The mGluR5 Positive Allosteric Modulator CDPPB Inhibits SO2-Induced Protein Radical Formation and Mitochondrial Dysfunction Through Activation of Akt in Mouse Hippocampal HT22 Cells

Sulfur dioxide, a double-faced molecule in mammals

(2014) Xin-Bao Wang et al.   LIFE SCIENCES

Allicin protects rat cortical neurons against mechanical trauma injury by regulating nitric oxide synthase pathways

(2013) Yue-fei Zhou et al.   BRAIN RESEARCH BULLETIN

Metabotropic glutamate receptor 5 positive allosteric modulators are neuroprotective in a mouse model of Huntington's disease

(2013) JG Doria et al.   BRITISH JOURNAL OF PHARMACOLOGY

Homer1 knockdown protects dopamine neurons through regulating calcium homeostasis in an in vitro model of Parkinson's disease

(2013) Tao Chen et al.   CELLULAR SIGNALLING

SO2 inhalation causes synaptic injury in rat hippocampus via its derivatives in vivo

(2013) Yang Yun et al.   CHEMOSPHERE

Enhancing Mitochondrial Calcium Buffering Capacity Reduces Aggregation of Misfolded SOD1 and Motor Neuron Cell Death without Extending Survival in Mouse Models of Inherited Amyotrophic Lateral Sclerosis

(2013) P. A. Parone et al.   JOURNAL OF NEUROSCIENCE

Neuroglobin overexpression inhibits oxygen–glucose deprivation-induced mitochondrial permeability transition pore opening in primary cultured mouse cortical neurons

(2013) Zhanyang Yu et al.   NEUROBIOLOGY OF DISEASE

The Role of Free Radicals in Traumatic Brain Injury

(2012) K. M. O'Connell et al.   Biological Research for Nursing

Group I Metabotropic Glutamate Receptor Signalling and its Implication in Neurological Disease

(2012) Fabiola M. Ribeiro et al.   CNS & Neurological Disorders-Drug Targets

Protective effect of Homer 1a against hydrogen peroxide-induced oxidative stress in PC12 cells

(2012) Peng Luo et al.   FREE RADICAL RESEARCH

Therapeutic effects of metabotropic glutamate receptor 5 positive allosteric modulator CDPPB on phencyclidine-induced cognitive deficits in mice

(2012) Mao Horio et al.   FUNDAMENTAL & CLINICAL PHARMACOLOGY

Involvement of metabotropic glutamate receptor 5, AKT/PI3K Signaling and NF-κB pathway in methamphetamine-mediated increase in IL-6 and IL-8 expression in astrocytes

(2012) Ankit Shah et al.   Journal of Neuroinflammation

Effects of a metabotropic glutamate receptor 5 positive allosteric modulator, CDPPB, on spatial learning task performance in rodents

(2012) S.W. Fowler et al.   NEUROBIOLOGY OF LEARNING AND MEMORY

Protective Effects of mGluR5 Positive Modulators Against Traumatic Neuronal Injury Through PKC-Dependent Activation of MEK/ERK Pathway

(2012) Tao Chen et al.   NEUROCHEMICAL RESEARCH

In vitro characterisation of the novel positive allosteric modulators of the mGlu5 receptor, LSN2463359 and LSN2814617, and their effects on sleep architecture and operant responding in the rat

(2012) Gary Gilmour et al.   NEUROPHARMACOLOGY

Progress toward Positive Allosteric Modulators of the Metabotropic Glutamate Receptor Subtype 5 (mGlu5)

(2011) Shaun R. Stauffer   ACS Chemical Neuroscience

Positive Allosteric Modulators of Type 5 Metabotropic Glutamate Receptors (mGluR5) and Their Therapeutic Potential for the Treatment of CNS Disorders

(2011) Richard M. Cleva et al.   MOLECULES

SO2-Induced Neurotoxicity Is Mediated by Cyclooxygenases-2-Derived Prostaglandin E2 and its Downstream Signaling Pathway in Rat Hippocampal Neurons

(2011) Nan Sang et al.   TOXICOLOGICAL SCIENCES

Metabotropic Glutamate Receptors: Physiology, Pharmacology, and Disease

(2010) Colleen M. Niswender et al.   Annual Review of Pharmacology and Toxicology

Sulfur dioxide upregulates the aortic nitric oxide pathway in rats

(2010) Junling Li et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Activation of type 5 metabotropic glutamate receptors attenuates deficits in cognitive flexibility induced by NMDA receptor blockade

(2010) Mark R. Stefani et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

SO2inhalation modulates the expression of apoptosis-related genes in rat hippocampus via its derivativesin vivo

(2010) Yang Yun et al.   INHALATION TOXICOLOGY

Metabotropic glutamate receptor 5, but not 1, modulates NMDA receptor-mediated activation of neuronal nitric oxide synthase

(2010) Marta Llansola et al.   NEUROCHEMISTRY INTERNATIONAL

Differential effects of the mGluR5 positive allosteric modulator CDPPB in the cortex and striatum following repeated administration

(2010) Sophie Parmentier-Batteur et al.   NEUROPHARMACOLOGY

SO2 Inhalation Contributes to the Development and Progression of Ischemic Stroke in the Brain

(2010) Nan Sang et al.   TOXICOLOGICAL SCIENCES

Activation of Metabotropic Glutamate Receptor 5 Modulates Microglial Reactivity and Neurotoxicity by Inhibiting NADPH Oxidase

(2009) David J. Loane et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Aldose reductase mediates myocardial ischemia-reperfusion injury in part by opening mitochondrial permeability transition pore

(2008) Radha Ananthakrishnan et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Positive Allosteric Modulation of mGluR5 Receptors Facilitates Extinction of a Cocaine Contextual Memory

(2008) Justin T. Gass et al.   BIOLOGICAL PSYCHIATRY

SO2 inhalation induces protein oxidation, DNA–protein crosslinks and apoptosis in rat hippocampus

(2008) Nan Sang et al.   ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY

Metabotropic glutamate receptor 5 activation inhibits microglial associated inflammation and neurotoxicity

(2008) Kimberly R. Byrnes et al.   GLIA

Metabotropic glutamate receptors as targets for multipotential treatment of neurological disorders

(2008) Kimberly R. Byrnes et al.   Neurotherapeutics

Human health effects of air pollution

(2007) Marilena Kampa et al.   ENVIRONMENTAL POLLUTION