Journal
CELLULAR IMMUNOLOGY
Volume 282, Issue 2, Pages 71-78Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.cellimm.2013.04.009
Keywords
Growth hormone; GHRH receptors; Lymphocytes; Aging
Categories
Funding
- National Institute of Health of Neurology and Communicative Disorders [RO1 NS24636]
- National Institute of Arthritis, Diabetes, Digestive and Kidney Diseases [RO1 DK38024]
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In the present study, we show that higher levels of lymphocyte GH are expressed in spleen cells from aging animals compared to young animals. Further, leukocytes from primary and secondary immune tissues and splenic T and B cells from aging rats all express higher levels of GHRH receptors compared to younger animals. Bone marrow and splenic T cells express the highest levels of GHRH receptor in aging animals. Spleen cells from aging animals showed no significant change in proliferation or GH induction after treatment with GHRH. Taken together, the data for the first time show alterations in GH synthesis and expression of the GHRH receptor on cells of the immune system that may play a role in the immune response in aging. (C) 2013 Elsevier Inc. All rights reserved.
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