Low-Dose Colchicine after Myocardial Infarction

(2019) Jean-Claude Tardif et al.   NEW ENGLAND JOURNAL OF MEDICINE

The NLRP3 inflammasome and the emerging role of colchicine to inhibit atherosclerosis-associated inflammation

(2018) Gonzalo J. Martínez et al.   ATHEROSCLEROSIS

The natural course of nonculprit coronary artery lesions; analysis by serial quantitative coronary angiography

(2018) Jeehoon Kang et al.   BMC Cardiovascular Disorders

Old Drugs for New Indications in Cardiovascular Medicine

(2018) Yaron Arbel et al.   CARDIOVASCULAR DRUGS AND THERAPY

NLRP3 Inflammasome and the IL-1 Pathway in Atherosclerosis

(2018) Alena Grebe et al.   CIRCULATION RESEARCH

Colchicine in Gout: An Update

(2018) Tristan Pascart et al.   CURRENT PHARMACEUTICAL DESIGN

Interleukin-1β has atheroprotective effects in advanced atherosclerotic lesions of mice

(2018) Delphine Gomez et al.   NATURE MEDICINE

Role of inflammation in the pathogenesis of atherosclerosis and therapeutic interventions

(2018) Paolo Raggi et al.   ATHEROSCLEROSIS

Low-Dose Methotrexate for the Prevention of Atherosclerotic Events

(2018) Paul M Ridker et al.   NEW ENGLAND JOURNAL OF MEDICINE

The NLRP3 inflammasome in acute myocardial infarction

(2017) Stefano Toldo et al.   Nature Reviews Cardiology

Antiinflammatory Therapy with Canakinumab for Atherosclerotic Disease

(2017) Paul M Ridker et al.   NEW ENGLAND JOURNAL OF MEDICINE

Use of colchicine in pregnancy: a systematic review and meta-analysis

(2017) Praveen L Indraratna et al.   RHEUMATOLOGY

Update on colchicine, 2017

(2017) Anastasia Slobodnick et al.   RHEUMATOLOGY

2016 updated EULAR evidence-based recommendations for the management of gout

(2016) P Richette et al.   ANNALS OF THE RHEUMATIC DISEASES

From C-Reactive Protein to Interleukin-6 to Interleukin-1

(2016) Paul M Ridker   CIRCULATION RESEARCH

The selective NLRP3-inflammasome inhibitor MCC950 reduces infarct size and preserves cardiac function in a pig model of myocardial infarction

(2016) Gerardus P.J. van Hout et al.   EUROPEAN HEART JOURNAL

Effect of a single dose of the interleukin-6 receptor antagonist tocilizumab on inflammation and troponin T release in patients with non-ST-elevation myocardial infarction: a double-blind, randomized, placebo-controlled phase 2 trial

(2016) Ola Kleveland et al.   EUROPEAN HEART JOURNAL

Effect of Losmapimod on Cardiovascular Outcomes in Patients Hospitalized With Acute Myocardial Infarction

(2016) Michelle L. O’Donoghue et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

NEK7 is an essential mediator of NLRP3 activation downstream of potassium efflux

(2016) Yuan He et al.   NATURE

Familial Mediterranean fever mutations lift the obligatory requirement for microtubules in Pyrin inflammasome activation

(2016) Hanne Van Gorp et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Multicentre, prospective, randomised, open-label, blinded end point trial of the efficacy of allopurinol therapy in improving cardiovascular outcomes in patients with ischaemic heart disease: protocol of the ALL-HEART study

(2016) Isla S Mackenzie et al.   BMJ Open

NLRP3 Inflammasome Expression and Activation in Human Atherosclerosis

(2016) Geena Paramel Varghese et al.   Journal of the American Heart Association

Circulating Levels of IL‐6 Receptor and gp130 and Long‐Term Clinical Outcomes in ST‐Elevation Myocardial Infarction

(2016) Vibeke N. Ritschel et al.   Journal of the American Heart Association

Effects of colchicine on risk of cardiovascular events and mortality among patients with gout: a cohort study using electronic medical records linked with Medicare claims

(2015) Daniel H Solomon et al.   ANNALS OF THE RHEUMATIC DISEASES

Colchicine in cardiac disease: a systematic review and meta-analysis of randomized controlled trials

(2015) Subodh Verma et al.   BMC Cardiovascular Disorders

Achievement of Dual Low-Density Lipoprotein Cholesterol and High-Sensitivity C-Reactive Protein Targets More Frequent With the Addition of Ezetimibe to Simvastatin and Associated With Better Outcomes in IMPROVE-ITCLINICAL PERSPECTIVES

(2015) Erin A. Bohula et al.   CIRCULATION

The effect of interleukin-1 receptor antagonist therapy on markers of inflammation in non-ST elevation acute coronary syndromes: the MRC-ILA Heart Study

(2014) A. C. Morton et al.   EUROPEAN HEART JOURNAL

Nlrp3 plays no role in acute cardiac infarction due to low cardiac expression

(2014) Willeke M.C. Jong et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Effect of Darapladib on Major Coronary Events After an Acute Coronary Syndrome

(2014) Michelle L. O’Donoghue et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Synergistic effects of colchicine combined with atorvastatin in rats with hyperlipidemia

(2014) Congwu Huang et al.   Lipids in Health and Disease

Effect of interleukin-6 receptor blockade on surrogates of vascular risk in rheumatoid arthritis: MEASURE, a randomised, placebo-controlled study

(2013) Iain B McInnes et al.   ANNALS OF THE RHEUMATIC DISEASES

Pro-atherogenic lipid changes and decreased hepatic LDL receptor expression by tocilizumab in rheumatoid arthritis

(2013) Aart C. Strang et al.   ATHEROSCLEROSIS

Sterol Regulatory Element Binding Protein 2 Activation of NLRP3 Inflammasome in Endothelium Mediates Hemodynamic-Induced Atherosclerosis Susceptibility

(2013) Han Xiao et al.   CIRCULATION

The effects of lowering LDL cholesterol with statin therapy in people at low risk of vascular disease: meta-analysis of individual data from 27 randomised trials

(2013)   LANCET

Microtubule-driven spatial arrangement of mitochondria promotes activation of the NLRP3 inflammasome

(2013) Takuma Misawa et al.   NATURE IMMUNOLOGY

Inflammation in Atherosclerosis

(2012) Peter Libby   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

The innate immune response in reperfused myocardium

(2012) L. Timmers et al.   CARDIOVASCULAR RESEARCH

Effect of interleukin 1β inhibition in cardiovascular disease

(2012) Arman Qamar et al.   CURRENT OPINION IN LIPIDOLOGY

Targeting Interleukin-6: All the Way to Treat Autoimmune and Inflammatory Diseases

(2012) Toshio Tanaka et al.   International Journal of Biological Sciences

Colchicine Use Is Associated with Decreased Prevalence of Myocardial Infarction in Patients with Gout

(2012) DARIA B. CRITTENDEN et al.   JOURNAL OF RHEUMATOLOGY

Low-Dose Colchicine for Secondary Prevention of Cardiovascular Disease

(2012) Stefan M. Nidorf et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

The interleukin-6 receptor as a target for prevention of coronary heart disease: a mendelian randomisation analysis

(2012)   LANCET

Therapeutic Targeting of the Interleukin-6 Receptor

(2011) Toshio Tanaka et al.   Annual Review of Pharmacology and Toxicology

Innate immune signaling in cardiac ischemia

(2011) Fatih Arslan et al.   Nature Reviews Cardiology

Subclinical atherosclerosis in gouty arthritis patients: a comparative study

(2011) Selçuk Çukurova et al.   RHEUMATOLOGY INTERNATIONAL

Antibody against interleukin-6 receptor attenuates left ventricular remodelling after myocardial infarction in mice

(2010) M. Kobara et al.   CARDIOVASCULAR RESEARCH

NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals

(2010) Peter Duewell et al.   NATURE

Effects of the anti-interleukin-6 receptor antibody, tocilizumab, on serum lipid levels in patients with rheumatoid arthritis

(2009) Shin-ya Kawashiri et al.   RHEUMATOLOGY INTERNATIONAL

Carotid Atherosclerotic Plaques Stabilize After Stroke

(2008) W. Peeters et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Rosuvastatin to Prevent Vascular Events in Men and Women with Elevated C-Reactive Protein

(2008) Paul M Ridker et al.   NEW ENGLAND JOURNAL OF MEDICINE

Genetically Elevated C-Reactive Protein and Ischemic Vascular Disease

(2008) Jeppe Zacho et al.   NEW ENGLAND JOURNAL OF MEDICINE

Colchicine: Its mechanism of action and efficacy in crystal-induced inflammation

(2008) George Nuki   Current Rheumatology Reports