Chromosome integrity checkpoints in stem and progenitor cells: transitions upon differentiation, pathogenesis, and aging

Aurora-A overexpression is linked to development of aggressive teratomas derived from humans iPS cells

(2018) Seiga Ohmine et al.   ONCOLOGY REPORTS

Centrosome and spindle assembly checkpoint loss leads to neural apoptosis and reduced brain size

(2017) John S. Poulton et al.   JOURNAL OF CELL BIOLOGY

The Spindle Assembly Checkpoint Is Required for Hematopoietic Progenitor Cell Engraftment

(2017) Andreas Brown et al.   Stem Cell Reports

Diagnosis and management of AML in adults: 2017 ELN recommendations from an international expert panel

(2016) Hartmut Döhner et al.   BLOOD

Aging of hematopoietic stem cells: DNA damage and mutations?

(2016) Bettina M. Moehrle et al.   EXPERIMENTAL HEMATOLOGY

Aneuploidy impairs hematopoietic stem cell fitness and is selected against in regenerating tissues in vivo

(2016) Sarah J. Pfau et al.   GENES & DEVELOPMENT

Targeting the kinase activities of ATR and ATM exhibits antitumoral activity in mouse models ofMLL-rearranged AML

(2016) Isabel Morgado-Palacin et al.   Science Signaling

Targeting the kinase activities of ATR and ATM exhibits antitumoral activity in mouse models ofMLL-rearranged AML

(2016) Isabel Morgado-Palacin et al.   Science Signaling

Comparison of Magnetic Resonance Imaging and Serum Biomarkers for Detection of Human Pluripotent Stem Cell-Derived Teratomas

(2016) Johannes Riegler et al.   Stem Cell Reports

Relationship of spindle assembly checkpoint fidelity to species body mass, lifespan, and developmental rate

(2016) Antonello Lorenzini et al.   Aging-US

Stochastic modeling indicates that aging and somatic evolution in the hematopoietic system are driven by non-cell-autonomous processes

(2016) Andrii I. Rozhok et al.   Aging-US

Selective killing of G2 decatenation checkpoint defective colon cancer cells by catalytic topoisomerase II inhibitor

(2015) Chetan Kumar Jain et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Investigating the Regulation of Stem and Progenitor Cell Mitotic Progression by In Situ Imaging

(2015) Abigail R. Gerhold et al.   CURRENT BIOLOGY

The spindle checkpoint and chromosome segregation in meiosis

(2015) Gary J. Gorbsky   FEBS Journal

Proteins of the mitotic checkpoint and spindle are related to chromosomal instability and unfavourable prognosis in patients with myelodysplastic syndrome

(2015) Kelly Roveran Genga et al.   JOURNAL OF CLINICAL PATHOLOGY

Fundamental properties of unperturbed haematopoiesis from stem cells in vivo

(2015) Katrin Busch et al.   NATURE

Spindle assembly checkpoint inactivation fails to suppress neuroblast tumour formation in aurA mutant Drosophila

(2015) Renaud Caous et al.   Nature Communications

Closing the Mad2 cycle

(2015) Andrea Musacchio   eLife

The Spindle Assembly Checkpoint Safeguards Genomic Integrity of Skeletal Muscle Satellite Cells

(2015) Swapna Kollu et al.   Stem Cell Reports

Aurora Kinase Inhibitors: Current Status and Outlook

(2015) Vassilios Bavetsias et al.   Frontiers in Oncology

Loss of CHFR in Human Mammary Epithelial Cells Causes Genomic Instability by Disrupting the Mitotic Spindle Assembly Checkpoint

(2015) Lisa M. Privette et al.   NEOPLASIA

Chromosome instability induced by Mps1 and p53 mutation generates aggressive lymphomas exhibiting aneuploidy-induced stress

(2014) Floris Foijer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Making an effective switch at the kinetochore by phosphorylation and dephosphorylation

(2013) Hironori Funabiki et al.   CHROMOSOMA

BubR1 is frequently repressed in acute myeloid leukemia and its re-expression sensitizes cells to antimitotic therapy

(2013) D. Schnerch et al.   HAEMATOLOGICA

Defective Decatenation Checkpoint Function Is a Common Feature of Melanoma

(2013) Kelly Brooks et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Spindle checkpoint deficiency is tolerated by murine epidermal cells but not hair follicle stem cells

(2013) F. Foijer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Stem and progenitor cells in myelodysplastic syndromes show aberrant stage-specific expansion and harbor genetic and epigenetic alterations

(2012) B. Will et al.   BLOOD

Increased expression of BubR1 protects against aneuploidy and cancer and extends healthy lifespan

(2012) Darren J. Baker et al.   NATURE CELL BIOLOGY

DNA damage checkpoints in stem cells, ageing and cancer

(2012) Tobias Sperka et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Coexistence of LMPP-like and GMP-like Leukemia Stem Cells in Acute Myeloid Leukemia

(2011) Nicolas Goardon et al.   CANCER CELL

2011: the immune hallmarks of cancer

(2011) Federica Cavallo et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Bub1 overexpression induces aneuploidy and tumor formation through Aurora B kinase hyperactivation

(2011) Robin M. Ricke et al.   JOURNAL OF CELL BIOLOGY

Protein Interaction Domain Mapping of Human Kinetochore Protein Blinkin Reveals a Consensus Motif for Binding of Spindle Assembly Checkpoint Proteins Bub1 and BubR1

(2011) T. Kiyomitsu et al.   MOLECULAR AND CELLULAR BIOLOGY

Prolonged mitotic arrest triggers partial activation of apoptosis, resulting in DNA damage and p53 induction

(2011) James D. Orth et al.   MOLECULAR BIOLOGY OF THE CELL

How APC/C–Cdc20 changes its substrate specificity in mitosis

(2011) Daisuke Izawa et al.   NATURE CELL BIOLOGY

Rad9A Is Required for G2Decatenation Checkpoint and to Prevent Endoreduplication in Response to Topoisomerase II Inhibition

(2010) Deborah A. Greer Card et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

High expression of AURKA and AURKB is associated with unfavorable cytogenetic abnormalities and high white blood cell count in patients with acute myeloid leukemia

(2010) Antonio R. Lucena-Araujo et al.   LEUKEMIA RESEARCH

ETV6/RUNX1 abrogates mitotic checkpoint function and targets its key player MAD2L1

(2010) G Krapf et al.   ONCOGENE

Evidence That a Defective Spindle Assembly Checkpoint Is Not the Primary Cause of Maternal Age-Associated Aneuploidy in Mouse Eggs1

(2009) Francesca E. Duncan et al.   BIOLOGY OF REPRODUCTION

Metnase mediates chromosome decatenation in acute leukemia cells

(2009) J. Wray et al.   BLOOD

Polo-like kinase 1 is overexpressed in acute myeloid leukemia and its inhibition preferentially targets the proliferation of leukemic cells

(2009) A. G. Renner et al.   BLOOD

Up-regulation of WRN and DNA ligase III  in chronic myeloid leukemia: consequences for the repair of DNA double-strand breaks

(2008) A. Sallmyr et al.   BLOOD

Telomerase Reverse Transcriptase Delays Aging in Cancer-Resistant Mice

(2008) Antonia Tomás-Loba et al.   CELL

Topoisomerase IIα controls the decatenation checkpoint

(2008) Kuntian Luo et al.   NATURE CELL BIOLOGY

Mouse Hematopoietic Stem Cells, Unlike Human and Mouse Embryonic Stem Cells, Exhibit Checkpoint–Apoptosis Coupling

(2008) Sara Rohrabaugh et al.   STEM CELLS AND DEVELOPMENT