Article
Environmental Sciences
Xue Lu, Zhu-Xia Tan, Wen-Jing Wang, Ping Zhan, Yan Wang, Lin Fu, Lan Gao, Hui Zhao, Hua Wang, De-Xiang Xu
Summary: Gestational arsenic exposure can affect developmental outcomes. This study explored the effects of arsenic exposure in different periods on susceptibility to allergic asthma. The results showed that juvenile exposure to arsenic increased the susceptibility to allergic asthma by aggravating goblet cell hyperplasia and airway mucus secretion, especially when exposed after weaning.
ENVIRONMENTAL POLLUTION
(2022)
Article
Plant Sciences
Xi Huang, Hang Yu, Cong Xie, Yao-Long Zhou, Meng-Meng Chen, Han-Lin Shi, Wei-Feng Tang, Jing-Cheng Dong, Qing-Li Luo
Summary: LKZP improves lung function and airway inflammation in asthma by modulating the IL-33/ST2-NF-kappa B/GSK3 β/mTOR signaling pathway, reducing mucus secretion and correcting immune imbalance.
PHARMACEUTICAL BIOLOGY
(2022)
Article
Pediatrics
Yuqin Li, Qiu Chen, Wei Ji, Yujie Fan, Li Huang, Chu Chu, Weifang Zhou
Summary: The study found that TLR2 plays a role in limiting lung inflammation post-OVA sensitization by promoting IgG1 and inhibiting IgE class switching, with IL21 and STAT3 regulating this process.
ITALIAN JOURNAL OF PEDIATRICS
(2021)
Article
Immunology
Masaya Matsuda, Miki Inaba, Junpei Hamaguchi, Hiro Tomita, Miyu Omori, Hayato Shimora, Harumi Sakae, Kazuyuki Kitatani, Takeshi Nabe
Summary: IL-10 can suppress eosinophil and neutrophil infiltration by inhibiting the proliferation of ICAM-1+ and VCAM1+ pulmonary vascular endothelial cells, resulting in inhibition of airway hyperresponsiveness in steroid-insensitive asthmatic mice.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Adriana Ariza, Cristobalina Mayorga, Gador Bogas, Francesco Gaeta, Maria Salas, Rocco L. Valluzzi, Marina Labella, Natalia Perez-Sanchez, Cristiano Caruso, Ana Molina, Tahia D. Fernandez, Maria Jose Torres, Antonino Romano
Summary: This study analyzed the utility of ImmunoCAP (R) for detecting sIgE to penicillin G (PG) and amoxicillin (AX) in patients with confirmed penicillin allergy. The results showed limitations of ImmunoCAP (R) in evaluating individuals with type I hypersensitivity reactions to penicillins.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Immunology
Kevin Plattner, Zahra Gharailoo, Simon Zinkhan, Paul Engeroff, Martin F. Bachmann, Monique Vogel
Summary: This study found that the glycosylation of IgE is crucial for initiating the anti-IgE IgG response, clearing serum IgE, and preventing systemic allergic reactions.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Chemistry, Applied
Natalia Ukleja-Sokolowska, Kinga Lis, Magdalena Zbikowska-Gotz, Rafal Adamczak, Zbigniew Bartuzi
Summary: The study found that the levels of IgG and IgE, as well as the concentrations of IL-25, IL-33, and TSLP, did not affect the nature or severity of clinical symptoms in patients with shrimp allergy. There was also no correlation between the concentrations of IL-25, IL-33, and TSLP and the age or sex of the participants.
FOOD AND AGRICULTURAL IMMUNOLOGY
(2021)
Article
Nutrition & Dietetics
Francesco Savino, Francesca Giuliani, Stefano Giraudi, Ilaria Galliano, Paola Montanari, Valentina Dapra, Massimiliano Bergallo
Summary: The aim of this study was to assess the serum values of IL-4, IL-5, IL-10, and IL-13 in infants with non-IgE mediated food allergies treated with a hydrolyzed formula. The study found that the levels of IL-4 and IL-13 were significantly higher in the non-IgE food allergy group compared to the control group, while IL-5 and IL-10 levels were significantly lower.
Article
Nutrition & Dietetics
Wenhua Yang, Wenjing Duan, Qiuhong Li, Dengle Duan, Qin Wang
Summary: This study investigated the effect of pulsed electric field (PEF) pretreatment combined with phosphorylation on the structure and immunoglobulin (Ig) G/IgE-binding ability of ovalbumin (OVA). The results showed that this treatment method significantly reduced the binding ability of OVA to IgG and IgE, and caused changes in the secondary and tertiary structure.
FRONTIERS IN NUTRITION
(2022)
Article
Food Science & Technology
Ruoya Zhou, Lina Zhang, Kai Zhang, Peng Zhou
Summary: This study investigated the difference in allergenicity between chicken egg and duck egg ovalbumin. It was found that chicken ovalbumin induced a stronger allergic reaction compared to duck ovalbumin, while duck ovalbumin showed a milder immune response and maintained the integrity of the intestinal barrier. Furthermore, cross-reactions were observed with consumption of duck ovalbumin in chicken ovalbumin allergic mice, but the allergic symptoms were milder.
EUROPEAN FOOD RESEARCH AND TECHNOLOGY
(2022)
Article
Veterinary Sciences
Michelle Wyler, Sophie Elena Sage, Eliane Marti, Samuel White, Vinzenz Gerber
Summary: This study characterized the IgE profiles of asthmatic horses in Switzerland using a protein microarray platform and found higher concentrations of allergen-specific IgE in asthmatic horses. The protein microarray performed better on bronchoalveolar lavage fluid (BALF) than serum for detection of asthma, and there was only weak correlation between serological IgE concentrations and BALF concentrations.
JOURNAL OF VETERINARY INTERNAL MEDICINE
(2023)
Article
Medicine, General & Internal
Maria Roca, Ester Donat, Ana Rodriguez Varela, Eva Carvajal, Francisco Cano, Ana Armisen, Helena Ekoff, Antonio Jose Canada-Martinez, Niclas Rydell, Carmen Ribes-Koninckx
Summary: The study aimed to evaluate fCP and fEDN as markers for diagnosing CMPA and monitoring infants' response to a CMP-free diet. However, the levels of fCP and fEDN were not able to differentiate between healthy infants and those with non-IgE-mediated CMPA, and there were no significant changes in fCP levels after a CMP-free diet in the CMPA group. Prospective studies with larger populations are needed for more robust conclusions.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Agriculture, Dairy & Animal Science
Morena Di Tommaso, Alessia Luciani, Paolo Emidio Crisi, Marica Beschi, Paolo Rosi, Francesca Rocconi, Arianna Miglio
Summary: Canine atopic dermatitis (CAD) is a pruritic allergic skin disease associated with IgE-mediated hypersensitivity. The present study used Serum Allergen-Specific IgE test (SAT) to identify relevant environmental allergens in atopic dogs living in Northern Italy, primarily house dust mites, Rumex acetosa pollen, and grasses. Specific panels for geographical areas should be considered and re-evaluated at time intervals.
Article
Pharmacology & Pharmacy
Yujue Deng, Hongbing Chen, Yong Wu, Jin Yuan, Qiang Shi, Ping Tong, Jinyan Gao
Summary: Food contaminated with Aflatoxin B1 (AFB1) is a widespread issue worldwide and can cause significant health damage to humans. In addition, some of these contaminated foods can lead to food allergies. This study aimed to investigate the impact of AFB1 exposure on food allergy using a mouse model. Results showed that exposure to AFB1 increased the production of specific IgE, IL-4, IL-5, IL-13, and mMCP-1 in allergic mice, while decreasing the level of IFN-gamma. The balance between Th1/Th2 cells was disrupted, favoring the development of Th2 cells. This research contributes to a better understanding of the risks associated with fungal toxins in food allergies.
Article
Pediatrics
Giulia Dodi, Paola Di Filippo, Sabrina Di Pillo, Francesco Chiarelli, Marina Attanasi
Summary: This study aimed to evaluate the association between total IgE levels at the diagnosis of food allergy and the duration of tolerance acquisition and food elimination diet. The findings showed a positive correlation between total serum IgE and the duration of the elimination diet, as well as significant correlations between total IgE values and the duration of the elimination diet, and between casein specific IgE values at diagnosis of food allergy and the severity of the clinical presentation.
FRONTIERS IN PEDIATRICS
(2022)
Article
Biochemistry & Molecular Biology
Renato Elias Moreira Junior, Luana Martins de Carvalho, Diego Carlos dos Reis, Geovanni Dantas Cassali, Ana Maria Caetano Faria, Tatiani Uceli Maioli, Ana Lucia Brunialti-Godard
Summary: Consumption of high-sugar and fat diets can induce obesity, leading to changes in gut microbiota and behavior, highlighting the multifactorial characteristics of obesity.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2021)
Article
Immunology
Priscila Valera Guerra, Camila Mattos Andrade, Ivaneia Valeriano Nunes, Brena Cardoso Gama, Rafael Tiburcio, Washington Luis Conrado Santos, Vasco Ariston Azevedo, Natalia Machado Tavares, Juliana de Souza Reboucas, Tatiani Uceli Maiolii, Ana Maria Caetano Faria, Claudia Ida Brodskyn
Summary: Orally administrated heat shock proteins (Hsp) can suppress inflammation and induce differentiation in regulatory cells, showing significant effects in experimental models. Hsp-producing L. lactis can be considered as an alternative candidate for treating autoimmune diseases and chronic infections causing inflammatory diseases.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Luciana Maria Oliveira, Denise Silva Nogueira, Ricardo Marcelo Geraldi, Fernando Sergio Barbosa, Chiara Cassia Oliveira Amorim, Ana Clara Gazzinelli-Guimaraes, Nathalia Maria Resende, Natalia Pinheiro-Rosa, Lucas Rocha Kraemer, Matheus Silverio Mattos, Lilian Lacerda Bueno, Ana Maria Caetano Faria, Remo Castro Russo, Soraya Gaze, Ricardo Toshio Fujiwara
Summary: This study evaluates the kinetic aspects of immune parasitological parameters in male mice with early ascariasis, and suggests a synergetic action of intestinal and pulmonary secretory IgA contributing to protection against early ascariasis by reducing the amount of migrating larvae and leukocyte influx.
INFECTION AND IMMUNITY
(2022)
Article
Microbiology
Denise Silva Nogueira, Luciana Maria de Oliveira, Chiara Cassia Oliveira Amorimid, Ana Clara Gazzinelli-Guimaraes, Fernando Sergio Barbosa, Fabricio Marcus Silva Oliveira, Lucas Kraemer, Matheus Mattos, Mariana Santos Cardoso, Nathalia Maria Resende, Marianna de Carvalho Climaco, Deborah Aparecida Negrao-Correa, Ana Maria Caetano Faria, Marcelo Vidigal Caliari, Lilian Lacerda Bueno, Soraya Gaze, Remo Castro Russo, Pedro Henrique Gazzinelli-Guimaraes, Ricardo Toshio Fujiwara
Summary: The study found that TLR2 and TLR4 signaling induces eosinophils and promotes SIgA production during parasite infection, controlling parasite burden. Additionally, eosinophils participate in tissue remodeling after lung injury caused by larval migration.
Article
Pharmacology & Pharmacy
Bruna Savassi, Barbara F. Cordeiro, Sara H. Silva, Emiliano R. Oliveira, Giovanna Belo, Alessandra Gomes Figueiroa, Maria Izabel Alves Queiroz, Ana Maria Caetano Faria, Juliana Alves, Tales Fernando da Silva, Gabriela Munis Campos, Erick A. Esmerino, Ramon S. Rocha, Monica Q. Freitas, Marcia C. Silva, Adriano G. Cruz, Katia Duarte Vital, Simone O. A. Fernandes, Valbert N. Cardoso, Leonardo Borges Acurcio, Gwenael Jan, Yves Le Loir, Alfonso Gala-Garcia, Fillipe Luiz R. do Carmo, Vasco Azevedo
Summary: The symbiotic product developed in this study shows significant improvement in symptoms of mucositis induced by 5-FU, including reducing weight loss and intestinal permeability, lowering inflammation score, and decreasing levels of pro-inflammatory cytokines.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Geriatrics & Gerontology
Joaquim Pedro Brito-de-Sousa, Ana Carolina Campi-Azevedo, Ismael Artur da Costa-Rocha, Jesuanne Carla Silva-Andrade, Lizandra Morgado-Santos, Jordana Grazziela Alves Coelho-dos-Reis, Vanessa Peruhype-Magalhaes, Matheus de Souza Gomes, Laurence Rodrigues Amaral, Andrea Teixeira-Carvalho, Thadia Evelyn Araujo, Eloisa Amalia Vieira Ferro, Rosiane Aparecida da Silva-Pereira, Lis Ribeiro do Valle Antonelli, Ana Maria Caetano de Faria, Angelica Oliveira Gomes, Olindo Assis Martins-Filho
Summary: This study reveals the impact of ageing on the pattern of serum soluble mediators. It shows a bimodal profile of serum soluble mediators, with one peak at 6-10 years and a second wave around 61-70 years. The study also identifies universal age-related biomarkers and differences in magnitude and timing between sexes.
EXPERIMENTAL GERONTOLOGY
(2022)
Article
Immunology
Ana Carolina de Sena Avellar, Mariana Naves Oliveira, Felipe Caixeta, Rafaela Cristina Vieira e Souza, Andrea Teixeira, Ana Maria Caetano Faria, Gabriela Silveira-Nunes, Elaine Spezialli Faria, Tatiani Uceli Maioli
Summary: Gestational diabetes mellitus (GDM) can affect the concentration of biomarkers in colostrum, potentially impacting the development of the newborn's immune system.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Immunology
Anne C. S. Ramos, Luciana M. Oliveira, Yvanna L. D. C. O. Santos, Marlon C. S. Dantas, Cristiani I. B. Walker, Ana M. C. Faria, Lilian L. Bueno, Silvio S. Dolabella, Ricardo T. Fujiwara
Summary: This systematic review aimed to investigate the role of Immunoglobulin-A (IgA) as a mediator of protective immunity against gastrointestinal helminths. The results showed consistent associations between higher IgA levels and lower parasitological parameters in mice, rats, and sheep. However, the role of IgA in other host species remained uncertain, highlighting the need for further research.
IMMUNOLOGY LETTERS
(2022)
Article
Immunology
Maria Cecilia Campos Canesso, Thais Garcias Moreira, Ana Maria Caetano Faria
Summary: The intestine is a complex organ with specific niches and microenvironments filled with different cell types that are involved in physiological and inflammatory processes. The specialized environments within the intestine are critical for the development and functional adaptation of immune cells in the gut and gut-draining lymph nodes.
IMMUNOLOGY LETTERS
(2022)
Article
Cell Biology
D. F. Durso, G. Silveira-Nunes, M. M. Coelho, G. C. Camatta, L. H. Ventura, L. S. Nascimento, F. Caixeta, E. H. M. Cunha, A. Castelo-Branco, D. M. Fonseca, T. U. Maioli, A. Teixeira-Carvalho, C. Sala, M. J. Bacalini, P. Garagnani, C. Nardini, C. Franceschi, A. M. C. Faria
Summary: Living in endemic areas for chronic infectious diseases results in remodeling of inflammaging and acceleration of epigenetic aging in individuals regardless of their infectious status.
MECHANISMS OF AGEING AND DEVELOPMENT
(2022)
Article
Cell Biology
Mauro A. F. Guimaraes, Natalia Pinheiro-Rosa, Rafael P. Oliveira, Sarah L. F. Aguiar, Mariana C. G. Miranda, Luisa Lemos, Adna L. Souza, Daniela S. dos Reis, Samara R. Medeiros, William A. Goncalves, Sylvia S. Amaral, Vanessa Pinho, Anderson Miyoshi, Vasco A. Z. Azevedo, Rafael M. Rezende, Ana M. C. Faria
Summary: Multiple sclerosis (MS) is an autoimmune disease that affects the central nervous system. In this study, a protocol of oral tolerance induction using HSP65-producing Lactococcus lactis was proposed and successfully prevented and controlled MOG-induced experimental autoimmune encephalomyelitis (EAE) in mice. The treatment resulted in a reduction in EAE clinical score, higher frequencies of regulatory T cells, and reduced leukocyte adherence in the spinal cord. These findings suggest a novel therapeutic strategy for MS and other autoimmune diseases.
CELLULAR IMMUNOLOGY
(2023)
Editorial Material
Immunology
Licia Torres, Ana M. C. Faria
Summary: This study demonstrates that gut regionalization can affect microbiota and immunity through the regulation of GATA4 expression, which controls bacterial colonization, retinol metabolism, and IgA production. This metabolic-immune axis plays a crucial role in limiting intestinal Th17 responses and immunopathology.
Article
Microbiology
Juliana Lima Alves, Luisa Lemos, Nubia Morais Rodrigues, Vanessa Bastos Pereira, Patricia A. Vieira Barros, Maria Cecilia Campos Canesso, Mauro A. F. Guimaraes, Denise Carmona Cara, Anderson Miyoshi, Vasco Ariston Azevedo, Tatiani Uceli Maioli, Ana Cristina Gomes-Santos, Ana Maria Caetano Faria
Summary: Inflammatory bowel diseases (IBD) are gastrointestinal disorders characterized by a breakdown in intestinal homeostasis by inflammatory immune responses. Novel strategies for ameliorating IBD have been proposed. The study showed that different strains of Lactococcus lactis improved clinical scores and parameters of colitis, confirming their anti-inflammatory properties in this model.
BRAZILIAN JOURNAL OF MICROBIOLOGY
(2023)
Article
Biotechnology & Applied Microbiology
Vivian C. Miranda, Ramon O. Souza, Monica F. Quintanilha, Bruno Gallotti, Helder C. Assis, Ana Maria C. Faria, Jacques R. Nicoli, Denise C. Cara, Flaviano S. Martins
Summary: This study aimed to evaluate the probiotic and postbiotic potential of Akkermansia muciniphila BAA-835 in an ovalbumin food allergy model. The results showed that treatment with viable A. muciniphila could alleviate weight loss, decrease serum levels of allergy-related antibodies, reduce intestinal injury and inflammation, and modify the gut microbiota composition. Additionally, the administration of inactivated bacteria also had a postbiotic effect by reducing allergy-related immune responses. These findings suggest that A. muciniphila BAA-835 has both probiotic and postbiotic properties in the prevention and treatment of food allergies.
PROBIOTICS AND ANTIMICROBIAL PROTEINS
(2023)
Article
Nutrition & Dietetics
Renato Elias Moreira-Junior, Mauro Andrade de Freitas Guimaraes, Miguel Etcheverria da Silva, Tatiani Uceli Maioli, Ana Maria Caetano Faria, Ana Lucia Brunialti-Godard
Summary: Mechanisms that dictate ethanol preference and addiction are not limited to the central nervous system, but also involve the immune system and gene transcription in the reward system. This study aimed to assess the impact of problematic alcohol consumption on the transcriptional profile of the Lrrk2 gene, neuroinflammation, and behavior, and investigate their interconnections.
FRONTIERS IN NUTRITION
(2023)
