Article
Immunology
Lauren R. Corulli, Denise L. Cecil, Ekram Gad, Marlese Koehnlein, Andrew L. Coveler, Jennifer S. Childs, Ronald A. Lubet, Mary L. Disis
Summary: Overexpression of proteins in colorectal cancer patients may make them immunogenic, and vaccines targeting these proteins could potentially inhibit tumor development. Further research is needed to develop multi-antigen vaccines for the treatment and prevention of colorectal cancer.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Oncology
Franziska Briest, Daniel Noerenberg, Cornelius Hennch, Kenichi Yoshida, Raphael Hablesreiter, Jose Nimo, Daniel Sasca, Marieluise Kirchner, Larry Mansouri, Yoshikage Inoue, Laura Wiegand, Annette M. Staiger, Beatrice Casadei, Penelope Korkolopoulou, January Weiner, Armando Lopez-Guillermo, Arne Warth, Tamas Schneider, Akos Nagy, Wolfram Klapper, Michael Hummel, George Kanellis, Ioannis Anagnostopoulos, Philipp Mertins, Lars Bullinger, Richard Rosenquist, Theodoros P. Vassilakopoulos, German Ott, Seishi Ogawa, Frederik Damm
Summary: Recent exome-wide studies have found frequent somatic mutations in the epigenetic modifier ZNF217 in primary mediastinal B cell lymphoma (PMBCL) and related disorders. The functional consequences of ZNF217 alterations were comprehensively evaluated in PMBCL, and it was found that these alterations led to changes in cytokine and interferon signal transduction, disturbed expression of certain genes, altered cell behavior, and aberrant differentiation. ZNF217 was also discovered to act within a histone modifier complex and interfere with chromatin structure.
Review
Cell Biology
Carlos S. Subauste
Summary: Toxoplasma gondii is an intracellular protozoan that can cause encephalitis and retinitis in humans, depending on its ability to form a parasitophorous vacuole for protection and replication. The vacuole can be targeted by autophagy, but the parasite has developed strategies to preserve its integrity. Recent advances have highlighted the importance of autophagy in regulating invasion into the brain and retina by T. gondii, with potential therapeutic applications being explored.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Dermatology
Shilpi Giri, Heikrujam Thoihen Meitei, Amrita Mishra, Girdhari Lal
Summary: This study investigates the mechanistic role of gamma delta T cells in costimulatory blockade-induced transplantation tolerance. Depletion of gamma delta T cells leads to acute rejection of skin allografts despite tolerogen treatment. Tolerogen treatment promotes the generation of regulatory V gamma 2(+) gamma delta T cells and suppresses IFN-gamma production. Adoptive transfer of these regulatory V gamma 2(+) gamma delta T cells prolongs the survival of allografts.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2022)
Article
Biology
Yangon Zhang, Shu Ma, Tie Li, Yu Tian, Huangao Zhou, Hongsheng Wang, Lan Huang
Summary: This study found that tumor-associated macrophages (TAMs) are increased in colon cancer and promote tumor progression. Type 1 innate lymphocytes (ILC1s) can promote the activation of macrophages towards an anti-tumor phenotype. In this study, ILC1s were found to promote the activation of M1-like macrophages through secretion of IFN-? and inhibit the progression of colon cancer.
Review
Biochemistry & Molecular Biology
Heather D. Ots, Jovanna A. Tracz, Katherine E. Vinokuroff, Alberto E. Musto
Summary: CD40-CD40L plays a key role in the central nervous system by upregulating proinflammatory molecules. Its function is well understood in the context of infection, but its role in neurological diseases of non-infectious etiology is unclear. This review examines the role of CD40-CD40L in various neurological diseases and highlights therapeutic advancements targeting the CD40 system.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Nutrition & Dietetics
Hiroshi Fujimoto, Soichiro Fukuzato, Kazuki Kanno, Taisuke Akutsu, Hironori Ohdaira, Yutaka Suzuki, Mitsuyoshi Urashima
Summary: Elevated sCD40L levels may serve as a biomarker for poor prognosis in patients with colorectal cancer, while vitamin D supplementation may improve relapse-free survival in patients with high sCD40L.
Article
Immunology
Sung Hee Choi, Alex Y. Huang, John J. Letterio, Byung-Gyu Kim
Summary: IFN-gamma promotes the progression of colitis-associated colorectal cancer by expanding effector memory T cells and restricting the expression of tumor suppressors.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Neurosciences
Jian Hu, Zixuan Wang, Biao Gong, Liyuan Feng, Yan Song, Shuo Zhang, Lin Wang, Yanghui Qu, Gen Li, Li Zhang, Chaonan Zheng, Fang Du, Peng Li, Yuan Wang
Summary: This study reveals that nestin-expressing progenitors (NEPs) in the developing cerebellum are resistant to irradiation and capable of regeneration. The regeneration of NEPs is dependent on the sonic hedgehog (Shh) pathway. Furthermore, irradiation increases the production of Shh ligand by Purkinje cells, while microglia produce more IFN-gamma, which further augments Shh ligand production and promotes NEP proliferation.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Article
Cell Biology
Yi-Hsin Liang, Kuo-Hsing Chen, Jia-Huei Tsai, Yung-Ming Cheng, Chang-Cheng Lee, Chiu-Hwa Kao, Kuang-Yu Chan, Yeh-Ting Chen, Wen-Ling Hsu, Kun-Huei Yeh
Summary: The study suggests a novel rationale for incorporating the proteasome inhibitor bortezomib into new immunotherapy combinations, which can enhance the expression of immune surface markers and improve tumor cell immunogenicity by activating the STAT1/pSTAT1 pathway.
JOURNAL OF BIOMEDICAL SCIENCE
(2021)
Editorial Material
Neurosciences
Lisa Johann, Ari Waisman
Summary: The study reveals a novel mechanism by which astrocytes maintain an anti-inflammatory state in the CNS. This mechanism involves IFNg-induced TRAIL expression on astrocytes, leading to effector T cell apoptosis and suppression of inflammation.
Article
Multidisciplinary Sciences
Shaofeng Yuan, Xiangdong Kong, Wei Yu, Jinhong Geng, Linwen Zeng, Shengchun Dang
Summary: Colon cancer is a leading cause of tumor lethality worldwide, and the development of multidrug resistance poses challenges for effective control. The upregulation of circRNA_100920 in CRC tissues and cells suggests its potential as a biomarker for diagnosis, treatment, and prognosis of CRC. Further research on circRNA_100920 may lead to new therapeutic strategies for CRC.
Article
Biochemistry & Molecular Biology
Qiang Chen, Shuqing Zhuang, Yilin Hong, Lingtao Yang, Peng Guo, Pingli Mo, Kesong Peng, Wengang Li, Nengming Xiao, Chundong Yu
Summary: The study found that PD-L1 and JMJD2D are frequently overexpressed in human CRC specimens and have a significant positive correlation. Knocking out JMJD2D in CRC cells weakens the expression of PD-L1, inhibits tumor growth, and increases the number and function of CD8(+) T cells in tumor infiltration. JMJD2D promotes the expression of PD-L1 by co-activating SP-1 to promote the expression of IFNGR1, thereby enhancing STAT3-IRF1 signaling. Pharmacological inhibition of JMJD2D can improve the therapeutic effect of PD-L1 antibody, increase the infiltration and function of CD8(+) T cells.
Article
Biochemistry & Molecular Biology
Alessia Furgiuele, Franca Marino, Emanuela Rasini, Massimiliano Legnaro, Alessandra Luini, Maria Giulia Albizzati, Alessia di Flora, Barbara Pacchetti, Marco Cosentino
Summary: This study investigated the effects of CBD on human peripheral blood mononuclear cells (PBMCs) and CD4+ T cells, and found that CBD can affect cytokine production, cell proliferation, and the functional properties of regulatory T cells. However, the effects of CBD on cell proliferation and protein production were inconsistent, suggesting a complex activity that warrants further investigation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Immunology
Conor M. Finlay, James E. Parkinson, Lili Zhang, Brian H. K. Chan, Jesuthas Ajendra, Alistair Chenery, Anya Morrison, Irem Kaymak, Emma L. Houlder, Syed Murtuza Baker, Ben R. Dickie, Louis Boon, Joanne E. Konkel, Matthew R. Hepworth, Andrew S. MacDonald, Gwendalyn J. Randolph, Dominik Ruckert, Judith E. Allen
Summary: The recent revolution in tissue-resident macrophage biology has largely relied on studies performed in C57BL/6 mice. In this study, using both C57BL/6 and BALB/c mice, researchers analyzed immune cells in the pleural cavity. They found that the tissue-resident macrophages of BALB/c mice failed to fully implement the tissue-residency program compared to C57BL/6 mice. Infection with a pleural-dwelling nematode further accentuated these differences, with only C57BL/6 mice showing expansion of tissue-resident macrophages.
Article
Cell Biology
Jeffrey Maslanka, Gretel Torres, Jennifer Londregan, Naomi Goldman, Daniel Silberman, John Somerville, James E. Riggs
Summary: This study investigates the immunobiology of the peritoneum in ovarian cancer, revealing reduced B1 cells in the ascites and selective loss of B1 and marginal zone B cell subsets in the spleen. These findings suggest a correlation between the depletion of B cell subsets and the influx of myeloid-derived suppressor cells during ovarian cancer.
CELLULAR IMMUNOLOGY
(2024)
