Article
Multidisciplinary Sciences
James M. Burke, Alison R. Gilchrist, Sara L. Sawyer, Roy Parker
Summary: The study demonstrates that RNase L-mediated mRNA decay does not completely limit protein synthesis of dengue virus and influenza A virus, as their mRNAs largely escape this process. However, activation of RNase L inhibits nuclear mRNA export, thereby restricting influenza A virus protein synthesis and cytokine production.
Review
Virology
Guillermo Blanco-Rodriguez, Francesca Di Nunzio
Summary: Viruses have evolved strategies to manipulate the cellular machinery in order to replicate their genetic material and gain access to the host nucleus. They utilize the nuclear pore complex to enter the nucleus and replicate, with each virus employing unique tactics to achieve this goal. These viruses all require capsid remodeling to interact with the nuclear import machinery.
Article
Cell Biology
Enrico Caragliano, Stefano Bonazza, Giada Frascaroli, Jiajia Tang, Timothy K. Soh, Kay Grunewald, Jens B. Bosse, Wolfram Brune
Summary: Human cytomegalovirus forms replication compartments in the host cell nucleus using liquid-liquid phase separation with specific proteins, ensuring efficient viral genome replication.
Review
Immunology
Shuang Tang, Jie Li, Yung-Fu Chang, Wencheng Lin
Summary: Avian leukosis virus (ALV) causes various diseases, including tumor formation and decreased fertility. In addition, ALV induces immunosuppression, increasing susceptibility to other microbial infections and the risk of vaccine failure against other diseases. Evidence shows an interaction between ALV and the host.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Multidisciplinary Sciences
Sebastian Zeltzer, Pierce Longmire, Marek Svoboda, Giovanni Bosco, Felicia Goodrum
Summary: Human cells have multiple specialized DNA polymerases for chromosomal DNA synthesis and repair, while complex DNA viruses may rely on host polymerases for synthesis. This study shows that error-prone Y-family polymerases can restrict human cytomegalovirus genome synthesis, while other TLS polymerases are required for optimal replication. Host polymerases also suppress viral genome rearrangements, indicating their role in ensuring viral genome stability.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Fisheries
Hao Tang, Mingxue Sun, Wei Duan, Yanrong Ying, Yijing Liao, Tiaoyi Xiao, Yaoguo Li
Summary: In this study, the functional characterization of Nucleophosmin 1a (NPM1a) from grass carp (Ctenopharyngodon idellus) was deciphered. It was found that NPM1a played a negative regulatory role in the induction of Type I interferon reaction and GCRV replication. The study also identified the NES domain as crucial for nucleous-cytoplasm shuttle and GCRV replication. Overall, NPM1a is a potential target for GCRV infection treatment and resistance strain breeding in grass carp.
FISH & SHELLFISH IMMUNOLOGY
(2023)
Review
Chemistry, Multidisciplinary
Yao Fan, Xiang Li, Lei Zhang, Zhi Zong, Fangwei Wang, Jun Huang, Linghui Zeng, Chong Zhang, Haiyan Yan, Long Zhang, Fangfang Zhou
Summary: SUMOylation, a post-translational modification, plays a crucial role in regulating viral protein function and host antiviral immune response. The review summarizes the regulatory mechanisms of SUMOylation in viral replication and infection, and discusses its potential therapeutic applications in virus-induced diseases.
Article
Virology
Eduardo G. Aguilar, Gabrielle Paniccia, Carolina Adura, Zakary S. Singer, Alison W. Ashbrook, Brandon S. Razooky, Charles M. Rice, Margaret R. MacDonald
Summary: Viral macrodomains are conserved in several virus families and have the potential to be targeted by drugs. These macrodomains remove posttranslational modifications on host or viral proteins to enhance replication. This study demonstrates the importance of poly-ADP-ribosylhydrolase (ARH) activity in efficient viral infection and replication.
JOURNAL OF VIROLOGY
(2022)
Article
Biochemical Research Methods
Haiting Chai, Quan Gu, Joseph Hughes, David L. Robertson
Summary: This study analyzed and predicted the directionality of the interactions between HIV-1 and human host proteins. Using support vector machine learning models, significant differences were found between VIPs and non-VIPs, and the direction of interactions between HIV-1 and 1351 human host proteins was inferred.
PLOS COMPUTATIONAL BIOLOGY
(2022)
Article
Multidisciplinary Sciences
Simona Pilotto, Thomas Fouqueau, Natalya Lukoyanova, Carol Sheppard, Soizick Lucas-Staat, Luis Miguel Diaz-Santin, Dorota Matelska, David Prangishvili, Alan C. M. Cheung, Finn Werner
Summary: The study investigates two complexes that inhibit RNA polymerase, from Acidianus two-tailed virus and Sulfolobus Turreted Icosahedral Virus, revealing their mechanisms of transcription inhibition. The findings are important for understanding the inhibitory effects of archaeal eukaryotic-like RNA polymerases in virus infection.
NATURE COMMUNICATIONS
(2021)
Article
Microbiology
Tianqiong He, Mingshu Wang, Anchun Cheng, Qiao Yang, Renyong Jia, Ying Wu, Juan Huang, Bin Tian, Mafeng Liu, Shun Chen, Xin-Xin Zhao, Dekang Zhu, Shaqiu Zhang, Xuming Ou, Sai Mao, Qun Gao, Di Sun
Summary: The protein encoded by the DPV UL41 gene degrades RNA and induces protein synthesis shutdown, affecting viral replication and spread.
VETERINARY MICROBIOLOGY
(2021)
Article
Microbiology
Xupeng Hong, Stephan Menne, Jianming Hu
Summary: This study reveals the importance of N-glycosylation in enhancing precore secretion levels and regulating core protein functions in virion secretion and infection. Both HBV and WHV core proteins can support intracellular viral replication, but not virion secretion of the heterologous virus.
Article
Microbiology
Thomas Kehrer, Anastasija Cupic, Chengjin Ye, Soner Yildiz, Mehdi Bouhaddou, Nicholas A. Crossland, Erika A. Barrall, Phillip Cohen, Anna Tseng, Tolga Cagatay, Raveen Rathnasinghe, Daniel Flores, Sonia Jangra, Fahmida Alam, Ignacio Mena, Sadaf Aslam, Anjali Saqi, Magdalena Rutkowska, Manisha R. Ummadi, Giuseppe Pisanelli, R. Blake Richardson, Ethan C. Veit, Jacqueline M. Fabius, Margaret Soucheray, Benjamin J. Polacco, Baran Ak, Arturo Marin, Matthew J. Evans, Danielle L. Swaney, Ana S. Gonzalez-Reiche, Emilia M. Sordillo, Harm van Bakel, Viviana Simon, Lorena Zuliani-Alvarez, Beatriz M. A. Fontoura, Brad R. Rosenberg, Nevan J. Krogan, Luis Martinez-Sobrido, Adolfo Garcia-Sastre, Lisa Miorin
Summary: The ORF6 protein of SARS-CoV-2 plays a crucial role in antagonizing the host's innate immunity by disrupting nuclear import and inhibiting cellular mRNA export. It also regulates viral protein expression. Mutations in ORF6 affect its interactions with host components and impair immune evasion in certain variants.
CELL HOST & MICROBE
(2023)
Article
Oncology
Jun Wang, Aftab Amin, Man Hei Cheung, Linjing Shi, Chun Liang
Summary: MicroRNAs are noncoding RNAs that can suppress gene expression by degrading target mRNA or impairing translation. MCM proteins, essential for DNA replication, are overexpressed in cancer cells but strictly regulated in normal cells. miRNA-214-3p targets MCM5 and MCM7, inhibiting DNA replication and cell proliferation.
Article
Virology
Diogo C. Mendonca, Erik. V. S. Reis, Nidia. E. C. Arias, Hugo J. Valencia, Claudio A. Bonjardim
Summary: Mayaro virus (MAYV) is a neglected disease mainly found in Central and South America, causing a febrile illness and long-term debilitating arthritis. This study analyzed the viral replication kinetics and discovered the chronological order of events during MAYV replication, providing new insights into the virus's replication cycle. The findings could contribute to future research in the field.
Article
Engineering, Mechanical
K. Nguyen, Miguel A. Sanz, Francisco J. Montans
INTERNATIONAL JOURNAL OF PLASTICITY
(2020)
Article
Optics
Michael A. Phillips, Maria Harkiolaki, David Miguel Susano Pinto, Richard M. Parton, Ana Palanca, Manuel Garcia-Moreno, Ilias Kounatidis, John W. Sedat, David Stuart, Alfredo Castello, Martin J. Booth, Ilan Davis, Ian M. Dobbie
Review
Cell Biology
Kate Dicker, Aino I. Jarvelin, Manuel Garcia-Moreno, Alfredo Castello
Summary: RNA viruses rely on cellular RNA-binding proteins to facilitate replication and spread, with a pool of RBPs typically incorporated into viral particles. These RBPs play crucial roles in viral particle formation and infectivity, suggesting broader implications for host RBPs in virus infection than previously thought.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2021)
Article
Mathematics, Interdisciplinary Applications
K. Nguyen, Victor Jesus Amores, Miguel A. Sanz, Francisco J. Montans
Summary: In this work, a consistent viscoplasticity formulation is derived from thermodynamical principles and utilizing the concept of continuum elastic corrector rate. The proposed model is based on the principle of maximum viscoplastic dissipation, using equivalent viscoplastic strain and its rate as state variables. The formulation distinguishes itself from other proposals by consistently using the viscoplastic strain rate to differentiate between conservative and dissipative behaviors, and by the immediate discretization of the continuum theory through the implicit integration algorithm. The inviscid solution can be obtained by simply setting the viscosity to zero, with linear viscoplasticity solutions obtained accurately for proportional loading cases.
COMPUTATIONAL MECHANICS
(2021)
Article
Engineering, Manufacturing
Raul Diaz, Khanh Nguyen, Francisco J. Montans, Miguel A. Sanz
Summary: Aluminum and high-strength steels are increasingly being used in sheet metal forming, but predicting springback effects accurately is more challenging than predicting plastic deformation. In this study, a novel hyperelastic-based multiplicative large strain elastoplasticity model is employed to achieve consistent and accurate predictions of springback effects.
INTERNATIONAL JOURNAL OF MATERIAL FORMING
(2022)
Article
Hematology
Catia Simoes, Maria-Carmen Chillon, David Martinez-Cuadron, Maria-Jose Calasanz, Maria-Belen Vridiales, Iria Vazquez, Montserrat Hernandez-Ruano, Benat Ariceta, Paula Aguirre-Ruiz, Leire Burgos, Diego Alignani, Sarai Sarvide, Sara Villar, Ana Alfonso Pierola, Felipe Prosper, Rosa Ayala, Joaquin Martinez-Lopez, Juan Miguel Bergua Burgues, Susana Vives, Jose A. Perez-Simon, Maria Garcia-Fortes, Teresa Bernal del Castillo, Mercedes Colorado, Mayte Olave, Juan I. Rodriguez-Gutierrez, Jorge Labrador, Marcos Gonzalez, Jesus F. San-Miguel, Miguel angel Sanz, Pau Montesinos, Bruno Paiva
Summary: Clonal evolution in acute myeloid leukemia (AML) can be reconstructed using integrated multidimensional flow cytometry (MFC) immunophenotyping and fluorescence-activated cell sorting (FACS) with next-generation sequencing (NGS). Mutational analysis of dysplastic cells and leukemic blasts at the onset of AML identified stable, branching, and clonal evolution patterns. Techniques other than single-cell multiomics can be used to detect measurable residual disease (MRD) and genetic traits associated with treatment resistance in patients achieving complete response (CR). Whole-exome sequencing revealed different clonal involvement in dysplastic myeloerythropoiesis, leukemic transformation, and chemoresistance.
Article
Engineering, Civil
Ismael Ben-Yelun, Miguel Diaz-Lago, Luis Saucedo-Mora, Miguel Angel Sanz, Ricardo Callado, Francisco Javier Montans
Summary: Applications of Structural Health Monitoring (SHM) combined with Machine Learning (ML) techniques enhance real-time performance tracking and increase structural integrity awareness of civil, aerospace and automotive infrastructures. In this paper, a novel ML algorithm is developed to predict fatigue damage in composite materials using the signals of Lamb Waves and other meaningful features. The proposed algorithm achieves good accuracy and computation times comparable to other ML algorithms.
ENGINEERING STRUCTURES
(2023)
Article
Chemistry, Physical
Ismael Ben-Yelun, Guillermo Gomez-Carano, Francisco J. San Millan, Miguel Angel Sanz, Francisco Javier Montans, Luis Saucedo-Mora
Summary: The goal of this research is to introduce a novel tunable 3D metamaterial that can reproduce a wide spectrum of 3D auxetic and non-auxetic Poisson's ratios and Young's moduli. By changing the connectivity and position of the cell's internal nodes, this metamaterial can accommodate different spatial curvatures and boundaries. This wide range of variation is achieved through simple spatial triangularization and allows for better adaptability to component design boundaries and shapes.
Article
Mathematics, Applied
Luis Saucedo-Mora, Ismael Ben-Yelun, Hugo Garcia-Modet, Miguel Angel Sanz-Gomez, Francisco Javier Montans
Summary: 3D printing is changing the design and manufacturing of high value industrial components, pursuing a macro-micro structural optimization of architected metamaterials to customize mechanical properties. Topology optimization techniques facilitate the design of microstructures and overall component topology. A novel topology optimization algorithm is proposed, aiming to homogenize the strain level by minimizing its standard deviation, without imposing constraints and reducing external parameters. The proposed technique, working directly with moduli, is suitable for material-component design using functionally graded metamaterials and can be extended to non-linear isotropic materials.
FINITE ELEMENTS IN ANALYSIS AND DESIGN
(2023)
Article
Horticulture
Marcos Guerra, Rosa Maria Gomez, Miguel Angel Sanz, Alvaro Rodriguez-Gonzalez, Pedro Antonio Casquero
Summary: Classifying bell pepper fruits by their weight can increase the yield and quality of roasted pepper. Large tetralocular and large trilocular fruits are suitable for industrial purposes, while small trilocular fruits are suitable for the fresh product market.
Article
Horticulture
Marcos Guerra, Miguel Angel Sanz, Alvaro Rodriguez-Gonzalez, Pedro Antonio Casquero
Summary: Consumers are willing to pay a premium for sustainable food products, especially those with a Protected Designation of Origin label. Combining the sustainable preharvest technique of summer pruning with a zero-residue postharvest treatment allowed in organic farming can effectively reduce senescent breakdown and bitter pit incidence in the 'Reinette du Canada' apple cultivar. This environmentally-friendly practice maintains high overall acceptability.
Proceedings Paper
Education, Scientific Disciplines
Stefano Masneri, Ana Dominguez, Miguel Sanz, Inigo Tamayo, Mikel Zorrilla, Mikel Larranaga, Ana Arruarte
Summary: In this paper, a new augmented reality platform is presented, aiming to facilitate collaboration and interaction between teachers and students through synchronization and multi-user capabilities. A case study is provided to demonstrate the platform's capabilities for student-teacher and student-student collaboration.
MOBILITY FOR SMART CITIES AND REGIONAL DEVELOPMENT - CHALLENGES FOR HIGHER EDUCATION (ICL2021), VOL 2
(2022)
Proceedings Paper
Computer Science, Artificial Intelligence
Miguel Sanz-Narrillos, Stefano Masneri, Mikel Zorrilla
Summary: This paper introduces a fully automatic audience engagement system optimized for live music events, utilizing a multi-modal approach including wireless-based person detection and computer vision algorithms. Experimental results show that this hybrid approach performs better in real-time, has been tested in laboratory and concert hall environments, and will be deployed in distributed live events.
AGENTS AND ARTIFICIAL INTELLIGENCE, ICAART 2020
(2021)
Article
Biochemistry & Molecular Biology
Wael Kamel, Marko Noerenberg, Berati Cerikan, Honglin Chen, Aino I. Ja, Mohamed Kammoun, Jeffrey Y. Lee, Ni Shuai, Manuel Garcia-Moreno, Anna Andrejeva, Michael J. Deery, Natasha Johnson, Christopher J. Neufeldt, Mirko Cortese, Michael L. Knight, Kathryn S. Lilley, Javier Martinez, Ilan Davis, Ralf Bartenschlager, Shabaz Mohammed, Alfredo Castello
Summary: This study systematically identified the cellular and viral RNA-binding proteins involved in SARS-CoV-2 infection, revealing significant remodeling of the cellular RNA-bound proteome and potential new antiviral therapy targets. The research uncovered the regulatory role of tRNA ligase complex components in SARS-CoV-2 infection and demonstrated the inhibitory effect of drugs targeting host RBPs interacting with SARS-CoV-2 RNA on viral infection.
Proceedings Paper
Computer Science, Artificial Intelligence
Miguel Sanz-Narrillos, Stefano Masneri, Mikel Zorrilla
ICAART: PROCEEDINGS OF THE 12TH INTERNATIONAL CONFERENCE ON AGENTS AND ARTIFICIAL INTELLIGENCE, VOL 2
(2020)